Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults

Diabetes Care

Volumn 36, Issue 2, 2013, Pages 443-449

  Willette, Auriel A ^a,b,c   Xu, Guofan ^a,c,d   Johnson, Sterling C ^a,b,c   Birdsill, Alex C ^a,c   Jonaitis, Erin M ^c   Sager, Mark A ^c   Hermann, Bruce P ^c   Rue, Asenath La ^c   Asthana, Sanjay ^a,c   Bendlin, Barbara B ^a,c  

^a WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BRAIN ATROPHY; BRAIN FUNCTION; BRAIN REGION; BRAIN SIZE; CHILD; COGNITION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GRAY MATTER; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PARIETAL GYRUS; PRECUNEUS; PREDICTION; PREFRONTAL CORTEX; SCHOOL CHILD; TEMPORAL LOBE;

AGED; ATROPHY; BRAIN DISEASES; BRAIN MAPPING; COGNITION; FEMALE; GENOTYPE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED;

EID: 84873817577     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-0922     Document Type: Article

References (40)

1. de la Monte SM, Wands Jr. Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease. J Alzheimers Dis 2005;7:45-61
2. Craft S, Watson GS. Insulin and neuro-degenerative disease: shared and specific mechanisms. Lancet Neurol 2004;3:169-178
3. Convit A, Wolf OT, Tarshish C, de Leon MJ. Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proc Natl Acad Sci USA 2003;100: 2019-2022
4. Schrijvers EM, Witteman JC, Sijbrands EJ, Hofman A, Koudstaal PJ, Breteler MM. Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study. Neurology 2010;75:1982-1987
5. Blalock EM, Grondin R, Chen KC, et al. Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. J Neurosci 2010;30:6058-6071
6. Willette AA, Bendlin BB, Colman RJ, et al. Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys. Diabetes 2012;61:1036-1042
7. Cersosimo E, DeFronzo RA. Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases. Diabetes Metab Res Rev 2006;22:423-436
8. Henneberg N, Hoyer S. Desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)? ArchGerontolGeriatr 1995; 21:63-74
9. Zhao WQ, Chen H, Quon MJ, Alkon DL. Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol 2004;490:71-81
10. Gasparini L, Gouras GK, Wang R, et al. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci 2001;21:2561-2570
11. Zhao WQ, Lacor PN, Chen H, et al. Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric abeta. J Biol Chem 2009;284:18742-18753
12. Planel E, Tatebayashi Y, Miyasaka T, et al. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci 2007;27:13635-13648
13. Rasgon NL, Kenna HA, Wroolie TE, et al. Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease. Neurobiol Aging 2011;32:1942-1948
14. Raji CA, Ho AJ, Parikshak NN, et al. Brain structure and obesity. Hum Brain Mapp 2010;31:353-364
15. Tan ZS, Beiser AS, Fox CS, et al. Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of sub-clinical brain aging in middle-aged adults: the Framingham Offspring Study. Diabetes Care 2011;34:1766-1770
16. Benedict C, Brooks SJ, Kullberg J, et al. Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly. Diabetes Care 2012;35:488-494
17. Burns JM, Honea RA, Vidoni ED, Hutfles LJ, Brooks WM, Swerdlow RH. Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging. Biochim Biophys Acta 2012;1822: 333-339
18. Ursache A, Wedin W, Tirsi A, Convit A. Preliminary evidence for obesity and elevations in fasting insulin mediating associations between cortisol awakening response and hippocampal volumes and frontal atrophy. Psychoneuroendocrinol-ogy 2012;37:1270-1276
19. Raz N. Diabetes: brain, mind, insulin-what is normal and do we need to know? Nat Rev Endocrinol 2011;7:636-637
20. Ashburner J, Friston KJ. Voxel-based morphometrydthe methods. Neuroimage 2000;11:805-821
21. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Ho-meostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28: 412-419
22. Baker LD, Cross DJ, Minoshima S, Belongia D, Watson GS, Craft S. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch Neurol 2011;68:51-57
23. Kriegeskorte N, Lindquist MA, Nichols TE, Poldrack RA, Vul E. Everything you never wanted to know about circular analysis, but were afraid to ask. J Cereb Blood Flow Metab 2010;30:1551-1557
24. Mesulam M. Principles of Behavior and Cognitive Neurology. Oxford, Oxford University Press, 2000
25. Jack CR Jr, Petersen RC, Xu YC, et al. Prediction of AD with MRI-based hippo-campal volume in mild cognitive impairment. Neurology 1999;52:1397-1403
26. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001;14:21-36
27. Sager MA, Hermann B, La Rue A. Middle-aged children of persons with Alzheimer's disease: APOE genotypes and cognitive function in the Wisconsin Registry for Alzheimer's Prevention. J Geriatr Psychiatry Neurol 2005;18:245-249
28. Johnson SC, La Rue A, Hermann BP, et al. The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ́3/́3 genotype. Alzheimers Dement 2011;7:456-465
29. Bendlin BB, Ries ML, Canu E, et al. White matter is altered with parental family history of Alzheimer's disease. Alzheimers Dement 2010;6:394-403
30. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944
31. Haroon E, Raison CL, Miller AH. Psycho-neuroimmunology meets neuropsycho-pharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2012;37: 137-162
32. Spreen O, Strauss E. A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. 2nd ed. New York, Oxford University Press, 1998
33. Gomar JJ, Bobes-Bascaran MT, Conejero-Goldberg C, Davies P, Goldberg TE; Alzheimer's Disease Neuroimaging Initiative. Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer's disease neuroimaging initiative. Arch Gen Psychiatry 2011;68:961-969
34. Ashburner J, Friston KJ. Unified segmentation. Neuroimage 2005;26:839-851
35. Kipps CM, Duggins AJ, Mahant N, Gomes L, Ashburner J, McCusker EA. Progression of structural neuropathology in preclinical Huntington's disease: a tensor based morphometry study. J Neurol Neurosurg Psychiatry 2005;76:650-655
36. Hayasaka S, Phan KL, Liberzon I, Worsley KJ, Nichols TE. Nonstationary cluster-size inference with random field and permutation methods. Neuroimage 2004;22: 676-687
37. Baron RM, Kenny DA. The moderatormediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 1986;51:1173-1182
38. McDonald CR, McEvoy LK, Gharapetian L, et al.; Alzheimer's Disease Neuro-imaging Initiative. Regional rates of neo-cortical atrophy from normal aging to early Alzheimer disease. Neurology 2009; 73:457-465
39. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997;42:85-94
40. Braak H, Thal DR, Ghebremedhin E, Del Tredici K. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol 2011;70:960-969