Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice

Neuroscience

Volumn 277, Issue , 2014, Pages 747-754

  Patil, S P ^a   Jain, P D ^a   Ghumatkar, P J ^a   Tambe, R ^a   Sathaye, S ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Metformin; Neuroprotective; Neurotrophic; Oxidative stress; Parkinson's disease

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CATALASE; GLUTATHIONE; METFORMIN; SUPEROXIDE DISMUTASE; TYROSINE 3 MONOOXYGENASE; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ANTIOXIDANT; NEUROPROTECTIVE AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LOCOMOTION; MALE; MESENCEPHALON; MOTOR COORDINATION; MOUSE; NERVE CELL DEGENERATION; NEUROPROTECTION; NISSL STAINING; NONHUMAN; OPEN FIELD TEST; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; ROTAROD TEST; SUBSTANTIA NIGRA; ENZYME ACTIVITY; GROOMING; IMMOBILITY; MPTP-INDUCED PARKINSONISM; PROTEIN CONTENT; PROTEIN DEPLETION; REARING; SUBSTANTIA NIGRA PARS COMPACTA; TREATMENT DURATION; TREATMENT OUTCOME; ANIMAL; DRUG EFFECTS; METABOLISM; MOTOR ACTIVITY; MPTP POISONING; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; ANTIOXIDANTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CATALASE; GLUTATHIONE; LIPID PEROXIDATION; MALE; METFORMIN; MICE; MOTOR ACTIVITY; MPTP POISONING; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RANDOM ALLOCATION; ROTAROD PERFORMANCE TEST; SUBSTANTIA NIGRA; SUPEROXIDE DISMUTASE; TYROSINE 3-MONOOXYGENASE;

EID: 84907032242     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.07.046     Document Type: Article

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