A novel neurotrophic property of glucagon-like peptide 1: A promoter of nerve growth factor-mediated differentiation in PC12 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 3, 2002, Pages 958-966

  Perry, Tracyann ^a,b,c,d,e   Lahiri, Debomoy K ^a,b,c,d   Chen, Demao ^a,b,c,d   Zhou, J I E ^a,b,c,d   Shaw, Karen T Y ^a,b,c,d   Egan, Josephine M ^a,b,c,d   Greig, Nigel H ^a,b,c,d  

^a Laboratory of Neuroscience   (United States)

^b Diabetes Section   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CYCLIC AMP; EXENDIN 4; EXENDIN 4 WOT; EXENDIN [9-39]; FORSKOLIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NERVE GROWTH FACTOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL DEATH; CELL STRAIN; CONTROLLED STUDY; DIABETIC NEUROPATHY; GENE EXPRESSION; NERVE FIBER GROWTH; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PARKINSON DISEASE; PERIPHERAL NEUROPATHY; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIMETABOLITES; APOPTOSIS; BLOTTING, WESTERN; BROMODEOXYURIDINE; CELL DIFFERENTIATION; CYCLIC AMP; DNA REPLICATION; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; IMMUNOHISTOCHEMISTRY; L-LACTATE DEHYDROGENASE; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTOR; NEURODEGENERATIVE DISEASES; PC12 CELLS; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN PRECURSORS; RATS; RECEPTORS, GLUCAGON; STIMULATION, CHEMICAL; TETRAZOLIUM SALTS; THIAZOLES; VENOMS;

EID: 0036182251     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.3.958     Document Type: Article

References (41)

1. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
2. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
3. Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse
4. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
5. Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain
6. Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
7. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
8. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells
9. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
10. Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations
11. Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus
12. Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases
13. 2+ signaling system stimulated by the insulin-otropic hormone glucagon-like peptide-1-(7-37)
14. Glucagon-like peptide 1 increases glucose-dependent activity of the hemoprotein IDX-1 transactivating domain in pancreatic β-cells
15. Identification and characterization of glucagon-like peptide-1 7-36 amide-binding sites in the rat brain and lung
16. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
17. Microinjection of activated phosphatidylinositol-3 kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway
18. Melatonin affects the metabolism of the β-amyloid precursor protein in different cell types
19. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin
20. NeuroD and neurogenesis
21. Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic β-cells
22. Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling
23. Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: Mechanisms of action
24. Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness
25. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in beta-2/neurcD-deficient mice
26. Overexpression of neuroD in PC12 cells alters morphology and enhances expression of the adenylate kinase isozyme 1 gene
27. Diabetes mellitus and the risk of dementia: The Rotterdam Study
28. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
29. Molecular cloning of the helodermin and exendin-4 cDNAs in the lizard. Relationship to vasoactive intestinal polypeptide/pituitary adenylate cyclase activating polypeptide and glucagon-like peptide 1 and evidence against the existence of mammalian homologues
30. PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity
31. Insulinotropic hormone glucagon-like peptide-1-(7-37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia
32. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
33. Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats
34. Expression cloning of the pancreatic β-cell receptor for the glucoincretin hormone glucagon-like peptide 1
35. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
36. A role for glucagon-like peptide-1 in the central regulation of feeding
37. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
38. Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats
39. Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C
40. Endogenous delta-opioid and ORL1 receptors couple to phosphorylation and activation of p38 MAPK in NG108-15 cells and this is regulated by protein kinase A and protein kinase C
41. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells