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Volumn 20, Issue 4, 2014, Pages 573-591

Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; ROSIGLITAZONE; ANTIDIABETIC AGENT;

EID: 84907990392     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.08.005     Document Type: Review
Times cited : (401)

References (198)
  • 1
    • 70349661686 scopus 로고    scopus 로고
    • ACOG Practice Bulletin No. 108: Polycystic ovary syndrome
    • ACOG Committee on Practice Bulletins - Gynecology
    • ACOG Committee on Practice Bulletins - Gynecology ACOG Practice Bulletin No. 108: polycystic ovary syndrome Obstet. Gynecol. 114 2009 936 949
    • (2009) Obstet. Gynecol. , vol.114 , pp. 936-949
  • 2
    • 84883260199 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
    • A.C. Adams, T. Coskun, C.C. Cheng, L.S. O'Farrell, S.L. Dubois, and A. Kharitonenkov Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones Mol. Metab. 2 2013 205 214
    • (2013) Mol. Metab. , vol.2 , pp. 205-214
    • Adams, A.C.1    Coskun, T.2    Cheng, C.C.3    O'Farrell, L.S.4    Dubois, S.L.5    Kharitonenkov, A.6
  • 5
    • 84892649479 scopus 로고    scopus 로고
    • Standards of medical care in diabetes - 2014
    • American Diabetes Association
    • American Diabetes Association Standards of medical care in diabetes - 2014 Diabetes Care 37 Suppl 1 2014 S14 S80
    • (2014) Diabetes Care , vol.37 , pp. 14-S80
  • 6
    • 84862684037 scopus 로고    scopus 로고
    • The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: Nested case-control study
    • L. Azoulay, H. Yin, K.B. Filion, J. Assayag, A. Majdan, M.N. Pollak, and S. Suissa The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study BMJ 344 2012 e3645
    • (2012) BMJ , vol.344 , pp. 3645
    • Azoulay, L.1    Yin, H.2    Filion, K.B.3    Assayag, J.4    Majdan, A.5    Pollak, M.N.6    Suissa, S.7
  • 7
    • 84882892659 scopus 로고    scopus 로고
    • Rosiglitazone and outcomes for patients with diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial
    • BARI 2D Investigators
    • R.G. Bach, M.M. Brooks, M. Lombardero, S. Genuth, T.W. Donner, A. Garber, L. Kennedy, E.S. Monrad, R. Pop-Busui, S.F. Kelsey, R.L. Frye BARI 2D Investigators Rosiglitazone and outcomes for patients with diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial Circulation 128 2013 785 794
    • (2013) Circulation , vol.128 , pp. 785-794
    • Bach, R.G.1    Brooks, M.M.2    Lombardero, M.3    Genuth, S.4    Donner, T.W.5    Garber, A.6    Kennedy, L.7    Monrad, E.S.8    Pop-Busui, R.9    Kelsey, S.F.10    Frye, R.L.11
  • 8
    • 84868477903 scopus 로고    scopus 로고
    • Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist
    • S. Bajare, J. Anthony, A. Nair, R. Marita, A. Damre, D. Patel, C. Rao, H. Sivaramakrishnan, and N. Deka Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist Eur. J. Med. Chem. 58 2012 355 360
    • (2012) Eur. J. Med. Chem. , vol.58 , pp. 355-360
    • Bajare, S.1    Anthony, J.2    Nair, A.3    Marita, R.4    Damre, A.5    Patel, D.6    Rao, C.7    Sivaramakrishnan, H.8    Deka, N.9
  • 10
    • 33744974237 scopus 로고    scopus 로고
    • Effects of pioglitazone versus glipizide on body fat distribution, body water content, and hemodynamics in type 2 diabetes
    • A. Basu, M.D. Jensen, F. McCann, D. Mukhopadhyay, M.J. Joyner, and R.A. Rizza Effects of pioglitazone versus glipizide on body fat distribution, body water content, and hemodynamics in type 2 diabetes Diabetes Care 29 2006 510 514
    • (2006) Diabetes Care , vol.29 , pp. 510-514
    • Basu, A.1    Jensen, M.D.2    McCann, F.3    Mukhopadhyay, D.4    Joyner, M.J.5    Rizza, R.A.6
  • 11
    • 84873936996 scopus 로고    scopus 로고
    • The effects of thiazolidinediones on human bone marrow stromal cell differentiation in vitro and in thiazolidinedione-treated patients with type 2 diabetes
    • G.R. Beck Jr., N.B. Khazai, G.F. Bouloux, C.E. Camalier, Y. Lin, L.M. Garneys, J. Siqueira, L. Peng, F. Pasquel, and D. Umpierrez The effects of thiazolidinediones on human bone marrow stromal cell differentiation in vitro and in thiazolidinedione-treated patients with type 2 diabetes Transl. Res. 161 2013 145 155
    • (2013) Transl. Res. , vol.161 , pp. 145-155
    • Beck, G.R.1    Khazai, N.B.2    Bouloux, G.F.3    Camalier, C.E.4    Lin, Y.5    Garneys, L.M.6    Siqueira, J.7    Peng, L.8    Pasquel, F.9    Umpierrez, D.10
  • 13
    • 84876548389 scopus 로고    scopus 로고
    • Thiazolidinedione-induced fluid retention: Recent insights into the molecular mechanisms
    • J. Bełtowski, J. Rachańczyk, and M. Włodarczyk Thiazolidinedione-induced fluid retention: recent insights into the molecular mechanisms PPAR Res. 2013 2013 628628
    • (2013) PPAR Res. , vol.2013 , pp. 628628
    • Bełtowski, J.1    Rachańczyk, J.2    Włodarczyk, M.3
  • 17
    • 70350233465 scopus 로고    scopus 로고
    • Incidence and mortality of hip fractures in the United States
    • C.A. Brauer, M. Coca-Perraillon, D.M. Cutler, and A.B. Rosen Incidence and mortality of hip fractures in the United States JAMA 302 2009 1573 1579
    • (2009) JAMA , vol.302 , pp. 1573-1579
    • Brauer, C.A.1    Coca-Perraillon, M.2    Cutler, D.M.3    Rosen, A.B.4
  • 19
    • 0032989265 scopus 로고    scopus 로고
    • A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat
    • K.K. Brown, B.R. Henke, S.G. Blanchard, J.E. Cobb, R. Mook, I. Kaldor, S.A. Kliewer, J.M. Lehmann, J.M. Lenhard, and W.W. Harrington A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat Diabetes 48 1999 1415 1424
    • (1999) Diabetes , vol.48 , pp. 1415-1424
    • Brown, K.K.1    Henke, B.R.2    Blanchard, S.G.3    Cobb, J.E.4    Mook, R.5    Kaldor, I.6    Kliewer, S.A.7    Lehmann, J.M.8    Lenhard, J.M.9    Harrington, W.W.10
  • 22
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • N. Chalasani, Z. Younossi, J.E. Lavine, A.M. Diehl, E.M. Brunt, K. Cusi, M. Charlton, and A.J. Sanyal The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association Hepatology 55 2012 2005 2023
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6    Charlton, M.7    Sanyal, A.J.8
  • 23
    • 84865489581 scopus 로고    scopus 로고
    • Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis
    • L. Chang, L. Villacorta, R. Li, M. Hamblin, W. Xu, C. Dou, J. Zhang, J. Wu, R. Zeng, and Y.E. Chen Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis Circulation 126 2012 1067 1078
    • (2012) Circulation , vol.126 , pp. 1067-1078
    • Chang, L.1    Villacorta, L.2    Li, R.3    Hamblin, M.4    Xu, W.5    Dou, C.6    Zhang, J.7    Wu, J.8    Zeng, R.9    Chen, Y.E.10
  • 25
    • 0028015713 scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) gamma: Adipose-predominant expression and induction early in adipocyte differentiation
    • A. Chawla, E.J. Schwarz, D.D. Dimaculangan, and M.A. Lazar Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation Endocrinology 135 1994 798 800
    • (1994) Endocrinology , vol.135 , pp. 798-800
    • Chawla, A.1    Schwarz, E.J.2    Dimaculangan, D.D.3    Lazar, M.A.4
  • 26
    • 84863609131 scopus 로고    scopus 로고
    • Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione
    • Z. Chen, P.A. Vigueira, K.T. Chambers, A.M. Hall, M.S. Mitra, N. Qi, W.G. McDonald, J.R. Colca, R.F. Kletzien, and B.N. Finck Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione J. Biol. Chem. 287 2012 23537 23548
    • (2012) J. Biol. Chem. , vol.287 , pp. 23537-23548
    • Chen, Z.1    Vigueira, P.A.2    Chambers, K.T.3    Hall, A.M.4    Mitra, M.S.5    Qi, N.6    McDonald, W.G.7    Colca, J.R.8    Kletzien, R.F.9    Finck, B.N.10
  • 27
    • 7044253431 scopus 로고    scopus 로고
    • A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors
    • E. Chiquette, G. Ramirez, and R. Defronzo A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors Arch. Intern. Med. 164 2004 2097 2104
    • (2004) Arch. Intern. Med. , vol.164 , pp. 2097-2104
    • Chiquette, E.1    Ramirez, G.2    Defronzo, R.3
  • 31
    • 84892689100 scopus 로고    scopus 로고
    • Leveraging cross-species transcription factor binding site patterns: From diabetes risk loci to disease mechanisms
    • DIAGRAM+Consortium
    • M. Claussnitzer, S.N. Dankel, B. Klocke, H. Grallert, V. Glunk, T. Berulava, H. Lee, N. Oskolkov, J. Fadista, K. Ehlers DIAGRAM+Consortium Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms Cell 156 2014 343 358
    • (2014) Cell , vol.156 , pp. 343-358
    • Claussnitzer, M.1    Dankel, S.N.2    Klocke, B.3    Grallert, H.4    Glunk, V.5    Berulava, T.6    Lee, H.7    Oskolkov, N.8    Fadista, J.9    Ehlers, K.10
  • 34
    • 84867571503 scopus 로고    scopus 로고
    • Hospitalised hip fracture risk with rosiglitazone and pioglitazone use compared with other glucose-lowering drugs
    • Scottish Diabetes Research Network Epidemiology Group
    • H.M. Colhoun, S.J. Livingstone, H.C. Looker, A.D. Morris, S.H. Wild, R.S. Lindsay, C. Reed, P.T. Donnan, B. Guthrie, G.P. Leese Scottish Diabetes Research Network Epidemiology Group Hospitalised hip fracture risk with rosiglitazone and pioglitazone use compared with other glucose-lowering drugs Diabetologia 55 2012 2929 2937
    • (2012) Diabetologia , vol.55 , pp. 2929-2937
    • Colhoun, H.M.1    Livingstone, S.J.2    Looker, H.C.3    Morris, A.D.4    Wild, S.H.5    Lindsay, R.S.6    Reed, C.7    Donnan, P.T.8    Guthrie, B.9    Leese, G.P.10
  • 35
    • 84865858873 scopus 로고    scopus 로고
    • Use of thiazolidinediones and the risk of bladder cancer among people with type 2 diabetes: A meta-analysis
    • I.N. Colmers, S.L. Bowker, S.R. Majumdar, and J.A. Johnson Use of thiazolidinediones and the risk of bladder cancer among people with type 2 diabetes: a meta-analysis CMAJ 184 2012 E675 E683
    • (2012) CMAJ , vol.184 , pp. 675-E683
    • Colmers, I.N.1    Bowker, S.L.2    Majumdar, S.R.3    Johnson, J.A.4
  • 36
    • 84870685371 scopus 로고    scopus 로고
    • Thiazolidinedione use and cancer incidence in type 2 diabetes: A systematic review and meta-analysis
    • I.N. Colmers, S.L. Bowker, and J.A. Johnson Thiazolidinedione use and cancer incidence in type 2 diabetes: a systematic review and meta-analysis Diabetes Metab. 38 2012 475 484
    • (2012) Diabetes Metab. , vol.38 , pp. 475-484
    • Colmers, I.N.1    Bowker, S.L.2    Johnson, J.A.3
  • 37
    • 35148837113 scopus 로고    scopus 로고
    • Pioglitazone and rosiglitazone have different effects on serum lipoprotein particle concentrations and sizes in patients with type 2 diabetes and dyslipidemia
    • GLAI Study Investigators
    • M.A. Deeg, J.B. Buse, R.B. Goldberg, D.M. Kendall, A.J. Zagar, S.J. Jacober, M.A. Khan, A.T. Perez, M.H. Tan GLAI Study Investigators Pioglitazone and rosiglitazone have different effects on serum lipoprotein particle concentrations and sizes in patients with type 2 diabetes and dyslipidemia Diabetes Care 30 2007 2458 2464
    • (2007) Diabetes Care , vol.30 , pp. 2458-2464
    • Deeg, M.A.1    Buse, J.B.2    Goldberg, R.B.3    Kendall, D.M.4    Zagar, A.J.5    Jacober, S.J.6    Khan, M.A.7    Perez, A.T.8    Tan, M.H.9
  • 38
    • 4143151942 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes mellitus
    • ix
    • R.A. DeFronzo Pathogenesis of type 2 diabetes mellitus Med. Clin. North Am. 88 2004 787 835 ix
    • (2004) Med. Clin. North Am. , vol.88 , pp. 787-835
    • Defronzo, R.A.1
  • 40
    • 84903550477 scopus 로고    scopus 로고
    • Can a selective PPARγ modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone?
    • DePaoli, A.M., Higgins, L.S., Henry, R.R., Mantzoros, C., and Dunn, F.L. (2014). Can a selective PPARγ modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone? Diabetes Care DC-132480.
    • (2014) Diabetes Care , pp. DC132480
    • Depaoli, A.M.1    Higgins, L.S.2    Henry, R.R.3    Mantzoros, C.4    Dunn, F.L.5
  • 43
    • 84870248203 scopus 로고    scopus 로고
    • Inverse relation of body weight and weight change with mortality and morbidity in patients with type 2 diabetes and cardiovascular co-morbidity: An analysis of the PROactive study population
    • W. Doehner, E. Erdmann, R. Cairns, A.L. Clark, J.A. Dormandy, E. Ferrannini, and S.D. Anker Inverse relation of body weight and weight change with mortality and morbidity in patients with type 2 diabetes and cardiovascular co-morbidity: an analysis of the PROactive study population Int. J. Cardiol. 162 2012 20 26
    • (2012) Int. J. Cardiol. , vol.162 , pp. 20-26
    • Doehner, W.1    Erdmann, E.2    Cairns, R.3    Clark, A.L.4    Dormandy, J.A.5    Ferrannini, E.6    Anker, S.D.7
  • 44
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial in macroVascular Events): A randomised controlled trial
    • PROactive investigators
    • J.A. Dormandy, B. Charbonnel, D.J.A. Eckland, E. Erdmann, M. Massi-Benedetti, I.K. Moules, A.M. Skene, M.H. Tan, P.J. Lefèbvre, G.D. Murray PROactive investigators Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial Lancet 366 2005 1279 1289
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.A.3    Erdmann, E.4    Massi-Benedetti, M.5    Moules, I.K.6    Skene, A.M.7    Tan, M.H.8    Lefèbvre, P.J.9    Murray, G.D.10
  • 45
    • 24044476859 scopus 로고    scopus 로고
    • Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice
    • S.Z. Duan, C.Y. Ivashchenko, M.W. Russell, D.S. Milstone, and R.M. Mortensen Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice Circ. Res. 97 2005 372 379
    • (2005) Circ. Res. , vol.97 , pp. 372-379
    • Duan, S.Z.1    Ivashchenko, C.Y.2    Russell, M.W.3    Milstone, D.S.4    Mortensen, R.M.5
  • 46
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    • P.A. Dutchak, T. Katafuchi, A.L. Bookout, J.H. Choi, R.T. Yu, D.J. Mangelsdorf, and S.A. Kliewer Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones Cell 148 2012 556 567
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3    Choi, J.H.4    Yu, R.T.5    Mangelsdorf, D.J.6    Kliewer, S.A.7
  • 47
    • 33847675510 scopus 로고    scopus 로고
    • The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction: Results from the PROactive (PROactive 05) Study
    • PROactive Investigators
    • E. Erdmann, J.A. Dormandy, B. Charbonnel, M. Massi-Benedetti, I.K. Moules, A.M. Skene PROactive Investigators The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction: results from the PROactive (PROactive 05) Study J. Am. Coll. Cardiol. 49 2007 1772 1780
    • (2007) J. Am. Coll. Cardiol. , vol.49 , pp. 1772-1780
    • Erdmann, E.1    Dormandy, J.A.2    Charbonnel, B.3    Massi-Benedetti, M.4    Moules, I.K.5    Skene, A.M.6
  • 50
    • 84887072282 scopus 로고    scopus 로고
    • Scientific evidence and controversies about pioglitazone and bladder cancer: Which lessons can be drawn?
    • J.-L. Faillie, P. Petit, J.-L. Montastruc, and D. Hillaire-Buys Scientific evidence and controversies about pioglitazone and bladder cancer: which lessons can be drawn? Drug Saf. 36 2013 693 707
    • (2013) Drug Saf. , vol.36 , pp. 693-707
    • Faillie, J.-L.1    Petit, P.2    Montastruc, J.-L.3    Hillaire-Buys, D.4
  • 57
    • 4644257496 scopus 로고    scopus 로고
    • Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation
    • Z.E. Floyd, and J.M. Stephens Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation Obes. Res. 12 2004 921 928
    • (2004) Obes. Res. , vol.12 , pp. 921-928
    • Floyd, Z.E.1    Stephens, J.M.2
  • 58
    • 0020552510 scopus 로고
    • Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent
    • T. Fujita, Y. Sugiyama, S. Taketomi, T. Sohda, Y. Kawamatsu, H. Iwatsuka, and Z. Suzuoki Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent Diabetes 32 1983 804 810
    • (1983) Diabetes , vol.32 , pp. 804-810
    • Fujita, T.1    Sugiyama, Y.2    Taketomi, S.3    Sohda, T.4    Kawamatsu, Y.5    Iwatsuka, H.6    Suzuoki, Z.7
  • 59
    • 84878276246 scopus 로고    scopus 로고
    • Is type 2 diabetes a category error?
    • E.A.M. Gale Is type 2 diabetes a category error? Lancet 381 2013 1956 1957
    • (2013) Lancet , vol.381 , pp. 1956-1957
    • Gale, E.A.M.1
  • 60
    • 84891763374 scopus 로고    scopus 로고
    • Epidemiology and molecular mechanisms tying obesity, diabetes, and the metabolic syndrome with cancer
    • E.J. Gallagher, and D. LeRoith Epidemiology and molecular mechanisms tying obesity, diabetes, and the metabolic syndrome with cancer Diabetes Care 36 Suppl 2 2013 S233 S239
    • (2013) Diabetes Care , vol.36 , pp. 233-S239
    • Gallagher, E.J.1    Leroith, D.2
  • 62
    • 33748748206 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial
    • DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators
    • H.C. Gerstein, S. Yusuf, J. Bosch, J. Pogue, P. Sheridan, N. Dinccag, M. Hanefeld, B. Hoogwerf, M. Laakso, V. Mohan DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial Lancet 368 2006 1096 1105
    • (2006) Lancet , vol.368 , pp. 1096-1105
    • Gerstein, H.C.1    Yusuf, S.2    Bosch, J.3    Pogue, J.4    Sheridan, P.5    Dinccag, N.6    Hanefeld, M.7    Hoogwerf, B.8    Laakso, M.9    Mohan, V.10
  • 63
    • 77949397703 scopus 로고    scopus 로고
    • The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: A HuGE review and meta-analysis
    • H.N. Gouda, G.S. Sagoo, A.-H. Harding, J. Yates, M.S. Sandhu, and J.P.T. Higgins The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis Am. J. Epidemiol. 171 2010 645 655
    • (2010) Am. J. Epidemiol. , vol.171 , pp. 645-655
    • Gouda, H.N.1    Sagoo, G.S.2    Harding, A.-H.3    Yates, J.4    Sandhu, M.S.5    Higgins, J.P.T.6
  • 65
    • 77954988618 scopus 로고    scopus 로고
    • Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone
    • D.J. Graham, R. Ouellet-Hellstrom, T.E. MaCurdy, F. Ali, C. Sholley, C. Worrall, and J.A. Kelman Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone JAMA 304 2010 411 418
    • (2010) JAMA , vol.304 , pp. 411-418
    • Graham, D.J.1    Ouellet-Hellstrom, R.2    Macurdy, T.E.3    Ali, F.4    Sholley, C.5    Worrall, C.6    Kelman, J.A.7
  • 66
    • 67649598394 scopus 로고    scopus 로고
    • MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema
    • F.M. Gregoire, F. Zhang, H.J. Clarke, T.A. Gustafson, D.D. Sears, S. Favelyukis, J. Lenhard, D. Rentzeperis, L.E. Clemens, Y. Mu, and B.E. Lavan MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema Mol. Endocrinol. 23 2009 975 988
    • (2009) Mol. Endocrinol. , vol.23 , pp. 975-988
    • Gregoire, F.M.1    Zhang, F.2    Clarke, H.J.3    Gustafson, T.A.4    Sears, D.D.5    Favelyukis, S.6    Lenhard, J.7    Rentzeperis, D.8    Clemens, L.E.9    Mu, Y.10    Lavan, B.E.11
  • 67
    • 61549098167 scopus 로고    scopus 로고
    • Thiazolidinedione-induced skeletal fragility - Mechanisms and implications
    • A. Grey Thiazolidinedione-induced skeletal fragility - mechanisms and implications Diabetes Obes. Metab. 11 2009 275 284
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 275-284
    • Grey, A.1
  • 68
    • 23844472901 scopus 로고    scopus 로고
    • Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption
    • Y. Guan, C. Hao, D.R. Cha, R. Rao, W. Lu, D.E. Kohan, M.A. Magnuson, R. Redha, Y. Zhang, and M.D. Breyer Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption Nat. Med. 11 2005 861 866
    • (2005) Nat. Med. , vol.11 , pp. 861-866
    • Guan, Y.1    Hao, C.2    Cha, D.R.3    Rao, R.4    Lu, W.5    Kohan, D.E.6    Magnuson, M.A.7    Redha, R.8    Zhang, Y.9    Breyer, M.D.10
  • 69
    • 84883253449 scopus 로고    scopus 로고
    • Acute genome-wide effects of rosiglitazone on PPARγ transcriptional networks in adipocytes
    • A.K. Haakonsson, M. Stahl Madsen, R. Nielsen, A. Sandelin, and S. Mandrup Acute genome-wide effects of rosiglitazone on PPARγ transcriptional networks in adipocytes Mol. Endocrinol. 27 2013 1536 1549
    • (2013) Mol. Endocrinol. , vol.27 , pp. 1536-1549
    • Haakonsson, A.K.1    Stahl Madsen, M.2    Nielsen, R.3    Sandelin, A.4    Mandrup, S.5
  • 70
    • 2442481645 scopus 로고    scopus 로고
    • Metabolic effects of rosiglitazone in HIV lipodystrophy: A randomized, controlled trial
    • C. Hadigan, S. Yawetz, A. Thomas, F. Havers, P.E. Sax, and S. Grinspoon Metabolic effects of rosiglitazone in HIV lipodystrophy: a randomized, controlled trial Ann. Intern. Med. 140 2004 786 794
    • (2004) Ann. Intern. Med. , vol.140 , pp. 786-794
    • Hadigan, C.1    Yawetz, S.2    Thomas, A.3    Havers, F.4    Sax, P.E.5    Grinspoon, S.6
  • 71
    • 41149127672 scopus 로고    scopus 로고
    • Treatment modalities of obesity: What fits whom?
    • V. Hainer, H. Toplak, and A. Mitrakou Treatment modalities of obesity: what fits whom? Diabetes Care 31 Suppl 2 2008 S269 S277
    • (2008) Diabetes Care , vol.31 , pp. 269-S277
    • Hainer, V.1    Toplak, H.2    Mitrakou, A.3
  • 73
    • 79551471791 scopus 로고    scopus 로고
    • Vascular smooth muscle cell peroxisome proliferator-activated receptor-γ mediates pioglitazone-reduced vascular lesion formation
    • M. Hamblin, L. Chang, H. Zhang, K. Yang, J. Zhang, and Y.E. Chen Vascular smooth muscle cell peroxisome proliferator-activated receptor-γ mediates pioglitazone-reduced vascular lesion formation Arterioscler. Thromb. Vasc. Biol. 31 2011 352 359
    • (2011) Arterioscler. Thromb. Vasc. Biol. , vol.31 , pp. 352-359
    • Hamblin, M.1    Chang, L.2    Zhang, H.3    Yang, K.4    Zhang, J.5    Chen, Y.E.6
  • 75
    • 84907994949 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A key regulator of energy balance with many roles in human disease
    • D.G. Hardie AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease J. Intern. Med. 2014 10.1111/joim.12268
    • (2014) J. Intern. Med.
    • Hardie, D.G.1
  • 77
    • 0034674567 scopus 로고    scopus 로고
    • Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation
    • S. Hauser, G. Adelmant, P. Sarraf, H.M. Wright, E. Mueller, and B.M. Spiegelman Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation J. Biol. Chem. 275 2000 18527 18533
    • (2000) J. Biol. Chem. , vol.275 , pp. 18527-18533
    • Hauser, S.1    Adelmant, G.2    Sarraf, P.3    Wright, H.M.4    Mueller, E.5    Spiegelman, B.M.6
  • 78
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
    • W. He, Y. Barak, A. Hevener, P. Olson, D. Liao, J. Le, M. Nelson, E. Ong, J.M. Olefsky, and R.M. Evans Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle Proc. Natl. Acad. Sci. USA 100 2003 15712 15717
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3    Olson, P.4    Liao, D.5    Le, J.6    Nelson, M.7    Ong, E.8    Olefsky, J.M.9    Evans, R.M.10
  • 79
    • 84896479122 scopus 로고    scopus 로고
    • Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor γ-independent mitochondrial oxidative stress in mouse hearts
    • H. He, H. Tao, H. Xiong, S.Z. Duan, F.X. McGowan Jr., R.M. Mortensen, and J.A. Balschi Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor γ-independent mitochondrial oxidative stress in mouse hearts Toxicol. Sci. 138 2014 468 481
    • (2014) Toxicol. Sci. , vol.138 , pp. 468-481
    • He, H.1    Tao, H.2    Xiong, H.3    Duan, S.Z.4    McGowan, F.X.5    Mortensen, R.M.6    Balschi, J.A.7
  • 81
    • 79955730238 scopus 로고    scopus 로고
    • Efficacy and safety of the PPARγ partial agonist balaglitazone compared with pioglitazone and placebo: A phase III, randomized, parallel-group study in patients with type 2 diabetes on stable insulin therapy
    • BALLET Trial Investigators
    • K. Henriksen, I. Byrjalsen, P. Qvist, H. Beck-Nielsen, G. Hansen, B.J. Riis, H. Perrild, O.L. Svendsen, J. Gram, M.A. Karsdal, C. Christiansen BALLET Trial Investigators Efficacy and safety of the PPARγ partial agonist balaglitazone compared with pioglitazone and placebo: a phase III, randomized, parallel-group study in patients with type 2 diabetes on stable insulin therapy Diabetes Metab. Res. Rev. 27 2011 392 401
    • (2011) Diabetes Metab. Res. Rev. , vol.27 , pp. 392-401
    • Henriksen, K.1    Byrjalsen, I.2    Qvist, P.3    Beck-Nielsen, H.4    Hansen, G.5    Riis, B.J.6    Perrild, H.7    Svendsen, O.L.8    Gram, J.9    Karsdal, M.A.10    Christiansen, C.11
  • 84
    • 80155171575 scopus 로고    scopus 로고
    • Pioglitazone and bladder cancer
    • author reply 1544-1545
    • D. Hillaire-Buys, J.-L. Faillie, and J.-L. Montastruc Pioglitazone and bladder cancer Lancet 378 2011 1543 1544 author reply 1544-1545
    • (2011) Lancet , vol.378 , pp. 1543-1544
    • Hillaire-Buys, D.1    Faillie, J.-L.2    Montastruc, J.-L.3
  • 86
    • 67149146438 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): A multicentre, randomised, open-label trial
    • RECORD Study Team
    • P.D. Home, S.J. Pocock, H. Beck-Nielsen, P.S. Curtis, R. Gomis, M. Hanefeld, N.P. Jones, M. Komajda, J.J.V. McMurray RECORD Study Team Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial Lancet 373 2009 2125 2135
    • (2009) Lancet , vol.373 , pp. 2125-2135
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3    Curtis, P.S.4    Gomis, R.5    Hanefeld, M.6    Jones, N.P.7    Komajda, M.8    McMurray, J.J.V.9
  • 88
    • 0038776380 scopus 로고    scopus 로고
    • Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
    • E. Hu, J.B. Kim, P. Sarraf, and B.M. Spiegelman Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma Science 274 1996 2100 2103
    • (1996) Science , vol.274 , pp. 2100-2103
    • Hu, E.1    Kim, J.B.2    Sarraf, P.3    Spiegelman, B.M.4
  • 91
    • 84863694353 scopus 로고    scopus 로고
    • Association between thiazolidinedione treatment and risk of macular edema among patients with type 2 diabetes
    • I. Idris, G. Warren, and R. Donnelly Association between thiazolidinedione treatment and risk of macular edema among patients with type 2 diabetes Arch. Intern. Med. 172 2012 1005 1011
    • (2012) Arch. Intern. Med. , vol.172 , pp. 1005-1011
    • Idris, I.1    Warren, G.2    Donnelly, R.3
  • 92
    • 84892637705 scopus 로고    scopus 로고
    • A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of Saroglitazar 2 and 4 mg compared with placebo in type 2 diabetes mellitus patients having hypertriglyceridemia not controlled with atorvastatin therapy (PRESS VI)
    • R.H. Jani, V. Pai, P. Jha, G. Jariwala, S. Mukhopadhyay, A. Bhansali, and S. Joshi A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of Saroglitazar 2 and 4 mg compared with placebo in type 2 diabetes mellitus patients having hypertriglyceridemia not controlled with atorvastatin therapy (PRESS VI) Diabetes Technol. Ther. 16 2014 63 71
    • (2014) Diabetes Technol. Ther. , vol.16 , pp. 63-71
    • Jani, R.H.1    Pai, V.2    Jha, P.3    Jariwala, G.4    Mukhopadhyay, S.5    Bhansali, A.6    Joshi, S.7
  • 93
  • 94
    • 84907976646 scopus 로고    scopus 로고
    • Inhibition of HDAC3 promotes ligand-independent PPARgamma activation by protein acetylation
    • X. Jiang, X. Ye, W. Guo, H. Lu, and Z. Gao Inhibition of HDAC3 promotes ligand-independent PPARgamma activation by protein acetylation J. Mol. Endocrinol. 2014 10.1530/JME-14-0066
    • (2014) J. Mol. Endocrinol.
    • Jiang, X.1    Ye, X.2    Guo, W.3    Lu, H.4    Gao, Z.5
  • 97
    • 78650885151 scopus 로고    scopus 로고
    • Rosiglitazone, PPARγ, and type 2 diabetes
    • B.B. Kahn, and T.E. McGraw Rosiglitazone, PPARγ, and type 2 diabetes N. Engl. J. Med. 363 2010 2667 2669
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2667-2669
    • Kahn, B.B.1    McGraw, T.E.2
  • 99
    • 48649095960 scopus 로고    scopus 로고
    • Rosiglitazone-associated fractures in type 2 diabetes: An Analysis from A Diabetes Outcome Progression Trial (ADOPT)
    • Diabetes Outcome Progression Trial (ADOPT) Study Group
    • S.E. Kahn, B. Zinman, J.M. Lachin, S.M. Haffner, W.H. Herman, R.R. Holman, B.G. Kravitz, D. Yu, M.A. Heise, R.P. Aftring, G. Viberti Diabetes Outcome Progression Trial (ADOPT) Study Group Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT) Diabetes Care 31 2008 845 851
    • (2008) Diabetes Care , vol.31 , pp. 845-851
    • Kahn, S.E.1    Zinman, B.2    Lachin, J.M.3    Haffner, S.M.4    Herman, W.H.5    Holman, R.R.6    Kravitz, B.G.7    Yu, D.8    Heise, M.A.9    Aftring, R.P.10    Viberti, G.11
  • 100
    • 63049133308 scopus 로고    scopus 로고
    • PPAR-gamma AF-2 domain functions as a component of a ubiquitin-dependent degradation signal
    • G.E. Kilroy, X. Zhang, and Z.E. Floyd PPAR-gamma AF-2 domain functions as a component of a ubiquitin-dependent degradation signal Obesity (Silver Spring) 17 2009 665 673
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 665-673
    • Kilroy, G.E.1    Zhang, X.2    Floyd, Z.E.3
  • 101
    • 84857393204 scopus 로고    scopus 로고
    • The ubiquitin ligase Siah2 regulates PPARγ activity in adipocytes
    • G. Kilroy, H. Kirk-Ballard, L.E. Carter, and Z.E. Floyd The ubiquitin ligase Siah2 regulates PPARγ activity in adipocytes Endocrinology 153 2012 1206 1218
    • (2012) Endocrinology , vol.153 , pp. 1206-1218
    • Kilroy, G.1    Kirk-Ballard, H.2    Carter, L.E.3    Floyd, Z.E.4
  • 104
    • 0033988825 scopus 로고    scopus 로고
    • Hepatotoxicity due to troglitazone: Report of two cases and review of adverse events reported to the United States Food and Drug Administration
    • J. Kohlroser, J. Mathai, J. Reichheld, B.F. Banner, and H.L. Bonkovsky Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration Am. J. Gastroenterol. 95 2000 272 276
    • (2000) Am. J. Gastroenterol. , vol.95 , pp. 272-276
    • Kohlroser, J.1    Mathai, J.2    Reichheld, J.3    Banner, B.F.4    Bonkovsky, H.L.5
  • 105
    • 34249747832 scopus 로고    scopus 로고
    • Cancer risks in thiazolidinedione users compared to other anti-diabetic agents
    • C. Koro, S. Barrett, and N. Qizilbash Cancer risks in thiazolidinedione users compared to other anti-diabetic agents Pharmacoepidemiol. Drug Saf. 16 2007 485 492
    • (2007) Pharmacoepidemiol. Drug Saf. , vol.16 , pp. 485-492
    • Koro, C.1    Barrett, S.2    Qizilbash, N.3
  • 107
    • 34648832073 scopus 로고    scopus 로고
    • Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: A meta-analysis of randomised clinical trials
    • R.M. Lago, P.P. Singh, and R.W. Nesto Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials Lancet 370 2007 1129 1136
    • (2007) Lancet , vol.370 , pp. 1129-1136
    • Lago, R.M.1    Singh, P.P.2    Nesto, R.W.3
  • 108
    • 84873419516 scopus 로고    scopus 로고
    • Prescribing pattern of glucose lowering drugs in the United Kingdom in the last decade: A focus on the effects of safety warnings about rosiglitazone
    • I. Leal, S.A. Romio, M. Schuemie, A. Oteri, M. Sturkenboom, and G. Trifirò Prescribing pattern of glucose lowering drugs in the United Kingdom in the last decade: a focus on the effects of safety warnings about rosiglitazone Br. J. Clin. Pharmacol. 75 2013 861 868
    • (2013) Br. J. Clin. Pharmacol. , vol.75 , pp. 861-868
    • Leal, I.1    Romio, S.A.2    Schuemie, M.3    Oteri, A.4    Sturkenboom, M.5    Trifirò, G.6
  • 111
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • J.M. Lehmann, L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma) J. Biol. Chem. 270 1995 12953 12956
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 112
    • 28944446431 scopus 로고    scopus 로고
    • The many faces of PPARgamma
    • M. Lehrke, and M.A. Lazar The many faces of PPARgamma Cell 123 2005 993 999
    • (2005) Cell , vol.123 , pp. 993-999
    • Lehrke, M.1    Lazar, M.A.2
  • 113
    • 84914144408 scopus 로고    scopus 로고
    • Hepatic molecular effects of rosiglitazone in human non-alcoholic steatohepatitis suggest long-term pro-inflammatory damage
    • M. Lemoine, L. Serfaty, P. Cervera, J. Capeau, and V. Ratziu Hepatic molecular effects of rosiglitazone in human non-alcoholic steatohepatitis suggest long-term pro-inflammatory damage Hepatol. Res. 2013 10.1111/hepr.12244
    • (2013) Hepatol. Res.
    • Lemoine, M.1    Serfaty, L.2    Cervera, P.3    Capeau, J.4    Ratziu, V.5
  • 115
  • 116
    • 0033864582 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
    • A.C. Li, K.K. Brown, M.J. Silvestre, T.M. Willson, W. Palinski, and C.K. Glass Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice J. Clin. Invest. 106 2000 523 531
    • (2000) J. Clin. Invest. , vol.106 , pp. 523-531
    • Li, A.C.1    Brown, K.K.2    Silvestre, M.J.3    Willson, T.M.4    Palinski, W.5    Glass, C.K.6
  • 117
    • 81055144760 scopus 로고    scopus 로고
    • Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity
    • P. Li, W. Fan, J. Xu, M. Lu, H. Yamamoto, J. Auwerx, D.D. Sears, S. Talukdar, D. Oh, and A. Chen Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity Cell 147 2011 815 826
    • (2011) Cell , vol.147 , pp. 815-826
    • Li, P.1    Fan, W.2    Xu, J.3    Lu, M.4    Yamamoto, H.5    Auwerx, J.6    Sears, D.D.7    Talukdar, S.8    Oh, D.9    Chen, A.10
  • 119
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials
    • A.M. Lincoff, K. Wolski, S.J. Nicholls, and S.E. Nissen Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials JAMA 298 2007 1180 1188
    • (2007) JAMA , vol.298 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 120
    • 84898614282 scopus 로고    scopus 로고
    • Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: The AleCardio randomized clinical trial
    • AleCardio Investigators
    • A.M. Lincoff, J.-C. Tardif, G.G. Schwartz, S.J. Nicholls, L. Rydén, B. Neal, K. Malmberg, H. Wedel, J.B. Buse, R.R. Henry AleCardio Investigators Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial JAMA 311 2014 1515 1525
    • (2014) JAMA , vol.311 , pp. 1515-1525
    • Lincoff, A.M.1    Tardif, J.-C.2    Schwartz, G.G.3    Nicholls, S.J.4    Rydén, L.5    Neal, B.6    Malmberg, K.7    Wedel, H.8    Buse, J.B.9    Henry, R.R.10
  • 122
    • 84877039529 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Current issues and novel treatment approaches
    • R. Lomonaco, N.E. Sunny, F. Bril, and K. Cusi Nonalcoholic fatty liver disease: current issues and novel treatment approaches Drugs 73 2013 1 14
    • (2013) Drugs , vol.73 , pp. 1-14
    • Lomonaco, R.1    Sunny, N.E.2    Bril, F.3    Cusi, K.4
  • 124
    • 84901805653 scopus 로고    scopus 로고
    • Increasing adiposity: Consequence or cause of overeating?
    • D.S. Ludwig, and M.I. Friedman Increasing adiposity: consequence or cause of overeating? JAMA 311 2014 2167 2168
    • (2014) JAMA , vol.311 , pp. 2167-2168
    • Ludwig, D.S.1    Friedman, M.I.2
  • 130
    • 13844264424 scopus 로고    scopus 로고
    • No, really, how do they work?
    • D.D. Moore "No, really, how do they work?" Genes Dev. 19 2005 413 414
    • (2005) Genes Dev. , vol.19 , pp. 413-414
    • Moore, D.D.1
  • 131
    • 33244464265 scopus 로고    scopus 로고
    • Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: A systematic review
    • A. Natali, and E. Ferrannini Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review Diabetologia 49 2006 434 441
    • (2006) Diabetologia , vol.49 , pp. 434-441
    • Natali, A.1    Ferrannini, E.2
  • 132
    • 84907967841 scopus 로고    scopus 로고
    • National Program of Cancer Registries United States Cancer Statistics (USCS) (2006-2010).
    • National Program of Cancer Registries United States Cancer Statistics (USCS) (2006-2010).
  • 133
    • 33646346627 scopus 로고    scopus 로고
    • Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists
    • A.R. Nawrocki, M.W. Rajala, E. Tomas, U.B. Pajvani, A.K. Saha, M.E. Trumbauer, Z. Pang, A.S. Chen, N.B. Ruderman, and H. Chen Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists J. Biol. Chem. 281 2006 2654 2660
    • (2006) J. Biol. Chem. , vol.281 , pp. 2654-2660
    • Nawrocki, A.R.1    Rajala, M.W.2    Tomas, E.3    Pajvani, U.B.4    Saha, A.K.5    Trumbauer, M.E.6    Pang, Z.7    Chen, A.S.8    Ruderman, N.B.9    Chen, H.10
  • 134
    • 10744221639 scopus 로고    scopus 로고
    • Thiazolidinedione use, fluid retention, and congestive heart failure: A consensus statement from the American Heart Association and American Diabetes Association
    • R.W. Nesto, D. Bell, R.O. Bonow, V. Fonseca, S.M. Grundy, E.S. Horton, M. Le Winter, D. Porte, C.F. Semenkovich, and S. Smith Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association Diabetes Care 27 2004 256 263
    • (2004) Diabetes Care , vol.27 , pp. 256-263
    • Nesto, R.W.1    Bell, D.2    Bonow, R.O.3    Fonseca, V.4    Grundy, S.M.5    Horton, E.S.6    Le Winter, M.7    Porte, D.8    Semenkovich, C.F.9    Smith, S.10
  • 135
    • 84866358522 scopus 로고    scopus 로고
    • Pioglitazone and risk of bladder cancer among diabetic patients in France: A population-based cohort study
    • A. Neumann, A. Weill, P. Ricordeau, J.P. Fagot, F. Alla, and H. Allemand Pioglitazone and risk of bladder cancer among diabetic patients in France: a population-based cohort study Diabetologia 55 2012 1953 1962
    • (2012) Diabetologia , vol.55 , pp. 1953-1962
    • Neumann, A.1    Weill, A.2    Ricordeau, P.3    Fagot, J.P.4    Alla, F.5    Allemand, H.6
  • 136
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • S.E. Nissen, and K. Wolski Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes N. Engl. J. Med. 356 2007 2457 2471
    • (2007) N. Engl. J. Med. , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 137
    • 77955285732 scopus 로고    scopus 로고
    • Rosiglitazone revisited: An updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
    • S.E. Nissen, and K. Wolski Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality Arch. Intern. Med. 170 2010 1191 1201
    • (2010) Arch. Intern. Med. , vol.170 , pp. 1191-1201
    • Nissen, S.E.1    Wolski, K.2
  • 138
    • 41649084422 scopus 로고    scopus 로고
    • Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: The PERISCOPE randomized controlled trial
    • PERISCOPE Investigators
    • S.E. Nissen, S.J. Nicholls, K. Wolski, R. Nesto, S. Kupfer, A. Perez, H. Jure, R. De Larochellière, C.S. Staniloae, K. Mavromatis PERISCOPE Investigators Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial JAMA 299 2008 1561 1573
    • (2008) JAMA , vol.299 , pp. 1561-1573
    • Nissen, S.E.1    Nicholls, S.J.2    Wolski, K.3    Nesto, R.4    Kupfer, S.5    Perez, A.6    Jure, H.7    De Larochellière, R.8    Staniloae, C.S.9    Mavromatis, K.10
  • 142
    • 84858039282 scopus 로고    scopus 로고
    • PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
    • H. Ohno, K. Shinoda, B.M. Spiegelman, and S. Kajimura PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein Cell Metab. 15 2012 395 404
    • (2012) Cell Metab. , vol.15 , pp. 395-404
    • Ohno, H.1    Shinoda, K.2    Spiegelman, B.M.3    Kajimura, S.4
  • 143
    • 3142716146 scopus 로고    scopus 로고
    • Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification
    • T. Ohshima, H. Koga, and K. Shimotohno Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification J. Biol. Chem. 279 2004 29551 29557
    • (2004) J. Biol. Chem. , vol.279 , pp. 29551-29557
    • Ohshima, T.1    Koga, H.2    Shimotohno, K.3
  • 145
    • 80051975559 scopus 로고    scopus 로고
    • Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting
    • C. Piccinni, D. Motola, G. Marchesini, and E. Poluzzi Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting Diabetes Care 34 2011 1369 1371
    • (2011) Diabetes Care , vol.34 , pp. 1369-1371
    • Piccinni, C.1    Motola, D.2    Marchesini, G.3    Poluzzi, E.4
  • 148
    • 84906263508 scopus 로고    scopus 로고
    • Impact of rosiglitazone on body composition, hepatic fat, fatty acids, adipokines and glucose in persons with impaired fasting glucose or impaired glucose tolerance: A sub-study of the DREAM trial
    • Z. Punthakee, N. Alméras, J.-P. Després, G.R. Dagenais, S.S. Anand, D.L. Hunt, A.M. Sharma, H. Jung, S. Yusuf, and H.C. Gerstein Impact of rosiglitazone on body composition, hepatic fat, fatty acids, adipokines and glucose in persons with impaired fasting glucose or impaired glucose tolerance: a sub-study of the DREAM trial Diabet. Med. 31 2014 1086 1092
    • (2014) Diabet. Med. , vol.31 , pp. 1086-1092
    • Punthakee, Z.1    Alméras, N.2    Després, J.-P.3    Dagenais, G.R.4    Anand, S.S.5    Hunt, D.L.6    Sharma, A.M.7    Jung, H.8    Yusuf, S.9    Gerstein, H.C.10
  • 150
    • 0037177058 scopus 로고    scopus 로고
    • The dawn of the SPPARMs?
    • S.M. Rangwala, and M.A. Lazar The dawn of the SPPARMs? Sci. STKE 2002 2002 pe9
    • (2002) Sci. STKE , vol.2002 , pp. 9
    • Rangwala, S.M.1    Lazar, M.A.2
  • 152
    • 75449116707 scopus 로고    scopus 로고
    • Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial
    • LIDO Study Group
    • V. Ratziu, F. Charlotte, C. Bernhardt, P. Giral, M. Halbron, G. Lenaour, A. Hartmann-Heurtier, E. Bruckert, T. Poynard LIDO Study Group Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial Hepatology 51 2010 445 453
    • (2010) Hepatology , vol.51 , pp. 445-453
    • Ratziu, V.1    Charlotte, F.2    Bernhardt, C.3    Giral, P.4    Halbron, M.5    Lenaour, G.6    Hartmann-Heurtier, A.7    Bruckert, E.8    Poynard, T.9
  • 153
    • 84901939004 scopus 로고    scopus 로고
    • Review of the quality of observational studies of the association between rosiglitazone and acute myocardial infarction
    • N.S.B. Rawson Review of the quality of observational studies of the association between rosiglitazone and acute myocardial infarction J. Popul. Ther. Clin. Pharmacol. 21 2014 e214 e232
    • (2014) J. Popul. Ther. Clin. Pharmacol. , vol.21 , pp. 214-e232
    • Rawson, N.S.B.1
  • 154
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • G.M. Reaven Banting lecture 1988. Role of insulin resistance in human disease Diabetes 37 1988 1595 1607
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 155
    • 42149134825 scopus 로고    scopus 로고
    • The effect of thiazolidinediones on adiponectin serum level: A meta-analysis
    • N. Riera-Guardia, and D. Rothenbacher The effect of thiazolidinediones on adiponectin serum level: a meta-analysis Diabetes Obes. Metab. 10 2008 367 375
    • (2008) Diabetes Obes. Metab. , vol.10 , pp. 367-375
    • Riera-Guardia, N.1    Rothenbacher, D.2
  • 156
    • 84859254879 scopus 로고    scopus 로고
    • PPAR gamma, bioactive lipids, and cancer progression
    • G.T. Robbins, and D. Nie PPAR gamma, bioactive lipids, and cancer progression Front. Biosci. (Landmark Ed.) 17 2012 1816 1834
    • (2012) Front. Biosci. (Landmark Ed.) , vol.17 , pp. 1816-1834
    • Robbins, G.T.1    Nie, D.2
  • 158
    • 84902216056 scopus 로고    scopus 로고
    • Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes
    • C.L. Roumie, R.A. Greevy, C.G. Grijalva, A.M. Hung, X. Liu, H.J. Murff, T.A. Elasy, and M.R. Griffin Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes JAMA 311 2014 2288 2296
    • (2014) JAMA , vol.311 , pp. 2288-2296
    • Roumie, C.L.1    Greevy, R.A.2    Grijalva, C.G.3    Hung, A.M.4    Liu, X.5    Murff, H.J.6    Elasy, T.A.7    Griffin, M.R.8
  • 159
    • 84907603924 scopus 로고    scopus 로고
    • Effects of Rosiglitazone vs Metformin on Circulating Osteoclast and Osteogenic Precursor Cells in Postmenopausal Women with Type 2 Diabetes Mellitus
    • Published online June 6, 2014
    • M. Rubin, J. Manavalan, S. Agarwal, D. McMahon, A. Nino, L.A. Fitzpatrick, and J. Bilezikian Effects of Rosiglitazone vs Metformin on Circulating Osteoclast and Osteogenic Precursor Cells in Postmenopausal Women with Type 2 Diabetes Mellitus J. Clin. Endocrinol. Metab. 2014 10.1210/jc.2013-3666 Published online June 6, 2014
    • (2014) J. Clin. Endocrinol. Metab.
    • Rubin, M.1    Manavalan, J.2    Agarwal, S.3    McMahon, D.4    Nino, A.5    Fitzpatrick, L.A.6    Bilezikian, J.7
  • 160
    • 79955692835 scopus 로고    scopus 로고
    • A role for central nervous system PPAR-γ in the regulation of energy balance
    • K.K. Ryan, B. Li, B.E. Grayson, E.K. Matter, S.C. Woods, and R.J. Seeley A role for central nervous system PPAR-γ in the regulation of energy balance Nat. Med. 17 2011 623 626
    • (2011) Nat. Med. , vol.17 , pp. 623-626
    • Ryan, K.K.1    Li, B.2    Grayson, B.E.3    Matter, E.K.4    Woods, S.C.5    Seeley, R.J.6
  • 163
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: Unravelling the mechanism
    • V.T. Samuel, K.F. Petersen, and G.I. Shulman Lipid-induced insulin resistance: unravelling the mechanism Lancet 375 2010 2267 2277
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 166
    • 59649109871 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis
    • D.A. Sarruf, F. Yu, H.T. Nguyen, D.L. Williams, R.L. Printz, K.D. Niswender, and M.W. Schwartz Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis Endocrinology 150 2009 707 712
    • (2009) Endocrinology , vol.150 , pp. 707-712
    • Sarruf, D.A.1    Yu, F.2    Nguyen, H.T.3    Williams, D.L.4    Printz, R.L.5    Niswender, K.D.6    Schwartz, M.W.7
  • 167
    • 79952007219 scopus 로고    scopus 로고
    • Suppressive effects of acid-forming diet against the tumorigenic potential of pioglitazone hydrochloride in the urinary bladder of male rats
    • K. Sato, Y. Awasaki, H. Kandori, Z.-Y. Tanakamaru, H. Nagai, D. Baron, and M. Yamamoto Suppressive effects of acid-forming diet against the tumorigenic potential of pioglitazone hydrochloride in the urinary bladder of male rats Toxicol. Appl. Pharmacol. 251 2011 234 244
    • (2011) Toxicol. Appl. Pharmacol. , vol.251 , pp. 234-244
    • Sato, K.1    Awasaki, Y.2    Kandori, H.3    Tanakamaru, Z.-Y.4    Nagai, H.5    Baron, D.6    Yamamoto, M.7
  • 168
    • 78650317248 scopus 로고    scopus 로고
    • Endogenous ligands for nuclear receptors: Digging deeper
    • M. Schupp, and M.A. Lazar Endogenous ligands for nuclear receptors: digging deeper J. Biol. Chem. 285 2010 40409 40415
    • (2010) J. Biol. Chem. , vol.285 , pp. 40409-40415
    • Schupp, M.1    Lazar, M.A.2
  • 171
    • 34548580881 scopus 로고    scopus 로고
    • Long-term risk of cardiovascular events with rosiglitazone: A meta-analysis
    • S. Singh, Y.K. Loke, and C.D. Furberg Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis JAMA 298 2007 1189 1195
    • (2007) JAMA , vol.298 , pp. 1189-1195
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 173
    • 84899710827 scopus 로고    scopus 로고
    • Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers
    • S.E. Step, H.-W. Lim, J.M. Marinis, A. Prokesch, D.J. Steger, S.-H. You, K.-J. Won, and M.A. Lazar Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers Genes Dev. 28 2014 1018 1028
    • (2014) Genes Dev. , vol.28 , pp. 1018-1028
    • Step, S.E.1    Lim, H.-W.2    Marinis, J.M.3    Prokesch, A.4    Steger, D.J.5    You, S.-H.6    Won, K.-J.7    Lazar, M.A.8
  • 176
    • 75249084816 scopus 로고    scopus 로고
    • Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat
    • S. Suzuki, L.L. Arnold, K.L. Pennington, S. Kakiuchi-Kiyota, M. Wei, H. Wanibuchi, and S.M. Cohen Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat Toxicol. Sci. 113 2010 349 357
    • (2010) Toxicol. Sci. , vol.113 , pp. 349-357
    • Suzuki, S.1    Arnold, L.L.2    Pennington, K.L.3    Kakiuchi-Kiyota, S.4    Wei, M.5    Wanibuchi, H.6    Cohen, S.M.7
  • 177
    • 34447627877 scopus 로고    scopus 로고
    • PPARgamma, a lipid-activated transcription factor as a regulator of dendritic cell function
    • I. Szatmari, E. Rajnavolgyi, and L. Nagy PPARgamma, a lipid-activated transcription factor as a regulator of dendritic cell function Ann. N Y Acad. Sci. 1088 2006 207 218
    • (2006) Ann. N y Acad. Sci. , vol.1088 , pp. 207-218
    • Szatmari, I.1    Rajnavolgyi, E.2    Nagy, L.3
  • 178
    • 79960003581 scopus 로고    scopus 로고
    • Thiazolidinediones regulate adipose lineage dynamics
    • W. Tang, D. Zeve, J. Seo, A.-Y. Jo, and J.M. Graff Thiazolidinediones regulate adipose lineage dynamics Cell Metab. 14 2011 116 122
    • (2011) Cell Metab. , vol.14 , pp. 116-122
    • Tang, W.1    Zeve, D.2    Seo, J.3    Jo, A.-Y.4    Graff, J.M.5
  • 180
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: The diverse biology of PPARgamma
    • P. Tontonoz, and B.M. Spiegelman Fat and beyond: the diverse biology of PPARgamma Annu. Rev. Biochem. 77 2008 289 312
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 183
    • 84870549306 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor agonists and bladder cancer: Lessons from animal studies
    • C.-H. Tseng, and F.-H. Tseng Peroxisome proliferator-activated receptor agonists and bladder cancer: lessons from animal studies J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 30 2012 368 402
    • (2012) J Environ Sci Health C Environ Carcinog Ecotoxicol Rev , vol.30 , pp. 368-402
    • Tseng, C.-H.1    Tseng, F.-H.2
  • 185
    • 84860117993 scopus 로고    scopus 로고
    • Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: Retrospective cohort study using UK general practice research database
    • I. Tzoulaki, M. Molokhia, V. Curcin, M.P. Little, C.J. Millett, A. Ng, R.I. Hughes, K. Khunti, M.R. Wilkins, A. Majeed, and P. Elliott Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database BMJ 339 2009 b4731
    • (2009) BMJ , vol.339 , pp. 4731
    • Tzoulaki, I.1    Molokhia, M.2    Curcin, V.3    Little, M.P.4    Millett, C.J.5    Ng, A.6    Hughes, R.I.7    Khunti, K.8    Wilkins, M.R.9    Majeed, A.10    Elliott, P.11
  • 186
    • 68849107400 scopus 로고    scopus 로고
    • C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists
    • C. Vernochet, S.B. Peres, K.E. Davis, M.E. McDonald, L. Qiang, H. Wang, P.E. Scherer, and S.R. Farmer C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists Mol. Cell. Biol. 29 2009 4714 4728
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 4714-4728
    • Vernochet, C.1    Peres, S.B.2    Davis, K.E.3    McDonald, M.E.4    Qiang, L.5    Wang, H.6    Scherer, P.E.7    Farmer, S.R.8
  • 187
    • 73849127495 scopus 로고    scopus 로고
    • Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol
    • A. von Knethen, N. Tzieply, C. Jennewein, and B. Brüne Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol J. Cell Sci. 123 2010 192 201
    • (2010) J. Cell Sci. , vol.123 , pp. 192-201
    • Von Knethen, A.1    Tzieply, N.2    Jennewein, C.3    Brüne, B.4
  • 188
    • 84887474124 scopus 로고    scopus 로고
    • Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ
    • F. Wang, S.E. Mullican, J.R. DiSpirito, L.C. Peed, and M.A. Lazar Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ Proc. Natl. Acad. Sci. USA 110 2013 18656 18661
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 18656-18661
    • Wang, F.1    Mullican, S.E.2    Dispirito, J.R.3    Peed, L.C.4    Lazar, M.A.5
  • 191
    • 33947539408 scopus 로고    scopus 로고
    • Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: Results from PROactive (PROspective pioglitAzone Clinical Trial in macroVascular Events 04)
    • PROactive Investigators
    • R. Wilcox, M.-G. Bousser, D.J. Betteridge, G. Schernthaner, V. Pirags, S. Kupfer, J. Dormandy PROactive Investigators Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: results from PROactive (PROspective pioglitAzone Clinical Trial In macroVascular Events 04) Stroke 38 2007 865 873
    • (2007) Stroke , vol.38 , pp. 865-873
    • Wilcox, R.1    Bousser, M.-G.2    Betteridge, D.J.3    Schernthaner, G.4    Pirags, V.5    Kupfer, S.6    Dormandy, J.7
  • 192
    • 7944236265 scopus 로고    scopus 로고
    • The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain
    • D. Yamashita, T. Yamaguchi, M. Shimizu, N. Nakata, F. Hirose, and T. Osumi The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain Genes Cells 9 2004 1017 1029
    • (2004) Genes Cells , vol.9 , pp. 1017-1029
    • Yamashita, D.1    Yamaguchi, T.2    Shimizu, M.3    Nakata, N.4    Hirose, F.5    Osumi, T.6
  • 193
    • 84907994948 scopus 로고    scopus 로고
    • A comparison of all-cause mortality with pioglitazone and insulin in type 2 diabetes: An expanded analysis from a retrospective cohort study
    • Published online July 16, 2014
    • J. Yang, C. Vallarino, M. Bron, A. Perez, H. Liang, G. Joseph, and S. Yu A comparison of all-cause mortality with pioglitazone and insulin in type 2 diabetes: an expanded analysis from a retrospective cohort study Curr. Med. Res. Opin. 2014 10.1185/03007995.2014.941054 Published online July 16, 2014
    • (2014) Curr. Med. Res. Opin.
    • Yang, J.1    Vallarino, C.2    Bron, M.3    Perez, A.4    Liang, H.5    Joseph, G.6    Yu, S.7
  • 194
    • 84877764669 scopus 로고    scopus 로고
    • The future of thiazolidinedione therapy in the management of type 2 diabetes mellitus
    • H. Yau, K. Rivera, R. Lomonaco, and K. Cusi The future of thiazolidinedione therapy in the management of type 2 diabetes mellitus Curr. Diab. Rep. 13 2013 329 341
    • (2013) Curr. Diab. Rep. , vol.13 , pp. 329-341
    • Yau, H.1    Rivera, K.2    Lomonaco, R.3    Cusi, K.4
  • 195
    • 4143075930 scopus 로고    scopus 로고
    • Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: Comparison with metformin
    • J.-M. Ye, N. Dzamko, M.E. Cleasby, B.D. Hegarty, S.M. Furler, G.J. Cooney, and E.W. Kraegen Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin Diabetologia 47 2004 1306 1313
    • (2004) Diabetologia , vol.47 , pp. 1306-1313
    • Ye, J.-M.1    Dzamko, N.2    Cleasby, M.E.3    Hegarty, B.D.4    Furler, S.M.5    Cooney, G.J.6    Kraegen, E.W.7
  • 198
    • 21544479710 scopus 로고    scopus 로고
    • Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention
    • H. Zhang, A. Zhang, D.E. Kohan, R.D. Nelson, F.J. Gonzalez, and T. Yang Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention Proc. Natl. Acad. Sci. USA 102 2005 9406 9411
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 9406-9411
    • Zhang, H.1    Zhang, A.2    Kohan, D.E.3    Nelson, R.D.4    Gonzalez, F.J.5    Yang, T.6


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