Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

Neuron

Volumn 32, Issue 4, 2001, Pages 579-589

  Annaert, Wim G ^a   Esselens, Cary ^a   Baert, Veerle ^a   Boeve, Christine ^a   Snellings, Greet ^a   Cupers, Philippe ^a   Craessaerts, Katleen ^a   De Strooper, Bart ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; MEMBRANE PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVE SITE; HIPPOCAMPUS; MOUSE; MUTATION; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STEADY STATE; TELENCEPHALON;

EID: 0035923750     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(01)00512-8     Document Type: Article

References (72)

1. Presenilins: Molecular switches between proteolysis and signal transduction
2. Presenilin 1 controls gamma-secretase processing of the amyloid precursor protein in pre-golgi compartments of hippocampal neurons
3. The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during caenorhabditis elegans spermatogenesis
4. Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule
5. Notch1 inhibits neurite outgrowth in postmitotic primary neurons
6. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
7. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
8. Mutant presenilins of Alzheimer's disease increase production of 42- residue amyloid beta-protein in both transfected cells and transgenic mice
9. Presenilin mutations in Alzheimer's disease
10. Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment
11. The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
12. Proteolytic processing and cell biological functions of the amyloid precursor protein
13. Where Notch and Wnt signaling meet: The presenilin hub
14. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins
15. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
16. Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
17. Protein topology of presenilin 1
18. The establishment of polarity by hippocampal neurons in culture
19. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
20. A portrait of Alzheimer secretases-New features and familiar faces
21. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins
22. Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules
23. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts
24. Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure
25. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
26. Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
27. Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells
28. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells
29. Subcellular localization of presenilins: Association with a unique membrane pool in cultured cells
30. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
31. Candidate gene for the chromosome 1 familial Alzheimer's disease locus
32. Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins
33. Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
34. Genetic characterization of cytological region 77A-D harboring the presenilin gene of Drosophila melanogaster
35. Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule
36. A loss of function mutant of the presenilin homologue sel-12 undergoes abberant endoproteolysis in Caenorhabditis elegans and increased A-beta-42 generation in human cells
37. Mapping the APP/presenilin (PS) binding domains: The hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction
38. Evidence for a physical interaction between presenilin and Notch
39. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
40. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing
41. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants
42. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
43. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
44. Alzheimer's disease: Genes, proteins, and therapy
45. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling
46. Skeletal and CNS defects in Presenilin-1-deficient mice
47. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
48. Gamma-secretase: Enigmatic as ever
49. Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and Notch processing
50. Intramembrane proteolysis by presenilins
51. The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing
52. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis
53. Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
54. Presenilin is required for activity and nuclear access of Notch in Drosophila
55. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
56. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors
57. Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18
58. Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion
59. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42
60. C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin
61. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins
62. Inhibiting amyloid precursor protein C-terminal cleavage promotes an Interaction with presenilin 1
63. Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and beta-amyloid precursor protein
64. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity
65. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease
66. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm
67. Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease
68. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation
69. Telencephalin: A neuronal area code molecule?
70. An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression
71. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
72. App processing and synaptic plasticity in presenilin-1 conditional knockout mice