메뉴 건너뛰기




Volumn 22, Issue 13, 2015, Pages 1573-1581

Mechanisms of neurodegeration in type 2 diabetes and the neuroprotective potential of dipeptidyl peptidase 4 inhibitors

Author keywords

Alzheimer disease; Diabetes mellitus; Dipeptidyl peptidase 4 inhibitors; Parkinson disease; Vascular dementia

Indexed keywords

ALOGLIPTIN; CALCITONIN GENE RELATED PEPTIDE; CHEMOKINE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIN RELEASING PEPTIDE; GLUCAGON LIKE PEPTIDE 1; HYDROLASE; INCRETIN; INTERMEDIN; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; NEUROPEPTIDE; NEUROPEPTIDE Y; SAXAGLIPTIN; SITAGLIPTIN; VILDAGLIPTIN; DIPEPTIDYL PEPTIDASE IV; NEUROPROTECTIVE AGENT;

EID: 84931292010     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867322666150227153308     Document Type: Article
Times cited : (31)

References (91)
  • 1
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann, G.; Drachman, D.; Folstein, M.; Katzman, R.; Price, D.; Stadlan, E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 1984, 34, 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 4
    • 84901188020 scopus 로고    scopus 로고
    • Insights into the physiological function of the ß-amyloid precursor protein: Beyond Alzheimer's disease
    • Dawkins, E.; Small, D.H. Insights into the physiological function of the ß-amyloid precursor protein: beyond Alzheimer's disease. J. Neurochem., 2014, 129, 756-769.
    • (2014) J. Neurochem. , vol.129 , pp. 756-769
    • Dawkins, E.1    Small, D.H.2
  • 5
    • 84905110102 scopus 로고    scopus 로고
    • Transport and diffusion of Tau protein in neurons
    • Scholz, T.; Mandelkow, E. Transport and diffusion of Tau protein in neurons. Cell. Mol. Life Sci., 2014, 71(16): 3139-3150.
    • (2014) Cell. Mol. Life Sci. , vol.71 , Issue.16 , pp. 3139-3150
    • Scholz, T.1    Mandelkow, E.2
  • 7
    • 84879950313 scopus 로고    scopus 로고
    • Dementia in the oldest old: A multi-factorial and growing public health issue
    • Gardner, R.C.; Valcour, V.; Yaffe, K. Dementia in the oldest old: A multi-factorial and growing public health issue. Alzheimers Res. Ther., 2013, 5, 27.
    • (2013) Alzheimers Res. Ther. , vol.5 , pp. 27
    • Gardner, R.C.1    Valcour, V.2    Yaffe, K.3
  • 8
    • 84896971038 scopus 로고    scopus 로고
    • In vitro aggregation assays for the characterization of α-synuclein prion-like properties
    • Narkiewicz, J.; Giachin, G.; Legname, G. In vitro aggregation assays for the characterization of α-synuclein prion-like properties. Prion, 2014, 8, 19-32.
    • (2014) Prion , vol.8 , pp. 19-32
    • Narkiewicz, J.1    Giachin, G.2    Legname, G.3
  • 10
    • 76849101075 scopus 로고    scopus 로고
    • Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders
    • Profenno, L.A.; Porsteinsson, A.P.; Faraone, S.V. Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol. Psychiatry, 2010, 67, 505-512.
    • (2010) Biol. Psychiatry , vol.67 , pp. 505-512
    • Profenno, L.A.1    Porsteinsson, A.P.2    Faraone, S.V.3
  • 12
    • 84861450111 scopus 로고    scopus 로고
    • Diabetes as a risk factor for dementia and mild cognitive impairment: A meta-analysis of longitudinal studies
    • Cheng, G.; Huang, C.; Deng, H.; Wang, H. Diabetes as a risk factor for dementia and mild cognitive impairment: A meta-analysis of longitudinal studies. Intern. Med. J., 2012, 42, 484-491.
    • (2012) Intern. Med. J. , vol.42 , pp. 484-491
    • Cheng, G.1    Huang, C.2    Deng, H.3    Wang, H.4
  • 15
  • 16
    • 84860850000 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease in relation to diabetes: A population-based cohort study
    • Wang, K.C.; Woung, L.C.; Tsai, M.T.; Liu, C.C.; Su, Y.H.; Li, C.Y. Risk of Alzheimer's disease in relation to diabetes: A population-based cohort study. Neuroepidemiology, 2012, 38, 237-244.
    • (2012) Neuroepidemiology , vol.38 , pp. 237-244
    • Wang, K.C.1    Woung, L.C.2    Tsai, M.T.3    Liu, C.C.4    Su, Y.H.5    Li, C.Y.6
  • 17
    • 84865861369 scopus 로고    scopus 로고
    • Newly diagnosed type 2 diabetes and risk of dementia: A population-based 7-year follow-up study in Taiwan
    • Cheng, P.Y.; Sy, H.N.; Wu, S.L.; Wang, W.F.; Chen, Y.Y. Newly diagnosed type 2 diabetes and risk of dementia: A population-based 7-year follow-up study in Taiwan. J. Diabetes Complications, 2012, 26, 382-387.
    • (2012) J. Diabetes Complications , vol.26 , pp. 382-387
    • Cheng, P.Y.1    Sy, H.N.2    Wu, S.L.3    Wang, W.F.4    Chen, Y.Y.5
  • 21
    • 0026021161 scopus 로고
    • Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
    • DeFronzo, R.A.; Ferrannini, E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care, 1993, 14, 173-194.
    • (1993) Diabetes Care , vol.14 , pp. 173-194
    • Defronzo, R.A.1    Ferrannini, E.2
  • 22
    • 0030044787 scopus 로고    scopus 로고
    • Diabetes mellitus as a risk factor for death from stroke. Prospective study of the middle-aged Finnish population
    • Tuomilehto, J.; Rastenyte, D.; Jousilahti, P.; Sarti, C., Vartiainen, E. Diabetes mellitus as a risk factor for death from stroke. Prospective study of the middle-aged Finnish population. Stroke, 1996, 27, 210-215.
    • (1996) Stroke , vol.27 , pp. 210-215
    • Tuomilehto, J.1    Rastenyte, D.2    Jousilahti, P.3    Sarti, C.4    Vartiainen, E.5
  • 23
    • 84893580325 scopus 로고    scopus 로고
    • Rates of complications and mortality in older patients with diabetes mellitus: The diabetes and aging study
    • Huang, E.S.; Laiteerapong, N.; Liu, J.Y.; John, P.M.; Moffet, H.H.; Karter, A.J. Rates of complications and mortality in older patients with diabetes mellitus: The diabetes and aging study. JAMA Intern. Med., 2014, 174, 251-258.
    • (2014) JAMA Intern. Med. , vol.174 , pp. 251-258
    • Huang, E.S.1    Laiteerapong, N.2    Liu, J.Y.3    John, P.M.4    Moffet, H.H.5    Karter, A.J.6
  • 26
    • 84897930403 scopus 로고    scopus 로고
    • Current pathophysiological concepts in cerebral small vessel disease
    • Rincon, F.; Wright, C.B. Current pathophysiological concepts in cerebral small vessel disease. Front. Aging Neurosci., 2014, 6, 24.
    • (2014) Front. Aging Neurosci. , vol.6 , pp. 24
    • Rincon, F.1    Wright, C.B.2
  • 32
    • 84887105869 scopus 로고    scopus 로고
    • Glucose levels and risk of dementia
    • Kielstein, J.T. Glucose levels and risk of dementia. N. Engl. J. Med., 2013, 369, 1863.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1863
    • Kielstein, J.T.1
  • 33
    • 84862780458 scopus 로고    scopus 로고
    • Advanced glycation end products and neurodegenerative diseases: Mechanisms and perspective
    • Li, J.; Liu, D.; Sun, L.; Lu, Y.; Zhang, Z. Advanced glycation end products and neurodegenerative diseases: mechanisms and perspective. J. Neurol. Sci., 2012, 317, 1-5.
    • (2012) J. Neurol. Sci. , vol.317 , pp. 1-5
    • Li, J.1    Liu, D.2    Sun, L.3    Lu, Y.4    Zhang, Z.5
  • 34
    • 84892391503 scopus 로고    scopus 로고
    • The potential mechanisms of Aβ-receptor for advanced glycation end-products interaction disrupting tight junctions of the blood-brain barrier in Alzheimer's disease
    • Wan, W.; Chen, H.; Li, Y. The potential mechanisms of Aβ-receptor for advanced glycation end-products interaction disrupting tight junctions of the blood-brain barrier in Alzheimer's disease. Int. J. Neurosci., 2014, 124, 75-81.
    • (2014) Int. J. Neurosci. , vol.124 , pp. 75-81
    • Wan, W.1    Chen, H.2    Li, Y.3
  • 35
    • 84888058168 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation
    • Chen, S.; An, F.M.; Yin, L.; Liu, A.R.; Yin, D.K.; Yao, W.B.; Gao, X.D. Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation. Neuroscience, 2014, 256, 137-146.
    • (2014) Neuroscience , vol.256 , pp. 137-146
    • Chen, S.1    An, F.M.2    Yin, L.3    Liu, A.R.4    Yin, D.K.5    Yao, W.B.6    Gao, X.D.7
  • 36
    • 84899940393 scopus 로고    scopus 로고
    • Deregulation of brain insulin signaling in Alzheimer's disease
    • Chen, Y.; Deng, Y.; Zhang, B.; Gong, C.X. Deregulation of brain insulin signaling in Alzheimer's disease. Neurosci. Bull., 2014, 30, 282-294.
    • (2014) Neurosci. Bull. , vol.30 , pp. 282-294
    • Chen, Y.1    Deng, Y.2    Zhang, B.3    Gong, C.X.4
  • 37
    • 84897954482 scopus 로고    scopus 로고
    • Brain metabolic dysfunction at the core of Alzheimer's disease
    • de la Monte, S.M.; Tong, M. Brain metabolic dysfunction at the core of Alzheimer's disease. Biochem. Pharmacol., 2014, 88, 548-559.
    • (2014) Biochem. Pharmacol. , vol.88 , pp. 548-559
    • De La Monte, S.M.1    Tong, M.2
  • 38
    • 84909590793 scopus 로고    scopus 로고
    • System-based approaches to decode the molecular links in Parkinson's disease and diabetes
    • Santiago, J.A.; Potashkin, J.A. System-based approaches to decode the molecular links in Parkinson's disease and diabetes. Neurobiol. Dis,. 2014, 72 PtA: 84-91.
    • (2014) Neurobiol. Dis,. , vol.72 , pp. 84-91
    • Santiago, J.A.1    Potashkin, J.A.2
  • 40
    • 70349386312 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 (CD26): Knowing the function before inhibiting the enzyme
    • Matteucci, E.; Giampietro, O. Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme. Curr. Med. Chem., 2009, 16, 2943-2951.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 2943-2951
    • Matteucci, E.1    Giampietro, O.2
  • 41
    • 80054871921 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition: Linking chemical properties to clinical safety
    • Matteucci, E.; Giampietro, O. Dipeptidyl peptidase-4 inhibition: linking chemical properties to clinical safety. Curr. Med. Chem., 2011, 18, 4753-4760.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 4753-4760
    • Matteucci, E.1    Giampietro, O.2
  • 45
    • 84897848470 scopus 로고    scopus 로고
    • Central effects of GLP-1: New opportunities for treatments of neurodegenerative diseases
    • Hölscher, C. Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases. J. Endocrinol., 2014, 221, T31-41.
    • (2014) J. Endocrinol. , vol.221 , pp. T31-41
    • Hölscher, C.1
  • 46
    • 84875439056 scopus 로고    scopus 로고
    • DPP-4 inhibition and neuroprotection: Do mechanisms matter?
    • Shannon, R.P. DPP-4 inhibition and neuroprotection: do mechanisms matter? Diabetes, 2013, 62, 1029-1031
    • (2013) Diabetes , vol.62 , pp. 1029-1031
    • Shannon, R.P.1
  • 48
    • 78649686908 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: A comparative review
    • Deacon, C.F. Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: A comparative review. Diabetes Obes. Metab., 2011, 13, 7-18.
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 7-18
    • Deacon, C.F.1
  • 49
    • 84878781836 scopus 로고    scopus 로고
    • DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats
    • Pintana, H.; Apaijai, N.; Chattipakorn, N.; Chattipakorn, S.C. DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats. J. Endocrinol., 2013, 218, 1-11.
    • (2013) J. Endocrinol. , vol.218 , pp. 1-11
    • Pintana, H.1    Apaijai, N.2    Chattipakorn, N.3    Chattipakorn, S.C.4
  • 50
    • 54849405942 scopus 로고    scopus 로고
    • Benzimidazolium salts as small, nonpeptidic and BBBpermeable human prolyl oligopeptidase inhibitors
    • Tarragó, T.; Masdeu, C.; Gómez, E.; Isambert, N.; Lavilla, R.; Giralt, E. Benzimidazolium salts as small, nonpeptidic and BBBpermeable human prolyl oligopeptidase inhibitors. ChemMed-Chem., 2008, 3, 1558-1565.
    • (2008) ChemMed-Chem. , vol.3 , pp. 1558-1565
    • Tarragó, T.1    Masdeu, C.2    Gómez, E.3    Isambert, N.4    Lavilla, R.5    Giralt, E.6
  • 51
    • 84891804220 scopus 로고    scopus 로고
    • MEROPS: The database of proteolytic enzymes, their substrates and inhibitors
    • Rawlings, N.D.; Waller, M.; Barrett, A.J.; Bateman, A. MEROPS: The database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res., 2014, 42, D503-509.
    • (2014) Nucleic Acids Res. , vol.42 , pp. D503-509
    • Rawlings, N.D.1    Waller, M.2    Barrett, A.J.3    Bateman, A.4
  • 52
    • 84905911804 scopus 로고    scopus 로고
    • Neuroprotective roles of pituitary adenylate cyclase-activating polypeptide in neurodegenerative diseases
    • Lee, E.H.; Seo, S.R. Neuroprotective roles of pituitary adenylate cyclase-activating polypeptide in neurodegenerative diseases. B.M.B. Rep., 2014, 47, 369-375.
    • (2014) B.M.B. Rep. , vol.47 , pp. 369-375
    • Lee, E.H.1    Seo, S.R.2
  • 54
    • 84907011084 scopus 로고    scopus 로고
    • Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase
    • Wang, Q.; Chu, C.H.; Qian, L.; Chen, S.H.; Wilson, B.; Oyarzabal, E.; Jiang, L.; Ali, S.; Robinson, B.; Kim, H.C.; Hong, J.S. Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. J. Neurosci., 2014, 34, 12490-12503.
    • (2014) J. Neurosci. , vol.34 , pp. 12490-12503
    • Wang, Q.1    Chu, C.H.2    Qian, L.3    Chen, S.H.4    Wilson, B.5    Oyarzabal, E.6    Jiang, L.7    Ali, S.8    Robinson, B.9    Kim, H.C.10    Hong, J.S.11
  • 55
    • 84861230070 scopus 로고    scopus 로고
    • Stromal cell-derived factor 1α decreases β-amyloid deposition in Alzheimer's disease mouse model
    • Wang, Q.; Xu, Y.; Chen, J.C.; Qin, Y.Y.; Liu, M.; Liu, Y.; Xie, M.J.; Yu, Z.Y.; Zhu, Z.; Wang, W. Stromal cell-derived factor 1α decreases β-amyloid deposition in Alzheimer's disease mouse model. Brain Res., 2012, 1459, 15-26.
    • (2012) Brain Res. , vol.1459 , pp. 15-26
    • Wang, Q.1    Xu, Y.2    Chen, J.C.3    Qin, Y.Y.4    Liu, M.5    Liu, Y.6    Xie, M.J.7    Yu, Z.Y.8    Zhu, Z.9    Wang, W.10
  • 57
    • 84871612985 scopus 로고    scopus 로고
    • Enhanced expression of glia maturation factor correlates with glial activation in the brain of triple transgenic Alzheimer's disease mice
    • Zaheer, S.; Thangavel, R.; Wu, Y.; Khan, M.M.; Kempuraj, D.; Zaheer, A. Enhanced expression of glia maturation factor correlates with glial activation in the brain of triple transgenic Alzheimer's disease mice. Neurochem. Res., 2013, 38, 218-225.
    • (2013) Neurochem. Res. , vol.38 , pp. 218-225
    • Zaheer, S.1    Thangavel, R.2    Wu, Y.3    Khan, M.M.4    Kempuraj, D.5    Zaheer, A.6
  • 58
    • 84855328900 scopus 로고    scopus 로고
    • α-Synuclein potentiates interleukin-1β-induced CXCL10 expression in human A172 astrocytoma cells
    • Tousi, N.S.; Buck, D.J.; Curtis, J.T.; Davis, R.L. α-Synuclein potentiates interleukin-1β-induced CXCL10 expression in human A172 astrocytoma cells. Neurosci. Lett., 2012, 507, 133-136.
    • (2012) Neurosci. Lett. , vol.507 , pp. 133-136
    • Tousi, N.S.1    Buck, D.J.2    Curtis, J.T.3    Davis, R.L.4
  • 59
    • 84899869409 scopus 로고    scopus 로고
    • The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse
    • Savolainen, M.H.; Richie, C.T.; Harvey, B.K.; Männistö, P.T.; Maguire-Zeiss, K.A.; Myöhänen, T.T. The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse. Neurobiol. Dis., 2014, 68, 1-15.
    • (2014) Neurobiol. Dis. , vol.68 , pp. 1-15
    • Savolainen, M.H.1    Richie, C.T.2    Harvey, B.K.3    Männistö, P.T.4    Maguire-Zeiss, K.A.5    Myöhänen, T.T.6
  • 60
    • 84857368498 scopus 로고    scopus 로고
    • DPP-4 inhibitors in the treatment of type 2 diabetes
    • (a) Duez, H.; Cariou, B.; Staels, B. DPP-4 inhibitors in the treatment of type 2 diabetes. Biochem. Pharmacol., 2012, 83, 823-832;
    • (2012) Biochem. Pharmacol. , vol.83 , pp. 823-832
    • Duez, H.1    Cariou, B.2    Staels, B.3
  • 61
    • 84884977867 scopus 로고    scopus 로고
    • Prognostic implications of DPP-4 inhibitor vs. Sulfonylurea use on top of metformin in a real world setting-results of the 1 year follow-up of the prospective DiaRegis registry
    • (b) Gitt, A.K.; Bramlage, P.; Binz, C.; Krekler, M.; Deeg, E.; Tschöpe, D. Prognostic implications of DPP-4 inhibitor vs. sulfonylurea use on top of metformin in a real world setting-results of the 1 year follow-up of the prospective DiaRegis registry. Int. J. Clin. Pract., 2013, 67, 1005-1014.
    • (2013) Int. J. Clin. Pract. , vol.67 , pp. 1005-1014
    • Gitt, A.K.1    Bramlage, P.2    Binz, C.3    Krekler, M.4    Deeg, E.5    Tschöpe, D.6
  • 62
    • 84882336972 scopus 로고    scopus 로고
    • Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: Part i
    • Paneni, F.; Beckman, J.A.; Creager, M.A.; Cosentino, F. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Eur. Heart J., 2013, 34, 2436-2443.
    • (2013) Eur. Heart J. , vol.34 , pp. 2436-2443
    • Paneni, F.1    Beckman, J.A.2    Creager, M.A.3    Cosentino, F.4
  • 63
    • 84904007147 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and cardiovascular outcomes: Meta-analysis of randomized clinical trials with 55,141 participants
    • Wu, S.; Hopper, I.; Skiba, M.; Krum, H. Dipeptidyl peptidase-4 inhibitors and cardiovascular outcomes: Meta-analysis of randomized clinical trials with 55,141 participants. Cardiovasc. Ther., 2014, 32(4): 147-158.
    • (2014) Cardiovasc. Ther. , vol.32 , Issue.4 , pp. 147-158
    • Wu, S.1    Hopper, I.2    Skiba, M.3    Krum, H.4
  • 64
    • 84865492997 scopus 로고    scopus 로고
    • Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus
    • Patil, H.R.; Al Badarin, F.J.; Al Shami, H.A.; Bhatti, S.K.; Lavie, C.J.; Bell, D.S.; O'Keefe, J.H. Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus. Am. J. Cardiol., 2012, 110, 826-833.
    • (2012) Am. J. Cardiol. , vol.110 , pp. 826-833
    • Patil, H.R.1    Al Badarin, F.J.2    Al Shami, H.A.3    Bhatti, S.K.4    Lavie, C.J.5    Bell, D.S.6    O'Keefe, J.H.7
  • 65
    • 84871936025 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: A meta-analysis of randomized clinical trials
    • Monami, M.; Ahrén, B.; Dicembrini, I.; Mannucci, E. Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: A meta-analysis of randomized clinical trials. Diabetes Obes. Metab., 2013, 15, 112-120.
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 112-120
    • Monami, M.1    Ahrén, B.2    Dicembrini, I.3    Mannucci, E.4
  • 68
    • 77951168113 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice
    • Sauvé, M.; Ban, K.; Momen, M.A.; Zhou, Y.Q.; Henkelman, R.M.; Husain, M.; Drucker, D.J. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice. Diabetes, 2010, 59, 1063-1073.
    • (2010) Diabetes , vol.59 , pp. 1063-1073
    • Sauvé, M.1    Ban, K.2    Momen, M.A.3    Zhou, Y.Q.4    Henkelman, R.M.5    Husain, M.6    Drucker, D.J.7
  • 69
    • 79959966874 scopus 로고    scopus 로고
    • Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, prediabetic rats
    • Huisamen, B.; Genis, A.; Marais, E.; Lochner, A. Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, prediabetic rats. Cardiovasc. Drugs Ther., 2011, 25, 13-20.
    • (2011) Cardiovasc. Drugs Ther. , vol.25 , pp. 13-20
    • Huisamen, B.1    Genis, A.2    Marais, E.3    Lochner, A.4
  • 71
    • 84867847993 scopus 로고    scopus 로고
    • Dipeptidyl peptidase 4 as a therapeutic target in ischemia/reperfusion injury
    • Matheeussen, V.; Jungraithmayr, W.; De Meester, I. Dipeptidyl peptidase 4 as a therapeutic target in ischemia/reperfusion injury. Pharmacol. Ther., 2012, 136, 267-282.
    • (2012) Pharmacol. Ther. , vol.136 , pp. 267-282
    • Matheeussen, V.1    Jungraithmayr, W.2    De Meester, I.3
  • 72
    • 84857903646 scopus 로고    scopus 로고
    • DPP-4 inhibitors and lipids: Systematic review and meta-analysis
    • Monami, M.; Lamanna, C.; Desideri, C.M.; Mannucci, E. DPP-4 inhibitors and lipids: systematic review and meta-analysis. Adv. Ther., 2012, 29, 14-25.
    • (2012) Adv. Ther. , vol.29 , pp. 14-25
    • Monami, M.1    Lamanna, C.2    Desideri, C.M.3    Mannucci, E.4
  • 73
    • 79959773411 scopus 로고    scopus 로고
    • DPP-4 inhibitors: Impact on glycemic control and cardiovascular risk factors
    • Dicker, D. DPP-4 inhibitors: impact on glycemic control and cardiovascular risk factors. Diabetes Care, 2011, 34, S276-S278.
    • (2011) Diabetes Care , vol.34 , pp. S276-S278
    • Dicker, D.1
  • 74
    • 84870053428 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition with saxagliptin enhanced nitric oxide release and reduced blood pressure and sICAM-1 levels in hypertensive rats
    • Mason, R.P.; Jacob, R.F.; Kubant, R.; Ciszewski, A.; Corbalan, J.J.; Malinski, T. Dipeptidyl peptidase-4 inhibition with saxagliptin enhanced nitric oxide release and reduced blood pressure and sICAM-1 levels in hypertensive rats. J. Cardiovasc. Pharmacol., 2012, 60, 467-473.
    • (2012) J. Cardiovasc. Pharmacol. , vol.60 , pp. 467-473
    • Mason, R.P.1    Jacob, R.F.2    Kubant, R.3    Ciszewski, A.4    Corbalan, J.J.5    Malinski, T.6
  • 77
    • 79951677095 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats
    • Pacheco, B.P.; Crajoinas, R.O.; Couto, G.K.; Davel, A.P.; Lessa, L.M.; Rossoni, L.V.; Girardi, A.C. Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats. J. Hypertens., 2011, 29, 520-528.
    • (2011) J. Hypertens. , vol.29 , pp. 520-528
    • Pacheco, B.P.1    Crajoinas, R.O.2    Couto, G.K.3    Davel, A.P.4    Lessa, L.M.5    Rossoni, L.V.6    Girardi, A.C.7
  • 78
    • 84883084459 scopus 로고    scopus 로고
    • Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor
    • Ishibashi, Y.; Matsui, T.; Maeda, S.; Higashimoto, Y.; Yamagishi, S. Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor. Cardiovasc. Diabetol., 2013, 12, 125.
    • (2013) Cardiovasc. Diabetol. , vol.12 , pp. 125
    • Ishibashi, Y.1    Matsui, T.2    Maeda, S.3    Higashimoto, Y.4    Yamagishi, S.5
  • 80
    • 84874525661 scopus 로고    scopus 로고
    • DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption
    • Pipatpiboon, N.; Pintana, H.; Pratchayasakul, W.; Chattipakorn, N.; Chattipakorn, S.C. DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption. Eur. J. Neurosci., 2013, 37, 839-849.
    • (2013) Eur. J. Neurosci. , vol.37 , pp. 839-849
    • Pipatpiboon, N.1    Pintana, H.2    Pratchayasakul, W.3    Chattipakorn, N.4    Chattipakorn, S.C.5
  • 81
    • 35048821410 scopus 로고    scopus 로고
    • Effects of PACAP, VIP and related peptides on cyclic AMP formation in rat neuronal and astrocyte cultures and cerebral cortical slices
    • Jozwiak-Bebenista, M.; Dejda, A.; Nowak, J.Z. Effects of PACAP, VIP and related peptides on cyclic AMP formation in rat neuronal and astrocyte cultures and cerebral cortical slices. Pharmacol. Rep., 2007, 59, 414-420.
    • (2007) Pharmacol. Rep. , vol.59 , pp. 414-420
    • Jozwiak-Bebenista, M.1    Dejda, A.2    Nowak, J.Z.3
  • 82
    • 84885349138 scopus 로고    scopus 로고
    • Cyclic AMP promotes axon regeneration, lesion repair and neuronal survival in lampreys after spinal cord injury
    • Lau, B.Y.; Fogerson, S.M.; Walsh, R.B.; Morgan, J.R. Cyclic AMP promotes axon regeneration, lesion repair and neuronal survival in lampreys after spinal cord injury. Exp. Neurol., 2013, 250, 31-42.
    • (2013) Exp. Neurol. , vol.250 , pp. 31-42
    • Lau, B.Y.1    Fogerson, S.M.2    Walsh, R.B.3    Morgan, J.R.4
  • 83
    • 84903701668 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects
    • Werner, H.; LeRoith, D. Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects. Eur. Neuropsychopharmacol., 2014, 24, 1947-1953.
    • (2014) Eur. Neuropsychopharmacol. , vol.24 , pp. 1947-1953
    • Werner, H.1    Leroith, D.2
  • 84
    • 84898021381 scopus 로고    scopus 로고
    • Interventions that improve body and brain bioenergetics for Parkinson's disease risk reduction and therapy
    • Mattson, M.P. Interventions that improve body and brain bioenergetics for Parkinson's disease risk reduction and therapy. J. Parkinsons. Dis., 2014, 4, 1-13
    • (2014) J. Parkinsons. Dis. , vol.4 , pp. 1-13
    • Mattson, M.P.1
  • 85
    • 84911872075 scopus 로고    scopus 로고
    • Insulin regulates brain function, but how does it get there?
    • Gray, S.M.; Meijer, R.I.; Barrett, E.J. Insulin regulates brain function, but how does it get there? Diabetes, 2014, 63, 3992-3997.
    • (2014) Diabetes , vol.63 , pp. 3992-3997
    • Gray, S.M.1    Meijer, R.I.2    Barrett, E.J.3
  • 87
    • 84888008405 scopus 로고    scopus 로고
    • Vildagliptin: An antidiabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease
    • Kosaraju, J.; Murthy, V.; Khatwal, R.B.; Dubala, A.; Chinni, S.; Muthureddy Nataraj, S.K.; Basavan, D. Vildagliptin: an antidiabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease. J. Pharm. Pharmacol., 2013, 65, 1773-1784.
    • (2013) J. Pharm. Pharmacol. , vol.65 , pp. 1773-1784
    • Kosaraju, J.1    Murthy, V.2    Khatwal, R.B.3    Dubala, A.4    Chinni, S.5    Muthureddy Nataraj, S.K.6    Basavan, D.7
  • 89
    • 84897429031 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition by Pterocarpus marsupium and Eugenia jambolana ameliorates streptozotocin induced Alzheimer's disease
    • Kosaraju, J.; Madhunapantula, S.V.; Chinni, S.; Khatwal, R.B.; Dubala, A.; Muthureddy Nataraj, S.K.; Basavan, D. Dipeptidyl peptidase-4 inhibition by Pterocarpus marsupium and Eugenia jambolana ameliorates streptozotocin induced Alzheimer's disease. Behav. Brain Res., 2014, 267, 55-65.
    • (2014) Behav. Brain Res. , vol.267 , pp. 55-65
    • Kosaraju, J.1    Madhunapantula, S.V.2    Chinni, S.3    Khatwal, R.B.4    Dubala, A.5    Muthureddy Nataraj, S.K.6    Basavan, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.