Brain PPAR-γ promotes obesity and is required for the insuling-sensitizing effect of thiazolidinediones

Nature Medicine

Volumn 17, Issue 5, 2011, Pages 618-622

  Lu, Min ^a   Sarruf, David A ^b   Talukdar, Saswata ^a   Sharma, Shweta ^a,c   Li, Pingping ^a   Bandyopadhyay, Gautam ^a   Nalbandian, Sarah ^a   Fan, Wuqiang ^a   Gayen, Jiaur R ^a,c   Mahata, Sushil K ^a,c   Webster, Nicholas J ^a,c   Schwartz, Michael W ^b   Olefsky, Jerrold M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN RECEPTOR; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; DRUG EFFECT; ENERGY EXPENDITURE; FOOD INTAKE; GLUCOSE METABOLISM; HYPERINSULINEMIA; HYPERPHAGIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THERMOGENESIS; WEIGHT GAIN;

AGED; ANIMALS; BRAIN; DIABETES MELLITUS, TYPE 2; ENERGY METABOLISM; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MICE; MICE, KNOCKOUT; MIDDLE AGED; OBESITY; PPAR GAMMA; SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES; WEIGHT GAIN;

MUS;

EID: 79955694276     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2332     Document Type: Article

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