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Volumn , Issue , 2009, Pages

Cross-Talk between PPARγ and insulin signaling and modulation of Insulin Sensitivity

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXY 3 [4 [5 (4 PHENOXY)PENT 1 YNYL]PHENYL] PROPIONIC ACID; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 (2,4 DIOXO 5 THIAZOLIDINYLMETHYL) 2 METHOXY N [4 (TRIFLUOROMETHYL)BENZYL]BENZAMIDE; ADENYLATE KINASE; ARYLMANDELIC ACID; CYTOKINE; FATTY ACID; GLITAZONE DERIVATIVE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LSN 862; LY 465608; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PHOSPHATIDYLINOSITOL 3 KINASE; PIOGLITAZONE; PROTEIN KINASE B; RAGAGLITAZAR; RETINOID X RECEPTOR; ROSIGLITAZONE; TRANSFORMING GROWTH FACTOR BETA1; TROGLITAZONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 77749295756     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2009/818945     Document Type: Review
Times cited : (189)

References (116)
  • 2
    • 0034712589 scopus 로고    scopus 로고
    • A PPAR mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus
    • Berger J., Patel H. V., Woods J. et al., A PPAR mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus Molecular and Cellular Endocrinology 2000 162 1-2 57 67
    • (2000) Molecular and Cellular Endocrinology , vol.162 , Issue.1-2 , pp. 57-67
    • Berger, J.1    Patel, H.V.2    Woods, J.3
  • 3
    • 0032505096 scopus 로고    scopus 로고
    • Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor- γ
    • Nolte R. T., Wisely G. B., Westin S. et al., Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ Nature 1998 395 6698 137 143
    • (1998) Nature , vol.395 , Issue.6698 , pp. 137-143
    • Nolte, R.T.1    Wisely, G.B.2    Westin, S.3
  • 4
    • 0033777133 scopus 로고    scopus 로고
    • Discrete roles for peroxisome proliferator-activated receptor and retinoid X receptor in recruiting nuclear receptor coactivators
    • Yang W., Rachez C., Freedman L. P., Discrete roles for peroxisome proliferator-activated receptor and retinoid X receptor in recruiting nuclear receptor coactivators Molecular and Cellular Biology 2000 20 21 8008 8017
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.21 , pp. 8008-8017
    • Yang, W.1    Rachez, C.2    Freedman, L.P.3
  • 5
    • 40049109970 scopus 로고    scopus 로고
    • Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis
    • Hansen M. K., Connolly T. M., Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis Current Opinion in Investigational Drugs 2008 9 3 247 255
    • (2008) Current Opinion in Investigational Drugs , vol.9 , Issue.3 , pp. 247-255
    • Hansen, M.K.1    Connolly, T.M.2
  • 7
    • 52949099182 scopus 로고    scopus 로고
    • PPAR- / agonists for type 2 diabetes and dyslipidemia: An adopted orphan still looking for a home
    • Billin A. N., PPAR- / agonists for type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home Expert Opinion on Investigational Drugs 2008 17 10 1465 1471
    • (2008) Expert Opinion on Investigational Drugs , vol.17 , Issue.10 , pp. 1465-1471
    • Billin, A.N.1
  • 8
    • 53849149299 scopus 로고    scopus 로고
    • Structure and physiological functions of the human peroxisome proliferator-activated receptor γ
    • Zieleniak A., Wjcik M., Woniak L. A., Structure and physiological functions of the human peroxisome proliferator-activated receptor γ Archivum Immunologiae et Therapiae Experimentalis 2008 56 5 331 345
    • (2008) Archivum Immunologiae et Therapiae Experimentalis , vol.56 , Issue.5 , pp. 331-345
    • Zieleniak, A.1    Wjcik, M.2    Woniak, L.A.3
  • 9
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors
    • Forman B. M., Chen J., Evans R. M., Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors and Proceedings of the National Academy of Sciences of the United States of America 1997 94 9 4312 4317
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.9 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 10
    • 0006132932 scopus 로고    scopus 로고
    • Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
    • Kliewer S. A., Sundseth S. S., Jones S. A. et al., Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ Proceedings of the National Academy of Sciences of the United States of America 1997 94 9 4318 4323
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.9 , pp. 4318-4323
    • Kliewer, S.A.1    Sundseth, S.S.2    Jones, S.A.3
  • 11
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
    • Krey G., Braissant O., LHorset F. et al., Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay Molecular Endocrinology 1997 11 6 779 791
    • (1997) Molecular Endocrinology , vol.11 , Issue.6 , pp. 779-791
    • Krey, G.1    Braissant, O.2    Lhorset, F.3
  • 14
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR γ
    • Nagy L., Tontonoz P., Alvarez J. G. A., Chen H., Evans R. M., Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ Cell 1998 93 2 229 240
    • (1998) Cell , vol.93 , Issue.2 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.A.3    Chen, H.4    Evans, R.M.5
  • 15
    • 12144288490 scopus 로고    scopus 로고
    • Lysophosphatidic acid induces neointima formation through PPARγ activation
    • Zhang C., Baker D. L., Yasuda S. et al., Lysophosphatidic acid induces neointima formation through PPARγ activation Journal of Experimental Medicine 2004 199 6 763 774
    • (2004) Journal of Experimental Medicine , vol.199 , Issue.6 , pp. 763-774
    • Zhang, C.1    Baker, D.L.2    Yasuda, S.3
  • 17
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann J. M., Lenhard J. M., Oliver B. B., Ringold G. M., Kliewer S. A., Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs Journal of Biological Chemistry 1997 272 6 3406 3410
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.6 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 18
    • 0026517080 scopus 로고
    • Enhancement of adipocyte differentiation by an insulin-sensitizing agent
    • Kletzien R. F., Clarke S. D., Ulrich R. G., Enhancement of adipocyte differentiation by an insulin-sensitizing agent Molecular Pharmacology 1992 41 2 393 398
    • (1992) Molecular Pharmacology , vol.41 , Issue.2 , pp. 393-398
    • Kletzien, R.F.1    Clarke, S.D.2    Ulrich, R.G.3
  • 19
    • 0030062325 scopus 로고    scopus 로고
    • The structureactivity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones
    • Willson T. M., Cobb J. E., Cowan D. J. et al., The structureactivity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones Journal of Medicinal Chemistry 1996 39 3 665 668
    • (1996) Journal of Medicinal Chemistry , vol.39 , Issue.3 , pp. 665-668
    • Willson, T.M.1    Cobb, J.E.2    Cowan, D.J.3
  • 20
    • 22344446185 scopus 로고    scopus 로고
    • A peroxisome proliferator-activated receptor α/γ dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent models of type 2 diabetes and dyslipidemia
    • Reifel-Miller A., Otto K., Hawkins E. et al., A peroxisome proliferator-activated receptor α/γ dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent models of type 2 diabetes and dyslipidemia Molecular Endocrinology 2005 19 6 1593 1605
    • (2005) Molecular Endocrinology , vol.19 , Issue.6 , pp. 1593-1605
    • Reifel-Miller, A.1    Otto, K.2    Hawkins, E.3
  • 21
    • 33646449916 scopus 로고    scopus 로고
    • Structure-based drug design of a novel family of PPARγ partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities
    • Lu I.-L., Huang C.-F., Peng Y.-H. et al., Structure-based drug design of a novel family of PPAR γpartial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities Journal of Medicinal Chemistry 2006 49 9 2703 2712
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.9 , pp. 2703-2712
    • Lu, I.-L.1    Huang, C.-F.2    Peng, Y.-H.3
  • 23
    • 10744233673 scopus 로고    scopus 로고
    • O-arylmandelic acids as highly selective human PPAR α/γ agonists
    • Adams A. D., Hu Z., von Langen D.et al., O-arylmandelic acids as highly selective human PPAR α/γ agonists Bioorganic and Medicinal Chemistry Letters 2003 13 19 3185 3190
    • (2003) Bioorganic and Medicinal Chemistry Letters , vol.13 , Issue.19 , pp. 3185-3190
    • Adams, A.D.1    Hu, Z.2    Von Langen, D.3
  • 24
    • 0142216121 scopus 로고    scopus 로고
    • Ragaglitazar: A novel PPARα PPARγ agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models
    • Chakrabarti R., Vikramadithyan R. K., Misra P. et al., Ragaglitazar: a novel PPARα PPARγ agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models British Journal of Pharmacology 2003 140 3 527 537
    • (2003) British Journal of Pharmacology , vol.140 , Issue.3 , pp. 527-537
    • Chakrabarti, R.1    Vikramadithyan, R.K.2    Misra, P.3
  • 25
    • 0345255653 scopus 로고    scopus 로고
    • The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis
    • Wolf G., The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis Nutrition Reviews 2003 61 11 387 390
    • (2003) Nutrition Reviews , vol.61 , Issue.11 , pp. 387-390
    • Wolf, G.1
  • 26
    • 0036068327 scopus 로고    scopus 로고
    • Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110β protein levels in skeletal muscle of type 2 diabetic subjects
    • Kim Y.-B., Ciaraldi T. P., Kong A.et al., Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110β protein levels in skeletal muscle of type 2 diabetic subjects Diabetes 2002 51 2 443 448
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 443-448
    • Kim, Y.-B.1    Ciaraldi, T.P.2    Kong, A.3
  • 27
    • 0042093782 scopus 로고    scopus 로고
    • 3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: Amelioration by rosiglitazone and exercise
    • 3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise Diabetes 2003 52 8 1926 1934
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 1926-1934
    • Beeson, M.1    Sajan, M.P.2    Dizon, M.3
  • 28
    • 20944436591 scopus 로고    scopus 로고
    • Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: A randomized controlled study
    • Karlsson H. K. R., Hllsten K., Bjrnholm M. et al., Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study Diabetes 2005 54 5 1459 1467
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1459-1467
    • Karlsson, H.K.R.1    Hllsten, K.2    Bjrnholm, M.3
  • 29
    • 0036299982 scopus 로고    scopus 로고
    • Metformin increases AMP-activated protein-kinase activity in skeletal muscle of subjects with type 2 diabetes
    • Musi N., Hirshman M. F., Nygren J. et al., Metformin increases AMP-activated protein-kinase activity in skeletal muscle of subjects with type 2 diabetes Diabetes 2002 51 7 2074 2081
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2074-2081
    • Musi, N.1    Hirshman, M.F.2    Nygren, J.3
  • 30
    • 0036097556 scopus 로고    scopus 로고
    • Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects
    • Ciaraldi T. P., Kong A. P. S., Chu N. V. et al., Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects Diabetes 2002 51 1 30 36
    • (2002) Diabetes , vol.51 , Issue.1 , pp. 30-36
    • Ciaraldi, T.P.1    Kong, A.P.S.2    Chu, N.V.3
  • 31
    • 0036723741 scopus 로고    scopus 로고
    • Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes
    • Meyer M. M., Levin K., Grimmsmann T.et al., Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes Diabetes 2002 51 9 2691 2697
    • (2002) Diabetes , vol.51 , Issue.9 , pp. 2691-2697
    • Meyer, M.M.1    Levin, K.2    Grimmsmann, T.3
  • 32
    • 0037883037 scopus 로고    scopus 로고
    • Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients
    • Miyazaki Y., He H., Mandarino L. J., DeFronzo R. A., Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients Diabetes 2003 52 8 1943 1950
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 1943-1950
    • Miyazaki, Y.1    He, H.2    Mandarino, L.J.3    Defronzo, R.A.4
  • 33
    • 61449222837 scopus 로고    scopus 로고
    • Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: A randomised trial
    • Coletta D. K., Sriwijitkamol A., Wajcberg E. et al., Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial Diabetologia 2009 52 4 723 732
    • (2009) Diabetologia , vol.52 , Issue.4 , pp. 723-732
    • Coletta, D.K.1    Sriwijitkamol, A.2    Wajcberg, E.3
  • 35
    • 12944325312 scopus 로고    scopus 로고
    • Improved insulin sensitivity and adipose tissue dysregulation after short-term treatment with pioglitazone in non-diabetic, insulin-resistant subjects
    • Hammarstedt A., Sopasakis V. R., Gogg S., Jansson P.-A., Smith U., Improved insulin sensitivity and adipose tissue dysregulation after short-term treatment with pioglitazone in non-diabetic, insulin-resistant subjects Diabetologia 2005 48 1 96 104
    • (2005) Diabetologia , vol.48 , Issue.1 , pp. 96-104
    • Hammarstedt, A.1    Sopasakis, V.R.2    Gogg, S.3    Jansson, P.-A.4    Smith, U.5
  • 36
    • 0942268725 scopus 로고    scopus 로고
    • Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor γ (PPARγ), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo
    • Jiang G., Dallas-Yang Q., Biswas S., Li Z., Zhang B. B., Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor γ (PPARγ), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo Biochemical Journal 2004 377 2 339 346
    • (2004) Biochemical Journal , vol.377 , Issue.2 , pp. 339-346
    • Jiang, G.1    Dallas-Yang, Q.2    Biswas, S.3    Li, Z.4    Zhang, B.B.5
  • 37
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • Griffin M. E., Marcucci M. J., Cline G. W. et al., Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade Diabetes 1999 48 6 1270 1274
    • (1999) Diabetes , vol.48 , Issue.6 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3
  • 38
    • 0036326005 scopus 로고    scopus 로고
    • Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPAR agonists
    • Jiang G., Dallas-Yang Q., Li Z. et al., Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPAR agonists Diabetes 2002 51 8 2412 24 19
    • (2002) Diabetes , vol.51 , Issue.8 , pp. 2412-2419
    • Jiang, G.1    Dallas-Yang, Q.2    Li, Z.3
  • 39
    • 0035172839 scopus 로고    scopus 로고
    • Thiazolidinediones (PPARγ agonists) but not PPAR agonists increase IRS-2α gene expression in 3T3-L1 and human adipocytes
    • Smith U., Gogg S., Johansson A., Olausson T., Rotter V., Svalstedt B., Thiazolidinediones (PPARγ agonists) but not PPARα agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes The FASEB Journal 2001 15 1 215 220
    • (2001) The FASEB Journal , vol.15 , Issue.1 , pp. 215-220
    • Smith, U.1    Gogg, S.2    Johansson, A.3    Olausson, T.4    Rotter, V.5    Svalstedt, B.6
  • 40
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G., Myers R., Li Y.et al., Role of AMP-activated protein kinase in mechanism of metformin action Journal of Clinical Investigation 2001 108 8 1167 1174
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.8 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 41
    • 0029775642 scopus 로고    scopus 로고
    • Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ
    • Zhang B., Berger J., Zhou G. et al., Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ Journal of Biological Chemistry 1996 271 50 31771 31774
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.50 , pp. 31771-31774
    • Zhang, B.1    Berger, J.2    Zhou, G.3
  • 42
    • 0031057517 scopus 로고    scopus 로고
    • Transcriptional activation by peroxisome proliferator-activated receptor γ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
    • Adams M., Reginato M. J., Shao D., Lazar M. A., Chatterjee V. K., Transcriptional activation by peroxisome proliferator-activated receptor γ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site Journal of Biological Chemistry 1997 272 8 5128 5132
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.8 , pp. 5128-5132
    • Adams, M.1    Reginato, M.J.2    Shao, D.3    Lazar, M.A.4    Chatterjee, V.K.5
  • 43
    • 0032894240 scopus 로고    scopus 로고
    • C-jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor- γ1 and negatively regulates its transcriptional activity
    • Camp H. S., Tafuri S. R., Leff T., c-jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor- 1 and negatively regulates its transcriptional activity Endocrinology 1999 140 1 392 397
    • (1999) Endocrinology , vol.140 , Issue.1 , pp. 392-397
    • Camp, H.S.1    Tafuri, S.R.2    Leff, T.3
  • 45
    • 0030964085 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor γ activity by mitogen-activated protein kinase
    • Camp H. S., Tafuri S. R., Regulation of peroxisome proliferator-activated receptor γactivity by mitogen-activated protein kinase Journal of Biological Chemistry 1997 272 16 10811 10816
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.16 , pp. 10811-10816
    • Camp, H.S.1    Tafuri, S.R.2
  • 46
    • 0031057517 scopus 로고    scopus 로고
    • Transcriptional activation by peroxisome proliferator-activated receptor γ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
    • Adams M., Reginato M. J., Shao D., Lazar M. A., Chatterjee V. K., Transcriptional activation by peroxisome proliferator-activated receptor γ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site Journal of Biological Chemistry 1997 272 8 5128 5132
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.8 , pp. 5128-5132
    • Adams, M.1    Reginato, M.J.2    Shao, D.3    Lazar, M.A.4    Chatterjee, V.K.5
  • 47
    • 0033968252 scopus 로고    scopus 로고
    • Transforming growth factor-β1 (TGF-β1) and TGF-β2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-γ
    • Han J., Hajjar D. P., Tauras J. M., Feng J., Gotto A. M. Jr., Nicholson A. C., Transforming growth factor-β1 (TGF-β1) and TGF-β2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-γ Journal of Biological Chemistry 2000 275 2 1241 1246
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.2 , pp. 1241-1246
    • Han, J.1    Hajjar, D.P.2    Tauras, J.M.3    Feng, J.4    Gotto Jr., A.M.5    Nicholson, A.C.6
  • 48
    • 0037399647 scopus 로고    scopus 로고
    • Nuclear receptors: Integration of multiple signalling pathways through phosphorylation
    • Rochette-Egly C., Nuclear receptors: integration of multiple signalling pathways through phosphorylation Cellular Signalling 2003 15 4 355 366
    • (2003) Cellular Signalling , vol.15 , Issue.4 , pp. 355-366
    • Rochette-Egly, C.1
  • 49
    • 0037040272 scopus 로고    scopus 로고
    • Interferon-γ-mediated activation and ubiquitin-proteasome-dependent degradation of PPARγ in adipocytes
    • Floyd Z. E., Stephens J. M., Interferon-γ-mediated activation and ubiquitin-proteasome-dependent degradation of PPARγ in adipocytes Journal of Biological Chemistry 2002 277 6 4062 4068
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.6 , pp. 4062-4068
    • Floyd, Z.E.1    Stephens, J.M.2
  • 51
    • 0141920726 scopus 로고    scopus 로고
    • Genetic modulation of PPARγ phosphorylation regulates insulin sensitivity
    • Rangwala S. M., Rhoades B., Shapiro J. S.et al., Genetic modulation of PPARγ phosphorylation regulates insulin sensitivity Developmental Cell 2003 5 4 657 663
    • (2003) Developmental Cell , vol.5 , Issue.4 , pp. 657-663
    • Rangwala, S.M.1    Rhoades, B.2    Shapiro, J.S.3
  • 52
    • 0031595111 scopus 로고    scopus 로고
    • PPAR induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPα during the conversion of 3T3 fibroblasts into adipocytes
    • Wu Z., Xie Y., Morrison R. F., Bucher N. L. R., Farmer S. R., PPAR induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPγ during the conversion of 3T3 fibroblasts into adipocytes Journal of Clinical Investigation 1998 101 1 22 32
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.1 , pp. 22-32
    • Wu, Z.1    Xie, Y.2    Morrison, R.F.3    Bucher, N.L.R.4    Farmer, S.R.5
  • 53
    • 0034737576 scopus 로고    scopus 로고
    • Cloning and characterization of a functional peroxisome proliferator activator receptor-γ-responsive element in the promoter of the CAP gene
    • Baumann C. A., Chokshi N., Saltiel A. R., Ribon V., Cloning and characterization of a functional peroxisome proliferator activator receptor-γ-responsive element in the promoter of the CAP gene Journal of Biological Chemistry 2000 275 13 9131 9135
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.13 , pp. 9131-9135
    • Baumann, C.A.1    Chokshi, N.2    Saltiel, A.R.3    Ribon, V.4
  • 54
    • 0033547443 scopus 로고    scopus 로고
    • Regulation of gene expression by activation of the peroxisome proliferator-activated receptor γ with rosiglitazone (BRL 49653) in human adipocytes
    • Rieusset J., Auwerx J., Vidal H., Regulation of gene expression by activation of the peroxisome proliferator-activated receptor with rosiglitazone (BRL 49653) in human adipocytes Biochemical and Biophysical Research Communications 1999 265 1 265 271
    • (1999) Biochemical and Biophysical Research Communications , vol.265 , Issue.1 , pp. 265-271
    • Rieusset, J.1    Auwerx, J.2    Vidal, H.3
  • 55
    • 0036202197 scopus 로고    scopus 로고
    • Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus
    • Furuta M., Yano Y., Gabazza E. C. et al., Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus Diabetes Research and Clinical Practice 2002 56 3 159 171
    • (2002) Diabetes Research and Clinical Practice , vol.56 , Issue.3 , pp. 159-171
    • Furuta, M.1    Yano, Y.2    Gabazza, E.C.3
  • 56
    • 0043234630 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect
    • Armoni M., Kritz N., Harel C. et al., Peroxisome proliferator-activated receptor-γ represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect Journal of Biological Chemistry 2003 278 33 30614 30623
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.33 , pp. 30614-30623
    • Armoni, M.1    Kritz, N.2    Harel, C.3
  • 58
    • 34547096246 scopus 로고    scopus 로고
    • Suppression of PPAR-γ attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes
    • Liao W., Nguyen M. T. A., Yoshizaki T. et al., Suppression of PPAR-γ attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes American Journal of Physiology 2007 293 1 E219 E227
    • (2007) American Journal of Physiology , vol.293 , Issue.1
    • Liao, W.1    Nguyen, M.T.A.2    Yoshizaki, T.3
  • 59
    • 85047693638 scopus 로고    scopus 로고
    • Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    • Norris A. W., Chen L., Fisher S. J. et al., Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones Journal of Clinical Investigation 2003 112 4 608 618
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.4 , pp. 608-618
    • Norris, A.W.1    Chen, L.2    Fisher, S.J.3
  • 60
    • 0346027235 scopus 로고    scopus 로고
    • Muscle-specific Pparg deletion causes insulin resistance
    • Hevener A. L., He W., Barak Y.et al., Muscle-specific Pparg deletion causes insulin resistance Nature Medicine 2003 9 12 1491 1497
    • (2003) Nature Medicine , vol.9 , Issue.12 , pp. 1491-1497
    • Hevener, A.L.1    He, W.2    Barak, Y.3
  • 61
    • 34347353323 scopus 로고    scopus 로고
    • Phosphatase and tensin homolog deleted on chromosome 10 suppression is an important process in peroxisome proliferator-activated receptor-β signaling in adipocytes and myotubes
    • Kim K. Y., Cho H. S., Jung W. H., Kim S. S., Cheon H. G., Phosphatase and tensin homolog deleted on chromosome 10 suppression is an important process in peroxisome proliferator-activated receptor-β signaling in adipocytes and myotubes Molecular Pharmacology 2007 71 6 1554 1562
    • (2007) Molecular Pharmacology , vol.71 , Issue.6 , pp. 1554-1562
    • Kim, K.Y.1    Cho, H.S.2    Jung, W.H.3    Kim, S.S.4    Cheon, H.G.5
  • 62
    • 0642303113 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor δ controls muscle development and oxidative capability
    • Luquet S., Lopez-Soriano J., Holst D. et al., Peroxisome proliferator-activated receptor δcontrols muscle development and oxidative capability FASEB Journal 2003 17 15 2299 2301
    • (2003) FASEB Journal , vol.17 , Issue.15 , pp. 2299-2301
    • Luquet, S.1    Lopez-Soriano, J.2    Holst, D.3
  • 63
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • Wang Y.-X., Lee C.-H., Tiep S. et al., Peroxisome-proliferator-activated receptor δactivates fat metabolism to prevent obesity Cell 2003 113 2 159 170
    • (2003) Cell , vol.113 , Issue.2 , pp. 159-170
    • Wang, Y.-X.1    Lee, C.-H.2    Tiep, S.3
  • 64
    • 20144387426 scopus 로고    scopus 로고
    • Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptorδ
    • Krämer D. K., Al-Khalili L., Perrini S. et al., Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptorδ Diabetes 2005 54 4 1157 1163
    • (2005) Diabetes , vol.54 , Issue.4 , pp. 1157-1163
    • Krämer, D.K.1    Al-Khalili, L.2    Perrini, S.3
  • 66
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
    • He W., Barak Y., Hevener A. et al., Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle Proceedings of the National Academy of Sciences of the United States of America 2003 100 26 15712 15717
    • (2003) Proceedings of the National Academy of Sciences of the United States of America , vol.100 , Issue.26 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3
  • 68
    • 0028015713 scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)γ: Adipose-predominant expression and induction early in adipocyte differentiation
    • Chawla A., Schwarz E. J., Dimaculangan D. D., Lazar M. A., Peroxisome proliferator-activated receptor (PPAR)γ: adipose-predominant expression and induction early in adipocyte differentiation Endocrinology 1994 135 2 798 800
    • (1994) Endocrinology , vol.135 , Issue.2 , pp. 798-800
    • Chawla, A.1    Schwarz, E.J.2    Dimaculangan, D.D.3    Lazar, M.A.4
  • 69
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
    • Tontonoz P., Hu E., Spiegelman B. M., Stimulation of adipogenesis in fibroblasts by PPAR 2, a lipid-activated transcription factor Cell 1994 79 7 1147 1156
    • (1994) Cell , vol.79 , Issue.7 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 70
    • 0032540012 scopus 로고    scopus 로고
    • PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz P., Nagy L., Alvarez J. G. A., Thomazy V. A., Evans R. M., PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL Cell 1998 93 2 241 252
    • (1998) Cell , vol.93 , Issue.2 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.A.3    Thomazy, V.A.4    Evans, R.M.5
  • 72
    • 0029791412 scopus 로고    scopus 로고
    • PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
    • Schoonjans K., Peinado-Onsurbe J., Lefebvre A.-M. et al., PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene The EMBO Journal 1996 15 19 5336 5348
    • (1996) The EMBO Journal , vol.15 , Issue.19 , pp. 5336-5348
    • Schoonjans, K.1    Peinado-Onsurbe, J.2    Lefebvre, A.-M.3
  • 73
    • 12144291563 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor is required in mature white and brown adipocytes for their survival in the mouse
    • Imai T., Takakuwa R., Marchand S. et al., Peroxisome proliferator- activated receptor is required in mature white and brown adipocytes for their survival in the mouse Proceedings of the National Academy of Sciences of the United States of America 2004 101 13 4543 4547
    • (2004) Proceedings of the National Academy of Sciences of the United States of America , vol.101 , Issue.13 , pp. 4543-4547
    • Imai, T.1    Takakuwa, R.2    Marchand, S.3
  • 74
    • 29244474912 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ and the regulation of adipocyte function: Lesssons from human genetic studies
    • Gurnell M., Peroxisome proliferator-activated receptor γ and the regulation of adipocyte function: lesssons from human genetic studies Best Practice and Research: Clinical Endocrinology and Metabolism 2005 19 4 501 523
    • (2005) Best Practice and Research: Clinical Endocrinology and Metabolism , vol.19 , Issue.4 , pp. 501-523
    • Gurnell, M.1
  • 75
    • 0029905399 scopus 로고    scopus 로고
    • Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ , C/EBPδ , and glucocorticoids
    • Wu Z., Bucher N. L. R., Farmer S. R., Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ , C/EBPδ, and glucocorticoids Molecular and Cellular Biology 1996 16 8 4128 4136
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.8 , pp. 4128-4136
    • Wu, Z.1    Bucher, N.L.R.2    Farmer, S.R.3
  • 76
    • 0028971225 scopus 로고
    • Conditional ectopic expression of C/EBPβ in NIH-3T3 cells induces PPARγ and stimulates adipogenesis
    • Wu Z., Xie Y., Bucher N. L. R., Farmer S. R., Conditional ectopic expression of C/EBPβ in NIH-3T3 cells induces PPARγ and stimulates adipogenesis Genes and Development 1995 9 19 2350 2363
    • (1995) Genes and Development , vol.9 , Issue.19 , pp. 2350-2363
    • Wu, Z.1    Xie, Y.2    Bucher, N.L.R.3    Farmer, S.R.4
  • 77
    • 36649028245 scopus 로고    scopus 로고
    • Fat depot-related differences in gene expression, adiponectin secretion, and insulin action and signalling in human adipocytes differentiated in vitro from precursor stromal cells
    • Perrini S., Laviola L., Cignarelli A. et al., Fat depot-related differences in gene expression, adiponectin secretion, and insulin action and signalling in human adipocytes differentiated in vitro from precursor stromal cells Diabetologia 2008 51 1 155 164
    • (2008) Diabetologia , vol.51 , Issue.1 , pp. 155-164
    • Perrini, S.1    Laviola, L.2    Cignarelli, A.3
  • 78
    • 0030007427 scopus 로고    scopus 로고
    • ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
    • Kim J. B., Spiegelman B. M., ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism Genes and Development 1996 10 9 1096 1107
    • (1996) Genes and Development , vol.10 , Issue.9 , pp. 1096-1107
    • Kim, J.B.1    Spiegelman, B.M.2
  • 79
    • 0032793068 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor γ expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism
    • Fajas L., Schoonjans K., Gelman L. et al., Regulation of peroxisome proliferator-activated receptor γ expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism Molecular and Cellular Biology 1999 19 8 5495 5503
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.8 , pp. 5495-5503
    • Fajas, L.1    Schoonjans, K.2    Gelman, L.3
  • 80
    • 0033083803 scopus 로고    scopus 로고
    • Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity
    • Wu Z., Rosen E. D., Brun R. et al., Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity Molecular Cell 1999 3 2 151 158
    • (1999) Molecular Cell , vol.3 , Issue.2 , pp. 151-158
    • Wu, Z.1    Rosen, E.D.2    Brun, R.3
  • 81
    • 0030590074 scopus 로고    scopus 로고
    • Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2
    • Elbrecht A., Chen Y., Cullinan C. A. et al., Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2 Biochemical and Biophysical Research Communications 1996 224 2 431 437
    • (1996) Biochemical and Biophysical Research Communications , vol.224 , Issue.2 , pp. 431-437
    • Elbrecht, A.1    Chen, Y.2    Cullinan, C.A.3
  • 82
    • 0029847076 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated aeceptor-γ activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells
    • Gimble J. M., Robinson C. E., Wu X. et al., Peroxisome proliferator-activated aeceptor-γ activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells Molecular Pharmacology 1996 50 5 1087 1094
    • (1996) Molecular Pharmacology , vol.50 , Issue.5 , pp. 1087-1094
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3
  • 83
    • 0022385114 scopus 로고
    • A macrophage factor inhibits adipocyte gene expression: An in vitro model of cachexia
    • Torti F. M., Dieckmann B., Beutler B., A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia Science 1985 229 4716 867 869
    • (1985) Science , vol.229 , Issue.4716 , pp. 867-869
    • Torti, F.M.1    Dieckmann, B.2    Beutler, B.3
  • 84
    • 0026623508 scopus 로고
    • Transcriptional repression of the C/EBP-α and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-α. Regulation is coordinate and independent of protein synthesis
    • Stephens J. M., Pekala P. H., Transcriptional repression of the C/EBP- and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-. Regulation is coordinate and independent of protein synthesis Journal of Biological Chemistry 1992 267 19 13580 13584
    • (1992) Journal of Biological Chemistry , vol.267 , Issue.19 , pp. 13580-13584
    • Stephens, J.M.1    Pekala, P.H.2
  • 85
    • 0028916523 scopus 로고
    • Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor- on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells
    • Szalkowski D., White-Carrington S., Berger J., Zhang B., Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor- on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells Endocrinology 1995 136 4 1474 1481
    • (1995) Endocrinology , vol.136 , Issue.4 , pp. 1474-1481
    • Szalkowski, D.1    White-Carrington, S.2    Berger, J.3    Zhang, B.4
  • 86
    • 0030458404 scopus 로고    scopus 로고
    • Negative regulation of peroxisome proliferator-activated receptor- gene expression contributes to the antiadipogenic effects of tumor necrosis factor-α
    • Zhang B., Berger J., Hu E. et al., Negative regulation of peroxisome proliferator-activated receptor- gene expression contributes to the antiadipogenic effects of tumor necrosis factor-α Molecular Endocrinology 1996 10 11 1457 1466
    • (1996) Molecular Endocrinology , vol.10 , Issue.11 , pp. 1457-1466
    • Zhang, B.1    Berger, J.2    Hu, E.3
  • 87
    • 0026504540 scopus 로고
    • Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP)
    • Ron D., Brasier A. R., McGehee R. E. Jr., Habener J. F., Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP) Journal of Clinical Investigation 1992 89 1 223 233
    • (1992) Journal of Clinical Investigation , vol.89 , Issue.1 , pp. 223-233
    • Ron, D.1    Brasier, A.R.2    McGehee, Jr.R.E.3    Habener, J.F.4
  • 89
    • 0031051523 scopus 로고    scopus 로고
    • Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter
    • Hollenberg A. N., Susulic V. S., Madura J. P. et al., Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter Journal of Biological Chemistry 1997 272 8 5283 5290
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.8 , pp. 5283-5290
    • Hollenberg, A.N.1    Susulic, V.S.2    Madura, J.P.3
  • 90
    • 0032520921 scopus 로고    scopus 로고
    • Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
    • Okuno A., Tamemoto H., Tobe K.et al., Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats Journal of Clinical Investigation 1998 101 6 1354 1361
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.6 , pp. 1354-1361
    • Okuno, A.1    Tamemoto, H.2    Tobe, K.3
  • 91
    • 17544382289 scopus 로고    scopus 로고
    • AdipoQ is a novel adipose-specific gene dysregulated in obesity
    • Hu E., Liang P., Spiegelman B. M., AdipoQ is a novel adipose-specific gene dysregulated in obesity Journal of Biological Chemistry 1996 271 18 10697 10703
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.18 , pp. 10697-10703
    • Hu, E.1    Liang, P.2    Spiegelman, B.M.3
  • 92
    • 0036511213 scopus 로고    scopus 로고
    • ACRP30/adiponectin: An adipokine regulating glucose and lipid metabolism
    • Berg A. H., Combs T. P., Scherer P. E., ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism Trends in Endocrinology and Metabolism 2002 13 2 84 89
    • (2002) Trends in Endocrinology and Metabolism , vol.13 , Issue.2 , pp. 84-89
    • Berg, A.H.1    Combs, T.P.2    Scherer, P.E.3
  • 93
    • 0036789137 scopus 로고    scopus 로고
    • The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects
    • Yu J. G., Javorschi S., Hevener A. L. et al., The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects Diabetes 2002 51 10 2968 2974
    • (2002) Diabetes , vol.51 , Issue.10 , pp. 2968-2974
    • Yu, J.G.1    Javorschi, S.2    Hevener, A.L.3
  • 94
    • 11144355637 scopus 로고    scopus 로고
    • Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
    • Pajvani U. B., Hawkins M., Combs T. P. et al., Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity Journal of Biological Chemistry 2004 279 13 12152 12162
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.13 , pp. 12152-12162
    • Pajvani, U.B.1    Hawkins, M.2    Combs, T.P.3
  • 95
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T., Kamon J., Minokoshi Y. et al., Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nature Medicine 2002 8 11 1288 1295
    • (2002) Nature Medicine , vol.8 , Issue.11 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3
  • 96
    • 33646346627 scopus 로고    scopus 로고
    • Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor γ agonists
    • Nawrocki A. R., Rajala M. W., Tomas E. et al., Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor γagonists Journal of Biological Chemistry 2006 281 5 2654 2660
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.5 , pp. 2654-2660
    • Nawrocki, A.R.1    Rajala, M.W.2    Tomas, E.3
  • 97
    • 0035905758 scopus 로고    scopus 로고
    • The hormone resistin links obesity to diabetes
    • Steppan C. M., Bailey S. T., Bhat S. et al., The hormone resistin links obesity to diabetes Nature 2001 409 6818 307 312
    • (2001) Nature , vol.409 , Issue.6818 , pp. 307-312
    • Steppan, C.M.1    Bailey, S.T.2    Bhat, S.3
  • 98
    • 10744225368 scopus 로고    scopus 로고
    • Regulation of fasted blood glucose by resistin
    • Banerjee R. R., Rangwala S. M., Shapiro J. S.et al., Regulation of fasted blood glucose by resistin Science 2004 303 5661 1195 1198
    • (2004) Science , vol.303 , Issue.5661 , pp. 1195-1198
    • Banerjee, R.R.1    Rangwala, S.M.2    Shapiro, J.S.3
  • 99
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-α function
    • Uysal K. T., Wiesbrock S. M., Marino M. W., Hotamisligil G. S., Protection from obesity-induced insulin resistance in mice lacking TNF- function Nature 1997 389 6651 610 614
    • (1997) Nature , vol.389 , Issue.6651 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 100
    • 13744249406 scopus 로고    scopus 로고
    • PPARγ-mediated insulin sensitization: The importance of fat versus muscle
    • Kintscher U., Law R. E., PPARγ-mediated insulin sensitization: the importance of fat versus muscle American Journal of Physiology 2005 288 2 E287 E291
    • (2005) American Journal of Physiology , vol.288 , Issue.2
    • Kintscher, U.1    Law, R.E.2
  • 102
    • 0141446024 scopus 로고    scopus 로고
    • Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
    • Gavrilova O., Haluzik M., Matsusue K. et al., Liver peroxisome proliferator-activated receptor contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass Journal of Biological Chemistry 2003 278 36 34268 34276
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.36 , pp. 34268-34276
    • Gavrilova, O.1    Haluzik, M.2    Matsusue, K.3
  • 103
    • 0346003777 scopus 로고    scopus 로고
    • Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression
    • Yu S., Matsusue K., Kashireddy P.et al., Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression Journal of Biological Chemistry 2003 278 1 498 505
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.1 , pp. 498-505
    • Yu, S.1    Matsusue, K.2    Kashireddy, P.3
  • 104
    • 1442355447 scopus 로고    scopus 로고
    • A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
    • Promrat K., Lutchman G., Uwaifo G. I. et al., A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis Hepatology 2004 39 1 188 196
    • (2004) Hepatology , vol.39 , Issue.1 , pp. 188-196
    • Promrat, K.1    Lutchman, G.2    Uwaifo, G.I.3
  • 105
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: One-year results of the randomized placebo-controlled fatty liver improvement with rosiglitazone therapy (FLIRT) trial
    • Ratziu V., Giral P., Jacqueminet S. et al., Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled fatty liver improvement with rosiglitazone therapy (FLIRT) trial Gastroenterology 2008 135 1 100 110
    • (2008) Gastroenterology , vol.135 , Issue.1 , pp. 100-110
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3
  • 106
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R., Harrison S. A., Brown K. et al., A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis The New England Journal of Medicine 2006 355 22 2297 2307
    • (2006) The New England Journal of Medicine , vol.355 , Issue.22 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3
  • 107
    • 1442352339 scopus 로고    scopus 로고
    • Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach
    • Bays H., Mandarino L., DeFronzo R. A., Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach Journal of Clinical Endocrinology and Metabolism 2004 89 2 463 478
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.2 , pp. 463-478
    • Bays, H.1    Mandarino, L.2    Defronzo, R.A.3
  • 108
    • 0029791412 scopus 로고    scopus 로고
    • PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
    • Schoonjans K., Peinado-Onsurbe J., Lefebvre A.-M. et al., PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene The EMBO Journal 1996 15 19 5336 5348
    • (1996) The EMBO Journal , vol.15 , Issue.19 , pp. 5336-5348
    • Schoonjans, K.1    Peinado-Onsurbe, J.2    Lefebvre, A.-M.3
  • 109
    • 0033548216 scopus 로고    scopus 로고
    • Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene
    • Frohnert B. I., Hui T. Y., Bernlohr D. A., Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene Journal of Biological Chemistry 1999 274 7 3970 3977
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.7 , pp. 3970-3977
    • Frohnert, B.I.1    Hui, T.Y.2    Bernlohr, D.A.3
  • 112
    • 1242273636 scopus 로고    scopus 로고
    • The effects of oral anti-hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes
    • Buse J. B., Tan M. H., Prince M. J., Erickson P. P., The effects of oral anti-hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes Diabetes, Obesity and Metabolism 2004 6 2 133 156
    • (2004) Diabetes, Obesity and Metabolism , vol.6 , Issue.2 , pp. 133-156
    • Buse, J.B.1    Tan, M.H.2    Prince, M.J.3    Erickson, P.P.4
  • 114
    • 7044260753 scopus 로고    scopus 로고
    • Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-γ-deficient mice on a high-fat diet
    • Matsui J., Terauchi Y., Kubota N. et al., Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-γ-deficient mice on a high-fat diet Diabetes 2004 53 11 2844 2854
    • (2004) Diabetes , vol.53 , Issue.11 , pp. 2844-2854
    • Matsui, J.1    Terauchi, Y.2    Kubota, N.3
  • 115
    • 28744444020 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3' -kinase-dependent pathway
    • Lin C.-Y., Gurlo T., Haataja L., Hsueh W. A., Butler P. C., Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3′ -kinase-dependent pathway Journal of Clinical Endocrinology and Metabolism 2005 90 12 6678 6686
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.12 , pp. 6678-6686
    • Lin, C.-Y.1    Gurlo, T.2    Haataja, L.3    Hsueh, W.A.4    Butler, P.C.5
  • 116
    • 33748291464 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets
    • Lalloyer F., Vandewalle B., Percevault F., Peroxisome proliferator-activated receptor α improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets Diabetes 2006 55 6 1605 1613
    • (2006) Diabetes , vol.55 , Issue.6 , pp. 1605-1613
    • Lalloyer, F.1    Vandewalle, B.2    Percevault, F.3


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