메뉴 건너뛰기




Volumn 296, Issue 4, 2009, Pages

Phosphorylation of IRS proteins, insulin action, and insulin resistance

Author keywords

Insulin receptor substrate

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; SERINE; TYROSINE; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE; PROTEIN SERINE THREONINE KINASE;

EID: 65649098029     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90437.2008     Document Type: Review
Times cited : (452)

References (117)
  • 1
    • 0034708832 scopus 로고    scopus 로고
    • 307
    • DOI 10.1074/jbc.275.12.9047
    • Aguirre V, Uchida T, Yenush L, Davis R, White MF. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275: 9047-9054, 2000. (Pubitemid 30180265)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.12 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 2
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 277: 1531-1537, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 3
    • 13444306673 scopus 로고    scopus 로고
    • Adipotoxicity and the insulin resistance syndrome
    • Anderwald C, Roden M. Adipotoxicity and the insulin resistance syndrome. Pediatr Endocrinol Rev 1: 310-319, 2004. (Pubitemid 40204079)
    • (2004) Pediatric Endocrinology Reviews , vol.1 , Issue.3 , pp. 310-319
    • Anderwald, C.1    Roden, M.2
  • 6
    • 50949089015 scopus 로고    scopus 로고
    • SiRNAmediated reduction of nuclear factor-kappaB prevents TNF-alpha-induced insulin resistance in human skeletal muscle
    • Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A. siRNAmediated reduction of nuclear factor-kappaB prevents TNF-alpha-induced insulin resistance in human skeletal muscle. Diabetes 57: 2066-2073, 2008.
    • (2008) Diabetes , vol.57 , pp. 2066-2073
    • Austin, R.L.1    Rune, A.2    Bouzakri, K.3    Zierath, J.R.4    Krook, A.5
  • 8
    • 0030812546 scopus 로고    scopus 로고
    • Evidence for involvement of protein kinase C (PKC)-ζ and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes
    • DOI 10.1210/en.138.11.4721
    • Bandyopadhyay G, Standaert ML, Galloway L, Moscat J, Farese RV. Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes. Endocrinology 138: 4721-4731, 1997. (Pubitemid 27460908)
    • (1997) Endocrinology , vol.138 , Issue.11 , pp. 4721-4731
    • Bandyopadhyay, G.1    Standaert, M.L.2    Galloway, L.3    Moscat, J.4    Farese, R.V.5
  • 9
    • 8844255630 scopus 로고    scopus 로고
    • Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and β-cell dysfunction
    • DOI 10.1046/j.1365-2362.32.s3.3.x
    • Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32, Suppl 3: 14-23, 2002. (Pubitemid 41704996)
    • (2002) European Journal of Clinical Investigation , vol.32 , Issue.SUPPL. 3 , pp. 14-23
    • Boden, G.1    Shulman, G.I.2
  • 11
    • 0038321436 scopus 로고    scopus 로고
    • Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
    • DOI 10.2337/diabetes.52.6.1319
    • Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville M, Le Marchand-Brustel Y, Tanti JF, Vidal H. Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes. Diabetes 52: 1319-1325, 2003. (Pubitemid 36666183)
    • (2003) Diabetes , vol.52 , Issue.6 , pp. 1319-1325
    • Bouzakri, K.1    Roques, M.2    Gual, P.3    Espinosa, S.4    Guebre-Egziabher, F.5    Riou, J.-P.6    Laville, M.7    Le Marchand-Brustel, Y.8    Tanti, J.-F.9    Vidal, H.10
  • 12
    • 0034774069 scopus 로고    scopus 로고
    • Activation of protein kinase Cζ induces serine phosphorylation of VAMP2 in the GLUT4 compartment and increases glucose transport in skeletal muscle
    • DOI 10.1128/MCB.21.22.7852-7861.2001
    • Braiman L, Alt A, Kuroki T, Ohba M, Bak A, Tennenbaum T, Sampson SR. Activation of protein kinase C zeta induces serine phosphorylation of VAMP2 in the GLUT4 compartment and increases glucose transport in skeletal muscle. Mol Cell Biol 21: 7852-7861, 2001. (Pubitemid 32988793)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.22 , pp. 7852-7861
    • Braiman, L.1    Alt, A.2    Kuroki, T.3    Ohba, M.4    Bak, A.5    Tennenbaum, T.6    Sampson, S.R.7
  • 13
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
    • DOI 10.1038/nm1166
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11: 183-190, 2005. (Pubitemid 40321354)
    • (2005) Nature Medicine , vol.11 , Issue.2 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 14
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 296: 1655-1657, 2002.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 15
    • 1542616960 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation
    • Carlson CJ, White MF, Rondinone CM. Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem Biophys Res Commun 316: 533-539, 2004.
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 533-539
    • Carlson, C.J.1    White, M.F.2    Rondinone, C.M.3
  • 16
    • 34548098643 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3α in insulin action in cultured human skeletal muscle cells
    • DOI 10.1210/en.2006-0932
    • Ciaraldi TP, Nikoulina SE, Bandukwala RA, Carter L, Henry RR. Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells. Endocrinology 148: 4393-4399, 2007. (Pubitemid 47295685)
    • (2007) Endocrinology , vol.148 , Issue.9 , pp. 4393-4399
    • Ciaraldi, T.P.1    Nikoulina, S.E.2    Bandukwala, R.A.3    Carter, L.4    Henry, R.R.5
  • 17
    • 0036789185 scopus 로고    scopus 로고
    • Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats
    • Cline GW, Johnson K, Regittnig W, Perret P, Tozzo E, Xiao L, Damico C, Shulman GI. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes 51: 2903-2910, 2002.
    • (2002) Diabetes , vol.51 , pp. 2903-2910
    • Cline, G.W.1    Johnson, K.2    Regittnig, W.3    Perret, P.4    Tozzo, E.5    Xiao, L.6    Damico, C.7    Shulman, G.I.8
  • 19
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789, 1995. (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 20
    • 2342428466 scopus 로고    scopus 로고
    • Tumor Necrosis Factor α Produces Insulin Resistance in Skeletal Muscle by Activation of Inhibitor κB Kinase in a p38 MAPK-dependent Manner
    • DOI 10.1074/jbc.M312021200
    • de Alvaro C, Teruel T, Hernandez R, Lorenzo M. Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem 279: 17070-17078, 2004. (Pubitemid 38560462)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.17 , pp. 17070-17078
    • De Alvaro, C.1    Teruel, T.2    Hernandez, R.3    Lorenzo, M.4
  • 21
    • 0031465447 scopus 로고    scopus 로고
    • Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase
    • DOI 10.1074/jbc.272.50.31400
    • De Fea K, Roth RA. Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase. J Biol Chem 272: 31400-31406, 1997. (Pubitemid 28013276)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.50 , pp. 31400-31406
    • De Fea, K.1    Roth, R.A.2
  • 22
    • 33749342069 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance: Serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin
    • Draznin B. Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin. Diabetes 55: 2392-2397, 2006.
    • (2006) Diabetes , vol.55 , pp. 2392-2397
    • Draznin, B.1
  • 23
    • 40149106453 scopus 로고    scopus 로고
    • SIK2 can be activated by deprivation of nutrition and it inhibits expression of lipogenic genes in adipocytes
    • Du J, Chen Q, Takemori H, Xu H. SIK2 can be activated by deprivation of nutrition and it inhibits expression of lipogenic genes in adipocytes. Obesity (Silver Spring) 16: 531-538, 2008.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 531-538
    • Du, J.1    Chen, Q.2    Takemori, H.3    Xu, H.4
  • 24
    • 0034455290 scopus 로고    scopus 로고
    • Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes
    • DOI 10.1210/en.141.6.1930
    • Egawa K, Nakashima N, Sharma PM, Maegawa H, Nagai Y, Kashiwagi A, Kikkawa R, Olefsky JM. Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulininduced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes. Endocrinology 141: 1930-1935, 2000. (Pubitemid 32274339)
    • (2000) Endocrinology , vol.141 , Issue.6 , pp. 1930-1935
    • Egawa, K.1    Nakashima, N.2    Sharma, P.M.3    Maegawa, H.4    Nagai, Y.5    Kashiwagi, A.6    Kikkawa, R.7    Olefsky, J.M.8
  • 26
    • 0032802629 scopus 로고    scopus 로고
    • Increased glycogen synthase kinase-3 activity in diabetes- And obesity- prone C57BL/6J mice
    • DOI 10.2337/diabetes.48.8.1662
    • Eldar-Finkelman H, Schreyer SA, Shinohara MM, LeBoeuf RC, Krebs EG. Increased glycogen synthase kinase-3 activity in diabetesand obesity-prone C57BL/6J mice. Diabetes 48: 1662-1666, 1999. (Pubitemid 29356878)
    • (1999) Diabetes , vol.48 , Issue.8 , pp. 1662-1666
    • Eldar-Finkelman, H.1    Schreyer, S.A.2    Shinohara, M.M.3    Leboeuf, R.C.4    Krebs, E.G.5
  • 27
    • 2042480671 scopus 로고    scopus 로고
    • Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans
    • DOI 10.1210/en.2003-1336
    • Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145: 2273-2282, 2004. (Pubitemid 38535056)
    • (2004) Endocrinology , vol.145 , Issue.5 , pp. 2273-2282
    • Fain, J.N.1    Madan, A.K.2    Hiler, M.L.3    Cheema, P.4    Bahouth, S.W.5
  • 28
    • 0036288402 scopus 로고    scopus 로고
    • Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states
    • Farese RV. Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states. Am J Physiol Endocrinol Metab 283: E1-E11, 2002.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Farese, R.V.1
  • 29
    • 18044382930 scopus 로고    scopus 로고
    • Atypical protein kinase C in insulin action and insulin resistance
    • Farese RV, Sajan MP, Standaert ML. Atypical protein kinase C in insulin action and insulin resistance. Biochem Soc Trans 33: 350-353, 2005.
    • (2005) Biochem Soc Trans , vol.33 , pp. 350-353
    • Farese, R.V.1    Sajan, M.P.2    Standaert, M.L.3
  • 31
    • 0036788788 scopus 로고    scopus 로고
    • The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation
    • Farhang-Fallah J, Randhawa VK, Nimnual A, Klip A, Bar-Sagi D, Rozakis-Adcock M. The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol 22: 7325-7336, 2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 7325-7336
    • Farhang-Fallah, J.1    Randhawa, V.K.2    Nimnual, A.3    Klip, A.4    Bar-Sagi, D.5    Rozakis-Adcock, M.6
  • 33
    • 0037073679 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex
    • DOI 10.1074/jbc.M209459200
    • Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem 277: 48115-48121, 2002. (Pubitemid 35470759)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.50 , pp. 48115-48121
    • Gao, Z.1    Hwang, D.2    Bataille, F.3    Lefevre, M.4    York, D.5    Quon, M.J.6    Ye, J.7
  • 35
    • 0942276379 scopus 로고    scopus 로고
    • Nutrient-dependent and Insulin-stimulated Phosphorylation of Insulin Receptor Substrate-1 on Serine 302 Correlates with Increased Insulin Signaling
    • DOI 10.1074/jbc.M308631200
    • Giraud J, Leshan R, Lee YH, White MF. Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. J Biol Chem 279: 3447-3454, 2004. (Pubitemid 38140583)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.5 , pp. 3447-3454
    • Giraud, J.1    Leshan, R.2    Lee, Y.-H.3    White, M.F.4
  • 37
    • 0037424466 scopus 로고    scopus 로고
    • Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation
    • DOI 10.1074/jbc.M209153200
    • Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation. J Biol Chem 278: 8199-8211, 2003. (Pubitemid 36800563)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.10 , pp. 8199-8211
    • Greene, M.W.1    Sakaue, H.2    Wang, L.3    Alessi, D.R.4    Roth, R.A.5
  • 38
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade
    • DOI 10.2337/diabetes.48.6.1270
    • Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48: 1270-1274, 1999. (Pubitemid 29241025)
    • (1999) Diabetes , vol.48 , Issue.6 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3    Bell, K.4    Barucci, N.5    Lee, D.6    Goodyear, L.J.7    Kraegen, E.W.8    White, M.F.9    Shulman, G.I.10
  • 39
    • 0347123432 scopus 로고    scopus 로고
    • Positive and negative regulation of glucose uptake by hyperosmotic stress
    • Gual P, Le Marchand-Brustel Y, Tanti J. Positive and negative regulation of glucose uptake by hyperosmotic stress. Diabetes Metab 29: 566-575, 2003. (Pubitemid 38082158)
    • (2003) Diabetes and Metabolism , vol.29 , Issue.6 , pp. 566-575
    • Gual, P.1    Le Marchand-Brustel, Y.2    Tanti, J.F.3
  • 42
    • 0034463918 scopus 로고    scopus 로고
    • A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
    • DOI 10.1210/me.14.6.783
    • Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM, Olefsky JM, Kobayashi M. A rapamycin-sensitive pathway downregulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol 14: 783-794, 2000. (Pubitemid 32260492)
    • (2000) Molecular Endocrinology , vol.14 , Issue.6 , pp. 783-794
    • Haruta, T.1    Uno, T.2    Kawahara, J.3    Takano, A.4    Egawa, K.5    Sharma, P.M.6    Olefsky, J.M.7    Kobayashi, M.8
  • 43
    • 0029898718 scopus 로고    scopus 로고
    • Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2
    • DOI 10.1074/jbc.271.20.11641
    • He W, Craparo A, Zhu Y, O'Neill TJ, Wang LM, Pierce JH, Gustafson TA. Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2. J Biol Chem 271: 11641-11645, 1996. (Pubitemid 26161812)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.20 , pp. 11641-11645
    • He, W.1    Craparo, A.2    Zhu, Y.3    O'Neill, T.J.4    Wang, L.-M.5    Pierce, J.H.6    Gustafson, T.A.7
  • 45
    • 33750881942 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes
    • Henriksen EJ, Dokken BB. Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. Curr Drug Targets 7: 1435-1441, 2006.
    • (2006) Curr Drug Targets , vol.7 , pp. 1435-1441
    • Henriksen, E.J.1    Dokken, B.B.2
  • 46
    • 34547102518 scopus 로고    scopus 로고
    • Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance
    • DOI 10.1074/jbc.M610949200
    • Herschkovitz A, Liu YF, Ilan E, Ronen D, Boura-Halfon S, Zick Y. Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance. J Biol Chem 282: 18018-18027, 2007. (Pubitemid 47100249)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.25 , pp. 18018-18027
    • Herschkovitz, A.1    Liu, Y.-F.2    Ilan, E.3    Ronen, D.4    Boura-Halfon, S.5    Zick, Y.6
  • 51
    • 33644750396 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress and c-Jun NH2- Terminal kinase pathways in inflammation and origin of obesity and diabetes
    • Hotamisligil GS. Role of endoplasmic reticulum stress and c-Jun NH2- terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 54, Suppl 2: S73-S78, 2005.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Hotamisligil, G.S.1
  • 52
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91, 1993.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 53
  • 54
    • 0035861644 scopus 로고    scopus 로고
    • 5′-AMP-activated Protein Kinase Phosphorylates IRS-1 on Ser-789 in Mouse C2C12 Myotubes in Response to 5-Aminoimidazole-4-carboxamide Riboside
    • DOI 10.1074/jbc.C100483200
    • Jakobsen SN, Hardie DG, Morrice N, Tornqvist HE. 5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside. J Biol Chem 276: 46912-46916, 2001. (Pubitemid 37373061)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.50 , pp. 46912-46916
    • Jakobsen, S.N.1    Hardie, D.G.2    Morrice, N.3    Tornqvist, H.E.4
  • 55
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444: 840-846, 2006.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 56
    • 0035757603 scopus 로고    scopus 로고
    • Signal integration and the specificity of insulin action
    • DOI 10.1385/CBB:35:2:191
    • Kanzaki M, Pessin JE. Signal integration and the specificity of insulin action. Cell Biochem Biophys 35: 191-209, 2001. (Pubitemid 33622687)
    • (2001) Cell Biochemistry and Biophysics , vol.35 , Issue.2 , pp. 191-209
    • Kanzaki, M.1    Pessin, J.E.2
  • 57
    • 0033600604 scopus 로고    scopus 로고
    • The beginning of the end: Iκb kinase (IKK) and NF-κB activation
    • Karin M. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J Biol Chem 274: 27339-27342, 1999. (Pubitemid 129527772)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.39 , pp. 27339-27342
    • Karin, M.1
  • 58
    • 0036434431 scopus 로고    scopus 로고
    • Insulin regulation of glucose uptake: A complex interplay of intracellular signalling pathways
    • Khan AH, Pessin JE. Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 45: 1475-1483, 2002.
    • (2002) Diabetologia , vol.45 , pp. 1475-1483
    • Khan, A.H.1    Pessin, J.E.2
  • 59
    • 20744448048 scopus 로고    scopus 로고
    • 24 in the pleckstrin homology domain of insulin receptor substrate-1 by mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: Cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance
    • DOI 10.1074/jbc.M501439200
    • Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, Veenstra TD, Harrington MA, Quon MJ. Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance. J Biol Chem 280: 23173-23183, 2005. (Pubitemid 40853229)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.24 , pp. 23173-23183
    • Kim, J.-A.1    Yeh, D.C.2    Ver, M.3    Li, Y.4    Carranza, A.5    Conrads, T.P.6    Veenstra, T.D.7    Harrington, M.A.8    Quon, M.J.9
  • 63
    • 1842534924 scopus 로고    scopus 로고
    • Nutrient-induced insulin resistance in human skeletal muscle
    • DOI 10.2174/0929867043455620
    • Krebs M, Roden M. Nutrient-induced insulin resistance in human skeletal muscle. Curr Med Chem 11: 901-908, 2004. (Pubitemid 38425922)
    • (2004) Current Medicinal Chemistry , vol.11 , Issue.7 , pp. 901-908
    • Krebs, M.1    Roden, M.2
  • 64
    • 0035091266 scopus 로고    scopus 로고
    • Recent advances in our understanding of insulin action and insulin resistance
    • Le Roith D, Zick Y. Recent advances in our understanding of insulin action and insulin resistance. Diabetes Care 24: 588-597, 2001. (Pubitemid 32198431)
    • (2001) Diabetes Care , vol.24 , Issue.3 , pp. 588-597
    • Le Roith, D.1    Zick, Y.2
  • 65
    • 42449104397 scopus 로고    scopus 로고
    • Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4, but not -2: Isoform specific determinants of specificity in insulin signaling
    • Lee S, Lynn EG, Kim JA, Quon MJ. Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4, but not -2: isoform specific determinants of specificity in insulin signaling. Endocrinology 149: 2451-2458, 2008.
    • (2008) Endocrinology , vol.149 , pp. 2451-2458
    • Lee, S.1    Lynn, E.G.2    Kim, J.A.3    Quon, M.J.4
  • 66
    • 0037474274 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
    • DOI 10.1074/jbc.M208359200
    • Lee YH, Giraud J, Davis RJ, White MF. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem 278: 2896-2902, 2003. (Pubitemid 36801194)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.5 , pp. 2896-2902
    • Lee, Y.H.1    Giraud, J.2    Davis, R.J.3    White, M.F.4
  • 69
    • 14244255271 scopus 로고    scopus 로고
    • Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling
    • DOI 10.1074/jbc.M410610200
    • Liberman Z, Eldar-Finkelman H. Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling. J Biol Chem 280: 4422-4428, 2005. (Pubitemid 40288606)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.6 , pp. 4422-4428
    • Liberman, Z.1    Eldar-Finkelman, H.2
  • 71
    • 6344258131 scopus 로고    scopus 로고
    • Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance
    • DOI 10.1128/MCB.24.21.9668-9681.2004
    • Liu YF, Herschkovitz A, Boura-Halfon S, Ronen D, Paz K, Leroith D, Zick Y. Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance. Mol Cell Biol 24: 9668-9681, 2004. (Pubitemid 39391701)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.21 , pp. 9668-9681
    • Liu, Y.-F.1    Herschkovitz, A.2    Boura-Halfon, S.3    Ronen, D.4    Paz, K.5    Leroith, D.6    Zick, Y.7
  • 72
    • 0035957949 scopus 로고    scopus 로고
    • Insulin stimulates PKCζ-mediated phosphorylation of insulin receptor substrate-1 (IRS-1). a self-attenuated mechanism to negatively regulate the function of IRS proteins
    • Liu YF, Paz K, Herschkovitz A, Alt A, Tennenbaum T, Sampson SR, Ohba M, Kuroki T, LeRoith D, Zick Y. Insulin stimulates PKCzetamediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. J Biol Chem 276: 14459-14465, 2001. (Pubitemid 37391839)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.17 , pp. 14459-14465
    • Liu, Y.-F.1    Paz, K.2    Herschkovitz, A.3    Alt, A.4    Tennenbaum, T.5    Sampson, S.R.6    Ohba, M.7    Kuroki, T.8    Leroith, D.9    Zick, Y.10
  • 74
    • 34748845043 scopus 로고    scopus 로고
    • Phosphorylation of human insulin receptor substrate-1 at serine 629 plays a positive role in insulin signaling
    • DOI 10.1210/en.2007-0049
    • Luo M, Langlais P, Yi Z, Lefort N, De Filippis EA, Hwang H, Christ-Roberts CY, Mandarino LJ. Phosphorylation of human insulin receptor substrate-1 at serine 629 plays a positive role in insulin signaling. Endocrinology 148: 4895-4905, 2007. (Pubitemid 47481522)
    • (2007) Endocrinology , vol.148 , Issue.10 , pp. 4895-4905
    • Luo, M.1    Langlais, P.2    Yi, Z.3    Lefort, N.4    De Filippis, E.A.5    Hwang, H.6    Christ-Roberts, C.Y.7    Mandarino, L.J.8
  • 75
    • 24944576051 scopus 로고    scopus 로고
    • Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: Regulatory role of serine 1223
    • DOI 10.1210/en.2005-0260
    • Luo M, Reyna S, Wang L, Yi Z, Carroll C, Dong LQ, Langlais P, Weintraub ST, Mandarino LJ. Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223. Endocrinology 146: 4410-4416, 2005. (Pubitemid 41324038)
    • (2005) Endocrinology , vol.146 , Issue.10 , pp. 4410-4416
    • Luo, M.1    Reyna, S.2    Wang, L.3    Yi, Z.4    Carroll, C.5    Dong, L.Q.6    Langlais, P.7    Weintraub, S.T.8    Mandarino, L.J.9
  • 76
  • 77
    • 18444399216 scopus 로고    scopus 로고
    • Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
    • DOI 10.1038/sj.emboj.7600633
    • McManus EJ, Sakamoto K, Armit LJ, Ronaldson L, Shpiro N, Marquez R, Alessi DR. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J 24: 1571-1583, 2005. (Pubitemid 40646447)
    • (2005) EMBO Journal , vol.24 , Issue.8 , pp. 1571-1583
    • McManus, E.J.1    Sakamoto, K.2    Armit, L.J.3    Ronaldson, L.4    Shpiro, N.5    Marquez, R.6    Alessi, D.R.7
  • 78
    • 2942623679 scopus 로고    scopus 로고
    • 318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1
    • DOI 10.1074/jbc.M402477200
    • Moeschel K, Beck A, Weigert C, Lammers R, Kalbacher H, Voelter W, Schleicher ED, Haring HU, Lehmann R. Protein kinase C-zetainduced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J Biol Chem 279: 25157-25163, 2004. (Pubitemid 38756765)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.24 , pp. 25157-25163
    • Moeschel, K.1    Beck, A.2    Weigert, C.3    Lammers, R.4    Kalbacher, H.5    Voelter, W.6    Schleicher, E.D.7    Haring, H.-U.8    Lehmann, R.9
  • 80
    • 33845542745 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
    • Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 55, Suppl 2: S9-S15, 2006.
    • (2006) Diabetes , vol.55 , Issue.SUPPL. 2
    • Morino, K.1    Petersen, K.F.2    Shulman, G.I.3
  • 81
    • 15844389443 scopus 로고    scopus 로고
    • Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action
    • DOI 10.1074/jbc.271.19.11222
    • Mothe I, Van Obberghen E. Phosphorylation of insulin receptor substrate- 1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. J Biol Chem 271: 11222-11227, 1996. (Pubitemid 26155955)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.19 , pp. 11222-11227
    • Mothe, I.1    Van Obberghen, E.2
  • 84
    • 33746594548 scopus 로고    scopus 로고
    • Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: Role of serine 24 phosphorylation
    • DOI 10.1210/me.2005-0536
    • Nawaratne R, Gray A, Jorgensen CH, Downes CP, Siddle K, Sethi JK. Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. Mol Endocrinol 20: 1838-1852, 2006. (Pubitemid 44148088)
    • (2006) Molecular Endocrinology , vol.20 , Issue.8 , pp. 1838-1852
    • Nawaratne, R.1    Gray, A.2    Jorgensen, C.H.3    Downes, C.P.4    Siddle, K.5    Sethi, J.K.6
  • 85
    • 0036302960 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle
    • Nikoulina SE, Ciaraldi TP, Mudaliar S, Carter L, Johnson K, Henry RR. Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle. Diabetes 51: 2190-2198, 2002. (Pubitemid 34729024)
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2190-2198
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Mudaliar, S.3    Carter, L.4    Johnson, K.5    Henry, R.R.6
  • 86
    • 0030669392 scopus 로고    scopus 로고
    • A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
    • DOI 10.1074/jbc.272.47.29911
    • Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem 272: 29911-29918, 1997. (Pubitemid 27508092)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.47 , pp. 29911-29918
    • Paz, K.1    Hemi, R.2    Leroith, D.3    Karasik, A.4    Elhanany, E.5    Kanety, H.6    Zick, Y.7
  • 88
    • 0029924172 scopus 로고    scopus 로고
    • Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis
    • DOI 10.1074/jbc.271.12.6998
    • Paz K, Voliovitch H, Hadari YR, Roberts CT Jr, LeRoith D, Zick Y. Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis. J Biol Chem 271: 6998-7003, 1996. (Pubitemid 26104132)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.12 , pp. 6998-7003
    • Paz, K.1    Voliovitch, H.2    Hadari, Y.R.3    Roberts Jr., C.T.4    Leroith, D.5    Zick, Y.6
  • 89
    • 0037135547 scopus 로고    scopus 로고
    • In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents
    • Qiao LY, Zhande R, Jetton TL, Zhou G, Sun XJ. In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents. J Biol Chem 277: 26530-26539, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 26530-26539
    • Qiao, L.Y.1    Zhande, R.2    Jetton, T.L.3    Zhou, G.4    Sun, X.J.5
  • 90
    • 0035793592 scopus 로고    scopus 로고
    • Protein Kinase C-ζ Phosphorylates Insulin Receptor Substrate-1 and Impairs Its Ability to Activate Phosphatidylinositol 3-Kinase in Response to Insulin
    • DOI 10.1074/jbc.M007231200
    • Ravichandran LV, Esposito DL, Chen J, Quon MJ. Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin. J Biol Chem 276: 3543-3549, 2001. (Pubitemid 37411655)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.5 , pp. 3543-3549
    • Ravichandran, L.V.1    Esposito, D.L.2    Chen, J.3    Quon, M.J.4
  • 91
    • 0036263641 scopus 로고    scopus 로고
    • Differential effects of tumor necrosis factor-α on protein kinase C isoforms α and δ mediate inhibition of insulin receptor signaling
    • Rosenzweig T, Braiman L, Bak A, Alt A, Kuroki T, Sampson SR. Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling. Diabetes 51: 1921-1930, 2002. (Pubitemid 34564307)
    • (2002) Diabetes , vol.51 , Issue.6 , pp. 1921-1930
    • Rosenzweig, T.1    Braiman, L.2    Bak, A.3    Alt, A.4    Kuroki, T.5    Sampson, S.R.6
  • 92
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806, 2001.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 93
    • 33746983981 scopus 로고    scopus 로고
    • Specific protein kinase C isoforms as transducers and modulators of insulin signaling
    • Sampson SR, Cooper DR. Specific protein kinase C isoforms as transducers and modulators of insulin signaling. Mol Genet Metab 89: 32-47, 2006.
    • (2006) Mol Genet Metab , vol.89 , pp. 32-47
    • Sampson, S.R.1    Cooper, D.R.2
  • 95
    • 0029866195 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amine acids 591-786
    • DOI 10.1074/jbc.271.11.5980
    • Sawka-Verhelle D, Tartare-Deckert S, White MF, Van Obberghen E. Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. J Biol Chem 271: 5980-5983, 1996. (Pubitemid 26095397)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.11 , pp. 5980-5983
    • Sawka-Verhelle, D.1    Tartare-Deckert, S.2    White, M.F.3    Van Obberghen, E.4
  • 99
    • 33750823407 scopus 로고    scopus 로고
    • Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates
    • Solinas G, Naugler W, Galimi F, Lee MS, Karin M. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci USA 103: 16454-16459, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16454-16459
    • Solinas, G.1    Naugler, W.2    Galimi, F.3    Lee, M.S.4    Karin, M.5
  • 100
    • 2442544855 scopus 로고    scopus 로고
    • In Vitro Phosphorylation of Insulin Receptor Substrate 1 by Protein Kinase C-ζ: Functional Analysis and Identification of Novel Phosphorylation Sites
    • DOI 10.1021/bi049640v
    • Sommerfeld MR, Metzger S, Stosik M, Tennagels N, Eckel J. In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites. Biochemistry 43: 5888-5901, 2004. (Pubitemid 38623622)
    • (2004) Biochemistry , vol.43 , Issue.19 , pp. 5888-5901
    • Sommerfeld, M.R.1    Metzger, S.2    Stosik, M.3    Tennagels, N.4    Eckel, J.5
  • 103
    • 34547105803 scopus 로고    scopus 로고
    • Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794
    • DOI 10.1074/jbc.M610101200
    • Tzatsos A, Tsichlis PN. Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794. J Biol Chem 282: 18069-18082, 2007. (Pubitemid 47100251)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.25 , pp. 18069-18082
    • Tzatsos, A.1    Tsichlis, P.N.2
  • 104
    • 33744505375 scopus 로고    scopus 로고
    • Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
    • DOI 10.1016/j.cmet.2006.05.003, PII S1550413106001586
    • Um SH, D'Alessio D, Thomas G. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab 3: 393-402, 2006. (Pubitemid 43811780)
    • (2006) Cell Metabolism , vol.3 , Issue.6 , pp. 393-402
    • Um, S.H.1    D'Alessio, D.2    Thomas, G.3
  • 106
    • 27644433164 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Gαq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes
    • DOI 10.1210/me.2004-0429
    • Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, Olefsky JM. G protein-coupled receptor kinase 2 mediates endothelin- 1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol 19: 2760-2768, 2005. (Pubitemid 41577248)
    • (2005) Molecular Endocrinology , vol.19 , Issue.11 , pp. 2760-2768
    • Usui, I.1    Imamura, T.2    Babendure, J.L.3    Satoh, H.4    Lu, J.-C.5    Hupfeld, C.J.6    Olefsky, J.M.7
  • 107
    • 0029029892 scopus 로고
    • Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region
    • Voliovitch H, Schindler DG, Hadari YR, Taylor SI, Accili D, Zick Y. Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region. J Biol Chem 270: 18083-18087, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 18083-18087
    • Voliovitch, H.1    Schindler, D.G.2    Hadari, Y.R.3    Taylor, S.I.4    Accili, D.5    Zick, Y.6
  • 109
  • 110
    • 40949091903 scopus 로고    scopus 로고
    • Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2
    • Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol 15: 251-258, 2008.
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 251-258
    • Wu, J.1    Tseng, Y.D.2    Xu, C.F.3    Neubert, T.A.4    White, M.F.5    Hubbard, S.R.6
  • 111
    • 34249661732 scopus 로고    scopus 로고
    • Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle
    • DOI 10.2337/db06-1355
    • Yi Z, Langlais P, De Filippis EA, Luo M, Flynn CR, Schroeder S, Weintraub ST, Mapes R, Mandarino LJ. Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle. Diabetes 56: 1508-1516, 2007. (Pubitemid 46842594)
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1508-1516
    • Yi, Z.1    Langlais, P.2    De Filippis, E.A.3    Luo, M.4    Flynn, C.R.5    Schroeder, S.6    Weintraub, S.T.7    Mapes, R.8    Mandarino, L.J.9
  • 112
    • 34247140171 scopus 로고    scopus 로고
    • Regulation of insulin receptor function
    • Youngren JF. Regulation of insulin receptor function. Cell Mol Life Sci 64: 873-891, 2007.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 873-891
    • Youngren, J.F.1
  • 114
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- And diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ
    • DOI 10.1126/science.1061620
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293: 1673-1677, 2001. (Pubitemid 32807849)
    • (2001) Science , vol.293 , Issue.5535 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.-W.5    Karin, M.6    Shoelson, S.E.7
  • 115
    • 0035500813 scopus 로고    scopus 로고
    • Insulin resistance: A phosphorylation-based uncoupling of insulin signaling
    • DOI 10.1016/S0962-8924(01)02129-8, PII S0962892401021298
    • Zick Y. Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol 11: 437-441, 2001. (Pubitemid 33001425)
    • (2001) Trends in Cell Biology , vol.11 , Issue.11 , pp. 437-441
    • Zick, Y.1
  • 116
    • 16544371352 scopus 로고    scopus 로고
    • Molecular basis of insulin action
    • disucssion 50-35, 265-268
    • Zick Y. Molecular basis of insulin action. Novartis Found Symp 262: 36-50, disucssion 50-35, 265-268, 2004.
    • (2004) Novartis Found Symp , vol.262 , pp. 36-50
    • Zick, Y.1
  • 117
    • 33244481462 scopus 로고    scopus 로고
    • Ser/Thr phosphorylation of IRS proteins: A molecular basis for insulin resistance
    • Zick Y. Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE 2005: pe4, 2005.
    • (2005) Sci STKE , vol.2005
    • Zick, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.