Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes

Neuropharmacology

Volumn 60, Issue 6, 2011, Pages 910-920

  Gupta, Amit ^a,b   Bisht, Bharti ^a,c   Dey, Chinmoy Sankar ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Hyperinsulinemia; Metformin; Neuronal insulin resistance; Type 3 diabetes

Indexed keywords

GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DRUG TARGETING; HYPERINSULINEMIA; IN VITRO STUDY; INSULIN RESISTANCE; MOUSE; NERVE DEGENERATION; NEURONAL INSULIN RESISTANCE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PHASIC INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CELL LINE; CHOLINESTERASES; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; METFORMIN; MICE; NEURONS; PEPTIDE FRAGMENTS; PHOSPHATIDYLINOSITOL 3-KINASES;

EID: 79952439187     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.01.033     Document Type: Article

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