Glu-333 of nicastrin directly participates in γ-secretase activity

Journal of Biological Chemistry

Volumn 284, Issue 43, 2009, Pages 29714-29724

  Dries, Daniel R ^a   Shah, Sanjiv ^b   Han, Yu Hong ^a   Yu, Cong ^a   Yu, Sophie ^b   Shearman, Mark S ^b   Yu, Gang ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEINS; DUAL ROLE; EXTRACELLULAR; INTRACELLULAR LOOP; INTRINSIC ACTIVITIES; MEMBRANE PROTEINS; N-TERMINALS; NICASTRIN; NOTCH RECEPTOR; PRESENILINS; SECRETASE COMPLEX; SECRETASES; SUBSTRATE RECOGNITION;

AMINES; CELL MEMBRANES; ENZYME ACTIVITY; PROTEINS;

SUBSTRATES;

AMINE; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GLUTAMIC ACID; MEMBRANE PROTEIN; NICASTRIN; NOTCH RECEPTOR; PRESENILIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; INSECT CELL; MOLECULAR RECOGNITION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN TRANSPORT;

AMINO ACID SUBSTITUTION; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; GLUTAMIC ACID; HUMANS; MEMBRANE GLYCOPROTEINS; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; SPODOPTERA; SUBSTRATE SPECIFICITY;

EID: 70350353076     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.038737     Document Type: Article

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