Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

Journal of Biological Chemistry

Volumn 279, Issue 5, 2004, Pages 3685-3693

  Fortna, Ryan R ^a   Crystal, Adam S ^a   Morais, Vanessa A ^b,c   Pijak, Donald S ^a   Lee, Virginia M Y ^a   Doms, Robert W ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c Inst de Biol Exp e Tecologica   (Portugal)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; FLUORESCENCE; HYDROPHILICITY; PROTEINS; SUBSTRATES;

PLASMA MEMBRANES;

BIOCHEMISTRY;

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; APH 1 PROTEIN, HUMAN; APH-1 PROTEIN, HUMAN; CYCLOHEXIMIDE; GAMMA SECRETASE; MEMBRANE PROTEIN; NICASTRIN; NICASTRIN PROTEIN; PRESENILIN 1; PROTEIN; PROTEIN SYNTHESIS INHIBITOR; PROTEINASE; SECRETASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME STRUCTURE; FLUORESCENCE MICROSCOPY; GENE VECTOR; GENETIC TRANSFECTION; GLYCOSYLATION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MEMBRANE STRUCTURE; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; UPREGULATION;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELL MEMBRANE; CYCLOHEXIMIDE; CYTOSOL; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; GENETIC VECTORS; GLYCOSYLATION; HELA CELLS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTATION; POINT MUTATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SYNTHESIS INHIBITORS; TRANSFECTION; UP-REGULATION;

EID: 0942298101     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310505200     Document Type: Article

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