메뉴 건너뛰기




Volumn 29, Issue 5, 2009, Pages 954-963

PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease

Author keywords

Dopamine; Glia; Inflammation; Motor behaviour; MPP+; Tyrosine hydroxylase

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; CD11B ANTIGEN; DOPAMINE; DYNORPHIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROBENECID; ROSIGLITAZONE; TYROSINE 3 MONOOXYGENASE;

EID: 61449237400     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2009.06657.x     Document Type: Article
Times cited : (184)

References (71)
  • 1
    • 0030175903 scopus 로고    scopus 로고
    • Synaptic plasticity in the caudate nucleus of patients with Parkinson's disease
    • Anglade, P., Mouatt-Prigent, A., Agid, Y. Hirsch, E. (1996) Synaptic plasticity in the caudate nucleus of patients with Parkinson's disease. Neurodegeneration, 5, 121 128.
    • (1996) Neurodegeneration , vol.5 , pp. 121-128
    • Anglade, P.1    Mouatt-Prigent, A.2    Agid, Y.3    Hirsch, E.4
  • 4
    • 33644864102 scopus 로고    scopus 로고
    • PPAR-gamma agonists as regulators of microglial activation and brain inflammation. [Review]
    • Bernardo, A. Minghetti, L. (2006) PPAR-gamma agonists as regulators of microglial activation and brain inflammation. [Review]. Curr. Pharm. Des., 12, 93 109.
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 93-109
    • Bernardo, A.1    Minghetti, L.2
  • 5
    • 44049097234 scopus 로고    scopus 로고
    • Regulation of glial cell functions by PPAR-gamma Natural and synthetic agonists
    • Bernardo, A. Minghetti, L. (2008) Regulation of glial cell functions by PPAR-gamma Natural and synthetic agonists. PPAR Res., 2008, 864140.
    • (2008) PPAR Res. , vol.2008 , pp. 864140
    • Bernardo, A.1    Minghetti, L.2
  • 6
    • 0030984413 scopus 로고    scopus 로고
    • A chronic MPTP model reproducing the slow evolution of Parkinson's disease: Evolution of motor symptoms in the monkey
    • Bezard, E., Imbert, C., Deloire, X., Bioulac, B. Gross, C.E. (1997) A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey. Brain Res., 766, 107 112.
    • (1997) Brain Res. , vol.766 , pp. 107-112
    • Bezard, E.1    Imbert, C.2    Deloire, X.3    Bioulac, B.4    Gross, C.E.5
  • 7
    • 0034571915 scopus 로고    scopus 로고
    • Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice
    • Bezard, E., Dovero, S., Imbert, C., Boraud, T. Gross, C.E. (2000) Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice. Synapse, 38, 363 368.
    • (2000) Synapse , vol.38 , pp. 363-368
    • Bezard, E.1    Dovero, S.2    Imbert, C.3    Boraud, T.4    Gross, C.E.5
  • 8
    • 0028914811 scopus 로고
    • Long-term induction of tyrosine hydroxylase expression: Compensatory response to partial degeneration of the dopaminergic nigrostriatal system in the rat brain
    • Blanchard, V., Chritin, M., Vyas, S., Savasta, M., Feuerstein, C., Agid, Y., Javoy-Agid, F. Raisman-Vozari, R. (1995) Long-term induction of tyrosine hydroxylase expression: compensatory response to partial degeneration of the dopaminergic nigrostriatal system in the rat brain. J. Neurochem., 64, 1669 1679.
    • (1995) J. Neurochem. , vol.64 , pp. 1669-1679
    • Blanchard, V.1    Chritin, M.2    Vyas, S.3    Savasta, M.4    Feuerstein, C.5    Agid, Y.6    Javoy-Agid, F.7    Raisman-Vozari, R.8
  • 10
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • Braissant, O., Foufelle, F., Scotto, C., Dauça, M. Wahli, W. (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology, 137, 354 366.
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauça, M.4    Wahli, W.5
  • 11
    • 0036326074 scopus 로고    scopus 로고
    • Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease
    • Breidert, T., Callebert, J., Heneka, M.T., Landreth, G., Launay, J.M. Hirsch, E.C. (2002) Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. J. Neurochem., 82, 615 624.
    • (2002) J. Neurochem. , vol.82 , pp. 615-624
    • Breidert, T.1    Callebert, J.2    Heneka, M.T.3    Landreth, G.4    Launay, J.M.5    Hirsch, E.C.6
  • 12
    • 0033152442 scopus 로고    scopus 로고
    • Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice
    • Bush, T.G., Puvanachandra, N., Horner, C.H., Polito, A., Ostenfeld, T., Svendsen, C.N., Mucke, L., Johnson, M.H. Sofroniew, M.V. (1999) Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron, 23, 297 308.
    • (1999) Neuron , vol.23 , pp. 297-308
    • Bush, T.G.1    Puvanachandra, N.2    Horner, C.H.3    Polito, A.4    Ostenfeld, T.5    Svendsen, C.N.6    Mucke, L.7    Johnson, M.H.8    Sofroniew, M.V.9
  • 13
    • 33644878101 scopus 로고    scopus 로고
    • Cumulative effect of norepinephrine and dopamine carrier blockade on extracellular dopamine increase in the nucleus accumbens shell, bed nucleus of stria terminalis and prefrontal cortex
    • Carboni, E., Silvagni, A., Vacca, C. Di Chiara, G. (2006) Cumulative effect of norepinephrine and dopamine carrier blockade on extracellular dopamine increase in the nucleus accumbens shell, bed nucleus of stria terminalis and prefrontal cortex. J. Neurochem., 96, 473 481.
    • (2006) J. Neurochem. , vol.96 , pp. 473-481
    • Carboni, E.1    Silvagni, A.2    Vacca, C.3    Di Chiara, G.4
  • 14
    • 17144396262 scopus 로고    scopus 로고
    • Different responsiveness of striatonigral and striatopallidal neurons to L-DOPA after a subchronic intermittent L-DOPA treatment
    • Carta, A.R., Tronci, E., Pinna, A. Morelli, M. (2005) Different responsiveness of striatonigral and striatopallidal neurons to L-DOPA after a subchronic intermittent L-DOPA treatment. Eur. J. Neurosci., 21, 1196 1204.
    • (2005) Eur. J. Neurosci. , vol.21 , pp. 1196-1204
    • Carta, A.R.1    Tronci, E.2    Pinna, A.3    Morelli, M.4
  • 15
    • 0033677879 scopus 로고    scopus 로고
    • Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism
    • Chase, T.N. Oh, J.D. (2000) Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism. Trends Neurosci., 23, S86 S91.
    • (2000) Trends Neurosci. , vol.23
    • Chase, T.N.1    Oh, J.D.2
  • 16
    • 51649110738 scopus 로고    scopus 로고
    • PPAR: A therapeutic target in Parkinson's disease
    • Chaturvedi, R.K. Beal, M.F. (2008) PPAR: a therapeutic target in Parkinson's disease. J. Neurochem., 106, 506 518.
    • (2008) J. Neurochem. , vol.106 , pp. 506-518
    • Chaturvedi, R.K.1    Beal, M.F.2
  • 18
    • 0030859754 scopus 로고    scopus 로고
    • Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
    • Colburn, R.W., DeLeo, J.A., Rickman, A.J., Yeager, M.P., Kwon, P. Hickey, W.F. (1997) Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat. J. Neuroimmunol., 79, 163 175.
    • (1997) J. Neuroimmunol. , vol.79 , pp. 163-175
    • Colburn, R.W.1    Deleo, J.A.2    Rickman, A.J.3    Yeager, M.P.4    Kwon, P.5    Hickey, W.F.6
  • 19
    • 0035427881 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs) and peroxisomes in rat cortical and cerebellar astrocytes
    • Cristiano, L., Bernardo, A. Cerù, M.P. (2001) Peroxisome proliferator-activated receptors (PPARs) and peroxisomes in rat cortical and cerebellar astrocytes. J. Neurocytol., 30, 671 683.
    • (2001) J. Neurocytol. , vol.30 , pp. 671-683
    • Cristiano, L.1    Bernardo, A.2    Cerù, M.P.3
  • 20
    • 0031930111 scopus 로고    scopus 로고
    • Distribution of mRNAs encoding the peroxisome proliferator-activated receptor alpha, beta, and gamma and the retinoid X receptor alpha, beta, and gamma in rat central nervous system
    • Cullingford, T.E., Bhakoo, K., Peuchen, S., Dolphin, C.T., Patel, R. Clark, J.B. (1998) Distribution of mRNAs encoding the peroxisome proliferator-activated receptor alpha, beta, and gamma and the retinoid X receptor alpha, beta, and gamma in rat central nervous system. J. Neurochem., 70, 1366 1375.
    • (1998) J. Neurochem. , vol.70 , pp. 1366-1375
    • Cullingford, T.E.1    Bhakoo, K.2    Peuchen, S.3    Dolphin, C.T.4    Patel, R.5    Clark, J.B.6
  • 21
    • 0347087323 scopus 로고    scopus 로고
    • Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with i kappa B alpha induction and block of NF kappa B and iNOS activation
    • Dehmer, T., Heneka, M.T., Sastre, M., Dichgans, J. Schulz, J.B. (2004) Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. J. Neurochem., 88, 494 501.
    • (2004) J. Neurochem. , vol.88 , pp. 494-501
    • Dehmer, T.1    Heneka, M.T.2    Sastre, M.3    Dichgans, J.4    Schulz, J.B.5
  • 22
    • 0034114557 scopus 로고    scopus 로고
    • Relationship among nigrostriatal denervation, parkinsonism, and dyskinesias in the MPTP primate model
    • Di Monte, D.A., McCormack, A., Petzinger, G., Janson, A.M., Quik, M. Langston, W.J. (2000) Relationship among nigrostriatal denervation, parkinsonism, and dyskinesias in the MPTP primate model. Mov. Disord., 15, 459 466.
    • (2000) Mov. Disord. , vol.15 , pp. 459-466
    • Di Monte, D.A.1    McCormack, A.2    Petzinger, G.3    Janson, A.M.4    Quik, M.5    Langston, W.J.6
  • 23
    • 33745000762 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor agonist regulation of glial activation: Relevance to CNS inflammatory disorders. [Review]
    • Drew, P.D., Xu, J., Storer, P.D., Chavis, J.A. Racke, M.K. (2006) Peroxisome proliferator-activated receptor agonist regulation of glial activation: relevance to CNS inflammatory disorders. [Review]. Neurochem. Int., 49, 183 189.
    • (2006) Neurochem. Int. , vol.49 , pp. 183-189
    • Drew, P.D.1    Xu, J.2    Storer, P.D.3    Chavis, J.A.4    Racke, M.K.5
  • 24
    • 0344407056 scopus 로고    scopus 로고
    • Motor behaviour deficits and their histopathological and functional correlates in the nigrostriatal system of dopamine transporter knockout mice
    • Fernagut, P.O., Chalon, S., Diguet, E., Guilloteau, D., Tison, F. Jaber, M. (2003) Motor behaviour deficits and their histopathological and functional correlates in the nigrostriatal system of dopamine transporter knockout mice. Neuroscience, 116, 1123 1130.
    • (2003) Neuroscience , vol.116 , pp. 1123-1130
    • Fernagut, P.O.1    Chalon, S.2    Diguet, E.3    Guilloteau, D.4    Tison, F.5    Jaber, M.6
  • 27
    • 34249071696 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats
    • García-Bueno, B., Caso, J.R., Pérez-Nievas, B.G., Lorenzo, P. Leza, J.C. (2007) Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. Neuropsychopharmacology, 32, 1251 1260.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 1251-1260
    • García-Bueno, B.1    Caso, J.R.2    Pérez-Nievas, B.G.3    Lorenzo, P.4    Leza, J.C.5
  • 28
    • 0345016033 scopus 로고    scopus 로고
    • D1 dopamine receptor supersensitivity in the dopamine-depleted striatum animal model of Parkinson's disease
    • Gerfen, C.R. (2003) D1 dopamine receptor supersensitivity in the dopamine-depleted striatum animal model of Parkinson's disease. Neuroscientist, 9, 455 462.
    • (2003) Neuroscientist , vol.9 , pp. 455-462
    • Gerfen, C.R.1
  • 30
    • 0034666289 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo
    • Heneka, M.T., Klockgether, T. Feinstein, D.L. (2000) Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. J. Neurosci., 20, 1.
    • (2000) J. Neurosci. , vol.20 , pp. 1
    • Heneka, M.T.1    Klockgether, T.2    Feinstein, D.L.3
  • 31
    • 34548494847 scopus 로고    scopus 로고
    • Drug insight: Effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders
    • Heneka, M.T., Landreth, G.E. Hüll, M. (2007) Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders. Nat. Clin. Pract. Neurol., 3, 496 504.
    • (2007) Nat. Clin. Pract. Neurol. , vol.3 , pp. 496-504
    • Heneka, M.T.1    Landreth, G.E.2    Hüll, M.3
  • 34
    • 33846610917 scopus 로고    scopus 로고
    • Rosiglitazone protects human neuroblastoma SH-SY5Y cells against MPP+ induced cytotoxicity via inhibition of mitochondrial dysfunction and ROS production
    • Jung, T.W., Lee, J.Y., Shim, W.S., Kang, E.S., Kim, S.K., Ahn, C.W., Lee, H.C. Cha, B.S. (2007) Rosiglitazone protects human neuroblastoma SH-SY5Y cells against MPP+ induced cytotoxicity via inhibition of mitochondrial dysfunction and ROS production. J. Neurol. Sci., 253, 53 60.
    • (2007) J. Neurol. Sci. , vol.253 , pp. 53-60
    • Jung, T.W.1    Lee, J.Y.2    Shim, W.S.3    Kang, E.S.4    Kim, S.K.5    Ahn, C.W.6    Lee, H.C.7    Cha, B.S.8
  • 35
    • 0028111923 scopus 로고
    • Regulation of glucose transport by pioglitazone in cultured muscle cells
    • el-Kebbi, I.M., Roser, S. Pollet, R.J. (1994) Regulation of glucose transport by pioglitazone in cultured muscle cells. Metabolism, 43, 953 958.
    • (1994) Metabolism , vol.43 , pp. 953-958
    • El-Kebbi, I.M.1    Roser, S.2    Pollet, R.J.3
  • 36
    • 11844269951 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis
    • Kiaei, M., Kipiani, K., Chen, J., Calingasan, N.Y. Beal, M.F. (2005) Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis. Exp. Neurol., 191, 331 336.
    • (2005) Exp. Neurol. , vol.191 , pp. 331-336
    • Kiaei, M.1    Kipiani, K.2    Chen, J.3    Calingasan, N.Y.4    Beal, M.F.5
  • 37
    • 26844468856 scopus 로고    scopus 로고
    • Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients
    • Klotz, L., Schmidt, M., Giese, T., Sastre, M., Knolle, P., Klockgether, T. Heneka, M.T. (2005) Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients. J. Immunol., 175, 4948 4955.
    • (2005) J. Immunol. , vol.175 , pp. 4948-4955
    • Klotz, L.1    Schmidt, M.2    Giese, T.3    Sastre, M.4    Knolle, P.5    Klockgether, T.6    Heneka, M.T.7
  • 40
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston, J.W., Forno, L.S., Tetrud, J., Reeves, A.G., Kaplan, J.A. Karluk, D. (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol., 46, 598 605.
    • (1999) Ann. Neurol. , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 41
    • 33645323521 scopus 로고    scopus 로고
    • Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    • Luo, Y., Yin, W., Signore, A.P., Zhang, F., Hong, Z., Wang, S., Graham, S.H. Chen, J. (2006) Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. J. Neurochem., 97, 435 448.
    • (2006) J. Neurochem. , vol.97 , pp. 435-448
    • Luo, Y.1    Yin, W.2    Signore, A.P.3    Zhang, F.4    Hong, Z.5    Wang, S.6    Graham, S.H.7    Chen, J.8
  • 42
    • 34548400209 scopus 로고    scopus 로고
    • Model fusion, the next phase in developing animal models for Parkinson's disease
    • Manning-Bog, A.B. Langston, J.W. (2007) Model fusion, the next phase in developing animal models for Parkinson's disease. Neurotox. Res., 11, 219 240.
    • (2007) Neurotox. Res. , vol.11 , pp. 219-240
    • Manning-Bog, A.B.1    Langston, J.W.2
  • 43
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer, P.L., Itagaki, S., Boyes, B.E. McGeer, E.G. (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology, 38, 1285 1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 44
    • 0242384667 scopus 로고    scopus 로고
    • Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine administration
    • McGeer, P.L., Schwab, C., Parent, A. Doudet, D. (2003) Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-l,2, 3,6-tetrahydropyridine administration. Ann. Neurol., 54, 599 604.
    • (2003) Ann. Neurol. , vol.54 , pp. 599-604
    • McGeer, P.L.1    Schwab, C.2    Parent, A.3    Doudet, D.4
  • 45
    • 47349104402 scopus 로고    scopus 로고
    • Glial reactions in Parkinson's disease
    • McGeer, P.L. McGeer, E.G. (2008) Glial reactions in Parkinson's disease. Mov. Disord., 23, 474 483.
    • (2008) Mov. Disord. , vol.23 , pp. 474-483
    • McGeer, P.L.1    McGeer, E.G.2
  • 46
    • 33748300291 scopus 로고    scopus 로고
    • Behavioral models of Parkinson's disease in rodents: A new look at an old problem. [Review]
    • Meredith, G.E. Kang, U.J. (2006) Behavioral models of Parkinson's disease in rodents: a new look at an old problem. [Review]. Mov. Disord., 21, 1595 1606.
    • (2006) Mov. Disord. , vol.21 , pp. 1595-1606
    • Meredith, G.E.1    Kang, U.J.2
  • 47
    • 0037159608 scopus 로고    scopus 로고
    • Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease
    • Meredith, G.E., Totterdell, S., Petroske, E., Santa Cruz, K., Callison, R.C. Jr. Lau, Y.S. (2002) Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease. Brain Res., 22, 156 165.
    • (2002) Brain Res. , vol.22 , pp. 156-165
    • Meredith, G.E.1    Totterdell, S.2    Petroske, E.3    Santa Cruz, K.4    Callison Jr., R.C.5    Lau, Y.S.6
  • 48
    • 47049105408 scopus 로고    scopus 로고
    • Activated microglia persist in the substantia nigra of a chronic MPTP mouse model of Parkinson's disease
    • In. Bolam, J.P., Ingham, C.A. Magill, P.J. Eds. Springer Science, Singapore.
    • Meredith, G.E., Dervan, A.G. Totterdell, S. (2005) Activated microglia persist in the substantia nigra of a chronic MPTP mouse model of Parkinson's disease. In Bolam, J.P., Ingham, C.A. Magill, P.J Eds The Basal Ganglia VIII. Springer Science, Singapore.
    • (2005) The Basal Ganglia VIII.
    • Meredith, G.E.1    Dervan, A.G.2    Totterdell, S.3
  • 49
    • 0032581386 scopus 로고    scopus 로고
    • Spontaneous regeneration of nigrostriatal dopaminergic neurons in MPTP-treated C57BL/6 mice
    • Mitsumoto, Y., Watanabe, A., Mori, A. Koga, N. (1998) Spontaneous regeneration of nigrostriatal dopaminergic neurons in MPTP-treated C57BL/6 mice. Biochem. Biophys. Res. Commun., 248, 660 663.
    • (1998) Biochem. Biophys. Res. Commun. , vol.248 , pp. 660-663
    • Mitsumoto, Y.1    Watanabe, A.2    Mori, A.3    Koga, N.4
  • 50
    • 0345118108 scopus 로고    scopus 로고
    • Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS
    • Moreno, S., Farioli-Vecchioli, S. Cerù, M.P. (2004) Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS. Neuroscience, 123, 131 145.
    • (2004) Neuroscience , vol.123 , pp. 131-145
    • Moreno, S.1    Farioli-Vecchioli, S.2    Cerù, M.P.3
  • 51
    • 33749508895 scopus 로고    scopus 로고
    • Essential protective roles of reactive astrocytes in traumatic brain injury
    • Myer, D.J., Gurkoff, G.G., Lee, S.M., Hovda, D.A. Sofroniew, M.V. (2006) Essential protective roles of reactive astrocytes in traumatic brain injury. Brain, 129, 2761 2772.
    • (2006) Brain , vol.129 , pp. 2761-2772
    • Myer, D.J.1    Gurkoff, G.G.2    Lee, S.M.3    Hovda, D.A.4    Sofroniew, M.V.5
  • 52
    • 33646338882 scopus 로고    scopus 로고
    • Early signs of neuronal apoptosis in the substantia nigra pars compacta of the progressive neurodegenerative mouse 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine/probenecid model of Parkinson's disease
    • Novikova, L., Garris, B.L., Garris, D.R. Lau, Y.S. (2006) Early signs of neuronal apoptosis in the substantia nigra pars compacta of the progressive neurodegenerative mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of Parkinson's disease. Neuroscience, 140, 67 76.
    • (2006) Neuroscience , vol.140 , pp. 67-76
    • Novikova, L.1    Garris, B.L.2    Garris, D.R.3    Lau, Y.S.4
  • 53
    • 0038352039 scopus 로고    scopus 로고
    • 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia
    • Park, E.J., Park, S.Y., Joe, E.H. Jou, I. (2003) 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. J. Biol. Chem., 278, 14747 14752.
    • (2003) J. Biol. Chem. , vol.278 , pp. 14747-14752
    • Park, E.J.1    Park, S.Y.2    Joe, E.H.3    Jou, I.4
  • 54
    • 33847093475 scopus 로고    scopus 로고
    • Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats
    • Park, S.W., Yi, J.H., Miranpuri, G., Satriotomo, I., Bowen, K., Resnick, D.K. Vemuganti, R. (2007) Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats. J. Pharmacol. Exp. Ther., 320, 1002 1012.
    • (2007) J. Pharmacol. Exp. Ther. , vol.320 , pp. 1002-1012
    • Park, S.W.1    Yi, J.H.2    Miranpuri, G.3    Satriotomo, I.4    Bowen, K.5    Resnick, D.K.6    Vemuganti, R.7
  • 56
    • 0035960066 scopus 로고    scopus 로고
    • Mouse model of Parkinsonism: A comparison between subacute MPTP and chronic MPTP/probenecid treatment
    • Petroske, E., Meredith, G.E., Callen, S., Totterdell, S. Lau, Y.S. (2001) Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment. Neuroscience, 106, 589 601.
    • (2001) Neuroscience , vol.106 , pp. 589-601
    • Petroske, E.1    Meredith, G.E.2    Callen, S.3    Totterdell, S.4    Lau, Y.S.5
  • 57
    • 42949100802 scopus 로고    scopus 로고
    • The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B
    • Quinn, L.P., Crook, B., Hows, M.E., Vidgeon-Hart, M., Chapman, H., Upton, N., Medhurst, A.D. Virley, D.J. (2008) The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B. Br. J. Pharmacol., 154, 226 233.
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 226-233
    • Quinn, L.P.1    Crook, B.2    Hows, M.E.3    Vidgeon-Hart, M.4    Chapman, H.5    Upton, N.6    Medhurst, A.D.7    Virley, D.J.8
  • 58
    • 34547380204 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and Parkinson's disease: Are microglia pathogenic in either disorder? [Review]
    • Rogers, J., Mastroeni, D., Leonard, B., Joyce, J. Grover, A. (2007) Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? [Review]. Int. Rev. Neurobiol., 82, 235 246.
    • (2007) Int. Rev. Neurobiol. , vol.82 , pp. 235-246
    • Rogers, J.1    Mastroeni, D.2    Leonard, B.3    Joyce, J.4    Grover, A.5
  • 60
    • 0035214256 scopus 로고    scopus 로고
    • Neurochemical findings in the MPTP model of Parkinson's disease
    • Schmidt, N. Ferger, B. (2001) Neurochemical findings in the MPTP model of Parkinson's disease. J. Neural Transm., 108, 1263 1282.
    • (2001) J. Neural Transm. , vol.108 , pp. 1263-1282
    • Schmidt, N.1    Ferger, B.2
  • 61
    • 0034804726 scopus 로고    scopus 로고
    • Pioglitazone mechanism of action
    • Smith, U. (2001) Pioglitazone mechanism of action. Int J. Clin. Pract. Suppl., 121, 13 18.
    • (2001) Int J. Clin. Pract. Suppl. , vol.121 , pp. 13-18
    • Smith, U.1
  • 62
    • 25144440471 scopus 로고    scopus 로고
    • Reactive astrocytes in neural repair and protection
    • Sofroniew, M.V. (2005) Reactive astrocytes in neural repair and protection. Neuroscientist, 11, 400 407.
    • (2005) Neuroscientist , vol.11 , pp. 400-407
    • Sofroniew, M.V.1
  • 64
    • 0035134830 scopus 로고    scopus 로고
    • Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease
    • Teismann, P. Ferger, B. (2001) Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease. Synapse, 39, 167 174.
    • (2001) Synapse , vol.39 , pp. 167-174
    • Teismann, P.1    Ferger, B.2
  • 65
    • 34548637886 scopus 로고    scopus 로고
    • Differential ability of a thiazolidinedione PPARgamma agonist to attenuate cytokine secretion in primary microglia and macrophage-like cells
    • Woster, A.P. Combs, C.K. (2007) Differential ability of a thiazolidinedione PPARgamma agonist to attenuate cytokine secretion in primary microglia and macrophage-like cells. J. Neurochem., 103, 67 76.
    • (2007) J. Neurochem. , vol.103 , pp. 67-76
    • Woster, A.P.1    Combs, C.K.2
  • 66
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    • Wu, D.C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.K., Ischiropoulos, H. Przedborski, S. (2002) Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model of Parkinson disease. J. Neurosci., 22, 1763 1771.
    • (2002) J. Neurosci. , vol.22 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6    Choi, D.K.7    Ischiropoulos, H.8    Przedborski, S.9
  • 67
    • 33846468972 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia
    • Xu, J. Drew, P.D. (2007) Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia. J. Immunol., 178, 1904 1913.
    • (2007) J. Immunol. , vol.178 , pp. 1904-1913
    • Xu, J.1    Drew, P.D.2
  • 68
    • 0041921071 scopus 로고    scopus 로고
    • Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease
    • Yan, Q., Zhang, J., Liu, H., Bbu-Khan, S., Vassar, R., Biere, A.L., Citron, M. Landreth, G. (2003) Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J. Neurosci., 23, 7504 7509.
    • (2003) J. Neurosci. , vol.23 , pp. 7504-7509
    • Yan, Q.1    Zhang, J.2    Liu, H.3    Bbu-Khan, S.4    Vassar, R.5    Biere, A.L.6    Citron, M.7    Landreth, G.8
  • 69
    • 33746089104 scopus 로고    scopus 로고
    • Rat model of Parkinson's disease: Chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+)
    • Yazdani, U., German, D.C., Liang, C.L., Manzino, L., Sonsalla, P.K. Zeevalk, G.D. (2006) Rat model of Parkinson's disease: chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+). Exp. Neurol., 200, 172 183.
    • (2006) Exp. Neurol. , vol.200 , pp. 172-183
    • Yazdani, U.1    German, D.C.2    Liang, C.L.3    Manzino, L.4    Sonsalla, P.K.5    Zeevalk, G.D.6
  • 70
    • 1942468747 scopus 로고    scopus 로고
    • Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: Involvements of Bcl-2 and Bax
    • Youdim, M.B. Arraf, Z. (2004) Prevention of MPTP (N-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax. Neuropharmacology, 46, 1130 1140.
    • (2004) Neuropharmacology , vol.46 , pp. 1130-1140
    • Youdim, M.B.1    Arraf, Z.2
  • 71
    • 33745983234 scopus 로고    scopus 로고
    • Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats
    • Zhao, Y., Patzer, A., Herdegen, T., Gohlke, P. Culman, J. (2006) Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats. FASEB J., 20, 1162 1175.
    • (2006) FASEB J. , vol.20 , pp. 1162-1175
    • Zhao, Y.1    Patzer, A.2    Herdegen, T.3    Gohlke, P.4    Culman, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.