A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 22, 2003, Pages 13075-13080

  Schroeter, Eric H ^a   Ilagan, Ma Xenia G ^a   Brunkan, Anne L ^a   Hecimovic, Silva ^a   Li, Yue Ming ^b   Xu, Min ^b   Lewis, Huw D ^d   Saxena, Meera T ^a   De Strooper, Bart ^g   Coonrod, Archie ^a   Tomita, Taisuke ^c   Iwatsubo, Takeshi ^c   Moore, Chad L ^f   Goate, Alison ^a   Wolfe, Michael S ^e,f   Shearman, Mark ^d   Kopan, Raphael ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

^d NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^e Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

^f UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^g UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELLS, CULTURED; DIMERIZATION; ENDOPEPTIDASES; FIBROBLASTS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PRESENILIN-1; PRESENILIN-2; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0242331600     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1735338100     Document Type: Article

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