Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis

Journal of Molecular Neuroscience

Volumn 47, Issue 2, 2012, Pages 267-277

  Hsuchou, Hung ^a   Kastin, Abba J ^a   Pan, Weihong ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

CRP; Leptin; Microgliosis; Obesity; Reactive astrogliosis; Trauma

Indexed keywords

C REACTIVE PROTEIN; CD11B ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; LEPTIN; MINOCYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL CULTURE; CELL STRUCTURE; CONTROLLED STUDY; DISEASE EXACERBATION; DOSE RESPONSE; DRUG EFFECT; GLIA CELL; GLIOSIS; IMMUNOREACTIVITY; MICROGLIA; MOUSE; NONHUMAN; OBESITY; PROTEIN BLOOD LEVEL;

ANIMALS; ASTROCYTES; GLIOSIS; MICE; MICE, INBRED C57BL; MICROGLIA; NEUROGENIC INFLAMMATION; OBESITY; PRIMARY CELL CULTURE;

MUS;

EID: 84863875558     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9734-4     Document Type: Article

References (55)

1. Ahima RS, Osei SY (2004) Leptin signaling. Physiol Behav 81:223-241 (Pubitemid 38670089)
2. Banks WA (2001) Leptin transport across the blood-brain barrier: implications for the cause and treatment of obesity. Curr Pharm Des 7:125-133
3. BanksWA, Kastin AJ, HuangW, Jaspan JB, Maness LM (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311 (Pubitemid 26124406)
4. Chen X, Pi R, Liu M, Ma X, Jiang Y, Liu Y, Mao X, Hu X (2010) Combination of methylprednisolone and minocycline synergistically improves experimental autoimmune encephalomyelitis in C57 BL/6 mice. J Neuroimmunol 226:104-109
5. Eng LF, Vanderhaeghen JJ, Bignami A, Gerstl B (1971) An acidic protein isolated from fibrous astrocytes. Brain Res 28:351-354
6. Eng LF, Ghirnikar RS, Lee YL (2000) Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res 25:1439-1451
7. Farr SA, Banks WA, Morley JE (2006) Effects of leptin on memory processing. Peptides 27:1420-1425 (Pubitemid 43767004)
8. Farr SA, Yamada KA, Butterfield DA, Abdul HM, Xu L, Miller NE, Banks WA, Morley JE (2008) Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology 149:2628-2636 (Pubitemid 351574482)
9. He Y, Kastin AJ, Hsuchou H, Pan W (2009) The Cdk5/p35 kinases modulate leptin-induced STAT3 signaling. J Mol Neurosci 39:49-58
10. Henry CJ, Huang Y, Wynne A, Hanke M, Himler J, Bailey MT, Sheridan JF, Godbout JP (2008) Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J Neuroinflammation 5:15
11. Hoane MR, Swan AA, Heck SE (2011) The effects of a high-fat sucrose diet on functional outcome following cortical contusion injury in the rat. Behav Brain Res 223:119-124
12. Hosoi T, Okuma Y, Wada S, Nomura Y (2003) Inhibition of leptin-induced IL-1beta expression by glucocorticoids in the brain. Brain Res 969:95-101 (Pubitemid 36372074)
13. Hsuchou H, He Y, Kastin AJ, Tu H, Markadakis EN, Rogers RC, Fossier PB, Pan W (2009a) Obesity induces functional astrocytic leptin receptors in hypothalamus. Brain 132:889-902
14. Hsuchou H, Pan W, Barnes MJ, Kastin AJ (2009b) Leptin receptor mRNA in rat brain astrocytes. Peptides 30:2275-2280
15. Hwang LL, Wang CH, Li TL, Chang SD, Lin LC, Chen CP, Chen CT, Liang KC, Ho IK, Yang WS, Chiou LC (2010) Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. Obes Silver Spring 18:463-469
16. Kanoski SE, Davidson TL (2011) Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol Behav 103:59-68
17. Kanoski SE, Zhang Y, Zheng W, Davidson TL (2010) The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. J Alzheimers Dis 21:207-219
18. Kastin AJ, Pan W (2003) Feeding peptides interact in several ways with the blood-brain barrier. Curr Pharm Des 9:789-794 (Pubitemid 36367600)
19. Kastin AJ, Pan W (2006) Intranasal leptin: blood-brain barrier bypass (BBBB) for obesity? Endocrinol 147:2086-2087
20. Kastin AJ, Pan W (2008) Blood-brain barrier and feeding: regulatory roles of saturable transport systems for ingestive peptides. Curr Pharm Des 14:1615-1619 (Pubitemid 352002989)
21. Kastin AJ, Akerstrom V, Pan W (2001) Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls. Peptides 22:2127-2136
22. Katano H, Fujita K, Kato T, Asai K, Kawamura Y, Masago A, Yamada K (1999) Traumatic injury in vitro induces IEG mRNAs in cultured glial cells, suppressed by co-culture with neurons. NeuroReport 10:2439-2448 (Pubitemid 29418116)
23. Kibayashi E, Urakaze M, Kobashi C, Kishida M, Takata M, Sato A, Yamazaki K, Kobayashi M (2005) Inhibitory effect of pitavastatin (NK-104) on the C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells. Clin Sci Lond 108:515-521 (Pubitemid 40827559)
24. Kornyei Z, Czirok A, Vicsek T, Madarasz E (2000) Proliferative and migratory responses of astrocytes to in vitro injury. J Neurosci Res 61:421-429 (Pubitemid 30620226)
25. Lafrance V, InoueW, Kan B, Luheshi GN (2010) Leptin modulates cell morphology and cytokine release in microglia. Brain Behav Immun 24:358-365
26. Langdon KD, Clarke J, Corbett D (2011) Long-term exposure to high fat diet is bad for your brain: exacerbation of focal ischemic brain injury. Neuroscience 182:82-87
27. Lau LT, Yu AC (2001) Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury. J Neurotrauma 18:351-359 (Pubitemid 32230637)
28. Lavin DN, Joesting JJ, Chiu GS, Moon ML, Meng J, Dilger RN, Freund GG (2011) Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents. Obes Silver Spring 19:1586-1594
29. Magdalena J, Millard TH, Etienne-Manneville S, Launay S, Warwick HK, Machesky LM (2003) Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models. Mol Biol Cell 14:670-684 (Pubitemid 36237024)
30. Mahajan N, Bahl A, Dhawan V (2010) C-reactive protein (CRP) up-regulates expression of receptor for advanced glycation end products (RAGE) and its inflammatory ligand EN-RAGE in THP-1 cells: inhibitory effects of atorvastatin. Int J Cardiol 142:273-278
31. Malhotra SK, Luong LT, Bhatnagar R, Shnitka TK (1997) Upregulation of reactive astrogliosis in the rat glioma 9L cell line by combined mechanical and chemical injuries. Cytobios 89:115-134 (Pubitemid 127532581)
32. Marnell L, Mold C, Du Clos TW (2005) C-reactive protein: ligands, receptors and role in inflammation. Clin Immunol 117:104-111 (Pubitemid 41407719)
33. Mattace RG, Esposito E, Iacono A, Pacilio M, Coppola A, Bianco G, Diano S, Di Carlo R, Meli R (2006) Leptin induces nitric oxide synthase type II in C6 glioma cells. Role for nuclear factor-kappaB in hormone effect. Neurosci Lett 396:121-126 (Pubitemid 43276425)
34. Ohnishi S, Maeda S, Nishiguchi S, Arao T, Shimada K (1988) Structure of the mouse C-reactive protein gene. Biochem Biophys Res Commun 156:814-822 (Pubitemid 18263904)
35. Pan W, Kastin AJ (2007) Adipokines and the blood-brain barrier. Peptides 28:1317-1330 (Pubitemid 46843398)
36. Pan W, Tu H, Hsuchou H, Daniel J, Kastin AJ (2007) Unexpected amplification of leptin-induced Stat3 signaling by urocortin: implications for obesity. J Mol Neurosci 33:232-238 (Pubitemid 350242532)
37. Pan W, Hsuchou H, He Y, Sakharkar A, Cain C, Yu C, Kastin AJ (2008) Astrocyte leptin receptor (ObR) and leptin transport in adult-onset obese mice. Endocrinology 149:2798-2806 (Pubitemid 351724513)
38. Pan W, Hsuchou H, He Y, Kastin AJ (2011) Glial leptin receptors and obesity. In: Preedy VR (ed) Modern insights into disease from molecules to man: Adipokines. Science Publishers, Enfield, pp 185-196
39. Pan W, Hsuchou H, Jayaram B, Khan RS, Huang EYK, Wu X, Chen C, Kastin AJ (2012) Leptin action on non-neuronal cells in the CNS: potential clinical implications. Ann N Y Acad Sci. In press
40. Peisajovich A, Marnell L, Mold C, Du Clos TW (2008) C-reactive protein at the interface between innate immunity and inflammation. Expert Rev Clin Immunol 4:379-390 (Pubitemid 351903275)
41. Pepys MB (1981) C-reactive protein fifty years on. Lancet 1:653-657
42. Pinteaux E, Inoue W, Schmidt L, Molina-Holgado F, Rothwell NJ, Luheshi GN (2007) Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism. J Neurochem 102:826-833 (Pubitemid 47057280)
43. Raji CA, Ho AJ, Parikshak NN, Becker JT, Lopez OL, Kuller LH, Hua X, Leow AD, Toga AW, Thompson PM (2010) Brain structure and obesity. Hum Brain Mapp 31:353-364
44. Streit WJ (2002) Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40:133-139
45. Tang H, Fu WY, Ip NY (2000) Altered expression of tissue-type plasminogen activator and type 1 inhibitor in astrocytes of mouse cortex following scratch injury in culture. Neurosci Lett 285:143-146 (Pubitemid 30227640)
46. Tang CH, Lu DY, Yang RS, Tsai HY, Kao MC, Fu WM, Chen YF (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179:1292-1302
47. Tapanainen P, Leinonen E, Ruokonen A, Knip M (2001) Leptin concentrations are elevated in newborn infants of diabetic mothers. Horm Res 55:185-190 (Pubitemid 34701721)
48. Tikka TM, Koistinaho JE (2001) Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol 166:7527-7533 (Pubitemid 32525632)
49. Walther K, Birdsill AC, Glisky EL, Ryan L (2010) Structural brain differences and cognitive functioning related to body mass index in older females. Hum Brain Mapp 31:1052-1064
50. Wu X, Kastin AJ, He Y, Hsuchou H, Rood JC, Pan W (2010) Essential role of interleukin-15 receptor in normal anxiety behavior. Brain Behav Immun 24:1340-1346
51. Yang H, Cheng XP, Li JW, Yao Q, Ju G (2009) De-differentiation response of cultured astrocytes to injury induced by scratch or conditioned culture medium of scratch-insulted astrocytes. Cell Mol Neurobiol 29:455-473
52. Yu AC, Lee YL, Eng LF (1993) Astrogliosis in culture: I. The model and the effect of antisense oligonucleotides on glial fibrillary acidic protein synthesis. J Neurosci Res 34:295-303 (Pubitemid 23060114)
53. Zhang Y, Wu X, He Y, Kastin AJ, Hsuchou H, Rosenblum CI, Pan W (2009) Melanocortin potentiates leptin-induced STAT3 signaling via MAPK pathway. J Neurochem 110:390-399
54. Zhang D, Hu X, Qian L, O'Callaghan JP, Hong JS (2010) Astrogliosis in CNS pathologies: is there a role for microglia? Mol Neurobiol 41:232-241
55. Zhao XQ, Zhang MW, Wang F, Zhao YX, Li JJ, Wang XP, Bu PL, Yang JM, Liu XL, Zhang MX, Gao F, Zhang C, Zhang Y (2011) CRP enhances soluble LOX-1 release from macrophages by activating TNF-alpha converting enzyme. J Lipid Res 52:923-933