Peptidomimetic probes and molecular modeling suggest that Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease

Biochemistry

Volumn 38, Issue 15, 1999, Pages 4720-4727

  Wolfe, Michael S ^a   Xia, Weiming ^b   Moore, Chad L ^a   Leatherwood, Dartha D ^a   Ostaszewski, Beth ^b   Rahmati, Talat ^b   Donkor, Isaac O ^a   Selkoe, Dennis J ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; GAMMA SECRETASE; PROTEINASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; HUMAN CELL; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; HUMANS; HYDROLYSIS; KETONES; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR PROBES; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; PROTEIN BINDING;

ANIMALIA;

EID: 0033551099     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982562p     Document Type: Article

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