PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Nature Genetics

Volumn 34, Issue 3, 2003, Pages 267-273

  Mootha, Vamsi K ^a,b,c   Lindgren, Cecilia M ^a,d   Eriksson, Karl Fredrik ^d   Subramanian, Aravind ^a   Sihag, Smita ^a   Lehar, Joseph ^a   Puigserver, Pere ^b   Carlsson, Emma ^d   Ridderstråle, Martin ^d   Laurila, Esa ^d   Houstis, Nicholas ^a   Daly, Mark J ^a   Patterson, Nick ^a   Mesirov, Jill P ^a   Golub, Todd R ^a,b   Tamayo, Pablo ^a   Spiegelman, Bruce ^b   Lander, Eric S ^a,e   Hirschhorn, Joel N ^a,b,f   Altshuler, David ^a,b,g   Groop, Leif C ^d   more..

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MAS   (Sweden)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATOR PROTEIN GAMMA COACTIVATOR; UNCLASSIFIED DRUG; GLUCOSE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA COACTIVATOR-1; TRANSCRIPTION FACTOR;

ADULT; AEROBIC CAPACITY; AGED; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DNA FINGERPRINTING; DNA MICROARRAY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MATURITY ONSET DIABETES MELLITUS; MUSCLE MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; SEQUENCE HOMOLOGY; ANIMAL; CELL CULTURE; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; GLUCOSE TOLERANCE TEST; METABOLISM; MOUSE; MYOBLAST; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DOWN-REGULATION; GENE EXPRESSION PROFILING; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; MALE; MICE; MUSCLE, SKELETAL; MYOBLASTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE PHOSPHORYLATION; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0038054341     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1180     Document Type: Article

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