Novel γ-secretase enzyme modulators directly target presenilin protein

Journal of Biological Chemistry

Volumn 286, Issue 43, 2011, Pages 37181-37186

  Ebke, Amelie ^a,b   Luebbers, Thomas ^d   Fukumori, Akio ^a,b   Shirotani, Keiro ^c   Haass, Christian ^a,b   Baumann, Karlheinz ^d   Steiner, Harald ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATION; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; C-TERMINAL FRAGMENTS; CATALYTIC SUBUNITS; DRUG TARGETS; HYDROPHOBIC PEPTIDES; MOLECULAR TARGETS; N-TERMINALS; PHOTOPROBES; PHYSIOLOGICAL FUNCTIONS; PRESENILINS; SECOND GENERATION; SECRETASES; STRUCTURAL CLASS;

AMINO ACIDS; ENZYME ACTIVITY; GLYCOPROTEINS; MOLECULAR PHYSICS; PEPTIDES;

BINDING SITES;

AMINO TERMINAL TELOPEPTIDE; AMYLOID BETA PROTEIN; BEGACESTAT; CARBOXY TERMINAL TELOPEPTIDE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; L 685 458; LY 411 575; PEPTIDE FRAGMENT; PRESENILIN; PROTEIN SUBUNIT; RO 57; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION;

ALLOSTERIC REGULATION; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; BINDING SITES; HEK293 CELLS; HUMANS; PRESENILINS; PROTEIN STRUCTURE, TERTIARY;

EID: 80054801471     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C111.276972     Document Type: Article

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