The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

EMBO Journal

Volumn 31, Issue 10, 2012, Pages 2261-2274

  Chévez Gutiérrez, Lucía ^a   Bammens, Leen ^a   Benilova, Iryna ^a   Vandersteen, Annelies ^a,b   Benurwar, Manasi ^a   Borgers, Marianne ^a   Lismont, Sam ^a   Zhou, Lujia ^a   Van Cleynenbreugel, Simon ^a   Esselmann, Hermann ^c   Wiltfang, Jens ^c   Serneels, Lutgarde ^a   Karran, Eric ^a   Gijsen, Harrie ^d   Schymkowitz, Joost ^a,e   Rousseau, Frederic ^a,e   Broersen, Kerensa ^b,f   De Strooper, Bart ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF TWENTE   (Netherlands)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^e DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^f VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Alzheimer; amyloid; FAD mutations; g secretase; presenilin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CARBOXYPEPTIDASE; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME KINETICS; FAMILIAL DISEASE; GENE MUTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; QUALITATIVE ANALYSIS;

ALZHEIMER DISEASE; AMYLOID; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTIGENS, CD; CADHERINS; KINETICS; PRESENILIN-1; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, NOTCH1;

EID: 84861194622     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.79     Document Type: Article

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