-
1
-
-
33744982893
-
Etiology of Parkinson's disease
-
Schapira, A. H. Etiology of Parkinson's disease. Neurology 66 (10 Suppl. 4), S10-S23 (2006).
-
(2006)
Neurology
, vol.66
, Issue.10 SUPPL. 4
-
-
Schapira, A.H.1
-
2
-
-
61949269129
-
Genomic and proteomic biomarkers for Parkinson disease
-
Gasser, T. Genomic and proteomic biomarkers for Parkinson disease. Neurology 72 (7 Suppl.), S27-S31 (2009).
-
(2009)
Neurology
, vol.72
, Issue.7 SUPPL.
-
-
Gasser, T.1
-
3
-
-
70349235644
-
Perspectives on recent advances in the understanding and treatment of Parkinson's disease
-
Schapira, A. H. et al. Perspectives on recent advances in the understanding and treatment of Parkinson's disease. Eur. J. Neurol. 16, 1090-1099 (2009).
-
(2009)
Eur. J. Neurol.
, vol.16
, pp. 1090-1099
-
-
Schapira, A.H.1
-
4
-
-
61949235512
-
Diagnosis and the premotor phase of Parkinson disease
-
Tolosa, E., Gaig, C., Santamaria, J. & Compta, Y. Diagnosis and the premotor phase of Parkinson disease. Neurology 72 (7 Suppl.), S12-S20 (2009).
-
(2009)
Neurology
, vol.72
, Issue.7 SUPPL.
-
-
Tolosa, E.1
Gaig, C.2
Santamaria, J.3
Compta, Y.4
-
5
-
-
32544432029
-
Non-motor symptoms of Parkinson's disease: Diagnosis and management
-
Chaudhuri, K. R., Healy, D. G. & Schapira, A. H. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol. 5, 235-245 (2006).
-
(2006)
Lancet Neurol.
, vol.5
, pp. 235-245
-
-
Chaudhuri, K.R.1
Healy, D.G.2
Schapira, A.H.3
-
6
-
-
41149173996
-
The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
-
Hely, M. A., Reid, W. G., Adena, M. A., Halliday, G. M. & Morris, J. G. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov. Disord. 23, 837-844 (2008).
-
(2008)
Mov. Disord.
, vol.23
, pp. 837-844
-
-
Hely, M.A.1
Reid, W.G.2
Adena, M.A.3
Halliday, G.M.4
Morris, J.G.5
-
7
-
-
64349083816
-
Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment
-
Chaudhuri, K. R. & Schapira, A. H. Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol. 8, 464-474 (2009).
-
(2009)
Lancet Neurol.
, vol.8
, pp. 464-474
-
-
Chaudhuri, K.R.1
Schapira, A.H.2
-
8
-
-
1942520420
-
Challenges in Parkinson's disease: Restoration of the nigrostriatal dopamine system is not enough
-
Lang, A. E. & Obeso, J. A. Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough. Lancet Neurol. 3, 309-316 (2004).
-
(2004)
Lancet Neurol.
, vol.3
, pp. 309-316
-
-
Lang, A.E.1
Obeso, J.A.2
-
9
-
-
55949119836
-
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease
-
Bras, J., Singleton, A., Cookson, M. R. & Hardy, J. Emerging pathways in genetic Parkinson's disease: potential role of ceramide metabolism in Lewy body disease. FEBS J. 275, 5767-5773 (2008).
-
(2008)
FEBS J.
, vol.275
, pp. 5767-5773
-
-
Bras, J.1
Singleton, A.2
Cookson, M.R.3
Hardy, J.4
-
10
-
-
58349085737
-
What causes cell death in Parkinson's disease?
-
Gupta, A., Dawson, V. L. & Dawson, T. M. What causes cell death in Parkinson's disease? Ann. Neurol. 64 (Suppl. 2), S3-S15 (2008).
-
(2008)
Ann. Neurol.
, vol.64
, Issue.SUPPL. 2
-
-
Gupta, A.1
Dawson, V.L.2
Dawson, T.M.3
-
11
-
-
58149131277
-
Neurobiology and treatment of Parkinson's disease
-
Schapira, A. H. Neurobiology and treatment of Parkinson's disease. Trends Pharmacol. Sci. 30, 41-47 (2009).
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 41-47
-
-
Schapira, A.H.1
-
12
-
-
62549133546
-
Neuroinflammation in Parkinson's disease: A target for neuroprotection?
-
Hirsch, E. C. & Hunot, S. Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol. 8, 382-397 (2009).
-
(2009)
Lancet Neurol.
, vol.8
, pp. 382-397
-
-
Hirsch, E.C.1
Hunot, S.2
-
13
-
-
33847652900
-
Autophagy and neurodegeneration: When the cleaning crew goes on strike
-
Martinez-Vicente, M. & Cuervo, A. M. Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol. 6, 352-361 (2007).
-
(2007)
Lancet Neurol.
, vol.6
, pp. 352-361
-
-
Martinez-Vicente, M.1
Cuervo, A.M.2
-
14
-
-
41549114279
-
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
-
Pan, T., Kondo, S., Le, W. & Jankovic, J. The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 131, 1969-1978 (2008).
-
(2008)
Brain
, vol.131
, pp. 1969-1978
-
-
Pan, T.1
Kondo, S.2
Le, W.3
Jankovic, J.4
-
15
-
-
33750363298
-
The roles of intracellular proteindegradation pathways in neurodegeneration
-
Rubinsztein, D. C. The roles of intracellular proteindegradation pathways in neurodegeneration. Nature 443, 780-786 (2006).
-
(2006)
Nature
, vol.443
, pp. 780-786
-
-
Rubinsztein, D.C.1
-
16
-
-
4344673498
-
Mechanisms of chaperone-mediated autophagy
-
Majeski, A. E. & Dice, J. F. Mechanisms of chaperone-mediated autophagy. Int. J. Biochem. Cell Biol. 36, 2435-2444 (2004).
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 2435-2444
-
-
Majeski, A.E.1
Dice, J.F.2
-
17
-
-
0025294506
-
Peptide sequences that target cytosolic proteins for lysosomal proteolysis
-
Dice, J. F. Peptide sequences that target cytosolic proteins for lysosomal proteolysis. Trends Biochem. Sci. 15, 305-309 (1990).
-
(1990)
Trends Biochem. Sci.
, vol.15
, pp. 305-309
-
-
Dice, J.F.1
-
18
-
-
4344659685
-
Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
-
Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T. & Sulzer, D. Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy. Science 305, 1292-1295 (2004).
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stefanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
19
-
-
0242300619
-
α-Synuclein locus triplication causes Parkinson's disease
-
Singleton, A. B. et al. α-synuclein locus triplication causes Parkinson's disease. Science 302, 841 (2003).
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
-
20
-
-
43249120160
-
Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain
-
Fuchs, J. et al. Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain. FASEB J. 22, 1327-1334 (2008).
-
(2008)
FASEB J.
, vol.22
, pp. 1327-1334
-
-
Fuchs, J.1
-
21
-
-
67650496503
-
Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: Relevance to Parkinson's disease pathogenesis
-
Chau, K. Y., Ching H. L., Schapira, A. H. & Cooper, J. M. Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis. J. Neurochem. 110, 1005-1013 (2009).
-
(2009)
J. Neurochem.
, vol.110
, pp. 1005-1013
-
-
Chau, K.Y.1
Ching, H.L.2
Schapira, A.H.3
Cooper, J.M.4
-
22
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
-
Desplats, P. et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein. Proc. Natl Acad. Sci. USA 106, 13010-13015 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
-
23
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
-
Li, J. Y. et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat. Med. 14, 501-503 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 501-503
-
-
Li, J.Y.1
-
24
-
-
43249114934
-
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
-
Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B. & Olanow, C. W. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat. Med. 14, 504-506 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 504-506
-
-
Kordower, J.H.1
Chu, Y.2
Hauser, R.A.3
Freeman, T.B.4
Olanow, C.W.5
-
25
-
-
69149088365
-
Is Parkinson's disease a prion disorder?
-
Olanow, C. W. & Prusiner, S. B. Is Parkinson's disease a prion disorder? Proc. Natl Acad. Sci. USA 106, 12571-12572 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 12571-12572
-
-
Olanow, C.W.1
Prusiner, S.B.2
-
26
-
-
0024390719
-
Mitochondrial complex I deficiency in Parkinson's disease
-
Schapira, A. H. et al. Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1, 1269 (1989).
-
(1989)
Lancet
, vol.1
, pp. 1269
-
-
Schapira, A.H.1
-
27
-
-
37049004489
-
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
-
Schapira, A. H. Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol. 7, 97-109 (2008).
-
(2008)
Lancet Neurol.
, vol.7
, pp. 97-109
-
-
Schapira, A.H.1
-
28
-
-
33644778845
-
Parkin enhances mitochondrial biogenesis in proliferating cells
-
Kuroda, Y. et al. Parkin enhances mitochondrial biogenesis in proliferating cells. Hum. Mol. Genet. 15, 883-895 (2006).
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 883-895
-
-
Kuroda, Y.1
-
29
-
-
39449088321
-
The PINK1/Parkin pathway regulates mitochondrial morphology
-
Poole, A. C. et al. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc. Natl Acad. Sci. USA 105, 1638-1643 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 1638-1643
-
-
Poole, A.C.1
-
30
-
-
55749090654
-
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
Deng, H., Dodson, M. W., Huang, H. & Guo, M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl Acad. Sci. USA 105, 14503-14508 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
Dodson, M.W.2
Huang, H.3
Guo, M.4
-
31
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra, D., Tanaka, A., Suen, D. F. & Youle, R. J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803 (2008).
-
(2008)
J. Cell Biol.
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
32
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
Narendra, D. P. et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol. 8, e1000298 (2010).
-
(2010)
PLoS Biol.
, vol.8
-
-
Narendra, D.P.1
-
33
-
-
67649413521
-
Complex i deficiency and dopaminergic neuronal cell loss in parkindeficient zebrafish (Danio rerio)
-
Flinn, L. et al. Complex I deficiency and dopaminergic neuronal cell loss in parkindeficient zebrafish (Danio rerio). Brain 132, 1613-1623 (2009).
-
(2009)
Brain
, vol.132
, pp. 1613-1623
-
-
Flinn, L.1
-
34
-
-
62749113469
-
Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells
-
Gegg, M. E., Cooper, J. M., Schapira, A. H. & Taanman, J. W. Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells. PLoS ONE 4, e4756 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Gegg, M.E.1
Cooper, J.M.2
Schapira, A.H.3
Taanman, J.W.4
-
35
-
-
68549136513
-
Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology
-
Grünewald, A. et al. Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Exp. Neurol. 219, 266-273 (2009).
-
(2009)
Exp. Neurol.
, vol.219
, pp. 266-273
-
-
Grünewald, A.1
-
36
-
-
61649088435
-
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death
-
Gandhi, S. et al. PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol. Cell 33, 627-638 (2009).
-
(2009)
Mol. Cell
, vol.33
, pp. 627-638
-
-
Gandhi, S.1
-
37
-
-
77953666757
-
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
-
Morais V. A. et al. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol. Med. 1, 99-111 (2009).
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 99-111
-
-
Morais, V.A.1
-
38
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park, J. et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441, 1157-1161 (2006).
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
-
39
-
-
35748935851
-
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
-
Plun-Favreau, H. et al. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat. Cell Biol. 9, 1243-1252 (2007).
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1243-1252
-
-
Plun-Favreau, H.1
-
40
-
-
59749083796
-
Analysis of mutant DNA polymerase γ in patients with mitochondrial DNA depletion
-
Taanman, J. W. et al. Analysis of mutant DNA polymerase γ in patients with mitochondrial DNA depletion. Hum. Mutat. 30, 248-254 (2009).
-
(2009)
Hum. Mutat.
, vol.30
, pp. 248-254
-
-
Taanman, J.W.1
-
41
-
-
34247122280
-
Mutation of the linker region of the polymerase γ-1 (POLG1) gene associated with progressive external ophthalmoplegia and parkinsonism
-
Hudson, G. et al. Mutation of the linker region of the polymerase γ-1 (POLG1) gene associated with progressive external ophthalmoplegia and parkinsonism. Arch. Neurol. 64, 553-557 (2007).
-
(2007)
Arch. Neurol.
, vol.64
, pp. 553-557
-
-
Hudson, G.1
-
42
-
-
13444270783
-
Analysis of the trinucleotide CAG repeat from the DNA polymerase γ gene (POLG) in patients with Parkinson's disease
-
Taanman, J. W. & Schapira, A. H. Analysis of the trinucleotide CAG repeat from the DNA polymerase γ gene (POLG) in patients with Parkinson's disease. Neurosci. Lett. 376, 56-59 (2005).
-
(2005)
Neurosci. Lett.
, vol.376
, pp. 56-59
-
-
Taanman, J.W.1
Schapira, A.H.2
-
43
-
-
34948862122
-
Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease
-
Luoma, P. T. et al. Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease. Neurology 69, 1152-1159 (2007).
-
(2007)
Neurology
, vol.69
, pp. 1152-1159
-
-
Luoma, P.T.1
-
44
-
-
50049104725
-
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: A case-control study
-
Healy, D. G. et al. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol. 7, 583-590 (2008).
-
(2008)
Lancet Neurol.
, vol.7
, pp. 583-590
-
-
Healy, D.G.1
-
45
-
-
56049091236
-
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
-
Kim, Y. et al. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem. Biophys. Res. Commun. 377, 975-980 (2008).
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.377
, pp. 975-980
-
-
Kim, Y.1
-
46
-
-
51949090816
-
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
-
Imai, Y. et al. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J. 27, 2432-2443 (2008).
-
(2008)
EMBO J.
, vol.27
, pp. 2432-2443
-
-
Imai, Y.1
-
47
-
-
69449084089
-
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
-
Tain, L. S. et al. Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat. Neurosci. 12, 1129-1135 (2009).
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 1129-1135
-
-
Tain, L.S.1
-
48
-
-
47749114984
-
The Parkinson diseaseassociated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
-
Greggio, E. et al. The Parkinson diseaseassociated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. J. Biol. Chem. 283, 16906-16914 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16906-16914
-
-
Greggio, E.1
-
49
-
-
39549117093
-
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
-
Plowey, E. D., Cherra, S. J., Liu, Y.-J. & Chu, C. T. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J. Neurochem. 105, 1048-1056 (2008).
-
(2008)
J. Neurochem.
, vol.105
, pp. 1048-1056
-
-
Plowey, E.D.1
Cherra, S.J.2
Liu, Y.-J.3
Chu, C.T.4
-
50
-
-
67649813448
-
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
-
Li, Y. et al. Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat. Neurosci. 12, 826-828 (2009).
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 826-828
-
-
Li, Y.1
-
51
-
-
70549084415
-
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
-
Satake, W., Nakabayashi, Y., Mizuta, I. & Hirota, Y. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat. Genet. 41, 1303-1307 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 1303-1307
-
-
Satake, W.1
Nakabayashi, Y.2
Mizuta, I.3
Hirota, Y.4
-
52
-
-
70549088602
-
Genome-wide association study reveals genetic risk underlying Parkinson's disease
-
Simón-Sánchez, J., Schulte, C., Bras, J. M. & Sharma, M. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet. 41, 1308-1312 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 1308-1312
-
-
Simón-Sánchez, J.1
Schulte, C.2
Bras, J.M.3
Sharma, M.4
-
53
-
-
70350319531
-
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease
-
Sidransk, E. et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N. Engl. J. Med. 361, 1651-1661 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1651-1661
-
-
Sidransk, E.1
-
54
-
-
7444237665
-
Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews
-
Haron-Peretz, J., Rosenbaum, H. & Gershoni-Baruch, R. Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews. N. Engl. J. Med. 351, 1972-1977 (2004).
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 1972-1977
-
-
Haron-Peretz, J.1
Rosenbaum, H.2
Gershoni-Baruch, R.3
-
55
-
-
67650087652
-
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
-
Neumann, J. et al. Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. Brain 132, 1783-1794 (2009).
-
(2009)
Brain
, vol.132
, pp. 1783-1794
-
-
Neumann, J.1
-
56
-
-
2942687937
-
The cell biology of lysosomal storage disorders
-
Futerman, A. H. & van Meer, G. The cell biology of lysosomal storage disorders. Nat. Rev. Mol. Cell Biol. 5, 554-565 (2004).
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 554-565
-
-
Futerman, A.H.1
Van Meer, G.2
-
57
-
-
34249864552
-
Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress
-
Deganuto, M. et al. Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress. J. Cell. Physiol. 212, 223-235 (2007).
-
(2007)
J. Cell. Physiol.
, vol.212
, pp. 223-235
-
-
Deganuto, M.1
-
58
-
-
0023188798
-
The progression of idiopathic Parkinson's disease is not explained by age-related changes. Clinical and pathological comparisons with post-encephalitic parkinsonian syndrome
-
Gibb, W. R. & Lees, A. J. The progression of idiopathic Parkinson's disease is not explained by age-related changes. Clinical and pathological comparisons with post-encephalitic parkinsonian syndrome. Acta Neuropathol. 73, 195-201 (1987).
-
(1987)
Acta Neuropathol.
, vol.73
, pp. 195-201
-
-
Gibb, W.R.1
Lees, A.J.2
-
59
-
-
0031898680
-
Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F]dopa PET
-
Morrish, P. K., Rakshi, J. S., Bailey, D. L., Sawle, G. V. & Brooks, D. J. Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F]dopa PET. J. Neurol. Neurosurg. Psychiatry 64, 314-319 (1998).
-
(1998)
J. Neurol. Neurosurg. Psychiatry
, vol.64
, pp. 314-319
-
-
Morrish, P.K.1
Rakshi, J.S.2
Bailey, D.L.3
Sawle, G.V.4
Brooks, D.J.5
-
60
-
-
0035846468
-
[123I]β-CIT SPECT imaging assessment of the rate of Parkinson's disease progression
-
Marek, K. et al. [123I]β-CIT SPECT imaging assessment of the rate of Parkinson's disease progression. Neurology 57, 2089-2094 (2001).
-
(2001)
Neurology
, vol.57
, pp. 2089-2094
-
-
Marek, K.1
-
61
-
-
57049123693
-
The prodromal phase of sporadic Parkinson's disease: Does it exist and if so how long is it?
-
Hawkes, C. H. The prodromal phase of sporadic Parkinson's disease: does it exist and if so how long is it? Mov. Disord. 23, 1799-1807 (2008).
-
(2008)
Mov. Disord.
, vol.23
, pp. 1799-1807
-
-
Hawkes, C.H.1
-
62
-
-
4043098888
-
Olfaction and Parkinson's syndromes: Its role in differential diagnosis
-
Katzenschlager, R. & Lees, A. J. Olfaction and Parkinson's syndromes: its role in differential diagnosis. Curr. Opin. Neurol. 17, 417-423 (2004).
-
(2004)
Curr. Opin. Neurol.
, vol.17
, pp. 417-423
-
-
Katzenschlager, R.1
Lees, A.J.2
-
63
-
-
40449083312
-
Association of olfactory dysfunction with risk for future Parkinson's disease
-
Ross, G. W. et al. Association of olfactory dysfunction with risk for future Parkinson's disease. Ann. Neurol. 63, 167-173 (2008).
-
(2008)
Ann. Neurol.
, vol.63
, pp. 167-173
-
-
Ross, G.W.1
-
64
-
-
4043078792
-
Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT
-
Sommer, U. et al. Detection of presymptomatic Parkinson's disease: combining smell tests, transcranial sonography, and SPECT. Mov. Disord. 19, 1196-1202 (2004).
-
(2004)
Mov. Disord.
, vol.19
, pp. 1196-1202
-
-
Sommer, U.1
-
65
-
-
3843078591
-
Idiopathic hyposmia as a preclinical sign of Parkinson's disease
-
Ponsen, M. M. et al. Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann. Neurol. 56, 173-181 (2004).
-
(2004)
Ann. Neurol.
, vol.56
, pp. 173-181
-
-
Ponsen, M.M.1
-
66
-
-
44949197557
-
Diagnostic performance of clinical motor and non-motor tests of Parkinson disease: A matched case- control study
-
Bohnen, N. I., Studenski, S. A., Constantine, G. M. & Moore, R. Y. Diagnostic performance of clinical motor and non-motor tests of Parkinson disease: a matched case- control study. Eur. J. Neurol. 15, 685-691 (2008).
-
(2008)
Eur. J. Neurol.
, vol.15
, pp. 685-691
-
-
Bohnen, N.I.1
Studenski, S.A.2
Constantine, G.M.3
Moore, R.Y.4
-
67
-
-
7044240846
-
Excessive daytime sleepiness in Parkinson's disease
-
Schapira, A. H. Excessive daytime sleepiness in Parkinson's disease. Neurology 63 (8 Suppl. 3), S24-S27 (2004).
-
(2004)
Neurology
, vol.63
, Issue.8 SUPPL. 3
-
-
Schapira, A.H.1
-
68
-
-
0029878953
-
Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder
-
Schenck, C. H., Bundlie, S. R. & Mahowald, M. W. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 46, 388-393 (1996).
-
(1996)
Neurology
, vol.46
, pp. 388-393
-
-
Schenck, C.H.1
Bundlie, S.R.2
Mahowald, M.W.3
-
69
-
-
33744991945
-
Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: A descriptive study
-
Iranzo, A. et al. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol. 5, 572-577 (2006).
-
(2006)
Lancet Neurol.
, vol.5
, pp. 572-577
-
-
Iranzo, A.1
-
70
-
-
33645836498
-
Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder
-
DOI 10.1212/01.wnl.0000203648.80727.5b, PII 0000611420060328000014
-
Postuma, R. B., Lang, A. E., Massicotte-Marquez, J. & Montplaisir, J. Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder. Neurology 66, 845-851 (2006). (Pubitemid 43739758)
-
(2006)
Neurology
, vol.66
, Issue.6
, pp. 845-851
-
-
Postuma, R.B.1
Lang, A.E.2
Massicotte-Marquez, J.3
Montplaisir, J.4
-
71
-
-
11244260421
-
Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for α-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT
-
Stiasny-Kolster, K. et al. Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for α-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT. Brain 128, 126-137 (2005).
-
(2005)
Brain
, vol.128
, pp. 126-137
-
-
Stiasny-Kolster, K.1
-
72
-
-
33646082266
-
α-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
-
Bloch, A., Probst, A., Bissig, H., Adams, H. & Tolnay, M. α-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol. Appl. Neurobiol. 32, 284-295 (2006).
-
(2006)
Neuropathol. Appl. Neurobiol.
, vol.32
, pp. 284-295
-
-
Bloch, A.1
Probst, A.2
Bissig, H.3
Adams, H.4
Tolnay, M.5
-
73
-
-
34249907298
-
Do α-synuclein aggregates in autonomic plexuses predate Lewy body disorders? A cohort study
-
Minguez-Castellanos, A. et al. Do α-synuclein aggregates in autonomic plexuses predate Lewy body disorders? A cohort study. Neurology 68, 2012-2018 (2007).
-
(2007)
Neurology
, vol.68
, pp. 2012-2018
-
-
Minguez-Castellanos, A.1
-
74
-
-
51649095345
-
Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease
-
Fujishiro, H. et al. Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease. Mov. Disord. 23, 1085-1092 (2008).
-
(2008)
Mov. Disord.
, vol.23
, pp. 1085-1092
-
-
Fujishiro, H.1
-
75
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak, H. et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24, 197-211 (2003).
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
-
76
-
-
61949220753
-
The Parkinson chimera
-
Lees, A. J. The Parkinson chimera. Neurology 72 (7 Suppl.), S2-S11 (2009).
-
(2009)
Neurology
, vol.72
, Issue.7 SUPPL.
-
-
Lees, A.J.1
-
77
-
-
0028091176
-
Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease
-
Dexter, D. T. et al. Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease. Ann. Neurol. 35, 38-44 (1994).
-
(1994)
Ann. Neurol.
, vol.35
, pp. 38-44
-
-
Dexter, D.T.1
-
78
-
-
49449097043
-
Incidental Lewy body disease and preclinical Parkinson disease
-
DelleDonne, A. et al. Incidental Lewy body disease and preclinical Parkinson disease. Arch. Neurol. 65, 1074-1080 (2008).
-
(2008)
Arch. Neurol.
, vol.65
, pp. 1074-1080
-
-
Delledonne, A.1
-
79
-
-
33645749795
-
Motor score of the Unified Parkinson Disease Rating Scale as a good predictor of Lewy body-associated neuronal loss in the substantia nigra
-
Greffard, S. et al. Motor score of the Unified Parkinson Disease Rating Scale as a good predictor of Lewy body-associated neuronal loss in the substantia nigra. Arch. Neurol. 63, 584-588 (2006).
-
(2006)
Arch. Neurol.
, vol.63
, pp. 584-588
-
-
Greffard, S.1
-
80
-
-
0035449393
-
Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1, 2, 3,6-tetrahydropyridinelesioned macaque model of Parkinson's disease
-
Bezard, E. et el. Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridinelesioned macaque model of Parkinson's disease. J. Neurosci. 21, 6853-6861 (2001).
-
(2001)
J. Neurosci.
, vol.21
, pp. 6853-6861
-
-
Bezard, E.1
-
81
-
-
33749247103
-
Novel pharmacological targets for the treatment of Parkinson's disease
-
Schapira, A. H. et al. Novel pharmacological targets for the treatment of Parkinson's disease. Nat. Rev. Drug Discov. 5, 845-854 (2006).
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 845-854
-
-
Schapira, A.H.1
-
82
-
-
0019519328
-
Evidence to support early Levodopa therapy in Parkinson disease
-
Markham, C. H. & Diamond S. G. Evidence to support early levodopa therapy in Parkinson disease. Neurology 31, 125-131 (1981).
-
(1981)
Neurology
, vol.31
, pp. 125-131
-
-
Markham, C.H.1
Diamond, S.G.2
-
83
-
-
34247238285
-
A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis
-
Grosset, D. et al. A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis. J. Neurol. Neurosurg. Psychiatry 78, 465-469 (2007).
-
(2007)
J. Neurol. Neurosurg. Psychiatry
, vol.78
, pp. 465-469
-
-
Grosset, D.1
-
84
-
-
33644824423
-
Timing of treatment initiation in Parkinson's disease: A need for reappraisal?
-
Schapira, A. H. & Obeso, J. Timing of treatment initiation in Parkinson's disease: a need for reappraisal? Ann. Neurol. 59, 559-562 (2006).
-
(2006)
Ann. Neurol.
, vol.59
, pp. 559-562
-
-
Schapira, A.H.1
Obeso, J.2
-
85
-
-
61949208134
-
Mechanisms compensating for dopamine loss in early Parkinson disease
-
Brotchie, J. & Fitzer-Attas, C. Mechanisms compensating for dopamine loss in early Parkinson disease. Neurology 72 (7 Suppl.), S32-S38 (2009).
-
(2009)
Neurology
, vol.72
, Issue.7 SUPPL.
-
-
Brotchie, J.1
Fitzer-Attas, C.2
-
86
-
-
70349456475
-
A double-blind, delayed-start trial of rasagiline in Parkinson's disease
-
Olanow, C. W. et al. A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N. Engl. J. Med. 361, 1268-1278 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1268-1278
-
-
Olanow, C.W.1
-
87
-
-
61949458087
-
Molecular and clinical pathways to neuroprotection of dopaminergic drugs in Parkinson disease
-
Schapira, A. H. Molecular and clinical pathways to neuroprotection of dopaminergic drugs in Parkinson disease. Neurology 72 (7 Suppl.), S44-S50 (2009).
-
(2009)
Neurology
, vol.72
, Issue.7 SUPPL.
-
-
Schapira, A.H.1
-
88
-
-
0033616458
-
Science medicine, and the future: Parkinson's disease
-
Schapira, A. H. Science, medicine, and the future: Parkinson's disease. BMJ 318, 311-314 (1999).
-
(1999)
BMJ
, vol.318
, pp. 311-314
-
-
Schapira, A.H.1
-
89
-
-
67651160657
-
Neuroprotection trials in Parkinson's disease: Systematic review
-
Hart, R. G., Pearce, L. A., Ravina, B. M, Yaltho, T. C. & Marler, J. R. Neuroprotection trials in Parkinson's disease: systematic review. Mov. Disord. 24, 647-654 (2009).
-
(2009)
Mov. Disord.
, vol.24
, pp. 647-654
-
-
Hart, R.G.1
Pearce, L.A.2
Ravina, B.M.3
Yaltho, T.C.4
Marler, J.R.5
-
90
-
-
58349122472
-
Why have we failed to achieve neuroprotection in Parkinson's disease?
-
Olanow, C. W., Kieburtz, K. & Schapira A. H. Why have we failed to achieve neuroprotection in Parkinson's disease? Ann. Neurol. 64 (Suppl. 2), S101-S110 (2008).
-
(2008)
Ann. Neurol.
, vol.64
, Issue.SUPPL. 2
-
-
Olanow, C.W.1
Kieburtz, K.2
Schapira, A.H.3
-
91
-
-
61949280270
-
"Disease-modification" trials in Parkinson disease: Target populations, endpoints and study design
-
Rascol, O. "Disease-modification" trials in Parkinson disease: target populations, endpoints and study design. Neurology 72 (7 Suppl.), S51-S58 (2009).
-
(2009)
Neurology
, vol.72
, Issue.7 SUPPL.
-
-
Rascol, O.1
-
92
-
-
33750719088
-
TCH346 as a neuroprotective drug in Parkinson's disease: A double-blind, randomised, controlled trial
-
Olanow, C. W. et al. TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol. 5, 1013-1020 (2006).
-
(2006)
Lancet Neurol.
, vol.5
, pp. 1013-1020
-
-
Olanow, C.W.1
-
93
-
-
61949278122
-
When and how should treatment be started in Parkinson disease?
-
Lang, A. E. When and how should treatment be started in Parkinson disease? Neurology 72 (7 Suppl.), S39-S43 (2009).
-
(2009)
Neurology
, vol.72
, Issue.7 SUPPL.
-
-
Lang, A.E.1
-
94
-
-
20844444331
-
Evidence-based medical review update: Pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004
-
Goetz, C. G., Poewe W., Rascol, O. & Sampaio C. Evidence-based medical review update: pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004. Mov. Disord. 20, 523-539 (2005).
-
(2005)
Mov. Disord.
, vol.20
, pp. 523-539
-
-
Goetz, C.G.1
Poewe, W.2
Rascol, O.3
Sampaio, C.4
-
95
-
-
33646076457
-
Practice Parameter: Treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology
-
Pahwa, R. et al. Practice Parameter: treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 66, 983-995 (2006).
-
(2006)
Neurology
, vol.66
, pp. 983-995
-
-
Pahwa, R.1
-
96
-
-
34547916390
-
Treatment options in the modern management of Parkinson disease
-
Schapira, A. H. Treatment options in the modern management of Parkinson disease. Arch. Neurol. 64, 1083-1088 (2007).
-
(2007)
Arch. Neurol.
, vol.64
, pp. 1083-1088
-
-
Schapira, A.H.1
-
97
-
-
68849113184
-
Levodopa in the treatment of Parkinson's disease
-
Schapira, A. H., Emre, M., Jenner, P. & Poewe, W. Levodopa in the treatment of Parkinson's disease. Eur. J. Neurol. 16, 982-989 (2009).
-
(2009)
Eur. J. Neurol.
, vol.16
, pp. 982-989
-
-
Schapira, A.H.1
Emre, M.2
Jenner, P.3
Poewe, W.4
|