Structure of γ-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy

Journal of Biological Chemistry

Volumn 286, Issue 24, 2011, Pages 21440-21449

  Renzi, Fabiana ^a,b   Zhang, Xulun ^c   Rice, William J ^d   Torres Arancivia, Celia ^a,e   Gomez Llorente, Yacob ^a   Diaz, Ruben ^d   Ahn, Kwangwook ^f   Yu, Chunjiang ^g   Li, Yue Ming ^f   Sisodia, Sangram S ^c   Ubarretxena Belandia, Iban ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF CHICAGO   (United States)

^d NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

^e CITY UNIVERSITY OF NEW YORK   (United States)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^g UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE ARCHITECTURE; ALZHEIMER DISEASE; CATALYTIC SUBUNITS; CRYO-ELECTRON MICROSCOPY; ENDOPROTEOLYSIS; MEMBRANE PROTEIN COMPLEX; NICASTRIN; PRE-ACTIVATION; PRESENILINS; SECRETASES; SINGLE-PARTICLE; THREE-DIMENSIONAL RECONSTRUCTION; TRANSITION STATE;

BIOLOGICAL MEMBRANES; ELECTRON MICROSCOPES; THREE DIMENSIONAL;

PROTEINS;

GAMMA SECRETASE; PRESENILIN 2;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; ELECTRON MICROSCOPY; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IMAGE PROCESSING; PARTICLE SIZE; PRIORITY JOURNAL; SINGLE PARTICLE CRYOELECTRON MICROSCOPY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; CATALYSIS; CATALYTIC DOMAIN; CRYOELECTRON MICROSCOPY; DIMERIZATION; HUMANS; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION;

EID: 79958718948     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.193326     Document Type: Article

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