-
1
-
-
0035687018
-
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
-
R. Abraham, A. Myers, F. Wavrant-DeVrieze, M.L. Hamshere, H.V. Thomas, H. Marshall, D. Compton, G. Spurlock, D. Turic, and B. Hoogendoorn Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease Hum. Genet. 109 2001 646 652
-
(2001)
Hum. Genet.
, vol.109
, pp. 646-652
-
-
Abraham, R.1
Myers, A.2
Wavrant-Devrieze, F.3
Hamshere, M.L.4
Thomas, H.V.5
Marshall, H.6
Compton, D.7
Spurlock, G.8
Turic, D.9
Hoogendoorn, B.10
-
3
-
-
0036845563
-
Polymorphisms in the promoter of the human APP gene: Functional evaluation and allele frequencies in Alzheimer disease
-
E.S. Athan, J.H. Lee, A. Arriaga, R.P. Mayeux, and B. Tycko Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease Arch. Neurol. 59 2002 1793 1799
-
(2002)
Arch. Neurol.
, vol.59
, pp. 1793-1799
-
-
Athan, E.S.1
Lee, J.H.2
Arriaga, A.3
Mayeux, R.P.4
Tycko, B.5
-
4
-
-
0035879373
-
Microglial interaction with beta-amyloid: Implications for the pathogenesis of Alzheimer's disease
-
M.E. Bamberger, and G.E. Landreth Microglial interaction with beta-amyloid: implications for the pathogenesis of Alzheimer's disease Microsc. Res. Tech. 54 2001 59 70
-
(2001)
Microsc. Res. Tech.
, vol.54
, pp. 59-70
-
-
Bamberger, M.E.1
Landreth, G.E.2
-
5
-
-
1842507631
-
Alzheimer's disease: One disorder, too many genes?
-
L. Bertram, and R.E. Tanzi Alzheimer's disease: one disorder, too many genes? Hum. Mol. Genet. 13 2004 R135 R141
-
(2004)
Hum. Mol. Genet.
, vol.13
-
-
Bertram, L.1
Tanzi, R.E.2
-
6
-
-
0033654196
-
Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies
-
L. Bertram, D. Blacker, A. Crystal, K. Mullin, D. Keeney, J. Jones, S. Basu, S. Yhu, S. Guenette, and M. McInnis Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies Exp. Gerontol. 35 2000 1353 1361
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 1353-1361
-
-
Bertram, L.1
Blacker, D.2
Crystal, A.3
Mullin, K.4
Keeney, D.5
Jones, J.6
Basu, S.7
Yhu, S.8
Guenette, S.9
McInnis, M.10
-
7
-
-
0034704198
-
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
-
L. Bertram, D. Blacker, K. Mullin, D. Keeney, J. Jones, S. Basu, S. Yhu, M.G. McInnis, R.C. Go, and K. Vekrellis Evidence for genetic linkage of Alzheimer's disease to chromosome 10q Science 290 2000 2302 2303
-
(2000)
Science
, vol.290
, pp. 2302-2303
-
-
Bertram, L.1
Blacker, D.2
Mullin, K.3
Keeney, D.4
Jones, J.5
Basu, S.6
Yhu, S.7
McInnis, M.G.8
Go, R.C.9
Vekrellis, K.10
-
8
-
-
0842282469
-
PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample
-
L. Bertram, R. Menon, K. Mullin, M. Parkinson, M.L. Bradley, D. Blacker, and R.E. Tanzi PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample Neurology 62 2004 304 306
-
(2004)
Neurology
, vol.62
, pp. 304-306
-
-
Bertram, L.1
Menon, R.2
Mullin, K.3
Parkinson, M.4
Bradley, M.L.5
Blacker, D.6
Tanzi, R.E.7
-
9
-
-
3242777669
-
Insulin-degrading enzyme and Alzheimer disease: A genetic association study in the Han Chinese
-
L. Bian, J.D. Yang, T.W. Guo, Y. Sun, S.W. Duan, W.Y. Chen, Y.X. Pan, G.Y. Feng, and L. He Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese Neurology 63 2004 241 245
-
(2004)
Neurology
, vol.63
, pp. 241-245
-
-
Bian, L.1
Yang, J.D.2
Guo, T.W.3
Sun, Y.4
Duan, S.W.5
Chen, W.Y.6
Pan, Y.X.7
Feng, G.Y.8
He, L.9
-
10
-
-
17744410836
-
ApoE-4 and age at onset of Alzheimer's disease: The NIMH genetics initiative
-
D. Blacker, J.L. Haines, L. Rodes, H. Terwedow, R.C. Go, L.E. Harrell, R.T. Perry, S.S. Bassett, G. Chase, and D. Meyers ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative Neurology 48 1997 139 147
-
(1997)
Neurology
, vol.48
, pp. 139-147
-
-
Blacker, D.1
Haines, J.L.2
Rodes, L.3
Terwedow, H.4
Go, R.C.5
Harrell, L.E.6
Perry, R.T.7
Bassett, S.S.8
Chase, G.9
Meyers, D.10
-
11
-
-
12244296117
-
Results of a high-resolution genome screen of 437 Alzheimer's disease families
-
D. Blacker, L. Bertram, A.J. Saunders, T.J. Moscarillo, M.S. Albert, H. Wiener, R.T. Perry, J.S. Collins, L.E. Harrell, and R.C. Go Results of a high-resolution genome screen of 437 Alzheimer's disease families Hum. Mol. Genet. 12 2003 23 32
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 23-32
-
-
Blacker, D.1
Bertram, L.2
Saunders, A.J.3
Moscarillo, T.J.4
Albert, M.S.5
Wiener, H.6
Perry, R.T.7
Collins, J.S.8
Harrell, L.E.9
Go, R.C.10
-
12
-
-
3042675764
-
Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease
-
M.E. Blomqvist, P.A. Silburn, D.D. Buchanan, N. Andreasen, K. Blennow, N.L. Pedersen, A.J. Brookes, G.D. Mellick, and J.A. Prince Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease Neurogenetics 5 2004 115 119
-
(2004)
Neurogenetics
, vol.5
, pp. 115-119
-
-
Blomqvist, M.E.1
Silburn, P.A.2
Buchanan, D.D.3
Andreasen, N.4
Blennow, K.5
Pedersen, N.L.6
Brookes, A.J.7
Mellick, G.D.8
Prince, J.A.9
-
13
-
-
0037162647
-
Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease
-
M. Boussaha, D. Hannequin, P. Verpillat, A. Brice, T. Frebourg, and D. Campion Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease Neurosci. Lett. 329 2002 121 123
-
(2002)
Neurosci. Lett.
, vol.329
, pp. 121-123
-
-
Boussaha, M.1
Hannequin, D.2
Verpillat, P.3
Brice, A.4
Frebourg, T.5
Campion, D.6
-
14
-
-
0141594627
-
Copper, beta-amyloid, and Alzheimer's disease: Tapping a sensitive connection
-
A.I. Bush, C.L. Masters, and R.E. Tanzi Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection Proc. Natl. Acad. Sci. USA 100 2003 11193 11194
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 11193-11194
-
-
Bush, A.I.1
Masters, C.L.2
Tanzi, R.E.3
-
15
-
-
0035816661
-
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
-
X. Cao, and T.C. Sudhof A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60 Science 293 2001 115 120
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
16
-
-
0037551741
-
Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders
-
B. Caughey, and P.T. Lansbury Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders Annu. Rev. Neurosci. 26 2003 267 298
-
(2003)
Annu. Rev. Neurosci.
, vol.26
, pp. 267-298
-
-
Caughey, B.1
Lansbury, P.T.2
-
17
-
-
4344580888
-
Strategies for disease modification in Alzheimer's disease
-
M. Citron Strategies for disease modification in Alzheimer's disease Nat. Rev. Neurosci. 5 2004 677 685
-
(2004)
Nat. Rev. Neurosci.
, vol.5
, pp. 677-685
-
-
Citron, M.1
-
18
-
-
0038521161
-
Possible increased risk for Alzheimer's disease associated with neprilysin gene
-
J. Clarimon, F.J. Munoz, M. Boada, L. Tarraga, J. Sunyer, J. Bertranpetit, and D. Comas Possible increased risk for Alzheimer's disease associated with neprilysin gene J. Neural Transm. 110 2003 651 657
-
(2003)
J. Neural Transm.
, vol.110
, pp. 651-657
-
-
Clarimon, J.1
Munoz, F.J.2
Boada, M.3
Tarraga, L.4
Sunyer, J.5
Bertranpetit, J.6
Comas, D.7
-
19
-
-
10744226038
-
Nicastrin gene in familial and sporadic Alzheimer's disease
-
A. Confaloni, L. Terreni, P. Piscopo, A. Crestini, L.M. Campeggi, C.S. Frigerio, I. Blotta, M. Perri, M. Di Natale, and R. Maletta Nicastrin gene in familial and sporadic Alzheimer's disease Neurosci. Lett. 353 2003 61 65
-
(2003)
Neurosci. Lett.
, vol.353
, pp. 61-65
-
-
Confaloni, A.1
Terreni, L.2
Piscopo, P.3
Crestini, A.4
Campeggi, L.M.5
Frigerio, C.S.6
Blotta, I.7
Perri, M.8
Di Natale, M.9
Maletta, R.10
-
20
-
-
0033518158
-
Alzheimer's disease. A firm base for drug development
-
B. De Strooper, and G. Konig Alzheimer's disease. A firm base for drug development Nature 402 1999 471 472
-
(1999)
Nature
, vol.402
, pp. 471-472
-
-
De Strooper, B.1
Konig, G.2
-
21
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
B. De Strooper, P. Saftig, K. Craessaerts, H. Vanderstichele, G. Guhde, W. Annaert, K. Von Figura, and F. Van Leuven Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein Nature 391 1998 387 390
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
22
-
-
4043061467
-
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms
-
R. Deane, Z. Wu, A. Sagare, J. Davis, S. Du Yan, K. Hamm, F. Xu, M. Parisi, B. LaRue, and H.W. Hu LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms Neuron 43 2004 333 344
-
(2004)
Neuron
, vol.43
, pp. 333-344
-
-
Deane, R.1
Wu, Z.2
Sagare, A.3
Davis, J.4
Du Yan, S.5
Hamm, K.6
Xu, F.7
Parisi, M.8
Larue, B.9
Hu, H.W.10
-
23
-
-
9144224765
-
ApoE and clusterin cooperatively suppress Abeta levels and deposition. Evidence that ApoE regulates extracellular Abeta metabolism in vivo
-
R.B. DeMattos, J.R. Cirrito, M. Parsadanian, P.C. May, M.A. O'Dell, J.W. Taylor, J.A. Harmony, B.J. Aronow, K.R. Bales, S.M. Paul, and D.M. Holtzman ApoE and clusterin cooperatively suppress Abeta levels and deposition. Evidence that ApoE regulates extracellular Abeta metabolism in vivo Neuron 41 2004 193 202
-
(2004)
Neuron
, vol.41
, pp. 193-202
-
-
Demattos, R.B.1
Cirrito, J.R.2
Parsadanian, M.3
May, P.C.4
O'Dell, M.A.5
Taylor, J.W.6
Harmony, J.A.7
Aronow, B.J.8
Bales, K.R.9
Paul, S.M.10
Holtzman, D.M.11
-
24
-
-
18344384560
-
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
-
B. Dermaut, J. Theuns, K. Sleegers, H. Hasegawa, M. van den Broeck, K. Vennekens, E. Corsmit, P. St George-Hyslop, M. Cruts, C.M. van Duijn, and C. van Broeckhoven The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample Am. J. Hum. Genet. 70 2002 1568 1574
-
(2002)
Am. J. Hum. Genet.
, vol.70
, pp. 1568-1574
-
-
Dermaut, B.1
Theuns, J.2
Sleegers, K.3
Hasegawa, H.4
Van Den Broeck, M.5
Vennekens, K.6
Corsmit, E.7
St George-Hyslop, P.8
Cruts, M.9
Van Duijn, C.M.10
Van Broeckhoven, C.11
-
25
-
-
11144357241
-
A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques
-
B. Dermaut, S. Kumar-Singh, S. Engelborghs, J. Theuns, R. Rademakers, J. Saerens, B.A. Pickut, K. Peeters, M. van den Broeck, and K. Vennekens A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques Ann. Neurol. 55 2004 617 626
-
(2004)
Ann. Neurol.
, vol.55
, pp. 617-626
-
-
Dermaut, B.1
Kumar-Singh, S.2
Engelborghs, S.3
Theuns, J.4
Rademakers, R.5
Saerens, J.6
Pickut, B.A.7
Peeters, K.8
Van Den Broeck, M.9
Vennekens, K.10
-
26
-
-
0037134505
-
Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)
-
D. Edbauer, M. Willem, S. Lammich, H. Steiner, and C. Haass Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD) J. Biol. Chem. 277 2002 13389 13393
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13389-13393
-
-
Edbauer, D.1
Willem, M.2
Lammich, S.3
Steiner, H.4
Haass, C.5
-
27
-
-
0038664363
-
Reconstitution of gamma-secretase activity
-
D. Edbauer, E. Winkler, J.T. Regula, B. Pesold, H. Steiner, and C. Haass Reconstitution of gamma-secretase activity Nat. Cell Biol. 5 2003 486 488
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
28
-
-
0034703979
-
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
-
N. Ertekin-Taner, N. Graff-Radford, L.H. Younkin, C. Eckman, M. Baker, J. Adamson, J. Ronald, J. Blangero, M. Hutton, and S.G. Younkin Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees Science 290 2000 2303 2304
-
(2000)
Science
, vol.290
, pp. 2303-2304
-
-
Ertekin-Taner, N.1
Graff-Radford, N.2
Younkin, L.H.3
Eckman, C.4
Baker, M.5
Adamson, J.6
Ronald, J.7
Blangero, J.8
Hutton, M.9
Younkin, S.G.10
-
29
-
-
1842765688
-
Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease
-
N. Ertekin-Taner, M. Allen, D. Fadale, L. Scanlin, L. Younkin, R.C. Petersen, N. Graff-Radford, and S.G. Younkin Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease Hum. Mutat. 23 2004 334 342
-
(2004)
Hum. Mutat.
, vol.23
, pp. 334-342
-
-
Ertekin-Taner, N.1
Allen, M.2
Fadale, D.3
Scanlin, L.4
Younkin, L.5
Petersen, R.C.6
Graff-Radford, N.7
Younkin, S.G.8
-
30
-
-
0030823158
-
Effects of age, sex, and ethnicity on the association between apolipoprotein e genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
-
L.A. Farrer, L.A. Cupples, J.L. Haines, B. Hyman, W.A. Kukull, R. Mayeux, R.H. Myers, M.A. Pericak-Vance, N. Risch, and C.M. van Duijn Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium JAMA 278 1997 1349 1356
-
(1997)
JAMA
, vol.278
, pp. 1349-1356
-
-
Farrer, L.A.1
Cupples, L.A.2
Haines, J.L.3
Hyman, B.4
Kukull, W.A.5
Mayeux, R.6
Myers, R.H.7
Pericak-Vance, M.A.8
Risch, N.9
Van Duijn, C.M.10
-
31
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
-
W. Farris, S. Mansourian, Y. Chang, L. Lindsley, E.A. Eckman, M.P. Frosch, C.B. Eckman, R.E. Tanzi, D.J. Selkoe, and S. Guenette Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo Proc. Natl. Acad. Sci. USA 100 2003 4162 4167
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
Lindsley, L.4
Eckman, E.A.5
Frosch, M.P.6
Eckman, C.B.7
Tanzi, R.E.8
Selkoe, D.J.9
Guenette, S.10
-
32
-
-
1642290835
-
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein
-
W. Farris, S. Mansourian, M.A. Leissring, E.A. Eckman, L. Bertram, C.B. Eckman, R.E. Tanzi, and D.J. Selkoe Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein Am. J. Pathol. 164 2004 1425 1434
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 1425-1434
-
-
Farris, W.1
Mansourian, S.2
Leissring, M.A.3
Eckman, E.A.4
Bertram, L.5
Eckman, C.B.6
Tanzi, R.E.7
Selkoe, D.J.8
-
33
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
R. Francis, G. McGrath, J. Zhang, D.A. Ruddy, M. Sym, J. Apfeld, M. Nicoll, M. Maxwell, B. Hai, and M.C. Ellis aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation Dev. Cell 3 2002 85 97
-
(2002)
Dev. Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
-
34
-
-
19944427262
-
Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease
-
B. Funalot, T. Ouimet, A. Claperon, C. Fallet, A. Delacourte, J. Epelbaum, T. Subkowski, N. Leonard, V. Codron, and J.P. David Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease Mol Psychiatry 9 2004 1122 1128
-
(2004)
Mol Psychiatry
, vol.9
, pp. 1122-1128
-
-
Funalot, B.1
Ouimet, T.2
Claperon, A.3
Fallet, C.4
Delacourte, A.5
Epelbaum, J.6
Subkowski, T.7
Leonard, N.8
Codron, V.9
David, J.P.10
-
35
-
-
0031824782
-
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
-
C. Geula, C.K. Wu, D. Saroff, A. Lorenzo, M. Yuan, and B.A. Yankner Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity Nat. Med. 4 1998 827 831
-
(1998)
Nat. Med.
, vol.4
, pp. 827-831
-
-
Geula, C.1
Wu, C.K.2
Saroff, D.3
Lorenzo, A.4
Yuan, M.5
Yankner, B.A.6
-
36
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
-
G.G. Glenner, and C.W. Wong Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein Biochem. Biophys. Res. Commun. 122 1984 1131 1135
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.122
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
37
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
A. Goate, M.C. Chartier-Harlin, M. Mullan, J. Brown, F. Crawford, L. Fidani, L. Giuffra, A. Haynes, N. Irving, and L. James Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease Nature 349 1991 704 706
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
-
38
-
-
0041318900
-
Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers
-
G. Gold, J.L. Blouin, F.R. Herrmann, A. Michon, R. Mulligan, G. Duriaux Sail, C. Bouras, P. Giannakopoulos, and S.E. Antonarakis Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers Am. J. Med. Genet. 119B 2003 44 47
-
(2003)
Am. J. Med. Genet.
, vol.119
, pp. 44-47
-
-
Gold, G.1
Blouin, J.L.2
Herrmann, F.R.3
Michon, A.4
Mulligan, R.5
Duriaux Sail, G.6
Bouras, C.7
Giannakopoulos, P.8
Antonarakis, S.E.9
-
39
-
-
0023132387
-
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
-
D. Goldgaber, M.I. Lerman, O.W. McBride, U. Saffiotti, and D.C. Gajdusek Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease Science 235 1987 877 880
-
(1987)
Science
, vol.235
, pp. 877-880
-
-
Goldgaber, D.1
Lerman, M.I.2
McBride, O.W.3
Saffiotti, U.4
Gajdusek, D.C.5
-
40
-
-
17644438751
-
Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism
-
L.M. Grimaldi, V.M. Casadei, C. Ferri, F. Veglia, F. Licastro, G. Annoni, I. Biunno, G. De Bellis, S. Sorbi, and C. Mariani Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism Ann. Neurol. 47 2000 361 365
-
(2000)
Ann. Neurol.
, vol.47
, pp. 361-365
-
-
Grimaldi, L.M.1
Casadei, V.M.2
Ferri, C.3
Veglia, F.4
Licastro, F.5
Annoni, G.6
Biunno, I.7
De Bellis, G.8
Sorbi, S.9
Mariani, C.10
-
41
-
-
10744232186
-
Mechanisms of Abeta clearance and catabolism
-
S.Y. Guenette Mechanisms of Abeta clearance and catabolism Neuromolecular Med. 4 2003 147 160
-
(2003)
Neuromolecular Med.
, vol.4
, pp. 147-160
-
-
Guenette, S.Y.1
-
42
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
43
-
-
3242669646
-
Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population
-
S. Helisalmi, B. Dermaut, M. Hiltunen, A. Mannermaa, M. van den Broeck, M. Lehtovirta, A.M. Koivisto, S. Iivonen, M. Cruts, H. Soininen, and C. van Broeckhoven Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population Neurology 63 2004 173 175
-
(2004)
Neurology
, vol.63
, pp. 173-175
-
-
Helisalmi, S.1
Dermaut, B.2
Hiltunen, M.3
Mannermaa, A.4
Van Den Broeck, M.5
Lehtovirta, M.6
Koivisto, A.M.7
Iivonen, S.8
Cruts, M.9
Soininen, H.10
Van Broeckhoven, C.11
-
44
-
-
0346727326
-
LRP: A bright beacon at the blood-brain barrier
-
J. Herz LRP: a bright beacon at the blood-brain barrier J. Clin. Invest. 112 2003 1483 1485
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1483-1485
-
-
Herz, J.1
-
45
-
-
0019402114
-
Dementia of the Alzheimer type. Clinical genetics, natural history, and associated conditions
-
L.L. Heston, A.R. Mastri, V.E. Anderson, and J. White Dementia of the Alzheimer type. Clinical genetics, natural history, and associated conditions Arch. Gen. Psychiatry 38 1981 1085 1090
-
(1981)
Arch. Gen. Psychiatry
, vol.38
, pp. 1085-1090
-
-
Heston, L.L.1
Mastri, A.R.2
Anderson, V.E.3
White, J.4
-
46
-
-
0035856462
-
Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland
-
M. Hiltunen, A. Mannermaa, D. Thompson, D. Easton, M. Pirskanen, S. Helisalmi, A.M. Koivisto, M. Lehtovirta, M. Ryynanen, and H. Soininen Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland Neurology 57 2001 1663 1668
-
(2001)
Neurology
, vol.57
, pp. 1663-1668
-
-
Hiltunen, M.1
Mannermaa, A.2
Thompson, D.3
Easton, D.4
Pirskanen, M.5
Helisalmi, S.6
Koivisto, A.M.7
Lehtovirta, M.8
Ryynanen, M.9
Soininen, H.10
-
47
-
-
5144227934
-
The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease
-
B. Hutter-Paier, H.J. Huttunen, L. Puglielli, C.B. Eckman, D.Y. Kim, A. Hofmeister, R.D. Moir, S.B. Domnitz, M.P. Frosch, M. Windisch, and D.M. Kovacs The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease Neuron 44 2004 227 238
-
(2004)
Neuron
, vol.44
, pp. 227-238
-
-
Hutter-Paier, B.1
Huttunen, H.J.2
Puglielli, L.3
Eckman, C.B.4
Kim, D.Y.5
Hofmeister, A.6
Moir, R.D.7
Domnitz, S.B.8
Frosch, M.P.9
Windisch, M.10
Kovacs, D.M.11
-
48
-
-
0027258525
-
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
-
J.T. Jarrett, E.P. Berger, and P.T. Lansbury Jr. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease Biochemistry 32 1993 4693 4697
-
(1993)
Biochemistry
, vol.32
, pp. 4693-4697
-
-
Jarrett, J.T.1
Berger, E.P.2
Lansbury Jr., P.T.3
-
49
-
-
0035997234
-
The channel hypothesis of Alzheimer's disease: Current status
-
B.L. Kagan, Y. Hirakura, R. Azimov, R. Azimova, and M.C. Lin The channel hypothesis of Alzheimer's disease: current status Peptides 23 2002 1311 1315
-
(2002)
Peptides
, vol.23
, pp. 1311-1315
-
-
Kagan, B.L.1
Hirakura, Y.2
Azimov, R.3
Azimova, R.4
Lin, M.C.5
-
50
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
J. Kang, H.G. Lemaire, A. Unterbeck, J.M. Salbaum, C.L. Masters, K.H. Grzeschik, G. Multhaup, K. Beyreuther, and B. Muller-Hill The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor Nature 325 1987 733 736
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
51
-
-
0032899712
-
A full genome scan for late onset Alzheimer's disease
-
P. Kehoe, F. Wavrant-De Vrieze, R. Crook, W.S. Wu, P. Holmans, I. Fenton, G. Spurlock, N. Norton, H. Williams, and N. Williams A full genome scan for late onset Alzheimer's disease Hum. Mol. Genet. 8 1999 237 245
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 237-245
-
-
Kehoe, P.1
Wavrant-De Vrieze, F.2
Crook, R.3
Wu, W.S.4
Holmans, P.5
Fenton, I.6
Spurlock, G.7
Norton, N.8
Williams, H.9
Williams, N.10
-
52
-
-
0037146553
-
Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage
-
D.Y. Kim, L.A. Ingano, and D.M. Kovacs Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage J. Biol. Chem. 277 2002 49976 49981
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49976-49981
-
-
Kim, D.Y.1
Ingano, L.A.2
Kovacs, D.M.3
-
53
-
-
0034984156
-
The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain
-
J.C. Lambert, D.M. Mann, J.M. Harris, M.C. Chartier-Harlin, A. Cumming, J. Coates, H. Lemmon, D. StClair, T. Iwatsubo, and C. Lendon The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain J. Med. Genet. 38 2001 353 355
-
(2001)
J. Med. Genet.
, vol.38
, pp. 353-355
-
-
Lambert, J.C.1
Mann, D.M.2
Harris, J.M.3
Chartier-Harlin, M.C.4
Cumming, A.5
Coates, J.6
Lemmon, H.7
Stclair, D.8
Iwatsubo, T.9
Lendon, C.10
-
54
-
-
0346101885
-
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
-
M.A. Leissring, W. Farris, A.Y. Chang, D.M. Walsh, X. Wu, X. Sun, M.P. Frosch, and D.J. Selkoe Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death Neuron 40 2003 1087 1093
-
(2003)
Neuron
, vol.40
, pp. 1087-1093
-
-
Leissring, M.A.1
Farris, W.2
Chang, A.Y.3
Walsh, D.M.4
Wu, X.5
Sun, X.6
Frosch, M.P.7
Selkoe, D.J.8
-
55
-
-
0025296269
-
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
-
E. Levy, M.D. Carman, I.J. Fernandez-Madrid, M.D. Power, I. Lieberburg, S.G. van Duinen, G.T. Bots, W. Luyendijk, and B. Frangione Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type Science 248 1990 1124 1126
-
(1990)
Science
, vol.248
, pp. 1124-1126
-
-
Levy, E.1
Carman, M.D.2
Fernandez-Madrid, I.J.3
Power, M.D.4
Lieberburg, I.5
Van Duinen, S.G.6
Bots, G.T.7
Luyendijk, W.8
Frangione, B.9
-
56
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
E. Levy-Lahad, W. Wasco, P. Poorkaj, D.M. Romano, J. Oshima, W.H. Pettingell, C.E. Yu, P.D. Jondro, S.D. Schmidt, and K. Wang Candidate gene for the chromosome 1 familial Alzheimer's disease locus Science 269 1995 973 977
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
Yu, C.E.7
Jondro, P.D.8
Schmidt, S.D.9
Wang, K.10
-
57
-
-
0031685162
-
Polymorphic tetranucleotide repeat site within intron 7 of the beta-amyloid precursor protein gene and its lack of association with Alzheimer's disease
-
L. Li, R. Perry, J. Wu, D. Pham, T. Ohman, L.E. Harrell, R.C. Go, and K. Fukuchi Polymorphic tetranucleotide repeat site within intron 7 of the beta-amyloid precursor protein gene and its lack of association with Alzheimer's disease Hum. Genet. 103 1998 86 89
-
(1998)
Hum. Genet.
, vol.103
, pp. 86-89
-
-
Li, L.1
Perry, R.2
Wu, J.3
Pham, D.4
Ohman, T.5
Harrell, L.E.6
Go, R.C.7
Fukuchi, K.8
-
58
-
-
18344393780
-
Age at onset in two common neurodegenerative diseases is genetically controlled
-
Y.J. Li, W.K. Scott, D.J. Hedges, F. Zhang, P.C. Gaskell, M.A. Nance, R.L. Watts, J.P. Hubble, W.C. Koller, and R. Pahwa Age at onset in two common neurodegenerative diseases is genetically controlled Am. J. Hum. Genet. 70 2002 985 993
-
(2002)
Am. J. Hum. Genet.
, vol.70
, pp. 985-993
-
-
Li, Y.J.1
Scott, W.K.2
Hedges, D.J.3
Zhang, F.4
Gaskell, P.C.5
Nance, M.A.6
Watts, R.L.7
Hubble, J.P.8
Koller, W.C.9
Pahwa, R.10
-
59
-
-
11144353586
-
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
-
J.W. Lustbader, M. Cirilli, C. Lin, H.W. Xu, K. Takuma, N. Wang, C. Caspersen, X. Chen, S. Pollak, and M. Chaney ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease Science 304 2004 448 452
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
Xu, H.W.4
Takuma, K.5
Wang, N.6
Caspersen, C.7
Chen, X.8
Pollak, S.9
Chaney, M.10
-
60
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
C.L. Masters, G. Simms, N.A. Weinman, G. Multhaup, B.L. McDonald, and K. Beyreuther Amyloid plaque core protein in Alzheimer disease and Down syndrome Proc. Natl. Acad. Sci. USA 82 1985 4245 4249
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
61
-
-
0031820439
-
APOE genotype predicts when-not whether-one is predisposed to develop Alzheimer disease
-
M.R. Meyer, J.T. Tschanz, M.C. Norton, K.A. Welsh-Bohmer, D.C. Steffens, B.W. Wyse, and J.C. Breitner APOE genotype predicts when-not whether-one is predisposed to develop Alzheimer disease Nat. Genet. 19 1998 321 322
-
(1998)
Nat. Genet.
, vol.19
, pp. 321-322
-
-
Meyer, M.R.1
Tschanz, J.T.2
Norton, M.C.3
Welsh-Bohmer, K.A.4
Steffens, D.C.5
Wyse, B.W.6
Breitner, J.C.7
-
62
-
-
0037947406
-
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo
-
B.C. Miller, E.A. Eckman, K. Sambamurti, N. Dobbs, K.M. Chow, C.B. Eckman, L.B. Hersh, and D.L. Thiele Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo Proc. Natl. Acad. Sci. USA 100 2003 6221 6226
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6221-6226
-
-
Miller, B.C.1
Eckman, E.A.2
Sambamurti, K.3
Dobbs, N.4
Chow, K.M.5
Eckman, C.B.6
Hersh, L.B.7
Thiele, D.L.8
-
63
-
-
0036813533
-
Regulation of amyloid beta-peptide levels by enzymatic degradation
-
A. Mukherjee, and L.B. Hersh Regulation of amyloid beta-peptide levels by enzymatic degradation J. Alzheimers Dis. 4 2002 341 348
-
(2002)
J. Alzheimers Dis.
, vol.4
, pp. 341-348
-
-
Mukherjee, A.1
Hersh, L.B.2
-
64
-
-
0030857328
-
Polymorphisms of the interleukin-6 gene are associated with bone mineral density
-
R.E. Murray, F. McGuigan, S.F. Grant, D.M. Reid, and S.H. Ralston Polymorphisms of the interleukin-6 gene are associated with bone mineral density Bone 21 1997 89 92
-
(1997)
Bone
, vol.21
, pp. 89-92
-
-
Murray, R.E.1
McGuigan, F.2
Grant, S.F.3
Reid, D.M.4
Ralston, S.H.5
-
65
-
-
0034704197
-
Susceptibility locus for Alzheimer's disease on chromosome 10
-
A. Myers, P. Holmans, H. Marshall, J. Kwon, D. Meyer, D. Ramic, S. Shears, J. Booth, F.W. DeVrieze, and R. Crook Susceptibility locus for Alzheimer's disease on chromosome 10 Science 290 2000 2304 2305
-
(2000)
Science
, vol.290
, pp. 2304-2305
-
-
Myers, A.1
Holmans, P.2
Marshall, H.3
Kwon, J.4
Meyer, D.5
Ramic, D.6
Shears, S.7
Booth, J.8
Devrieze, F.W.9
Crook, R.10
-
66
-
-
0035800212
-
Association studies using novel polymorphisms in BACE1 and BACE2
-
P. Nowotny, J.M. Kwon, S. Chakraverty, V. Nowotny, J.C. Morris, and A.M. Goate Association studies using novel polymorphisms in BACE1 and BACE2 Neuroreport 12 2001 1799 1802
-
(2001)
Neuroreport
, vol.12
, pp. 1799-1802
-
-
Nowotny, P.1
Kwon, J.M.2
Chakraverty, S.3
Nowotny, V.4
Morris, J.C.5
Goate, A.M.6
-
67
-
-
0034837775
-
The amyloid precursor protein locus and very-late-onset Alzheimer disease
-
J.M. Olson, K.A. Goddard, and D.M. Dudek The amyloid precursor protein locus and very-late-onset Alzheimer disease Am. J. Hum. Genet. 69 2001 895 899
-
(2001)
Am. J. Hum. Genet.
, vol.69
, pp. 895-899
-
-
Olson, J.M.1
Goddard, K.A.2
Dudek, D.M.3
-
68
-
-
0032914896
-
A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease
-
A. Papassotiropoulos, M. Bagli, F. Jessen, T.A. Bayer, W. Maier, M.L. Rao, and R. Heun A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease Ann. Neurol. 45 1999 666 668
-
(1999)
Ann. Neurol.
, vol.45
, pp. 666-668
-
-
Papassotiropoulos, A.1
Bagli, M.2
Jessen, F.3
Bayer, T.A.4
Maier, W.5
Rao, M.L.6
Heun, R.7
-
69
-
-
0025735884
-
Linkage studies in familial Alzheimer disease: Evidence for chromosome 19 linkage
-
M.A. Pericak-Vance, J.L. Bebout, P.C. Gaskell Jr., L.H. Yamaoka, W.Y. Hung, M.J. Alberts, A.P. Walker, R.J. Bartlett, C.A. Haynes, and K.A. Welsh Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage Am. J. Hum. Genet. 48 1991 1034 1050
-
(1991)
Am. J. Hum. Genet.
, vol.48
, pp. 1034-1050
-
-
Pericak-Vance, M.A.1
Bebout, J.L.2
Gaskell Jr., P.C.3
Yamaoka, L.H.4
Hung, W.Y.5
Alberts, M.J.6
Walker, A.P.7
Bartlett, R.J.8
Haynes, C.A.9
Welsh, K.A.10
-
70
-
-
0042827346
-
Association analysis between anterior-pharynx defective-1 genes polymorphisms and Alzheimer's disease
-
M. Poli, L.B. Gatta, S. Archetti, A. Padovani, A. Albertini, and D. Finazzi Association analysis between anterior-pharynx defective-1 genes polymorphisms and Alzheimer's disease Neurosci. Lett. 350 2003 77 80
-
(2003)
Neurosci. Lett.
, vol.350
, pp. 77-80
-
-
Poli, M.1
Gatta, L.B.2
Archetti, S.3
Padovani, A.4
Albertini, A.5
Finazzi, D.6
-
72
-
-
0242321663
-
Genetic variation in a haplotype block spanning IDE influences Alzheimer disease
-
J.A. Prince, L. Feuk, H.F. Gu, B. Johansson, M. Gatz, K. Blennow, and A.J. Brookes Genetic variation in a haplotype block spanning IDE influences Alzheimer disease Hum. Mutat. 22 2003 363 371
-
(2003)
Hum. Mutat.
, vol.22
, pp. 363-371
-
-
Prince, J.A.1
Feuk, L.2
Gu, H.F.3
Johansson, B.4
Gatz, M.5
Blennow, K.6
Brookes, A.J.7
-
73
-
-
0034693447
-
Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease
-
G.W. Rebeck Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease Neurosci. Lett. 293 2000 75 77
-
(2000)
Neurosci. Lett.
, vol.293
, pp. 75-77
-
-
Rebeck, G.W.1
-
74
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
C.W. Ritchie, A.I. Bush, A. Mackinnon, S. Macfarlane, M. Mastwyk, L. MacGregor, L. Kiers, R. Cherny, Q.X. Li, and A. Tammer Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial Arch. Neurol. 60 2003 1685 1691
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
MacKinnon, A.3
MacFarlane, S.4
Mastwyk, M.5
MacGregor, L.6
Kiers, L.7
Cherny, R.8
Li, Q.X.9
Tammer, A.10
-
75
-
-
2142777413
-
Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides
-
N.K. Robakis, N. Ramakrishna, G. Wolfe, and H.M. Wisniewski Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides Proc. Natl. Acad. Sci. USA 84 1987 4190 4194
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 4190-4194
-
-
Robakis, N.K.1
Ramakrishna, N.2
Wolfe, G.3
Wisniewski, H.M.4
-
76
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
E.I. Rogaev, R. Sherrington, E.A. Rogaeva, G. Levesque, M. Ikeda, Y. Liang, H. Chi, C. Lin, K. Holman, and T. Tsuda Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene Nature 376 1995 775 778
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
-
77
-
-
0035964209
-
Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations
-
E.A. Rogaeva, K.C. Fafel, Y.Q. Song, H. Medeiros, C. Sato, Y. Liang, E. Richard, E.I. Rogaev, P. Frommelt, and A.D. Sadovnick Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations Neurology 57 2001 621 625
-
(2001)
Neurology
, vol.57
, pp. 621-625
-
-
Rogaeva, E.A.1
Fafel, K.C.2
Song, Y.Q.3
Medeiros, H.4
Sato, C.5
Liang, Y.6
Richard, E.7
Rogaev, E.I.8
Frommelt, P.9
Sadovnick, A.D.10
-
78
-
-
3442888291
-
Metal and inflammatory targets for Alzheimer's disease
-
J.T. Rogers, and D.K. Lahiri Metal and inflammatory targets for Alzheimer's disease Curr. Drug Targets 5 2004 535 551
-
(2004)
Curr. Drug Targets
, vol.5
, pp. 535-551
-
-
Rogers, J.T.1
Lahiri, D.K.2
-
79
-
-
12144286112
-
Association of the Neprilysin gene with susceptibility to late-onset Alzheimer's disease
-
A. Sakai, H. Ujike, K. Nakata, Y. Takehisa, T. Imamura, N. Uchida, A. Kanzaki, M. Yamamoto, Y. Fujisawa, K. Okumura, and S. Kuroda Association of the Neprilysin gene with susceptibility to late-onset Alzheimer's disease Dement. Geriatr. Cogn. Disord. 17 2004 164 169
-
(2004)
Dement. Geriatr. Cogn. Disord.
, vol.17
, pp. 164-169
-
-
Sakai, A.1
Ujike, H.2
Nakata, K.3
Takehisa, Y.4
Imamura, T.5
Uchida, N.6
Kanzaki, A.7
Yamamoto, M.8
Fujisawa, Y.9
Okumura, K.10
Kuroda, S.11
-
80
-
-
0942290670
-
No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population
-
A. Sakai, H. Ujike, K. Nakata, Y. Takehisa, T. Imamura, N. Uchida, A. Kanzaki, M. Yamamoto, Y. Fujisawa, K. Okumura, and S. Kuroda No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population Am. J. Med. Genet. 125B 2004 87 91
-
(2004)
Am. J. Med. Genet.
, vol.125
, pp. 87-91
-
-
Sakai, A.1
Ujike, H.2
Nakata, K.3
Takehisa, Y.4
Imamura, T.5
Uchida, N.6
Kanzaki, A.7
Yamamoto, M.8
Fujisawa, Y.9
Okumura, K.10
Kuroda, S.11
-
81
-
-
0001050325
-
BACE maps to chromosome 11 and a BACE homolog, BACE2, reside in the obligate Down syndrome region of chromosome 21
-
A.J. Saunders, T.W. Kim, and R.E. Tanzi BACE maps to chromosome 11 and a BACE homolog, BACE2, reside in the obligate Down syndrome region of chromosome 21 Science 286 1999 1255a
-
(1999)
Science
, vol.286
-
-
Saunders, A.J.1
Kim, T.W.2
Tanzi, R.E.3
-
82
-
-
10744226703
-
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin
-
A.J. Saunders, L. Bertram, K. Mullin, A.J. Sampson, K. Latifzai, S. Basu, J. Jones, D. Kinney, L. MacKenzie-Ingano, and S. Yu Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin Hum. Mol. Genet. 12 2003 2765 2776
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2765-2776
-
-
Saunders, A.J.1
Bertram, L.2
Mullin, K.3
Sampson, A.J.4
Latifzai, K.5
Basu, S.6
Jones, J.7
Kinney, D.8
MacKenzie-Ingano, L.9
Yu, S.10
-
83
-
-
11144354609
-
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
-
C.A. Saura, S.Y. Choi, V. Beglopoulos, S. Malkani, D. Zhang, B.S. Shankaranarayana Rao, S. Chattarji, R.J. Kelleher 3rd, E.R. Kandel, and K. Duff Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration Neuron 42 2004 23 36
-
(2004)
Neuron
, vol.42
, pp. 23-36
-
-
Saura, C.A.1
Choi, S.Y.2
Beglopoulos, V.3
Malkani, S.4
Zhang, D.5
Shankaranarayana Rao, B.S.6
Chattarji, S.7
Kelleher III, R.J.8
Kandel, E.R.9
Duff, K.10
-
84
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
D. Scheuner, C. Eckman, M. Jensen, X. Song, M. Citron, N. Suzuki, T.D. Bird, J. Hardy, M. Hutton, and W. Kukull Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease Nat. Med. 2 1996 864 870
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
-
85
-
-
0027365822
-
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein e genotype in late-onset Alzheimer disease
-
D.E. Schmechel, A.M. Saunders, W.J. Strittmatter, B.J. Crain, C.M. Hulette, S.H. Joo, M.A. Pericak-Vance, D. Goldgaber, and A.D. Roses Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease Proc. Natl. Acad. Sci. USA 90 1993 9649 9653
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 9649-9653
-
-
Schmechel, D.E.1
Saunders, A.M.2
Strittmatter, W.J.3
Crain, B.J.4
Hulette, C.M.5
Joo, S.H.6
Pericak-Vance, M.A.7
Goldgaber, D.8
Roses, A.D.9
-
86
-
-
0242691247
-
Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22
-
W.K. Scott, E.R. Hauser, D.E. Schmechel, K.A. Welsh-Bohmer, G.W. Small, A.D. Roses, A.M. Saunders, J.R. Gilbert, J.M. Vance, J.L. Haines, and M.A. Pericak-Vance Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22 Am. J. Hum. Genet. 73 2003 1041 1051
-
(2003)
Am. J. Hum. Genet.
, vol.73
, pp. 1041-1051
-
-
Scott, W.K.1
Hauser, E.R.2
Schmechel, D.E.3
Welsh-Bohmer, K.A.4
Small, G.W.5
Roses, A.D.6
Saunders, A.M.7
Gilbert, J.R.8
Vance, J.M.9
Haines, J.L.10
Pericak-Vance, M.A.11
-
87
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
D.J. Selkoe Clearing the brain's amyloid cobwebs Neuron 32 2001 177 180
-
(2001)
Neuron
, vol.32
, pp. 177-180
-
-
Selkoe, D.J.1
-
88
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
R. Sherrington, E.I. Rogaev, Y. Liang, E.A. Rogaeva, G. Levesque, M. Ikeda, H. Chi, C. Lin, G. Li, and K. Holman Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease Nature 375 1995 754 760
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
-
89
-
-
0034521392
-
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
-
M. Shibata, S. Yamada, S.R. Kumar, M. Calero, J. Bading, B. Frangione, D.M. Holtzman, C.A. Miller, D.K. Strickland, J. Ghiso, and B.V. Zlokovic Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier J. Clin. Invest. 106 2000 1489 1499
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1489-1499
-
-
Shibata, M.1
Yamada, S.2
Kumar, S.R.3
Calero, M.4
Bading, J.5
Frangione, B.6
Holtzman, D.M.7
Miller, C.A.8
Strickland, D.K.9
Ghiso, J.10
Zlokovic, B.V.11
-
90
-
-
0023103748
-
The genetic defect causing familial Alzheimer's disease maps on chromosome 21
-
P.H. St George-Hyslop, R.E. Tanzi, R.J. Polinsky, J.L. Haines, L. Nee, P.C. Watkins, R.H. Myers, R.G. Feldman, D. Pollen, and D. Drachman The genetic defect causing familial Alzheimer's disease maps on chromosome 21 Science 235 1987 885 890
-
(1987)
Science
, vol.235
, pp. 885-890
-
-
St George-Hyslop, P.H.1
Tanzi, R.E.2
Polinsky, R.J.3
Haines, J.L.4
Nee, L.5
Watkins, P.C.6
Myers, R.H.7
Feldman, R.G.8
Pollen, D.9
Drachman, D.10
-
91
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
W.J. Strittmatter, A.M. Saunders, D. Schmechel, M. Pericak-Vance, J. Enghild, G.S. Salvesen, and A.D. Roses Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease Proc. Natl. Acad. Sci. USA 90 1993 1977 1981
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
Pericak-Vance, M.4
Enghild, J.5
Salvesen, G.S.6
Roses, A.D.7
-
92
-
-
0023109592
-
Amyloid beta protein gene: CDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
-
R.E. Tanzi, J.F. Gusella, P.C. Watkins, G.A. Bruns, P. St George-Hyslop, M.L. Van Keuren, D. Patterson, S. Pagan, D.M. Kurnit, and R.L. Neve Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus Science 235 1987 880 884
-
(1987)
Science
, vol.235
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
Bruns, G.A.4
St George-Hyslop, P.5
Van Keuren, M.L.6
Patterson, D.7
Pagan, S.8
Kurnit, D.M.9
Neve, R.L.10
-
93
-
-
4444276735
-
Clearance of Alzheimer's Abeta peptide: The many roads to perdition
-
R.E. Tanzi, R.D. Moir, and S.L. Wagner Clearance of Alzheimer's Abeta peptide: the many roads to perdition Neuron 43 2004 605 608
-
(2004)
Neuron
, vol.43
, pp. 605-608
-
-
Tanzi, R.E.1
Moir, R.D.2
Wagner, S.L.3
-
94
-
-
0242515917
-
Alzheimer-associated C allele of the promoter polymorphism-22C>T causes a critical neuron-specific decrease of presenilin 1 expression
-
J. Theuns, J. Remacle, R. Killick, E. Corsmit, K. Vennekens, D. Huylebroeck, M. Cruts, and C. Van Broeckhoven Alzheimer-associated C allele of the promoter polymorphism-22C>T causes a critical neuron-specific decrease of presenilin 1 expression Hum. Mol. Genet. 12 2003 869 877
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 869-877
-
-
Theuns, J.1
Remacle, J.2
Killick, R.3
Corsmit, E.4
Vennekens, K.5
Huylebroeck, D.6
Cruts, M.7
Van Broeckhoven, C.8
-
95
-
-
0030667426
-
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors
-
G. Thinakaran, C.L. Harris, T. Ratovitski, F. Davenport, H.H. Slunt, D.L. Price, D.R. Borchelt, and S.S. Sisodia Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors J. Biol. Chem. 272 1997 28415 28422
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28415-28422
-
-
Thinakaran, G.1
Harris, C.L.2
Ratovitski, T.3
Davenport, F.4
Slunt, H.H.5
Price, D.L.6
Borchelt, D.R.7
Sisodia, S.S.8
-
96
-
-
0025369198
-
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)
-
C. Van Broeckhoven, J. Haan, E. Bakker, J.A. Hardy, W. Van Hul, A. Wehnert, M. Vegter-Van der Vlis, and R.A. Roos Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch) Science 248 1990 1120 1122
-
(1990)
Science
, vol.248
, pp. 1120-1122
-
-
Van Broeckhoven, C.1
Haan, J.2
Bakker, E.3
Hardy, J.A.4
Van Hul, W.5
Wehnert, A.6
Vegter-Van Der Vlis, M.7
Roos, R.A.8
-
97
-
-
0036848549
-
Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein
-
E. Van Uden, M. Mallory, I. Veinbergs, M. Alford, E. Rockenstein, and E. Masliah Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein J. Neurosci. 22 2002 9298 9304
-
(2002)
J. Neurosci.
, vol.22
, pp. 9298-9304
-
-
Van Uden, E.1
Mallory, M.2
Veinbergs, I.3
Alford, M.4
Rockenstein, E.5
Masliah, E.6
-
98
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
R. Vassar, B.D. Bennett, S. Babu-Khan, S. Kahn, E.A. Mendiaz, P. Denis, D.B. Teplow, S. Ross, P. Amarante, and R. Loeloff Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE Science 286 1999 735 741
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
-
99
-
-
0033926434
-
The number of trait loci in late-onset Alzheimer disease
-
E. Warwick Daw, H. Payami, E.J. Nemens, D. Nochlin, T.D. Bird, G.D. Schellenberg, and E.M. Wijsman The number of trait loci in late-onset Alzheimer disease Am. J. Hum. Genet. 66 2000 196 204
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 196-204
-
-
Warwick Daw, E.1
Payami, H.2
Nemens, E.J.3
Nochlin, D.4
Bird, T.D.5
Schellenberg, G.D.6
Wijsman, E.M.7
-
100
-
-
0041876229
-
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity
-
S. Weggen, J.L. Eriksen, S.A. Sagi, C.U. Pietrzik, V. Ozols, A. Fauq, T.E. Golde, and E.H. Koo Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity J. Biol. Chem. 278 2003 31831 31837
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31831-31837
-
-
Weggen, S.1
Eriksen, J.L.2
Sagi, S.A.3
Pietrzik, C.U.4
Ozols, V.5
Fauq, A.6
Golde, T.E.7
Koo, E.H.8
-
101
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
M.S. Wolfe, W. Xia, B.L. Ostaszewski, T.S. Diehl, W.T. Kimberly, and D.J. Selkoe Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity Nature 398 1999 513 517
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
102
-
-
0030028429
-
Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group
-
M. Wragg, M. Hutton, and C. Talbot Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group Lancet 347 1996 509 512
-
(1996)
Lancet
, vol.347
, pp. 509-512
-
-
Wragg, M.1
Hutton, M.2
Talbot, C.3
-
103
-
-
0037017399
-
Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons
-
Y. Zhang, R. McLaughlin, C. Goodyer, and A. LeBlanc Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons J. Cell Biol. 156 2002 519 529
-
(2002)
J. Cell Biol.
, vol.156
, pp. 519-529
-
-
Zhang, Y.1
McLaughlin, R.2
Goodyer, C.3
Leblanc, A.4
-
104
-
-
2542475986
-
Clearing amyloid through the blood-brain barrier
-
B.V. Zlokovic Clearing amyloid through the blood-brain barrier J. Neurochem. 89 2004 807 811
-
(2004)
J. Neurochem.
, vol.89
, pp. 807-811
-
-
Zlokovic, B.V.1
|