Discovery of novel PTP1B inhibitors with antihyperglycemic activity

Acta Pharmacologica Sinica

Volumn 31, Issue 8, 2010, Pages 1005-1012

  Liu, Zhang ^a   Chai, Qian ^a   Li, Yuan Yuan ^a   Shen, Qiang ^a   Ma, Lan Ping ^a   Zhang, Li Na ^a   Wang, Xin ^a   Sheng, Li ^a   Li, Jing Ya ^a   Li, Jia ^a   Shen, Jing Kang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

antihyperglycemic activity; diabetes; drug screening; protein tyrosine phosphatases (PTPs)

Indexed keywords

2 [4 OXO 5 [(4' 2 FLUOROPHENYLBIPHENYL 4 YL)METHYLENE] 2 THIAXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [4 OXO 5 [(4' PHENOXYLBIPHENYL 4 YL)METHYLENE] 2 THIAXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [4 OXO 5 [(4' PHENYLBIPHENYL 4 YL)METHYLENE] 2 THIAXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [(4' ISOPROPOXYBIPHENYL 4 YL)METHYLENE] 4 OXO 2 THIAXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[4' (ALLYLOXY)BIPHENYL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[4' (BENZYLOXY)BIPHENYL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[4' (CYCLOPROPYLMETHOXY)BIPHENYL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 4 THIAZOLIDINONE DERIVATIVE; 5 ((4' (ALLYLOXY)BIPHENYL 4 YL)METHYLENE) 2 THIOXOTHIAZOLIDIN 4 ONE; 5 ((4' (ALLYLOXY)BIPHENYL 4 YL)METHYLENE)THIAZOLIDINE 2,4 DIONE; 5 ((4' (CYCLOPROPYLMETHOXY)BIPHENYL 4 YL)METHYLENE) 2 THIOXOTHIAZOLIDIN 4 ONE; 5 ((4' (CYCLOPROPYLMETHOXY)BIPHENYL 4 YL)METHYLENE)THIAZOLIDINE 2,4 DIONE; 5 ((4' 2 FLUOROPHENYLBIPHENYL 4 YL)METHYLENE) 2 THIAXOTHIAZOLIDINE 4 ONE; 5 ((4' 2 FLUOROPHENYLBIPHENYL 4 YL)METHYLENE)THIAZOLIDINE 2,4 DIONE; 5 ((4' BUTOXYBIPHENYL 4 YL)METHYLENE)THIAZOLIDINE 2,4 DIONE; 5 ((4' ISOPROPOXYBIPHENYL 4 YL)METHYLENE) 2 THIAXOTHIAZOLIDINE 4 ONE; 5 ((4' ISOPROPOXYBIPHENYL 4 YL)METHYLENE)THIAZOLIDINE 2,4 DIONE; 5 ((4' PHENOXYLBIPHENYL 4 YL)METHYLENE) 2 THIAXOTHIAZOLIDINE 4 ONE; 5 ((4' PHENOXYLBIPHENYL 4 YL)METHYLENE)THIAZOLIDINE 2,4 DIONE; 5 ((4' PHENYLBIPHENYL 4 YL)METHYLENE) 2 THIAXOTHIAZOLIDINE 4 ONE; 5 ((4' PHENYLBIPHENYL 4 YL)METHYLENE)THIAZOLIDINE 2,4 DIONE; [5 [[4' (BENZYLOXY)BIPHENYL 4 YL]METHYLENE]2 THIOXOTHIAZOLIDIN 4 ONE; ANTIDIABETIC AGENT; GLUCOSE; INSULIN; METFORMIN; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; TYROSINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHO CELL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; DRUG SCREENING; GLUCOSE BLOOD LEVEL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; TREATMENT DURATION;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG DESIGN; ENZYME INHIBITORS; HYPOGLYCEMIC AGENTS; MICE; MICE, INBRED C57BL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; THIAZOLIDINES;

EID: 77955461653     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.81     Document Type: Article

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