Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-β, and Tau: Effects on cognitive impairments

Journal of Biological Chemistry

Volumn 285, Issue 17, 2010, Pages 13107-13120

  Caccamo, Antonella ^a,b   Majumder, Smita ^a,b   Richardson, Arlan ^a,b,c   Strong, Randy ^a,b,c   Oddo, Salvatore ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ANIMAL MODEL; AUTOPHAGY; COGNITIVE DECLINE; COGNITIVE DEFICITS; COGNITIVE IMPAIRMENT; INVARIANT FEATURES; LEARNING AND MEMORY; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); MOLECULAR BASIS; MOLECULAR MECHANISM; MTOR SIGNALING; NEURONAL FUNCTION; RAPAMYCIN; TAU PATHOLOGY;

DISEASES; GLYCOPROTEINS; MAMMALS; PATHOLOGY; PROTEINS; SIGNALING;

ANTIBIOTICS;

AMYLOID BETA PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG BLOOD LEVEL; EMBRYO; LEARNING DISORDER; MEMORY DISORDER; MOLECULAR BIOLOGY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DISEASE MODELS, ANIMAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMORY; MICE; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SIROLIMUS; TAU PROTEINS;

ANIMALIA; MAMMALIA;

EID: 77951227122     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.100420     Document Type: Article

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