Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compound

Biochemical and Biophysical Research Communications

Volumn 458, Issue 1, 2015, Pages 21-27

  Qin, Zhaohong ^a   Pandey, Nihar R ^a   Zhou, Xun ^a   Stewart, Chloe A ^a,b   Hari, Aswin ^a   Huang, Hua ^a   Stewart, Alexandre F R ^b   Brunel, Jean Michel ^c,d   Chen, Hsiao Huei ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c AIX MARSEILLE UNIVERSITY   (France)

^d AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Body weight; Energy expenditure; Food intake; Protein tyrosine phosphatase; Trodusquemine; Type 2 diabetes

Indexed keywords

CLARAMINE; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; TRODUSQUEMINE; UNCLASSIFIED DRUG; 3-N-1(SPERMINE)-7, 24-DIHYDROXY-5-CHOLESTANE 24-SULFATE; CHOLESTANE DERIVATIVE; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; PTPN1 PROTEIN, MOUSE; PTPN2 PROTEIN, MOUSE; SPERMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; ENERGY EXPENDITURE; ENZYME INHIBITION; FEEDING BEHAVIOR; FOOD INTAKE; GLYCEMIC CONTROL; INSULIN RESPONSE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; MALE; MOUSE; NERVE CELL CULTURE; NEUROBLASTOMA CELL LINE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WEIGHT REDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; EATING; METABOLISM; MUTANT MOUSE STRAIN; NERVE CELL; SYNTHESIS;

MUS; SQUALIDAE; SQUALUS ACANTHIAS;

ANIMALS; CELLS, CULTURED; CHOLESTANES; DIABETES MELLITUS, EXPERIMENTAL; EATING; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; INSULIN; MALE; MICE; MICE, MUTANT STRAINS; NEURONS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SPERMINE; WEIGHT LOSS;

EID: 84922933651     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.01.040     Document Type: Article

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