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Volumn 6, Issue , 2016, Pages

Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; PEA15 PROTEIN, MOUSE; PHOSPHOPROTEIN; TYROSINE 3 MONOOXYGENASE;

EID: 84979255279     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep29967     Document Type: Article
Times cited : (26)

References (37)
  • 1
    • 0032527747 scopus 로고    scopus 로고
    • PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus
    • Condorelli, G. et al. PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus. EMBO J. 17, 3858-66 (1998).
    • (1998) EMBO J. , vol.17 , pp. 3858-3866
    • Condorelli, G.1
  • 2
    • 33750903520 scopus 로고    scopus 로고
    • The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes
    • Valentino, R. et al. The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes. Diabetologia 49, 3058-3066 (2006).
    • (2006) Diabetologia , vol.49 , pp. 3058-3066
    • Valentino, R.1
  • 3
    • 2442675414 scopus 로고    scopus 로고
    • Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action
    • Vigliotta, G. et al. Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action. Mol. Cell. Biol. 24, 5005-5015 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 5005-5015
    • Vigliotta, G.1
  • 4
    • 33847388518 scopus 로고    scopus 로고
    • PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells
    • Miele, C. et al. PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells. Diabetes 56, 622-633 (2007).
    • (2007) Diabetes , vol.56 , pp. 622-633
    • Miele, C.1
  • 5
    • 69049103284 scopus 로고    scopus 로고
    • Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism
    • Fiory, F. et al. Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism. Am. J. Physiol. Endocrinol. Metab. 297, E592-E601 (2009).
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297 , pp. E592-E601
    • Fiory, F.1
  • 6
    • 0027460528 scopus 로고
    • Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
    • Araujo, H. et al. Characterization of PEA-15, a major substrate for protein kinase C in astrocytes. J. Biol. Chem. 268, 5911-5920 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 5911-5920
    • Araujo, H.1
  • 7
    • 2942696314 scopus 로고    scopus 로고
    • The expression of PEA-15 (phosphoprotein enriched in astrocytes of 15 kDa) defines subpopulations of astrocytes and neurons throughout the adult mouse brain
    • Sharif, A. et al. The expression of PEA-15 (phosphoprotein enriched in astrocytes of 15 kDa) defines subpopulations of astrocytes and neurons throughout the adult mouse brain. Neuroscience 126, 263-275 (2004).
    • (2004) Neuroscience , vol.126 , pp. 263-275
    • Sharif, A.1
  • 8
    • 84880700448 scopus 로고    scopus 로고
    • Reactive astrocytes associated with plaques in TgCRND8 mouse brain and in human Alzheimer brain express phosphoprotein enriched in astrocytes (PEA-15)
    • Thomason, L. A. et al. Reactive astrocytes associated with plaques in TgCRND8 mouse brain and in human Alzheimer brain express phosphoprotein enriched in astrocytes (PEA-15). FEBS Lett. 587, 2448-2454 (2013).
    • (2013) FEBS Lett. , vol.587 , pp. 2448-2454
    • Thomason, L.A.1
  • 9
    • 0027561888 scopus 로고
    • The relationship between diabetes mellitus and Parkinson's disease
    • Sandyk, R. The relationship between diabetes mellitus and Parkinson's disease. Int. J. Neurosci. 69, 125-130 (1993).
    • (1993) Int. J. Neurosci. , vol.69 , pp. 125-130
    • Sandyk, R.1
  • 10
    • 84911872075 scopus 로고    scopus 로고
    • Insulin regulates brain function, but how does it get there?
    • Gray, S. M., Meijer, R. I. & Barrett, E. J. Insulin regulates brain function, but how does it get there? Diabetes 63, 3992-3997 (2014).
    • (2014) Diabetes , vol.63 , pp. 3992-3997
    • Gray, S.M.1    Meijer, R.I.2    Barrett, E.J.3
  • 11
    • 34147190028 scopus 로고    scopus 로고
    • Type 2 diabetes and the risk of Parkinson's disease
    • Hu, G. et al. Type 2 diabetes and the risk of Parkinson's disease. Diabetes Care 30, 842-847 (2007).
    • (2007) Diabetes Care , vol.30 , pp. 842-847
    • Hu, G.1
  • 12
    • 84969862314 scopus 로고    scopus 로고
    • Risk of Parkinson disease in diabetes mellitus: An updated meta-analysis of polpulation-based cohort studies
    • Yue, X. et al. Risk of parkinson disease in diabetes mellitus: an updated meta-analysis of polpulation-based cohort studies. Medicine 95, e3549 (2016).
    • (2016) Medicine , vol.95 , pp. e3549
    • Yue, X.1
  • 13
    • 84908160592 scopus 로고    scopus 로고
    • Diabetes and risk of Parkinson's disease: An updated meta-analysis of case-control studies
    • Lu, L. et al. Diabetes and risk of parkinson's disease: an updated meta-analysis of case-control studies. Plos One 9, e85781 (2014)
    • (2014) Plos One , vol.9 , pp. e85781
    • Lu, L.1
  • 14
    • 84938717912 scopus 로고    scopus 로고
    • Glitazone tratment and incidence of Parkinon's disease among peolple with diabetes: A retrospective cohort study
    • Brauer, R. et al. Glitazone tratment and incidence of Parkinon's disease among peolple with diabetes: a retrospective cohort study. Plos Med, 12, e1001854 (2015)
    • (2015) Plos Med , vol.12 , pp. e1001854
    • Brauer, R.1
  • 15
    • 33847759815 scopus 로고    scopus 로고
    • PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2
    • Glading, A. et al. PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2. Cancer Res. 67, 1536-1544 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 1536-1544
    • Glading, A.1
  • 16
    • 84902266821 scopus 로고    scopus 로고
    • Phospholipase D1 regulates autophagic flux and clearance of ?-synuclein aggregates
    • Bae, E. J. et al. Phospholipase D1 regulates autophagic flux and clearance of ?-synuclein aggregates. Cell. Death. Differ. 21, 1132-1141 (2014).
    • (2014) Cell. Death. Differ. , vol.21 , pp. 1132-1141
    • Bae, E.J.1
  • 17
    • 8744250363 scopus 로고    scopus 로고
    • Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15
    • Trencia, A. et al. Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15. J. Biol. Chem. 279, 46566-46572 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 46566-46572
    • Trencia, A.1
  • 18
    • 25444498785 scopus 로고    scopus 로고
    • Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
    • Strauss, K. M., et al. Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Hum. Mol. Genet. 14, 2099-2111 (2005).
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2099-2111
    • Strauss, K.M.1
  • 19
    • 77950368933 scopus 로고    scopus 로고
    • Brain distribution of genes related to changes in locomotor activity
    • Mignogna, P. & Viggiano, D. Brain distribution of genes related to changes in locomotor activity. Physiol. Behav. 99, 618-626 (2010).
    • (2010) Physiol. Behav. , vol.99 , pp. 618-626
    • Mignogna, P.1    Viggiano, D.2
  • 20
    • 84862133224 scopus 로고    scopus 로고
    • PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation
    • Iovino, S. et al. PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation. Cell Death Differ. 19, 1127-1138 (2012).
    • (2012) Cell Death Differ. , vol.19 , pp. 1127-1138
    • Iovino, S.1
  • 21
    • 0029588435 scopus 로고
    • Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
    • Zhou, Q. Y. & Palmiter, R. D. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 83, 1197-1209 (1995).
    • (1995) Cell , vol.83 , pp. 1197-1209
    • Zhou, Q.Y.1    Palmiter, R.D.2
  • 22
    • 14244261010 scopus 로고    scopus 로고
    • 3, 4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: Behavioral characterization of a novel genetic model of Parkinson's disease
    • Hwang, D. Y. et al. 3, 4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease. J Neurosci. 25, 2132-2137 (2005).
    • (2005) J Neurosci. , vol.25 , pp. 2132-2137
    • Hwang, D.Y.1
  • 23
    • 0038614833 scopus 로고    scopus 로고
    • Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons
    • Van den Munckhof, P. et al. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development 130, 2535-2542 (2003).
    • (2003) Development , vol.130 , pp. 2535-2542
    • Van Den Munckhof, P.1
  • 24
    • 33748944287 scopus 로고    scopus 로고
    • Regional brain variations of cytochrome oxidase activity and motor coordination in Girk2 (Wv) (Weaver) mutant mice
    • Strazielle, C. et al. Regional brain variations of cytochrome oxidase activity and motor coordination in Girk2 (Wv) (Weaver) mutant mice. Neuroscience 142, 437-449 (2006).
    • (2006) Neuroscience , vol.142 , pp. 437-449
    • Strazielle, C.1
  • 25
    • 39849101072 scopus 로고    scopus 로고
    • Neuroaxonal dystrophy caused by group VIA phospholipase A2 deficiency in mice: A model of human neurodegenerative disease
    • Shinzawa, K. et al. Neuroaxonal dystrophy caused by group VIA phospholipase A2 deficiency in mice: a model of human neurodegenerative disease. J. Neurosci. 28, 2212-2220 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 2212-2220
    • Shinzawa, K.1
  • 26
    • 34248168145 scopus 로고    scopus 로고
    • Nuclear factor i X deficiency causes brain malformation and severe skeletal defects
    • Driller, K. et al. Nuclear factor I X deficiency causes brain malformation and severe skeletal defects. Mol. Cell. Biol. 27, 3855-3867 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3855-3867
    • Driller, K.1
  • 27
    • 0036578784 scopus 로고    scopus 로고
    • Disruption of CREB function in brain leads to neurodegeneration
    • Mantamadiotis, T. et al. Disruption of CREB function in brain leads to neurodegeneration. Nat. Genet. 31, 47-54 (2002).
    • (2002) Nat. Genet. , vol.31 , pp. 47-54
    • Mantamadiotis, T.1
  • 28
    • 0036296296 scopus 로고    scopus 로고
    • Motor discoordination in mutant mice lacking junctophilin type 3
    • Nishi, M. et al. Motor discoordination in mutant mice lacking junctophilin type 3. Biochem. Biophys. Res. Commun. 292, 318-324 (2002).
    • (2002) Biochem. Biophys. Res. Commun. , vol.292 , pp. 318-324
    • Nishi, M.1
  • 29
    • 0033614772 scopus 로고    scopus 로고
    • Transgenic mice expressing mutated full-length HD cDNA: A paradigm for locomotor changes and selective neuronal loss in Huntington's disease
    • Reddy, P. H. et al. Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease. Philos. Trans. R Soc. Lond. B Biol. Sci. 354, 1035-1045 (1999).
    • (1999) Philos. Trans. R Soc. Lond. B Biol. Sci. , vol.354 , pp. 1035-1045
    • Reddy, P.H.1
  • 30
    • 84859729640 scopus 로고    scopus 로고
    • Mouse models of spinocerebellar ataxia type 3 (Machado-Joseph disease)
    • Colomer Gould, V. F. Mouse models of spinocerebellar ataxia type 3 (Machado-Joseph disease). Neurotherapeutics 9, 285-296 (2012).
    • (2012) Neurotherapeutics , vol.9 , pp. 285-296
    • Colomer Gould, V.F.1
  • 31
    • 0037421111 scopus 로고    scopus 로고
    • Transgenic mice expressing the PS1-A246E mutation: Effects on spatial learning, exploration, anxiety, and motor coordination
    • Lalonde, R., Qian, S. & Strazielle, C. Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination. Behav. Brain Res. 138, 71-79 (2003).
    • (2003) Behav. Brain Res. , vol.138 , pp. 71-79
    • Lalonde, R.1    Qian, S.2    Strazielle, C.3
  • 32
    • 33745852268 scopus 로고    scopus 로고
    • Neurological abnormalities in caveolin-1 knock out mice
    • Trushina, E. et al. Neurological abnormalities in caveolin-1 knock out mice. Behav. Brain Res. 172, 24-32 (2006).
    • (2006) Behav. Brain Res. , vol.172 , pp. 24-32
    • Trushina, E.1
  • 33
    • 26644440895 scopus 로고    scopus 로고
    • Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice
    • Brunskill, E. W. et al. Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. Eur. J. Neurosci. 22, 1265-1276 (2005).
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 1265-1276
    • Brunskill, E.W.1
  • 34
    • 16244405559 scopus 로고    scopus 로고
    • GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum
    • Chiu, C.-S. et al. GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. J. Neurosci. 25, 3234-3245 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 3234-3245
    • Chiu, C.-S.1
  • 35
    • 4644264945 scopus 로고    scopus 로고
    • Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype
    • Kan, L. et al. Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype. Am. J. Pathol. 165, 1107-1115 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 1107-1115
    • Kan, L.1
  • 36
    • 73349110124 scopus 로고    scopus 로고
    • Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities
    • Ramos, J. W. et al. Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities. BMC Neurosci. 10, 134 (2009).
    • (2009) BMC Neurosci. , vol.10 , pp. 134
    • Ramos, J.W.1
  • 37
    • 84897873665 scopus 로고    scopus 로고
    • PEP-1-PEA-15 protects against toxin-induced neuronal damage in a mouse model of Parkinson's disease
    • Ahn, E. H. et al. PEP-1-PEA-15 protects against toxin-induced neuronal damage in a mouse model of Parkinson's disease. Biochim. Biophys. Acta. 1840, 1686-1700 (2014).
    • (2014) Biochim. Biophys. Acta. , vol.1840 , pp. 1686-1700
    • Ahn, E.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.