A mathematical model of insulin resistance in Parkinson's disease

Computational Biology and Chemistry

Volumn 56, Issue , 2015, Pages 84-97

  Braatz, Elise M ^a   Coleman, Randolph A ^a  

^a The College of William and Mary   (United States)

Author keywords

Computational biology; Delayed treatment; Insulin resistance; Neurodegenerative disease; Parkinsons disease; Type II diabetes mellitus

Indexed keywords

BIOCHEMISTRY; BIOINFORMATICS; COMPUTATION THEORY; DIAGNOSIS; INSULIN; MATLAB; NEURODEGENERATIVE DISEASES;

COMPUTATIONAL BIOLOGY; DELAYED TREATMENT; INSULIN RESISTANCE; PARKINSONS DISEASE; TYPE II DIABETES MELLITUS;

DISEASES;

DOPAMINE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; TAU PROTEIN;

BIOLOGICAL MODEL; COMPLICATION; COMPUTER SIMULATION; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LEWY BODY; METABOLISM; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

COMPUTER SIMULATION; DOPAMINE; HUMANS; INFLAMMATION; INSULIN RESISTANCE; LEWY BODIES; MODELS, BIOLOGICAL; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARKINSON DISEASE; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TAU PROTEINS;

EID: 84927942044     PISSN: 14769271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compbiolchem.2015.04.003     Document Type: Article

References (52)

1. N.S. Ambhore, M. Prasanna, A.S. Antony, M.N.S. Kumar, and K. Elango Pharmacological and anti-oxidant evaluation of Aspirin, nimodipine and its combination for anti-Parkinson's activity in MPTP induced rat model Int. J. Health Allied Sci. 3 1 2014 14 22
2. K. Arima, S. Hirai, N. Sunohara, K. Aoto, Y. Izumiyama, and K. Ueda Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies Brain Res. 843 1-2 1999 53 61
3. C. Bancher, H. Braak, P. Fischer, and K.A. Jellinger Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients Neurosci. Lett. 162 1993 179 182
4. J.S. Beckman, and J.P. Crow Pathological implications of nitric oxide, superoxide, and peroxynitrite formation Biochem. Soc. Trans. 21 1993 330 334
5. D. Bosco, M. Plastino, D. Cristiano, C. Colica, C. Ermio, and M. De Bartolo Dementia is associated with insulin resistance in patients with Parkinson's disease J. Neurol. Sci. 315 1-2 2012 39 43
6. T.M. Broome, and R.A. Coleman A mathematical model of cell death in multiple sclerosis J. Neurosci. Methods 201 2 2011 420 425
7. J.M. Chang, M.C. Kuo, H.T. Kuo, S.J. Hwang, J.C. Tsai, and H.C. Chen 1-α,25-Dihydroxyvitamin D3 regulates inducible nitric oxide synthase messenger RNA expression and nitric oxide release in macrophage-like RAW 264.7 cells J. Lab. Clin. Med. 143 1 2004 14 22
8. B. Cheng, Y. Guo, C. Li, B. Ji, Y. Pan, J. Chen, and B. Bai Edaravone protected PC12 cells against MPP(+)-cytotoxicity via inhibiting oxidative stress and up-regulating heme oxygenase-1 expression J. Neurol. Sci. 343 1-2 2014 115 119
9. J.-S. Choi, J.-I. Oh, M. Na, S.-K. Lee, and S.H. Joo PKCδ promotes etoposide-induced cell death by phosphorylating Hsp27 in HeLa cells Biochem. Biophys. Res. Commun. 426 4 2012 590 595
10. W.-S. Choi, D.-S. Eom, B.S. Han, W.K. Kim, B.H. Han, and E.-J. Choi Phosphorylation of p38 MAPK Induced by oxidative stress is linked to activation of both caspase-8 and -9-mediated apoptotic pathways in dopaminergic neurons J. Biol. Chem. 279 19 2004 20451 20460
11. O. Dean, F. Giorlando, and M. Berk N-Acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action J. Psychiatry Neurosci. 36 2 2011 78 86
12. J.L. Evans, I.D. Goldfine, B.A. Maddux, and G.M. Grodsky Oxidative stress and stress-actived signaling pathways: a unifying hypothesis of type 2 diabetes Endocr. Rev. 23 5 2002 599 622
13. S. Gandhi, A. Wood-Kaczmar, Z. Yao, H. Plun-Favreau, E. Deas, and K. Klupsch PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death Mol. Cell 33 5 2009 627 638
14. Z. Gao, J. Yin, J. Zhang, R.E. Ward, R.J. Martin, and M. Lefevre Butyrate improves insulin sensitivity and increases energy expenditure in mice Diabetes 58 7 2009 1509 1517
15. A. Ghosh, A. Roy, X. Liu, J.H. Kordower, E.J. Mufson, and D.M. Hartley Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease Proc. Natl. Acad. Sci. 104 47 2007 18754 18759
16. C.K. Glass, K. Saijo, B. Winner, M.C. Marchetto, and F.H. Gage Mechanisms underlying inflammation in neurodegeneration Cell 140 6 2010 918 934
17. K.A. Heidenreich, and J.L. Kummer Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons J. Biol. Chem. 271 17 1996 9891 9894
18. S. Hunot, F. Boissiere, B. Faucheux, B. Brugg, A. Mouatt-Prigent, Y. Agid, and E.C. Hirsch Nitric oxide synthase and neuronal vulnerability in Parkinson's disease Neuroscience 72 2 1996 355 363
19. S.H. Hu, S.-S. Jiang, and Y. Yang Pioglitazone ameliorates intracerebral insulin resistance and tau-protein hyperphosphorylation in rats with type 2 diabetes Exp. Clin. Endocrinol. Diabetes 121 2013 220 224
20. H.S. Ko, R. von Coelln, S.R. Sriram, S.W. Kim, K.K.K. Chung, and O. Pletnikova Accumulation of the authentic parkin substrate aminoacyl-trna synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death J. Neurosci. 25 35 2005 7968 7978
21. F. Lamarche, C. Carcenac, B. Gonthier, C. Cottet-Rousselle, C. Chauvin, and L. Barret Mitochondrial permeability transition pore inhibitors prevent ethanol-induced neuronal death in mice Chem. Res. Toxicol. 26 2013 78 88
22. P. Lei, S. Ayton, D.I. Finkelstein, P.A. Adlard, C.L. Masters, and A.I. Bush Tau protein: relevance to Parkinson's disease Int. J. Biochem. Cell Biol. 42 2010 1775 1778
23. J.J. Lucas, F. Hernandez, P. Gomez-Ramos, M.A. Moran, R. Hen, and J. Avila Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice EMBO J. 20 1-2 2001 27 39
24. S.A. Marchitti, R.A. Deitrich, and V. Vasiliou Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase Pharmacol. Rev. 59 2 2007 125 150
25. P. Mehlen, K. Schulz-Osthoff, and A.P. Arrigo Small stress proteins as novel regulators of apoptosis: heat shock protein 27 blocks Fas/APO-1 and staurosporine-induced cell death J. Biol. Chem. 271 1996 16510 16514
26. P. Mehlen, C. Kretz-Remy, X. Preville, and A.P. Arrigo Human Hsp27, drosophila Hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNF-alpha-induced cell death EMBO J. 15 1996 2695 2706
27. S. Miranda, R. Foncea, J. Guerrero, and F. Leighton Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells Biochem. Biophys. Res. Commun. 258 1 1999 44 49
28. Y. Moon, K.H. Lee, J.-H. Park, D. Geum, and K. Kim Mitochondrial membrane depolarization and selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10 J. Neurochem. 93 5 2005 1199 1208
29. J.K. Morris, G.L. Bomhoff, B.K. Gorres, V.A. Davis, J. Kim, and P.-P. Lee Insulin resistance impairs nigrostriatal dopamine function Exp. Neurol. 231 1 2011 171 180
30. J.K. Morris, H. Zhang, A.A. Gupte, G.L. Bomhoff, J.A. Stanford, and P.C. Geiger Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease Brain Res. 1240 2008 185 195
31. G. Mudo, J. Makela, V. Di Liberto, T.V. Tselykh, M. Olivieri, and P. Piepponen Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease Cell. Mol. Life Sci. 69 7 2012 1153 1165
32. S. Oka, H. Kamata, K. Kamata, H. Yagisawa, and H. Hirata N-Acetylcysteine suppresses TNF-induced NF-kappa B activation through inhibition of I kappa B kinases FEBS Lett. 472 2000 196 202
33. A. Petit-Paitel, F. Brai, J. Cazareth, and J. Chabry Involvement of cytosolic and mitochondrial GSK-3β in mitochondrial dysfunction and neuronal cell death of MPTP/MPP+-treated neurons PLoS One 4 5 2009 1 12
34. Y. Piao, H.G. Kim, M.S. Oh, and Y.K. Pak Overexpression of TFAM, NRF-1, and myr-AKT protects the MPP+-induced mitochondrial dysfunctions in neuronal cells Biochim. Biophys. Acta 1820 5 2012 577 585
35. E. Puchacz, W.E. Stumpf, E.K. Stachowiak, and M.K. Stachowiak Vitamin D increases expression of the tyrosine hydroxylase gene in adrenal medullary cells Mol. Brain Res. 36 1 1996 193 196
36. M. Ricote, A.C. Li, T.M. Willson, C.J. Kelly, and C.K. Glass The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation Nature 391 1998 79 82
37. Y. Samuni, S. Goldstein, O.M. Dean, and M. Berk The chemistry and biological activities of N-acetycysteine Biochim. Biophys. Acta 1830 2013 4117 4129
38. M.B. Sass, A.N. Lorenz, R.L. Green, and R.A. Coleman A pragmatic approach to biochemical systems theory applied to an α-synuclein-based model of Parkinson's disease J. Neurosci. Methods 178 2 2009 366 377
39. H. Shimura, Y. Miura-Shimura, and K.S. Kosik Binding of tau to heat shock protein 27 leads to decerased concentration of hyperphosphorylated tau and enhanced cell survival J. Biol. Chem. 279 17 2004 17957 17962
40. C.M. Snyder, E.H. Shroff, J. Liu, and N.S. Chandel Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members PLoS One 4 9 2009
41. S.A. Susin, H.K. Lorenzo, N. Zamzami, I. Marzo, B.E. Snow, and G.M. Brothers Molecular characterization of mitochondrial apoptosis-inducing factor Nature 397 6718 1999 441 446
42. M. Takahashi, T. Yamada, I. Tooyama, I. Moroo, H. Kimura, T. Yamamoto, and H. Okada Insulin receptor mRNA in the substantia nigra in Parkinson's disease Neurosci. Lett. 204 3 1996 201 204
43. D.M. Taylor, R. Moser, E. Regulier, L. Breuillaud, M. Dixon, and A.A. Beesen MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in huntington's disease via additive effects of JNK and p38 inhibition J. Neurosci. 33 6 2013 2313 2325
44. K.F. Winklhofer, I.H. Henn, P.C. Kay-Jackson, U. Heller, and J. Tatzelt Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones J. Biol. Chem. 278 47 2003 199 208
45. B. Xing, M. Liu, and G. Bing Neuroprotection with pioglitazone against LPS insult on dopaminergic neurons may be associated with its inhibition of NF-κB and JNK activation and suppression of COX-2 activity J. Neuroimmunol. 192 1-2 2007 89 98
46. N. Xiong, J. Xiong, G. Khare, C. Chen, J. Huang, and Y. Zhao Edaravone guards dopamine neurons in a rotenone model for Parkinson's disease PLoS One 6 6 2011
47. M.P. Yeager, and R.A. Coleman In silico evidence for glutathione- and iron-related pathogeneses in Parkinson's disease J. Neurosci. Methods 188 1 2010 151 164
48. S. Yu, K. Ueda, and P. Chan α-Synuclein and dopamine metabolism Mol. Neurobiol. 31 1-3 2005 243 254
49. T. Zarubin, and J. Han Activation and signaling of the p38 MAP kinase pathway Cell Res. 15 1 2005 11 18
50. B. Zheng, L. Zhixiang, J.J. Locascio, K.A. Lesniak, S.S. Roderick, and M.L. Watt PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease Sci. Transl. Med. 2 52 2010 57 73
51. S. Zhou, G. Yu, L. Chi, J. Zhu, W. Zhang, Y. Zhang, and L. Zhang Neuroprotective effects of edaravone on cognitive deficit, oxidative stress and tau phosphorylation induced by intracerebroventricular streptozotocin in rats Neurotoxicology 38 2013 136 145
52. A. Zourlidou, M.D. Payne Smith, and D.S. Latchman HSP27 but not HSP70 has a potent protective effect against α-synuclein-induced cell death in mammalian neuronal cells J. Neurochem. 88 6 2004 1439 1448