메뉴 건너뛰기




Volumn 27, Issue 3, 2011, Pages 547-558

Neuroprotective properties of GLP-1: Theoretical and practical applications

Author keywords

Alzheimer's disease; GLP 1; Huntington'sdisease; Neurodegenerative; Parkinson's disease; Protection

Indexed keywords

CYCLIC AMP; DOPAMINE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; LEVODOPA; LIRAGLUTIDE; METFORMIN; NERVE GROWTH FACTOR; SITAGLIPTIN;

EID: 79951626557     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2010.549466     Document Type: Review
Times cited : (119)

References (141)
  • 1
    • 3242730474 scopus 로고    scopus 로고
    • Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans
    • DOI 10.1152/ajpendo.00545.2003
    • Holst JJ, Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab 2004;287:E199-206 (Pubitemid 38943883)
    • (2004) American Journal of Physiology - Endocrinology and Metabolism , vol.287 , Issue.2-50
    • Holst, J.J.1    Gromada, J.2
  • 3
    • 0023758530 scopus 로고
    • Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach
    • Orskov C, Holst JJ, Nielsen OV. Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach. Endocrinology 1988;123: 2009-13
    • (1988) Endocrinology , vol.123 , pp. 2009-13
    • Orskov, C.1    Holst, J.J.2    Nielsen, O.V.3
  • 4
    • 0023950336 scopus 로고
    • Distribution of glucagon-like peptide i (GLP-I), glucagon, and glicentin in the rat brain: An immunocytochemical study
    • Jin SL, Han VK, Simmons JG, et al. Distribution of glucagon-like peptide I (GLP-I), glucagon, and glicentin in the rat brain: an immunocytochemical study. J Comp Neurol 1988;271:519-32
    • (1988) J Comp Neurol , vol.271 , pp. 519-32
    • Jin, S.L.1    Han, V.K.2    Simmons, J.G.3
  • 6
    • 55849125147 scopus 로고    scopus 로고
    • Role of central nervous system glucagon-like peptide-1 receptors in enteric glucose sensing
    • Knauf C, Cani PD, Kim DH, et al. Role of central nervous system glucagon-like peptide-1 receptors in enteric glucose sensing. Diabetes 2008;57:2603-12
    • (2008) Diabetes , vol.57 , pp. 2603-12
    • Knauf, C.1    Cani, P.D.2    Kim, D.H.3
  • 7
    • 0031029936 scopus 로고    scopus 로고
    • Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem
    • DOI 10.1016/S0306-4522(96)00434-4, PII S0306452296004344
    • Larsen PJ, Tang-Christensen M, Holst JJ, et al. Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem. Neuroscience 1997;77:257-70 (Pubitemid 27060323)
    • (1997) Neuroscience , vol.77 , Issue.1 , pp. 257-270
    • Larsen, P.J.1    Tang-Christensen, M.2    Holst, J.J.3    Orskov, C.4
  • 8
    • 0032923740 scopus 로고    scopus 로고
    • Coexpression of glucagon-like peptide-1 (GLP-1) receptor, vasopressin, and oxytocin mRNAs in neurons of the rat hypothalamic supraoptic and paraventricular nuclei: Effect of GLP-1(7-36)amide on vasopressin and oxytocin release
    • DOI 10.1046/j.1471-4159.1999.0720010.x
    • Zueco JA, Esquifino AI, Chowen JA, et al. Coexpression of glucagon-like peptide-1 (GLP-1) receptor, vasopressin, and oxytocin mRNAs in neurons of the rat hypothalamic supraoptic and paraventricular nuclei: effect of GLP-1(7-36) amide on vasopressin and oxytocin release. J Neurochem 1999;72:10-6 (Pubitemid 29013872)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.1 , pp. 10-16
    • Zueco, J.A.1    Esquifino, A.I.2    Chowen, J.A.3    Alvarez, E.4    Castrillon, P.O.5    Blazquez, E.6
  • 9
    • 0029859220 scopus 로고    scopus 로고
    • Central administration of GLP-1-( 7-36) amide inhibits food and water intake in rats
    • Tang-Christensen M, Larsen PJ, Göke R, et al. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol 1996;271:R848-56
    • (1996) Am J Physiol , vol.271
    • Tang-Christensen, M.1    Larsen, P.J.2    Göke, R.3
  • 10
    • 0031891391 scopus 로고    scopus 로고
    • PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats
    • McMahon LR, Wellman PJ. PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats. Am J Physiol 1998;274:R23-9
    • (1998) Am J Physiol , vol.274
    • McMahon, L.R.1    Wellman, P.J.2
  • 13
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, et al. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 1998;101:515-20 (Pubitemid 28084232)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.3 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 14
    • 57649192347 scopus 로고    scopus 로고
    • Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity
    • Cabou C, Campistron G, Marsollier N, et al. Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity. Diabetes 2008;57:2577-87
    • (2008) Diabetes , vol.57 , pp. 2577-87
    • Cabou, C.1    Campistron, G.2    Marsollier, N.3
  • 15
    • 70449709114 scopus 로고    scopus 로고
    • A role for the gut-to-brain GLP-1-dependent axis in the control of metabolism
    • Burcelin R, Serino M, Cabou C. A role for the gut-to-brain GLP-1-dependent axis in the control of metabolism. Curr Opin Pharmacol 2009;9:744-52
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 744-52
    • Burcelin, R.1    Serino, M.2    Cabou, C.3
  • 16
    • 0029903111 scopus 로고    scopus 로고
    • Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I
    • Orskov C, Poulsen SS, Moller M, et al. Glucagon-like peptide 1 receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I. Diabetes 1996;45:832-5 (Pubitemid 26168585)
    • (1996) Diabetes , vol.45 , Issue.6 , pp. 832-835
    • Orskov, C.1    Poulsen, S.S.2    Moller, M.3    Holst, J.J.4
  • 17
    • 67449169287 scopus 로고    scopus 로고
    • Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat
    • Bucinskaite V, Tolessa T, Pedersen J, et al. Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat. Neurogastroenterol Motil 2009;21:978-e78
    • (2009) Neurogastroenterol Motil , vol.21
    • Bucinskaite, V.1    Tolessa, T.2    Pedersen, J.3
  • 18
    • 67649649953 scopus 로고    scopus 로고
    • Minireview: Finding the sweet spot: Peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis
    • Williams DL. Minireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis. Endocrinology 2009;150:2997-3001
    • (2009) Endocrinology , vol.150 , pp. 2997-3001
    • Williams, D.L.1
  • 19
    • 0026775150 scopus 로고
    • Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1
    • Thorens B. Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 1992;89:8641-5
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8641-5
    • Thorens, B.1
  • 20
    • 5044222306 scopus 로고    scopus 로고
    • Pyridoxine-induced toxicity in rats: A stereological quantification of the sensory neuropathy
    • DOI 10.1016/j.expneurol.2004.07.013, PII S0014488604002948
    • Perry TA, WeerasuriyaA, Mouton PR, etal. Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy. Exp Neurol 2004;190:133-44 (Pubitemid 39335713)
    • (2004) Experimental Neurology , vol.190 , Issue.1 , pp. 133-144
    • Perry, T.A.1    Weerasuriya, A.2    Mouton, P.R.3    Holloway, H.W.4    Greig, N.H.5
  • 22
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • DOI 10.1210/jc.2002-021053
    • Vilsbøll T, Agersø H, Krarup T, et al. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 2003;88:220-4 (Pubitemid 36115169)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.1 , pp. 220-224
    • Vilsboll, T.1    Agerso, H.2    Krarup, T.3    Holst, J.J.4
  • 23
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • DOI 10.1161/CIRCULATIONAHA.107.739938, PII 0000301720080506000007
    • Ban K, Noyan-Ashraf MH, Hoefer J, et al. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008;117:2340-50 (Pubitemid 351653542)
    • (2008) Circulation , vol.117 , Issue.18 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.-S.4    Drucker, D.J.5    Husain, M.6
  • 24
    • 77950267745 scopus 로고    scopus 로고
    • Glucagon-like peptide (GLP)-1 ( 9-36) amide-mediated cytoprotection is blocked by exendin (9-39) yet does not require the known GLP-1 receptor
    • Ban K, Kim KH, Cho CK, et al. Glucagon-like peptide (GLP)-1 (9-36) amide-mediated cytoprotection is blocked by exendin (9-39) yet does not require the known GLP-1 receptor. Endocrinology 2010;151:1520-31
    • (2010) Endocrinology , vol.151 , pp. 1520-31
    • Ban, K.1    Kim, K.H.2    Cho, C.K.3
  • 25
    • 3442896818 scopus 로고    scopus 로고
    • A new Alzheimer's disease interventive strategy: GLP-1
    • DOI 10.2174/1389450043345245
    • Perry TA, Greig N. A new Alzheimer's disease interventive strategy: GLP-1 Current Drug Targets 2004;5:565-71 (Pubitemid 39004431)
    • (2004) Current Drug Targets , vol.5 , Issue.6 , pp. 565-571
    • Perry, T.A.1    Greig, N.H.2
  • 27
    • 10244241840 scopus 로고    scopus 로고
    • Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: Evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake
    • Navarro M, de Fonseca R, Alvarez E, et al. Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J Neurochem 1996;67:1982-91 (Pubitemid 26349672)
    • (1996) Journal of Neurochemistry , vol.67 , Issue.5 , pp. 1982-1991
    • Navarro, M.1    Rodriguez De Fonseca, F.2    Alvarez, E.3    Chowen, J.A.4    Zueco, J.A.5    Gomez, R.6    Eng, J.7    Blazquez, E.8
  • 28
    • 0028867442 scopus 로고
    • Distribution of GLP-1 binding sites in the rat brain: Evidence that exendin-4 is a ligand of brain GLP-1 binding sites
    • Goke R, Larsen PJ, Mikkelsen JD, et al. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 1995;7:2294-300
    • (1995) Eur J Neurosci , vol.7 , pp. 2294-300
    • Goke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3
  • 29
    • 34250635159 scopus 로고    scopus 로고
    • GLP-1 receptor expression in human tumors and human normal tissues: Potential for in vivo targeting
    • DOI 10.2967/jnumed.106.038679
    • Körner M, Stöckli M, Waser B, et al. GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting. J Nucl Med 2007;48:736-43 (Pubitemid 47604973)
    • (2007) Journal of Nuclear Medicine , vol.48 , Issue.5 , pp. 736-743
    • Korner, M.1    Stockli, M.2    Waser, B.3    Reubi, J.C.4
  • 30
    • 70449111654 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor imaging for localization of insulinomas
    • Christ E, Wild D, Forrer F, et al. Glucagon-like peptide-1 receptor imaging for localization of insulinomas. J Clin Endocrinol Metab 2009;94:4398-405
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4398-405
    • Christ, E.1    Wild, D.2    Forrer, F.3
  • 31
    • 0037312818 scopus 로고    scopus 로고
    • Glucagon-like peptides: Regulators of cell proliferation, differentiation, and apoptosis
    • DOI 10.1210/me.2002-0306
    • Drucker DJ. Glucagon-like peptides: regulators of cell proliferation, differentiation and apoptosis. Molecular Endocrinology 2003;17:161-71 (Pubitemid 36183142)
    • (2003) Molecular Endocrinology , vol.17 , Issue.2 , pp. 161-171
    • Drucker, D.J.1
  • 32
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, KiefferTJ, HussainMA, etal. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000;49:741-8 (Pubitemid 30339989)
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.4    Bonner-Weir, S.5    Habener, J.F.6    Egan, J.M.7
  • 34
    • 0038248960 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron
    • DOI 10.1002/jnr.10611
    • Perry TA, Lahiri D, Sambamurti K, et al. Glucagon-like peptide-1 decreases endogenous amyloid-^ peptide (Ap) levels and protects hippocampal neurons from death induced by Ap and iron. J Neurosci Res 2003;72:603-12 (Pubitemid 36578646)
    • (2003) Journal of Neuroscience Research , vol.72 , Issue.5 , pp. 603-612
    • Perry, T.1    Lahiri, D.K.2    Sambamurti, K.3    Chen, D.4    Mattson, M.P.5    Egan, J.M.6    Greig, N.H.7
  • 35
    • 77649187436 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease
    • McClean PL, Gault VA, Harriott P, et al. Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. Eur J Pharmacol 2010;630:158-62
    • (2010) Eur J Pharmacol , vol.630 , pp. 158-62
    • McClean, P.L.1    Gault, V.A.2    Harriott, P.3
  • 36
    • 79951592496 scopus 로고    scopus 로고
    • Impairment of synaptic plasticity and learning in GLP-1 receptor knockout mice: Interaction between type 2 diabetes and Alzheimer's Disease
    • (abstract 252)
    • McClean PL, Abbas T, Faivre E, et al. Impairment of synaptic plasticity and learning in GLP-1 receptor knockout mice: interaction between type 2 diabetes and Alzheimer's Disease. Diabetologia 2009;52(Suppl 1):S109 (abstract 252)
    • (2009) Diabetologia , vol.52 , Issue.SUPPL. 1
    • McClean, P.L.1    Abbas, T.2    Faivre, E.3
  • 37
    • 0032957382 scopus 로고    scopus 로고
    • Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
    • DOI 10.1038/7449
    • Young D, Lawlor PA, Leone P, et al. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat Med 1999;5:448-53 (Pubitemid 29180587)
    • (1999) Nature Medicine , vol.5 , Issue.4 , pp. 448-453
    • Young, D.1    Lawlor, P.A.2    Leone, P.3    Dragunow, M.4    During, M.J.5
  • 38
    • 0035576894 scopus 로고    scopus 로고
    • Neuroprotective peptide drug delivery and development: Potential new therapeutics
    • DOI 10.1016/S0166-2236(00)01931-7, PII S0166223600019317
    • Gozes I. Neuroprotective peptide drug delivery and development: potential new therapeutics. Trends Neurosci 2001;24:700-5 (Pubitemid 33097536)
    • (2001) Trends in Neurosciences , vol.24 , Issue.12 , pp. 700-705
    • Gozes, I.1
  • 39
    • 79951599503 scopus 로고    scopus 로고
    • London, UK: European Medicines Agency Available at [Last accessed 8 July 2010]
    • European Medicines Agency Scientific Discussion of exenatide. London, UK: European Medicines Agency, 2006. Available at http://www.ema.europa.eu/ humandocs/PDFs/EPAR/byetta/H-698-en6.pdf [Last accessed 8 July 2010]
    • (2006) European Medicines Agency Scientific Discussion of Exenatide
  • 40
    • 0034752734 scopus 로고    scopus 로고
    • Pharmacokinetic actions of exendin-4 in the rat: Comparison with glucagon-like peptide-1
    • DOI 10.1002/ddr.1195
    • ParkesD, JodkaC, Smith P, etal. Pharmacokinetic actions of exendin-4 in the rat: comparison with glucagon-like peptide-1. Drug Dev Res 2001;54:260-7 (Pubitemid 33029654)
    • (2001) Drug Development Research , vol.53 , Issue.4 , pp. 260-267
    • Parkes, D.1
  • 41
    • 67649331128 scopus 로고    scopus 로고
    • Indianapolis, IN: Eli Lilly and Company Available at [Last accessed 8 July 2010]
    • Byetta® prescribing information. Indianapolis, IN: Eli Lilly and Company,2009. Available at http://pi.lilly.com/us/byetta-pi.pdf [Last accessed 8 July 2010]
    • (2009) Byetta® Prescribing Information
  • 42
    • 0037349072 scopus 로고    scopus 로고
    • Entry of exendin-4 into brain is rapid but may be limited at high doses
    • DOI 10.1038/sj.ijo.0802206
    • Kastin AJ, Akerstrom V. Entry of exendin-4 into brain is rapid but may be limited at high doses. Int J Obes Relat Metab Disord 2003;27:313-18 (Pubitemid 36384867)
    • (2003) International Journal of Obesity , vol.27 , Issue.3 , pp. 313-318
    • Kastin, A.J.1    Akerstrom, V.2
  • 43
    • 38149083367 scopus 로고    scopus 로고
    • Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heart
    • Sonne DP, Engstrøm T, Treiman M. Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heart. Regul Pept 2008;146:243-9
    • (2008) Regul Pept , vol.146 , pp. 243-9
    • Sonne, D.P.1    Engstrøm, T.2    Treiman, M.3
  • 44
    • 0036676385 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects
    • DOI 10.2337/diacare.25.8.1398
    • Elbrønd B, Jakobsen G, Larsen S, etal. Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting gluca-gon-like peptide 1 derivative, in healthy male subjects. Diabetes Care 2002;25:1398-404 (Pubitemid 41071152)
    • (2002) Diabetes Care , vol.25 , Issue.8 , pp. 1398-1404
    • Elbrond, B.1    Jakobsen, G.2    Larsen, S.3    Agerso, H.4    Jensen, L.B.5    Rolan, P.6    Sturis, J.7    Hatorp, V.8    Zdravkovic, M.9
  • 45
    • 77952362702 scopus 로고    scopus 로고
    • Bagsvaerd, Denmark: Novo Nordisk A/S Available [Last accessed 8 July 2010]
    • Victoza® Prescribing information. Bagsvaerd, Denmark: Novo Nordisk A/S, 2010. Available athttp://www.victoza.com/pdf/PI-(1-Column-Format).pdf [Last accessed 8 July 2010]
    • (2010) Victoza® Prescribing Information
  • 47
    • 74249114217 scopus 로고    scopus 로고
    • Current antihyperglycemic treatment strategies for patients with type 2 diabetes mellitus
    • Blonde L. Current antihyperglycemic treatment strategies for patients with type 2 diabetes mellitus. Cleve Clin J Med. 2009;76(Suppl 5):S4-11
    • (2009) Cleve Clin J Med. , vol.76 , Issue.SUPPL. 5
    • Blonde, L.1
  • 48
    • 69949163754 scopus 로고    scopus 로고
    • Exenatide and liraglutide: Different approaches to develop GLP-1 receptor agonists (incretin mimetics)-preclinical and clinical results
    • Madsbad S. Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics)-preclinical and clinical results. Best Pract Res Clin Endocrinol Metab 2009;23:463-77
    • (2009) Best Pract Res Clin Endocrinol Metab , vol.23 , pp. 463-77
    • Madsbad, S.1
  • 49
    • 0029903111 scopus 로고    scopus 로고
    • Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I
    • Orskov C, Poulsen SS, Møller M, et al. Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I. Diabetes 1996;45:832-5 (Pubitemid 26168585)
    • (1996) Diabetes , vol.45 , Issue.6 , pp. 832-835
    • Orskov, C.1    Poulsen, S.S.2    Moller, M.3    Holst, J.J.4
  • 50
    • 77956301808 scopus 로고    scopus 로고
    • Preproglucagon derived peptides GLP-1,GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides
    • Vrang N, Larsen PJ. Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides. Prog Neurobiol 2010;92:442-62
    • (2010) Prog Neurobiol , vol.92 , pp. 442-62
    • Vrang, N.1    Larsen, P.J.2
  • 51
    • 77949837737 scopus 로고    scopus 로고
    • Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the GLP-1 receptor agonist
    • Baraboi ED, Smith P, Ferguson AV, et al. Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the GLP-1 receptor agonist. Am J Physiol Regul Integr Comp Physiol 2010;298:R1098-110
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.298
    • Baraboi, E.D.1    Smith, P.2    Ferguson, A.V.3
  • 52
    • 79951634443 scopus 로고    scopus 로고
    • Liraglutide regulates key hypothalamic appetite-related signals in diet-induced obese rats
    • (abstract 583-P)
    • Vrang N, Jelsing J, Raun K, et al. Liraglutide regulates key hypothalamic appetite-related signals in diet-induced obese rats. Diabetes 2010;59(Suppl 1):A159 (abstract 583-P)
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Vrang, N.1    Jelsing, J.2    Raun, K.3
  • 53
    • 79951617559 scopus 로고    scopus 로고
    • The GLP-1 analog liraglutide activates brainstem and hypothalamic neurons involved in appetite regulation
    • (abstract 584-P)
    • Raun K, Vrang N, Jelsing J, et al. The GLP-1 analog liraglutide activates brainstem and hypothalamic neurons involved in appetite regulation. Diabetes 2010;59(Suppl 1):A159 (abstract 584-P)
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Raun, K.1    Vrang, N.2    Jelsing, J.3
  • 54
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • DOI 10.1016/S0140-6736(06)69705-5, PII S0140673606697055
    • Drucker D, Nauck M. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptiylpeptidase-4 inhibitors in type 2 diabetes. Lancet 2006;368:1696-705 (Pubitemid 46048557)
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 55
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin in patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
    • Pratley R, Nauck M, Bailey T, et al. Liraglutide versus sitagliptin in patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet 2010;375:1447-56
    • (2010) Lancet , vol.375 , pp. 1447-56
    • Pratley, R.1    Nauck, M.2    Bailey, T.3
  • 56
    • 77956920722 scopus 로고    scopus 로고
    • Liraglutide: Effects beyond glycaemic control in diabetes treatment
    • McGill J. Liraglutide: effects beyond glycaemic control in diabetes treatment. Int J Clin Pract 201064:28-34
    • (2010) Int J Clin Pract , vol.64 , pp. 28-34
    • McGill, J.1
  • 57
    • 57749109119 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor vildagliptin increases portal concentrations of active GLP-1 to a greater extent that the peripheral concentrations
    • Hjøllund KR, HughesTE, Deacon CF, etal. The dipeptidyl peptidase-4 inhibitor vildagliptin increases portal concentrations of active GLP-1 to a greater extent that the peripheral concentrations. Diabetologia 2008;57:A411
    • (2008) Diabetologia , vol.57
    • Hjøllund, K.R.1    Hughes, T.E.2    Deacon, C.F.3
  • 58
    • 0036198285 scopus 로고    scopus 로고
    • Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
    • Kastin AJ, Akerstrom V, Pan W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J Mol Neurosci 2002;18:7-14 (Pubitemid 34252619)
    • (2002) Journal of Molecular Neuroscience , vol.18 , Issue.1-2 , pp. 7-14
    • Kastin, A.J.1    Akerstrom, V.2    Pan, W.3
  • 59
    • 79951588488 scopus 로고    scopus 로고
    • Novel GLP-1 analogues can cross the blood brain barrier and enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's Disease
    • (abstract 790)
    • Hölscher C, Fung K, McCurtin R, et al. Novel GLP-1 analogues can cross the blood brain barrier and enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's Disease. Diabetologia 2009;52(Suppl 1):S311 (abstract 790)
    • (2009) Diabetologia , vol.52 , Issue.SUPPL. 1
    • Hölscher, C.1    Fung, K.2    McCurtin, R.3
  • 60
    • 9944251347 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
    • DOI 10.1016/j.regpep.2004.08.024, PII S0167011504003179
    • Nystrom T, Gonon AT, Sjoholm A, et al. Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism. Regul Pept 2005;125:173-7 (Pubitemid 39593722)
    • (2005) Regulatory Peptides , vol.125 , Issue.1-3 , pp. 173-177
    • Nystrom, T.1    Gonon, A.T.2    Sjoholm, A.3    Pernow, J.4
  • 61
    • 52049093652 scopus 로고    scopus 로고
    • GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP
    • Green BD, Hand KV, Dougan JE, et al. GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP. Arch Biochem Biophys 2008;478:136-42
    • (2008) Arch Biochem Biophys , vol.478 , pp. 136-42
    • Green, B.D.1    Hand, K.V.2    Dougan, J.E.3
  • 62
    • 0036721411 scopus 로고    scopus 로고
    • Functional maturation of fetal porcine β-cells by glucagon-like peptide 1 and cholecystokinin
    • DOI 10.1210/en.2001-211344
    • Hardikar AA, Wang XY, Williams LJ, et al. Functional maturation of fetal porcine j6-cells by glucagon-like peptide 1 and cholecystokinin. Endocrinology 2002;143:3505-14 (Pubitemid 34925725)
    • (2002) Endocrinology , vol.143 , Issue.9 , pp. 3505-3514
    • Hardikar, A.A.1    Wang, X.Y.2    Williams, L.J.3    Kwok, J.4    Wong, R.5    Yao, M.6    Tuch, B.E.7
  • 63
    • 0036775170 scopus 로고    scopus 로고
    • Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells
    • DOI 10.1210/jc.2002-020137
    • Movassat J, Beattie GM, Lopez AD, et al. Exendin 4 up-regulates expression of PDX1 and hastens differentiation and maturation of human fetal pancreatic cells. J Clin Endocrinol Metab 2002;87:4775-81 (Pubitemid 35247075)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.10 , pp. 4775-4781
    • Movassat, J.1    Beattie, G.M.2    Lopez, A.D.3    Hayek, A.4
  • 64
    • 0036323269 scopus 로고    scopus 로고
    • Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells
    • DOI 10.1210/en.143.8.3152
    • Abraham EJ, Leech CA, Lin JC, et al. Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology 2002;143:3152-61 (Pubitemid 34809888)
    • (2002) Endocrinology , vol.143 , Issue.8 , pp. 3152-3161
    • Abraham, E.J.1    Leech, C.A.2    Lin, J.C.3    Zulewski, H.4    Habener, J.F.5
  • 67
    • 78149466370 scopus 로고    scopus 로고
    • Differentiating effects of the glucagon-like peptide-1 analogue exendin-4 in a human neuronal cell model
    • Luciani P, Deledda C, Benvenuti S, et al. Differentiating effects of the glucagon-like peptide-1 analogue exendin-4 in a human neuronal cell model. Cell Mol Life Sci 2010;67:3711-23
    • (2010) Cell Mol Life Sci , vol.67 , pp. 3711-23
    • Luciani, P.1    Deledda, C.2    Benvenuti, S.3
  • 68
    • 67649476077 scopus 로고    scopus 로고
    • Incretin therapies: Effects beyond glycemic control
    • Mudaliar S, Henry RR. Incretin therapies: effects beyond glycemic control. Eur J Intern Med 2009;20(Suppl 2):S319-28
    • (2009) Eur J Intern Med , vol.20 , Issue.SUPPL. 2
    • Mudaliar, S.1    Henry, R.R.2
  • 69
    • 70350341465 scopus 로고    scopus 로고
    • Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: Potential therapeutic actions beyond glycaemic control
    • Grieve D, Cassidy R, Green B. Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic actions beyond glycaemic control. Br J Pharmacol 2009;157:1340-51
    • (2009) Br J Pharmacol , vol.157 , pp. 1340-51
    • Grieve, D.1    Cassidy, R.2    Green, B.3
  • 70
    • 0036312680 scopus 로고    scopus 로고
    • Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the β-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4
    • Tourrel C, Bailbe D, Lacorne M, et al. Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the /S-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4. Diabetes 2002;51:1443-52 (Pubitemid 34826610)
    • (2002) Diabetes , vol.51 , Issue.5 , pp. 1443-1452
    • Tourrel, C.1    Bailbe, D.2    Lacorne, M.3    Meile, M.-J.4    Kergoat, M.5    Portha, B.6
  • 71
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • DOI 10.1210/en.141.12.4600
    • Perfetti R, Zhou J, Doyle ME, et al. Glucagon-like peptide-1 induces cell proliferation and pancreatic duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose intolerant rats. Endocrinology 2000;141:4600-5 (Pubitemid 32055138)
    • (2000) Endocrinology , vol.141 , Issue.12 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.I.E.2    Doyle, M.E.3    Egan, J.M.4
  • 72
    • 0036784675 scopus 로고    scopus 로고
    • The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice
    • Rolin B, Larsen MO, Gotfredsen CF, et al. The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice. Am J Physiol Endocrinol Metab 2002;283:E745-52
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Rolin, B.1    Larsen, M.O.2    Gotfredsen, C.F.3
  • 74
    • 72749091486 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons
    • Belsham D, Fick L, Dalvi P, et al. Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons. FASEB J 2009;23: 4256-65
    • (2009) FASEB J , vol.23 , pp. 4256-65
    • Belsham, D.1    Fick, L.2    Dalvi, P.3
  • 75
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • DOI 10.1161/01.CIR.0000139339.85840.DD
    • Nikolaidis LA, Elahi D, Hentosz T, et al. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004;110:955-61 (Pubitemid 39128621)
    • (2004) Circulation , vol.110 , Issue.8 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6    Stolarski, C.7    Shen, Y.-T.8    Shannon, R.P.9
  • 76
    • 1442311383 scopus 로고    scopus 로고
    • Effects of Glucagon-Like Peptide-1 in Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction after Successful Reperfusion
    • DOI 10.1161/01.CIR.0000120505.91348.58
    • Nikolaidis LA, Mankad S, Sokos GG, etal. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004;109:962-5 (Pubitemid 38282847)
    • (2004) Circulation , vol.109 , Issue.8 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6    Shannon, R.P.7
  • 77
    • 66749102158 scopus 로고    scopus 로고
    • The extrapancreatic effects of glucagon-like peptide-1 and related peptides
    • Abu-Hamdah R, Rabiee A, Meneilly G, et al. The extrapancreatic effects of glucagon-like peptide-1 and related peptides. J Clin Endocrinol Metab 2009;94:1843-52
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1843-52
    • Abu-Hamdah, R.1    Rabiee, A.2    Meneilly, G.3
  • 78
  • 79
    • 0036381989 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
    • Wang Q, Brubaker PL. Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice. Diabetologia 2002;45:1263-73
    • (2002) Diabetologia , vol.45 , pp. 1263-73
    • Wang, Q.1    Brubaker, P.L.2
  • 82
    • 77951246517 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression
    • Cornu M, Modi H, Kawamori D, et al. Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression. J Biol Chem 2010;285: 10538-45
    • (2010) J Biol Chem , vol.285 , pp. 10538-45
    • Cornu, M.1    Modi, H.2    Kawamori, D.3
  • 83
    • 68049136013 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop
    • Cornu M, Yang JY, Jaccard E, et al. Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop. Diabetes 2009;58:1816-25
    • (2009) Diabetes , vol.58 , pp. 1816-25
    • Cornu, M.1    Yang, J.Y.2    Jaccard, E.3
  • 84
    • 48449104756 scopus 로고    scopus 로고
    • Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway
    • Ferdaoussi M, Abdelli S, Yang JY, et al. Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway. Diabetes 2008;57:1205-15
    • (2008) Diabetes , vol.57 , pp. 1205-15
    • Ferdaoussi, M.1    Abdelli, S.2    Yang, J.Y.3
  • 85
    • 47149095990 scopus 로고    scopus 로고
    • Pancreatic alpha-cell dysfunction in diabetes
    • Burcelin R, Knauf C, Cani PD. Pancreatic alpha-cell dysfunction in diabetes. Diabetes Metab 2008;34(Suppl 2):S49-55
    • (2008) Diabetes Metab , vol.34 , Issue.SUPPL. 2
    • Burcelin, R.1    Knauf, C.2    Cani, P.D.3
  • 87
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Ghatei MA, Williams G, et al. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987;2:1300-4 (Pubitemid 17156636)
    • (1987) Lancet , vol.2 , Issue.8571 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 88
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • Zhou J, Wang X, Pineyro MA, et al. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 1999;48:2358-66 (Pubitemid 30395427)
    • (1999) Diabetes , vol.48 , Issue.12 , pp. 2358-2366
    • Zhou, J.1    Wang, X.2    Pineyro, M.A.3    Egan, J.M.4
  • 89
    • 79951662884 scopus 로고    scopus 로고
    • Liraglutide: Shortlived effect on gastric emptying, long-lasting effects on body weight
    • (abstract 591-P)
    • Bjerre Knudsen L, Tang-Christensen M, Jelsing J, et al. Liraglutide: shortlived effect on gastric emptying, long-lasting effects on body weight. Diabetes 2010;59(Suppl 1):A161 (abstract 591-P)
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Bjerre Knudsen, L.1    Tang-Christensen, M.2    Jelsing, J.3
  • 90
    • 77953094551 scopus 로고    scopus 로고
    • Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells
    • Li Y, Tweedie D, Mattson MP, et al. Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells. J Neurochem 2010;113:1621-31
    • (2010) J Neurochem , vol.113 , pp. 1621-31
    • Li, Y.1    Tweedie, D.2    Mattson, M.P.3
  • 91
    • 0030068620 scopus 로고    scopus 로고
    • Gastric emptying, glucose response, and insulin secretion after a liquid test meal: Effects of exogenous glucagon-like peptide-1 (GLP-1)-( 7-36) amide in type 2 (noninsulin-dependent) diabetic patients
    • Willms B, Werner J, Holst JJ, et al. Gastric emptying, glucose response, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab 1996;81:327-32
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 327-32
    • Willms, B.1    Werner, J.2    Holst, J.J.3
  • 92
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • DOI 10.1210/jc.87.3.1239
    • Nauck MA, Heimesaat MM, Behle K, et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab 2002;87: 1239-46 (Pubitemid 36121094)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.3 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3    Holst, J.J.4    Nauck, M.S.5    Ritzel, R.6    Hufner, M.7    Schmiegel, W.H.8
  • 95
    • 0345726358 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites
    • Yamamoto H, Kishi T, Lee CE, et al. Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci 2003;23: 2939-46 (Pubitemid 36418630)
    • (2003) Journal of Neuroscience , vol.23 , Issue.7 , pp. 2939-2946
    • Yamamoto, H.1    Kishi, T.2    Lee, C.E.3    Choi, B.J.4    Fang, H.5    Hollenberg, A.N.6    Drucker, D.J.7    Elmquist, J.K.8
  • 96
    • 0042831025 scopus 로고    scopus 로고
    • Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility?
    • DOI 10.1385/NMM:2:2:197
    • Gilman CP, Mattson MP. Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility? Neuromolecular Med 2002;2:197-214 (Pubitemid 37012504)
    • (2002) NeuroMolecular Medicine , vol.2 , Issue.2 , pp. 197-214
    • Gilman, C.P.1    Mattson, M.P.2
  • 97
    • 0023931488 scopus 로고
    • Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons
    • Mattson MP, Dou P, Kater SB. Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons. J Neurosci 1988;8:2087-100
    • (1988) J Neurosci , vol.8 , pp. 2087-100
    • Mattson, M.P.1    Dou, P.2    Kater, S.B.3
  • 98
    • 0024109358 scopus 로고
    • Interactions between entorhinal axons and target hippocampal neurons: A role for glutamate in the development of hippocampal circuitry
    • Mattson MP, Lee RE, Adams ME, et al. Interactions between entorhinal axons and target hippocampal neurons: a role for glutamate in the development of hippocampal circuitry. Neuron 1988;1:865-76
    • (1988) Neuron , vol.1 , pp. 865-76
    • Mattson, M.P.1    Lee, R.E.2    Adams, M.E.3
  • 100
    • 77954953382 scopus 로고    scopus 로고
    • New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer's disease?
    • doi:10.1016/j.neurobiolaging.2008.08.023
    • Hö lscher C, Li L. New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer's disease? Neurobiol Aging 2008 doi:10.1016/j.neurobiolaging.2008.08.023
    • (2008) Neurobiol Aging
    • Hölscher, C.1    Li, L.2
  • 101
    • 59049087723 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
    • Li Y, Perry TA, Kindy M, et al. GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. PNAS 2009;106:1285-90
    • (2009) PNAS , vol.106 , pp. 1285-90
    • Li, Y.1    Perry, T.A.2    Kindy, M.3
  • 102
    • 1242316296 scopus 로고    scopus 로고
    • Insulin and neurodegenerative disease: Shared and specific mechanisms
    • DOI 10.1016/S1474-4422(04)00681-7
    • Craft S, Watson GS. Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol 2004;3:169-78 (Pubitemid 38229951)
    • (2004) Lancet Neurology , vol.3 , Issue.3 , pp. 169-178
    • Craft, S.1    Watson, G.S.2
  • 103
    • 67649682161 scopus 로고    scopus 로고
    • Adiposity, type 2 diabetes and Alzheimer's disease
    • Luchsinger JA, Gustafson D. Adiposity, type 2 diabetes and Alzheimer's disease. J Alzheimers Dis 2009;16:693-704
    • (2009) J Alzheimers Dis , vol.16 , pp. 693-704
    • Luchsinger, J.A.1    Gustafson, D.2
  • 104
    • 42249094013 scopus 로고    scopus 로고
    • Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: An epidemiological perspective
    • Luchsinger JA. Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective. Eur J Pharmacol 2008;585: 119-29
    • (2008) Eur J Pharmacol , vol.585 , pp. 119-29
    • Luchsinger, J.A.1
  • 105
    • 77955084717 scopus 로고    scopus 로고
    • Why pleiotropic interventions are needed for Alzheimer's disease
    • Frautschy S, Cole G. Why pleiotropic interventions are needed for Alzheimer's disease. Mol Neurobiol 2010;41:392-409
    • (2010) Mol Neurobiol , vol.41 , pp. 392-409
    • Frautschy, S.1    Cole, G.2
  • 106
    • 54049136095 scopus 로고    scopus 로고
    • Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology
    • Beeri MS, Schmeidler J, Silverman JM, et al. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology 2008;71:750-7
    • (2008) Neurology , vol.71 , pp. 750-7
    • Beeri, M.S.1    Schmeidler, J.2    Silverman, J.M.3
  • 107
    • 0036370776 scopus 로고    scopus 로고
    • Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease
    • DOI 10.1385/NMM:1:1:1
    • Sambamurti K, Greig N, Lahiri D. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Med 2002;1:1-31 (Pubitemid 37021521)
    • (2002) NeuroMolecular Medicine , vol.1 , Issue.1 , pp. 1-31
    • Sambamurti, K.1    Greig, N.H.2    Lahiri, D.K.3
  • 108
    • 57049125529 scopus 로고    scopus 로고
    • Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin
    • Jolivalt C, Lee C, Beiswenger K, et al. Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin. J Neurisci Res 2008;86:3265-74
    • (2008) J Neurisci Res , vol.86 , pp. 3265-74
    • Jolivalt, C.1    Lee, C.2    Beiswenger, K.3
  • 109
    • 18744438248 scopus 로고    scopus 로고
    • Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
    • Xie L, Helmerhorst E, Taddei K, et al. Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor. J Neurosci 2002;22:RC221
    • (2002) J Neurosci , vol.22
    • Xie, L.1    Helmerhorst, E.2    Taddei, K.3
  • 110
    • 38049110692 scopus 로고    scopus 로고
    • Amyloid beta oligomers induce impairment of neuronal insulin receptors
    • Zhao W, De Felice F, Fernandez S, et al. Amyloid beta oligomers induce impairment of neuronal insulin receptors. Faseb J 2008;22:246-60
    • (2008) Faseb J , vol.22 , pp. 246-60
    • Zhao, W.1    De Felice, F.2    Fernandez, S.3
  • 111
    • 44149122563 scopus 로고    scopus 로고
    • GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    • Gault V, Holscher C. GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid. Eur J Pharmacol 2008;587:112-17
    • (2008) Eur J Pharmacol , vol.587 , pp. 112-17
    • Gault, V.1    Holscher, C.2
  • 112
    • 36949030831 scopus 로고    scopus 로고
    • GLP-1 amplifies insulin signaling by up-regulation of IRβ, IRS-1 and Glut4 in 3T3-L1 adipocytes
    • DOI 10.1007/s12020-007-9011-4
    • Gao H, Wang X, Zhang Z, et al. GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes. Endocrine 2007;32:90-5 (Pubitemid 350242552)
    • (2007) Endocrine , vol.32 , Issue.1 , pp. 90-95
    • Gao, H.1    Wang, X.2    Zhang, Z.3    Yang, Y.4    Yang, J.5    Li, X.6    Ning, G.7
  • 113
    • 77950352189 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease
    • Li Y, Duffy K, Ottinger M, et al. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis 2010;19:1205-19
    • (2010) J Alzheimers Dis , vol.19 , pp. 1205-19
    • Li, Y.1    Duffy, K.2    Ottinger, M.3
  • 114
    • 82755176046 scopus 로고    scopus 로고
    • Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    • doi:10.1016/j.neurobiolaging.2010.02.014
    • Gengler S, McClean PL, McCurtin R, et al. Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol Aging 2010; doi:10.1016/j.neurobiolaging.2010.02.014
    • (2010) Neurobiol Aging
    • Gengler, S.1    McClean, P.L.2    McCurtin, R.3
  • 115
    • 76749116176 scopus 로고    scopus 로고
    • Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice
    • D'Amico M, Di Filippo C, Marfella R, et al. Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice. Exp Gerontol 2010;45:202-7
    • (2010) Exp Gerontol , vol.45 , pp. 202-7
    • D'Amico, M.1    Di Filippo, C.2    Marfella, R.3
  • 116
    • 74749108848 scopus 로고    scopus 로고
    • Pancreatic beta-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes
    • Asmar M, Højberg PV, Deacon CF, et al. Pancreatic beta-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes. Regul Pept 2010;160:175-80
    • (2010) Regul Pept , vol.160 , pp. 175-80
    • Asmar, M.1    Højberg, P.V.2    Deacon, C.F.3
  • 117
    • 33747188115 scopus 로고    scopus 로고
    • Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide
    • DOI 10.1016/j.bcp.2006.06.013, PII S0006295206003601
    • Irwin, N, Clarke G, Green B, et al. Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide. Biochem Pharmacol 2006;72:719-28 (Pubitemid 44233552)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.6 , pp. 719-728
    • Irwin, N.1    Clarke, G.C.2    Green, B.D.3    Greer, B.4    Harriott, P.5    Gault, V.A.6    O'Harte, F.P.M.7    Flatt, P.R.8
  • 118
    • 24944525045 scopus 로고    scopus 로고
    • Molecular pathogenesis of Parkinson's disease
    • DOI 10.1093/hmg/ddi308
    • Gandhi S, Wood N. Molecular pathogenesis of Parkinson's disease. Hum Mol Genet 2005;14:2749-55 (Pubitemid 41300647)
    • (2005) Human Molecular Genetics , vol.14 , Issue.18 , pp. 2749-2755
    • Gandhi, S.1    Wood, N.W.2
  • 119
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • DOI 10.1038/nrn2038, PII NRN2038
    • Block ML, Zecca L, Hong J-S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Neurosci 2007;8:57-69 (Pubitemid 46011999)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.1 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.-S.3
  • 120
    • 34247366072 scopus 로고    scopus 로고
    • Inflammation as a causative factor in the aetiology of Parkinson's disease
    • DOI 10.1038/sj.bjp.0707167, PII 0707167
    • Whitton P. Inflammation as a potential causative factor in the aetiology of Parkinsons disease. Br J Pharmacol 2007;150:963-76 (Pubitemid 46628616)
    • (2007) British Journal of Pharmacology , vol.150 , Issue.8 , pp. 963-976
    • Whitton, P.S.1
  • 121
    • 41149163183 scopus 로고    scopus 로고
    • Parkinson's disease: Clinical features and diagnosis
    • DOI 10.1136/jnnp.2007.131045
    • Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 2008;79:368-76 (Pubitemid 351441488)
    • (2008) Journal of Neurology, Neurosurgery and Psychiatry , vol.79 , Issue.4 , pp. 368-376
    • Jankovic, J.1
  • 122
    • 77953428393 scopus 로고    scopus 로고
    • Parkinson's disease: Health-related quality of life, economic cost, and implications of early treatment
    • Chen JJ. Parkinson's disease: health-related quality of life, economic cost, and implications of early treatment. Am J Manag Care 2010;16(Suppl Implications):S87-93
    • (2010) Am J Manag Care , vol.16 , Issue.SUPPL.
    • Chen, J.J.1
  • 125
    • 70349334516 scopus 로고    scopus 로고
    • Exendin-4 protects dopaminergic neurons by inhibition of microglial activation abd matrix metalloproteinase-3 expression in an animal model of Parkinson's disease
    • Kim S, Moon M, Park S. Exendin-4 protects dopaminergic neurons by inhibition of microglial activation abd matrix metalloproteinase-3 expression in an animal model of Parkinson's disease. J Endocrinol 2009;202:431-9
    • (2009) J Endocrinol , vol.202 , pp. 431-9
    • Kim, S.1    Moon, M.2    Park, S.3
  • 126
    • 70449701437 scopus 로고    scopus 로고
    • Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression
    • Kim Chung le T, Hosaka T, Yoshida M, et al. Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression. Biochem Biophys Res Commun 2009;390:613-18
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 613-18
    • Kim Chung Le, T.1    Hosaka, T.2    Yoshida, M.3
  • 127
    • 67849084815 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation
    • Dozier KC, Cureton EL, Kwan RO, et al. Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation. Peptides 2009;30:1735-41
    • (2009) Peptides , vol.30 , pp. 1735-41
    • Dozier, K.C.1    Cureton, E.L.2    Kwan, R.O.3
  • 128
    • 45549108268 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
    • Harkavyi A, Abuirmeileh A, Lever R, et al. Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease. J Neuroinflammation 2008;21;5:19
    • (2008) J Neuroinflammation , vol.21 , Issue.5 , pp. 19
    • Harkavyi, A.1    Abuirmeileh, A.2    Lever, R.3
  • 129
    • 8844220536 scopus 로고    scopus 로고
    • Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series
    • DOI 10.1038/sj.embor.7400250
    • Landles C, Bates GP. Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series. EMBO Rep 2004;5:958-63 (Pubitemid 39534452)
    • (2004) EMBO Reports , vol.5 , Issue.10 , pp. 958-963
    • Landles, C.1    Bates, G.P.2
  • 130
    • 77955398297 scopus 로고    scopus 로고
    • Uncovering the true prevalence of Huntington's disease
    • doi:10.1016/S1474-4422(10)70160-5
    • Spinney L. Uncovering the true prevalence of Huntington's disease. Lancet Neurol 2010; doi:10.1016/S1474-4422(10)70160-5
    • (2010) Lancet Neurol
    • Spinney, L.1
  • 131
    • 63249091158 scopus 로고    scopus 로고
    • Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntingdon's disease
    • Martin B, Golden E, Carlson OD, et al. Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntingdon's disease. Diabetes 2009;58:318-28
    • (2009) Diabetes , vol.58 , pp. 318-28
    • Martin, B.1    Golden, E.2    Carlson, O.D.3
  • 132
    • 36549030256 scopus 로고    scopus 로고
    • Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: Clinical consequences and therapeutic implications
    • Aziz N, Swaab D, Pijl H, et al. Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: clinical consequences and therapeutic implications. Rev Neurosci 2007;18:223-51
    • (2007) Rev Neurosci , vol.18 , pp. 223-51
    • Aziz, N.1    Swaab, D.2    Pijl, H.3
  • 133
    • 26044473385 scopus 로고    scopus 로고
    • Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents
    • DOI 10.1007/s00221-005-2357-z
    • Hunt M, Morton A. Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's Disease is not improved by treatment with hypoglycaemic agents. Exp Brain Res 2005;166:220-9 (Pubitemid 41406813)
    • (2005) Experimental Brain Research , vol.166 , Issue.2 , pp. 220-229
    • Hunt, M.J.1    Morton, A.J.2
  • 134
    • 70049083077 scopus 로고    scopus 로고
    • Therapeutic interventions for symptomatic treatment in Huntington's disease
    • Mestre T, Ferreira J, Coelho MM, et al. Therapeutic interventions for symptomatic treatment in Huntington's disease. Cochrane Database Syst Rev 2009(3):CD006456
    • (2009) Cochrane Database Syst Rev , Issue.3
    • Mestre, T.1    Ferreira, J.2    Coelho, M.M.3
  • 135
    • 70049091196 scopus 로고    scopus 로고
    • Therapeutic interventions for disease progression in Huntington's disease
    • Mestre T, Ferreira J, Coelho MM, et al. Therapeutic interventions for disease progression in Huntington's disease. Cochrane Database Syst Rev 2009(3):CD006455
    • (2009) Cochrane Database Syst Rev , Issue.3
    • Mestre, T.1    Ferreira, J.2    Coelho, M.M.3
  • 136
    • 37149029659 scopus 로고    scopus 로고
    • Diabetes, the metabolic syndrome, and ischemic stroke: Epidemiology and possible mechanisms
    • DOI 10.2337/dc06-1537
    • Air EL, Kissela BM. Diabetes, the metabolic syndrome, and ischemic stroke: epidemiology and possible mechanisms. Diabetes Care 2007;30: 3131-40 (Pubitemid 350258454)
    • (2007) Diabetes Care , vol.30 , Issue.12 , pp. 3131-3140
    • Air, E.L.1    Kissela, B.M.2
  • 137
    • 34249092704 scopus 로고    scopus 로고
    • Calcium and neurodegeneration
    • Mattson MP. Calcium and neurodegeneration. Aging Cell 2007;6:337-50
    • (2007) Aging Cell , vol.6 , pp. 337-50
    • Mattson, M.P.1
  • 138
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    • Noyan-Ashraf M, Momen M, Ban K, et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 2009;58:975-83
    • (2009) Diabetes , vol.58 , pp. 975-83
    • Noyan-Ashraf, M.1    Momen, M.2    Ban, K.3
  • 139
    • 33846501672 scopus 로고    scopus 로고
    • Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy
    • DOI 10.1016/j.expneurol.2006.09.028, PII S0014488606005474
    • Perry TA, Holloway H, Weerasuriya A, et al. Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. Exp Neurol 2007;203:293-301 (Pubitemid 46157226)
    • (2007) Experimental Neurology , vol.203 , Issue.2 , pp. 293-301
    • Perry, T.1    Holloway, H.W.2    Weerasuriya, A.3    Mouton, P.R.4    Duffy, K.5    Mattison, J.A.6    Greig, N.H.7
  • 141
    • 0035434115 scopus 로고    scopus 로고
    • Glucose Competence of the Hepatoportal Vein Sensor Requires the Presence of an Activated Glucagon-Like Peptide-1 Receptor
    • Burcelin R, Da Costa A, Drucker D, et al. Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor. Diabetes 2001;50:1720-8 (Pubitemid 33641588)
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1720-1728
    • Burcelin, R.1    Da Costa, A.2    Drucker, D.3    Thorens, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.