Detergent-Dependent Dissociation of Active γ-Secretase Reveals an Interaction between Pen-2 and PS1-NTF and Offers a Model for Subunit Organization within the Complex

Biochemistry

Volumn 43, Issue 2, 2004, Pages 323-333

  Fraering, Patrick C ^a   LaVoie, Matthew J ^a   Ye, Wenjuan ^a   Ostaszewski, Beth L ^a   Kimberly, W Taylor ^a   Selkoe, Dennis J ^a,b   Wolfe, Michael S ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DETERGENTS; DISSOCIATION; ENZYME KINETICS; PROTEINS;

CATALYTIC SITES;

BIOCHEMISTRY;

ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; DETERGENT; DODECYL BETA DEXTRO MALTOSIDE; GAMMA SECRETASE; MALTOSE; MEMBRANE PROTEIN; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1; PROTEIN; PROTEIN PEN 2; PROTEIN PS1 NTF; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL ANALYSIS; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVE SITE; FEMALE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CHO CELLS; CHROMOSOMAL PROTEINS, NON-HISTONE; CRICETINAE; DETERGENTS; DIMERIZATION; ENDOPEPTIDASES; ENZYME ACTIVATION; GLUCOSIDES; HELA CELLS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; PEPTIDE HYDROLASES; PROTEIN SUBUNITS; TRANSFECTION;

ANIMALIA;

EID: 0347093518     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035748j     Document Type: Article

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