BMS-708,163 targets presenilin and lacks notch-sparing activity

Biochemistry

Volumn 51, Issue 37, 2012, Pages 7209-7211

  Crump, Christina J ^a,b   Castro, Suita V ^b   Wang, Feng ^b   Pozdnyakov, Nikolay ^c   Ballard, T Eric ^c   Sisodia, Sangram S ^d   Bales, Kelly R ^c   Johnson, Douglas S ^c   Li, Yue Ming ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c PFIZER INC   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; CLINICAL TRIAL; DRUG CANDIDATES; IN-PHASE; N-TERMINALS; PHOTOAFFINITY; PRESENILINS; SECRETASES;

BIOCHEMISTRY;

CHEMISTRY;

ALKYNE; AVAGACESTAT; PRESENILIN 1;

AMINO TERMINAL SEQUENCE; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN CROSS LINKING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; CATALYTIC DOMAIN; CLINICAL TRIALS, PHASE II AS TOPIC; HELA CELLS; HUMANS; OXADIAZOLES; PRESENILINS; PROTEIN BINDING; RECEPTORS, NOTCH; SULFONAMIDES;

EID: 84866411763     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301137h     Document Type: Article

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