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Volumn 8, Issue , 2011, Pages

The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; PIOGLITAZONE; PLACEBO; TYROSINE 3 MONOOXYGENASE; VESICULAR MONOAMINE TRANSPORTER 2; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; DOPAMINE; NEUROPROTECTIVE AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 79961103714     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-8-91     Document Type: Article
Times cited : (167)

References (62)
  • 1
    • 0028144529 scopus 로고
    • Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure, in obese, insulin-resistant rhesus monkeys
    • 10.2337/diabetes.43.2.204, 8288044
    • Kemnitz J, Elson D, Roecker E, Baum S, Bergman R, Meglasson M. Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure, in obese, insulin-resistant rhesus monkeys. Diabetes 1994, 43:204-211. 10.2337/diabetes.43.2.204, 8288044.
    • (1994) Diabetes , vol.43 , pp. 204-211
    • Kemnitz, J.1    Elson, D.2    Roecker, E.3    Baum, S.4    Bergman, R.5    Meglasson, M.6
  • 2
    • 0033759610 scopus 로고    scopus 로고
    • Thiazolidinediones: a comparative review of approved uses
    • 10.1089/15209150050194297, 11467345
    • Sood V, Colleran K, Burge MR. Thiazolidinediones: a comparative review of approved uses. Diabetes Technol Ther 2000, 2:429-440. 10.1089/15209150050194297, 11467345.
    • (2000) Diabetes Technol Ther , vol.2 , pp. 429-440
    • Sood, V.1    Colleran, K.2    Burge, M.R.3
  • 3
    • 79955069801 scopus 로고    scopus 로고
    • Parkinson's disease and systemic inflammation
    • Ferrari CC, Tarelli R. Parkinson's disease and systemic inflammation. Parkinsons Dis 2011, 2011:1-9.
    • (2011) Parkinsons Dis , vol.2011 , pp. 1-9
    • Ferrari, C.C.1    Tarelli, R.2
  • 4
    • 62549133546 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: a target for neuroprotection?
    • 10.1016/S1474-4422(09)70062-6, 19296921
    • Hirsch EC, Hunot S. Neuroinflammation in Parkinson's disease: a target for neuroprotection?. Lancet Neurol 2009, 8:382-397. 10.1016/S1474-4422(09)70062-6, 19296921.
    • (2009) Lancet Neurol , vol.8 , pp. 382-397
    • Hirsch, E.C.1    Hunot, S.2
  • 5
    • 77957235446 scopus 로고    scopus 로고
    • Modeling neuroinflammatory pathogenesis of Parkinson's disease
    • Cenci MA: Elsevier, Bjorkland A
    • Barnum CJ, Tansey MJ. Modeling neuroinflammatory pathogenesis of Parkinson's disease. Progress in Brain Research 2010, 184:113-132. Cenci MA: Elsevier, Bjorkland A.
    • (2010) Progress in Brain Research , vol.184 , pp. 113-132
    • Barnum, C.J.1    Tansey, M.J.2
  • 6
    • 77956958953 scopus 로고    scopus 로고
    • Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy
    • 10.1007/s00702-010-0428-1, 20571837
    • Qian L, Flood PM, Hong JS. Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Transm 2010, 117:971-979. 10.1007/s00702-010-0428-1, 20571837.
    • (2010) J Neural Transm , vol.117 , pp. 971-979
    • Qian, L.1    Flood, P.M.2    Hong, J.S.3
  • 8
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in inflammation control
    • 10.1677/joe.0.1690453, 11375115
    • Delerive P, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol 2001, 169:453-459. 10.1677/joe.0.1690453, 11375115.
    • (2001) J Endocrinol , vol.169 , pp. 453-459
    • Delerive, P.1    Fruchart, J.C.2    Staels, B.3
  • 9
    • 51649110738 scopus 로고    scopus 로고
    • PPAR: a therapeutic target in Parkinson's disease
    • 10.1111/j.1471-4159.2008.05388.x, 18384649
    • Chaturvedi RK, Beal MF. PPAR: a therapeutic target in Parkinson's disease. J Neurochem 2008, 106:506-518. 10.1111/j.1471-4159.2008.05388.x, 18384649.
    • (2008) J Neurochem , vol.106 , pp. 506-518
    • Chaturvedi, R.K.1    Beal, M.F.2
  • 10
    • 33847005101 scopus 로고    scopus 로고
    • Inflammation induces mitochondirial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system
    • 10.1111/j.1471-4159.2006.04327.x, 17254027
    • Hunter RL, Dragicevic N, Seifert K, Choi DY, Liu M, Kim HC, Cass WA, Sullivan PG, Bing G. Inflammation induces mitochondirial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. J Neurochem 2007, 100:1375-1386. 10.1111/j.1471-4159.2006.04327.x, 17254027.
    • (2007) J Neurochem , vol.100 , pp. 1375-1386
    • Hunter, R.L.1    Dragicevic, N.2    Seifert, K.3    Choi, D.Y.4    Liu, M.5    Kim, H.C.6    Cass, W.A.7    Sullivan, P.G.8    Bing, G.9
  • 11
    • 39149116014 scopus 로고    scopus 로고
    • Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats
    • 10.1016/j.neulet.2007.12.019, 2699576, 18207323
    • Hunter RL, Choi DY, Ross SA, Bing G. Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats. Neurosci Lett 2008, 432:198-201. 10.1016/j.neulet.2007.12.019, 2699576, 18207323.
    • (2008) Neurosci Lett , vol.432 , pp. 198-201
    • Hunter, R.L.1    Choi, D.Y.2    Ross, S.A.3    Bing, G.4
  • 12
    • 0036326074 scopus 로고    scopus 로고
    • Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease
    • 10.1046/j.1471-4159.2002.00990.x, 12153485
    • Breidert T, Callebert J, Heneka MT, Landreth G, Launay JM, Hirsch EC. Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. J Neurochem 2002, 82:615-624. 10.1046/j.1471-4159.2002.00990.x, 12153485.
    • (2002) J Neurochem , vol.82 , pp. 615-624
    • Breidert, T.1    Callebert, J.2    Heneka, M.T.3    Landreth, G.4    Launay, J.M.5    Hirsch, E.C.6
  • 13
    • 0347087323 scopus 로고    scopus 로고
    • Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NFkappa B and iNOS activation
    • Dehmer T, Heneka MT, Sastre M, Dichgans J, Schulz JB. Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NFkappa B and iNOS activation. J Neurochem 2004, 88:494-501.
    • (2004) J Neurochem , vol.88 , pp. 494-501
    • Dehmer, T.1    Heneka, M.T.2    Sastre, M.3    Dichgans, J.4    Schulz, J.B.5
  • 14
    • 36048948687 scopus 로고    scopus 로고
    • Nonhuman primate models of Parkinson's disease
    • Emborg ME. Nonhuman primate models of Parkinson's disease. ILAR J 2007, 48:339-355.
    • (2007) ILAR J , vol.48 , pp. 339-355
    • Emborg, M.E.1
  • 16
    • 0242384667 scopus 로고    scopus 로고
    • Presence of Reactive Microglia in Monkey Substantia Nigra Years after 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Administration
    • 10.1002/ana.10728, 14595649
    • McGeer P, Schwab C, Parent A, Doudet D. Presence of Reactive Microglia in Monkey Substantia Nigra Years after 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Administration. Ann Neurol 2003, 54:599-604. 10.1002/ana.10728, 14595649.
    • (2003) Ann Neurol , vol.54 , pp. 599-604
    • McGeer, P.1    Schwab, C.2    Parent, A.3    Doudet, D.4
  • 17
    • 0033779617 scopus 로고    scopus 로고
    • In vivo PET studies of the dopamine D2 receptors in rhesus monkeys with long-term MPTP-induced parkinsonism
    • 10.1002/1098-2396(200011)38:2<105::AID-SYN1>3.0.CO;2-S, 11018784
    • Doudet DJ, Holden JE, Jivan S, McGeer E, Wyatt RJ. In vivo PET studies of the dopamine D2 receptors in rhesus monkeys with long-term MPTP-induced parkinsonism. Synapse 2000, 38:105-113. 10.1002/1098-2396(200011)38:2<105::AID-SYN1>3.0.CO;2-S, 11018784.
    • (2000) Synapse , vol.38 , pp. 105-113
    • Doudet, D.J.1    Holden, J.E.2    Jivan, S.3    McGeer, E.4    Wyatt, R.J.5
  • 18
    • 41049095853 scopus 로고    scopus 로고
    • Contributions of non-human primates to neuroscience research
    • 10.1016/S0140-6736(08)60489-4, 18374844
    • Capitanio JP, Emborg ME. Contributions of non-human primates to neuroscience research. Lancet 2008, 371:1126-1135. 10.1016/S0140-6736(08)60489-4, 18374844.
    • (2008) Lancet , vol.371 , pp. 1126-1135
    • Capitanio, J.P.1    Emborg, M.E.2
  • 19
    • 77952385324 scopus 로고    scopus 로고
    • Research ethics. Beyond access vs. protection in trials of innovative therapies
    • 10.1126/science.1189369, 20466907
    • London AJ, Kimmelman J, Emborg ME. Research ethics. Beyond access vs. protection in trials of innovative therapies. Science 2010, 328:829. 10.1126/science.1189369, 20466907.
    • (2010) Science , vol.328 , pp. 829
    • London, A.J.1    Kimmelman, J.2    Emborg, M.E.3
  • 20
    • 0032142748 scopus 로고    scopus 로고
    • MPTP-Induced hemiparkinsonism in nonhuman primates 6-8 years after a single unilateral intracarotid dose
    • Emborg-Knott ME, Domino EF. MPTP-Induced hemiparkinsonism in nonhuman primates 6-8 years after a single unilateral intracarotid dose. Exp Neurol 1998, 152:829-830.
    • (1998) Exp Neurol , vol.152 , pp. 829-830
    • Emborg-Knott, M.E.1    Domino, E.F.2
  • 21
    • 33748314622 scopus 로고    scopus 로고
    • A call for clinically driven experimental design in assessing neuroprotection in experimentla Parkinsonism
    • Bezard E. A call for clinically driven experimental design in assessing neuroprotection in experimentla Parkinsonism. Behavioral Pharmacology 2006, 17:379-382.
    • (2006) Behavioral Pharmacology , vol.17 , pp. 379-382
    • Bezard, E.1
  • 22
    • 5644293405 scopus 로고    scopus 로고
    • Evaluation of animal models of Parkinson's disease for neuroprotective strategies
    • 10.1016/j.jneumeth.2004.08.004, 15488225
    • Emborg ME. Evaluation of animal models of Parkinson's disease for neuroprotective strategies. J Neurosci Methods 2004, 139:121-143. 10.1016/j.jneumeth.2004.08.004, 15488225.
    • (2004) J Neurosci Methods , vol.139 , pp. 121-143
    • Emborg, M.E.1
  • 25
    • 0032538911 scopus 로고    scopus 로고
    • Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys
    • 10.1002/(SICI)1096-9861(19981116)401:2<253::AID-CNE7>3.0.CO;2-X, 9822152
    • Emborg ME, Ma SY, Mufson EJ, Levee A, Holden JE, Brown D, Kordower JH. Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys. J Comp Neurol 1998, 401:253-265. 10.1002/(SICI)1096-9861(19981116)401:2<253::AID-CNE7>3.0.CO;2-X, 9822152.
    • (1998) J Comp Neurol , vol.401 , pp. 253-265
    • Emborg, M.E.1    Ma, S.Y.2    Mufson, E.J.3    Levee, A.4    Holden, J.E.5    Brown, D.6    Kordower, J.H.7
  • 26
    • 0029939740 scopus 로고    scopus 로고
    • Estimation of the number of somatostatin neurons in the striatum: an in situ hybridization study using the optical fractionator method
    • 10.1002/(SICI)1096-9861(19960617)370:1<11::AID-CNE2>3.0.CO;2-O, 8797153
    • West MJ, Ostergaard K, Andreassen OA, Finsen B. Estimation of the number of somatostatin neurons in the striatum: an in situ hybridization study using the optical fractionator method. J Comp Neurol 1996, 370:11-22. 10.1002/(SICI)1096-9861(19960617)370:1<11::AID-CNE2>3.0.CO;2-O, 8797153.
    • (1996) J Comp Neurol , vol.370 , pp. 11-22
    • West, M.J.1    Ostergaard, K.2    Andreassen, O.A.3    Finsen, B.4
  • 27
    • 0025964041 scopus 로고
    • The absolutely number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method
    • 10.1136/jnnp.54.1.30, 1014294, 2010756
    • Pakkenberg B, Moller A, Gundersen HJ, Mouritzen Dam A, Pakkenberg H. The absolutely number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. J Neurol Neurosurg Psychiatry 1991, 54:30-33. 10.1136/jnnp.54.1.30, 1014294, 2010756.
    • (1991) J Neurol Neurosurg Psychiatry , vol.54 , pp. 30-33
    • Pakkenberg, B.1    Moller, A.2    Gundersen, H.J.3    Mouritzen Dam, A.4    Pakkenberg, H.5
  • 28
    • 33750295486 scopus 로고    scopus 로고
    • High-performance liquid chromatographic method for the determination of pioglitazone in human plasma using ultraviolet detection and its application to a pharmacokinetic study
    • 10.1016/j.jchromb.2006.05.032, 16815107
    • Sripalakit P, Neamhom P, Saraphanchotiwitthaya A. High-performance liquid chromatographic method for the determination of pioglitazone in human plasma using ultraviolet detection and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci 2006, 843:164-169. 10.1016/j.jchromb.2006.05.032, 16815107.
    • (2006) J Chromatogr B Analyt Technol Biomed Life Sci , vol.843 , pp. 164-169
    • Sripalakit, P.1    Neamhom, P.2    Saraphanchotiwitthaya, A.3
  • 29
    • 0026607265 scopus 로고
    • Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: evaluation of liver GLUT2 and phosphoenolpyruvate carboxykinase expression
    • 10.1210/en.130.2.735, 1733721
    • Hofmann CA, Edwards C, Hillman RM, Colca JR. Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: evaluation of liver GLUT2 and phosphoenolpyruvate carboxykinase expression. Endocrinology 1992, 130:735-740. 10.1210/en.130.2.735, 1733721.
    • (1992) Endocrinology , vol.130 , pp. 735-740
    • Hofmann, C.A.1    Edwards, C.2    Hillman, R.M.3    Colca, J.R.4
  • 31
    • 34147139093 scopus 로고    scopus 로고
    • Montvale: Thomson Healthcare, 64
    • Physician's Desk Reference 2008, Montvale: Thomson Healthcare, 64.
    • (2008) Physician's Desk Reference
  • 32
    • 0030875725 scopus 로고    scopus 로고
    • PET studies of functional compensation in a primate modle of Parkinson's disease
    • 10.1097/00001756-199708180-00017, 9295108
    • Eberling JL, Bankiewicz KS, Jordan S, Van Brocklin HF, Jagust WJ. PET studies of functional compensation in a primate modle of Parkinson's disease. NeuroReport 1997, 8:2727-2733. 10.1097/00001756-199708180-00017, 9295108.
    • (1997) NeuroReport , vol.8 , pp. 2727-2733
    • Eberling, J.L.1    Bankiewicz, K.S.2    Jordan, S.3    Van Brocklin, H.F.4    Jagust, W.J.5
  • 33
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • 10.1126/science.290.5492.767, 11052933
    • Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, McBride J, Chen E, Palfi S, Roitberg B, et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 2000, 290:767-773. 10.1126/science.290.5492.767, 11052933.
    • (2000) Science , vol.290 , pp. 767-773
    • Kordower, J.H.1    Emborg, M.E.2    Bloch, J.3    Ma, S.Y.4    Chu, Y.5    Leventhal, L.6    McBride, J.7    Chen, E.8    Palfi, S.9    Roitberg, B.10
  • 34
    • 0037150792 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2
    • 10.1016/S0006-8993(02)02480-0, 12031542
    • Kim EJ, Kwon KJ, Park JY, Lee SH, Moon CH, Baik EJ. Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2. Brain Res 2002, 941:1-10. 10.1016/S0006-8993(02)02480-0, 12031542.
    • (2002) Brain Res , vol.941 , pp. 1-10
    • Kim, E.J.1    Kwon, K.J.2    Park, J.Y.3    Lee, S.H.4    Moon, C.H.5    Baik, E.J.6
  • 35
    • 20444497357 scopus 로고    scopus 로고
    • Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?
    • 10.1016/j.bcp.2005.03.033, 15925327
    • Feinstein DL, Spagnolo A, Akar C, Weinberg G, Murphy P, Gavrilyuk V, Dello Russo C. Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?. Biochem Pharmacol 2005, 70:177-188. 10.1016/j.bcp.2005.03.033, 15925327.
    • (2005) Biochem Pharmacol , vol.70 , pp. 177-188
    • Feinstein, D.L.1    Spagnolo, A.2    Akar, C.3    Weinberg, G.4    Murphy, P.5    Gavrilyuk, V.6    Dello Russo, C.7
  • 37
    • 0031873331 scopus 로고    scopus 로고
    • Pioglitazone enhances splanchnic glucose uptake as well as peripheral glucose updtake in non-insulin dependent diabetes mellitus. AD-4833 Clamp-OGL Study Group
    • 10.1016/S0168-8227(98)00056-4, 9768370
    • Kawamori R, Matsuhisa M, Kinoshita J, Mochizuki K, Niwa M, Arisaka T, Ikeda M, Kubota M, Wada M, Kanda T, et al. Pioglitazone enhances splanchnic glucose uptake as well as peripheral glucose updtake in non-insulin dependent diabetes mellitus. AD-4833 Clamp-OGL Study Group. Diabetes Res Clin Pract 1998, 41:35-43. 10.1016/S0168-8227(98)00056-4, 9768370.
    • (1998) Diabetes Res Clin Pract , vol.41 , pp. 35-43
    • Kawamori, R.1    Matsuhisa, M.2    Kinoshita, J.3    Mochizuki, K.4    Niwa, M.5    Arisaka, T.6    Ikeda, M.7    Kubota, M.8    Wada, M.9    Kanda, T.10
  • 38
    • 0021348288 scopus 로고
    • Acute administration of 1-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP), a compound producing pakrinsonism in humans, stimulates, [2-14C]deoxyglucose uptake in the regions of the catecholaminergic cell bodies in the rat and guinea pig brains
    • 10.1016/0006-8993(84)90422-0, 6610458
    • Palacios JM, Wiederhold KH. Acute administration of 1-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP), a compound producing pakrinsonism in humans, stimulates, [2-14C]deoxyglucose uptake in the regions of the catecholaminergic cell bodies in the rat and guinea pig brains. Brain Res 1984, 301:187-191. 10.1016/0006-8993(84)90422-0, 6610458.
    • (1984) Brain Res , vol.301 , pp. 187-191
    • Palacios, J.M.1    Wiederhold, K.H.2
  • 39
    • 0023820072 scopus 로고
    • Administration of MPTP acutely increases glucose utilization in the substantia nigra of primates
    • 10.1016/0006-8993(88)90162-X, 3261197
    • Palombo E, Porrino LJ, Bankiewicz KS, Crane AM, Kopin IJ, Sokoloff L. Administration of MPTP acutely increases glucose utilization in the substantia nigra of primates. Brain Res 1988, 453:227-234. 10.1016/0006-8993(88)90162-X, 3261197.
    • (1988) Brain Res , vol.453 , pp. 227-234
    • Palombo, E.1    Porrino, L.J.2    Bankiewicz, K.S.3    Crane, A.M.4    Kopin, I.J.5    Sokoloff, L.6
  • 40
    • 42949100802 scopus 로고    scopus 로고
    • The PPAR-gamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B
    • 10.1038/bjp.2008.78, 2438969, 18332857
    • Quinn LP, Crook B, Hows ME, Vidgeon-Hart M, Chapman H, Upton N, Medhurst AD, Virley DJ. The PPAR-gamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B. Br J Pharmacol 2008, 154:226-233. 10.1038/bjp.2008.78, 2438969, 18332857.
    • (2008) Br J Pharmacol , vol.154 , pp. 226-233
    • Quinn, L.P.1    Crook, B.2    Hows, M.E.3    Vidgeon-Hart, M.4    Chapman, H.5    Upton, N.6    Medhurst, A.D.7    Virley, D.J.8
  • 41
    • 0023038827 scopus 로고
    • The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and structurally related compounds
    • 10.1002/med.2610060402, 3534484
    • Markey SP, Schmuff NR. The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and structurally related compounds. Med Res Rev 1986, 6:389-429. 10.1002/med.2610060402, 3534484.
    • (1986) Med Res Rev , vol.6 , pp. 389-429
    • Markey, S.P.1    Schmuff, N.R.2
  • 42
    • 0021893796 scopus 로고
    • Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects
    • 10.1016/0024-3205(85)90062-1, 3871242
    • Johannessen JN, Chiueh CC, Burns RS, Markey SP. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects. Life Sci 1985, 36:219-224. 10.1016/0024-3205(85)90062-1, 3871242.
    • (1985) Life Sci , vol.36 , pp. 219-224
    • Johannessen, J.N.1    Chiueh, C.C.2    Burns, R.S.3    Markey, S.P.4
  • 43
    • 0023817885 scopus 로고
    • Metabolism of [14C]MPTP in mouse and monkey implicates MPP+, and not bound metabolites, as the operative neurotoxin
    • 10.1021/tx00004a007, 2979736
    • Yang SC, Johannessen JN, Markey SP. Metabolism of [14C]MPTP in mouse and monkey implicates MPP+, and not bound metabolites, as the operative neurotoxin. Chem Res Toxicol 1988, 1:228-233. 10.1021/tx00004a007, 2979736.
    • (1988) Chem Res Toxicol , vol.1 , pp. 228-233
    • Yang, S.C.1    Johannessen, J.N.2    Markey, S.P.3
  • 44
    • 17844406615 scopus 로고    scopus 로고
    • Mechanisms of neuroprotective actions of the anti-Parkinsonian drug resagilline and its derivitives
    • 10.1016/j.brainresrev.2004.12.027, 15850677
    • Mandel S, Weinreb O, Amit T, Youdim MB. Mechanisms of neuroprotective actions of the anti-Parkinsonian drug resagilline and its derivitives. Brain Research Reviews 2005, 48:379-387. 10.1016/j.brainresrev.2004.12.027, 15850677.
    • (2005) Brain Research Reviews , vol.48 , pp. 379-387
    • Mandel, S.1    Weinreb, O.2    Amit, T.3    Youdim, M.B.4
  • 45
    • 67651165337 scopus 로고    scopus 로고
    • Long-term Outcome of Early Versus Delayed Rasagiline Treatment in Early Parkinson's Disease
    • 10.1002/mds.22402, 19086083
    • Hauser RA, Lew MF, Hurtig HI, Ondo WG, Wojcieszek J, Fitzer-Attas CJ. Long-term Outcome of Early Versus Delayed Rasagiline Treatment in Early Parkinson's Disease. Movement Disorders 2009, 24:564-573. 10.1002/mds.22402, 19086083.
    • (2009) Movement Disorders , vol.24 , pp. 564-573
    • Hauser, R.A.1    Lew, M.F.2    Hurtig, H.I.3    Ondo, W.G.4    Wojcieszek, J.5    Fitzer-Attas, C.J.6
  • 48
    • 34249879234 scopus 로고    scopus 로고
    • A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies
    • 10.1016/j.jneumeth.2007.03.013, 17477973
    • Peiris M, Monteith GR, Roberts-Thomson SJ, Cabot PJ. A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies. J Neurosci Methods 2007, 163:245-254. 10.1016/j.jneumeth.2007.03.013, 17477973.
    • (2007) J Neurosci Methods , vol.163 , pp. 245-254
    • Peiris, M.1    Monteith, G.R.2    Roberts-Thomson, S.J.3    Cabot, P.J.4
  • 49
    • 23944490153 scopus 로고    scopus 로고
    • The oral antidiabetic pioglitazone protects from neurodegenerative and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice
    • 10.1523/JNEUROSCI.2038-05.2005, 16120782
    • Schutz B, Reimann J, Dumitrescu-Ozimek L, Kappes = Horn K, Landreth GE, Schurmann B, Zimmer A, Heneka MT. The oral antidiabetic pioglitazone protects from neurodegenerative and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. J Neurosci 2005, 25:7805-7812. 10.1523/JNEUROSCI.2038-05.2005, 16120782.
    • (2005) J Neurosci , vol.25 , pp. 7805-7812
    • Schutz, B.1    Reimann, J.2    Dumitrescu-Ozimek, L.3    Kappes-Horn, K.4    Landreth, G.E.5    Schurmann, B.6    Zimmer, A.7    Heneka, M.T.8
  • 50
    • 33746214620 scopus 로고    scopus 로고
    • Ameliorative effect of pioglitazone on seizure responses in genetically epilepsy-suceptible EL mice
    • 10.1016/j.brainres.2006.04.108, 16806109
    • Okada K, Yamashita T, Tsuji S. Ameliorative effect of pioglitazone on seizure responses in genetically epilepsy-suceptible EL mice. Brain Res 2006, 1102:175-178. 10.1016/j.brainres.2006.04.108, 16806109.
    • (2006) Brain Res , vol.1102 , pp. 175-178
    • Okada, K.1    Yamashita, T.2    Tsuji, S.3
  • 51
    • 35748980879 scopus 로고    scopus 로고
    • Pioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, independently of blood pressure
    • 10.1161/STROKEAHA.107.486522, 17885259
    • Nakamura T, Yamamoto E, Kataoka K, Yamashita T, Tokutomi Y, Dong YF, Matsuba S, Ogawa H, Kim-Mitsuyama S. Pioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, independently of blood pressure. Stroke 2007, 38:3016-3022. 10.1161/STROKEAHA.107.486522, 17885259.
    • (2007) Stroke , vol.38 , pp. 3016-3022
    • Nakamura, T.1    Yamamoto, E.2    Kataoka, K.3    Yamashita, T.4    Tokutomi, Y.5    Dong, Y.F.6    Matsuba, S.7    Ogawa, H.8    Kim-Mitsuyama, S.9
  • 52
    • 79851512032 scopus 로고    scopus 로고
    • Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor kappa-B signaling pathway
    • Xu M, Wei C, Qin AP, Liu CF, Hong LZ, Zhao XY, Liu J, Qin ZH, Zhang HL. Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor kappa-B signaling pathway. Neuroscience 2010, 176:381-395.
    • (2010) Neuroscience , vol.176 , pp. 381-395
    • Xu, M.1    Wei, C.2    Qin, A.P.3    Liu, C.F.4    Hong, L.Z.5    Zhao, X.Y.6    Liu, J.7    Qin, Z.H.8    Zhang, H.L.9
  • 53
    • 33847093475 scopus 로고    scopus 로고
    • Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats
    • Park SW, Yi JH, Miranpuri G, Satriomoto I, Bowen KK, Resnick DK, Vemuganti R. Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats. J Pharmacol Exp Ther 2007, 320:1002-1012.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 1002-1012
    • Park, S.W.1    Yi, J.H.2    Miranpuri, G.3    Satriomoto, I.4    Bowen, K.K.5    Resnick, D.K.6    Vemuganti, R.7
  • 55
    • 78651322583 scopus 로고    scopus 로고
    • A randomized pilot clinical trial of the safety of piogltiazone in treatment of patients with Alzheimer disease
    • 10.1001/archneurol.2010.229, 20837824
    • Geldmacher DS, Fritsch T, McClendon MJ, Landreth G. A randomized pilot clinical trial of the safety of piogltiazone in treatment of patients with Alzheimer disease. Arch Neurol 2011, 68:45-50. 10.1001/archneurol.2010.229, 20837824.
    • (2011) Arch Neurol , vol.68 , pp. 45-50
    • Geldmacher, D.S.1    Fritsch, T.2    McClendon, M.J.3    Landreth, G.4
  • 57
  • 58
    • 77649270079 scopus 로고    scopus 로고
    • Effects of pioglitazone on diffusion tensor imaging indicies in multiple sclerosis patients
    • 10.1016/j.neulet.2010.01.046, 20144689
    • Shukla DK, Kaiser CC, Stebbins GT, Feinstein DL. Effects of pioglitazone on diffusion tensor imaging indicies in multiple sclerosis patients. Neurosci Lett 2010, 472:153-156. 10.1016/j.neulet.2010.01.046, 20144689.
    • (2010) Neurosci Lett , vol.472 , pp. 153-156
    • Shukla, D.K.1    Kaiser, C.C.2    Stebbins, G.T.3    Feinstein, D.L.4
  • 60
    • 80052763091 scopus 로고    scopus 로고
    • Insulin Resistance Intervention after Stroke
    • Insulin Resistance Intervention after Stroke. , http://clinicaltrials.gov/ct2/show/NCT00091949?term=NCT00091949&rank =1
  • 61
    • 80052783536 scopus 로고    scopus 로고
    • Combination Therapy in Amyotrophic Lateral Sclerosis (ALS) (PNA)
    • Combination Therapy in Amyotrophic Lateral Sclerosis (ALS) (PNA). , http://www.clinicaltrials.gov/ct2/show/NCT00919555?term=ALS+and+pioglita zone&rank=1
  • 62
    • 84984609745 scopus 로고    scopus 로고
    • Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept (ACTFRIE)
    • Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept (ACTFRIE). , http://clinicaltrials.gov/ct2/show/NCT00811681


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