Toward the structure of presenilin/γ-secretase and presenilin homologs

Biochimica et Biophysica Acta - Biomembranes

Volumn 1828, Issue 12, 2013, Pages 2886-2897

  Wolfe, Michael S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Alzheimer's disease; Membrane; Protease; Signal peptide peptidase

Indexed keywords

ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; ASPARTIC ACID; CYSTEINE; GAMMA SECRETASE; NICASTRIN; PEN 2 PROTEIN; PEPTIDASE; PRESENILIN; SIGNAL PEPTIDE; SIGNAL PEPTIDE PEPTIDASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; CATALYSIS; CROSS LINKING; CRYSTAL STRUCTURE; CYTOSOL; ELECTRON MICROSCOPY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBUNIT; GENE MUTATION; HUMAN; MICROORGANISM; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; REVIEW;

AΒ; AICD; ALZHEIMER'S DISEASE; AMYLOID Β-PROTEIN; AMYLOID Β-PROTEIN PRECURSOR; APP; APP INTRACELLULAR DOMAIN; C-TERMINAL FRAGMENT; CTF; I-CLIP; INTRAMEMBRANE-CLEAVING PROTEASE; MEMBRANE; METHANOCULLEUS MARISNIGRI JR1 PRESENILIN HOMOLOG; MMPSH; N-TERMINAL FRAGMENT; NTF; PRESENILIN HOMOLOG; PRESENILIN-1; PROTEASE; PS1; PSH; S2P; SIGNAL PEPTIDE PEPTIDASE; SITE 2 PROTEASE; SPP; TMD; TRANSMEMBRANE DOMAIN;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; COENZYMES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MODELS, MOLECULAR; PEPTIDE HYDROLASES; PRESENILIN-1; PRESENILIN-2; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 84885097856     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.04.015     Document Type: Review

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