Deducing the transmembrane domain organization of presenilin-1 in γ-secretase by cysteine disulfide cross-linking

Biochemistry

Volumn 45, Issue 24, 2006, Pages 7598-7604

  Kornilova, Anna Y ^a,b   Kim, Jennifer ^a   Laudon, Hanna ^a   Wolfe, Michael S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CATALYSIS; CROSSLINKING; DISEASES; ENZYME KINETICS; OXIDATION;

ALZHEIMER'S DISEASE; PRESENILIN; TRANSMEMBRANE; TRANSMEMBRANE DOMAIN (TMD);

ENZYMES;

ASPARTIC PROTEINASE; CYSTEINE; DISULFIDE; ENZYME INHIBITOR; GAMMA SECRETASE; MEMBRANE PROTEIN; PRESENILIN 1;

ALLOSTERISM; ALZHEIMER DISEASE; ARTICLE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; MUTAGENESIS; OXIDATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN STRUCTURE; TRANSMEMBRANE DOMAIN;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID; ASPARTIC ENDOPEPTIDASES; BINDING SITES; BLASTOCYST; CELLS, CULTURED; CONSERVED SEQUENCE; CROSS-LINKING REAGENTS; CYSTEINE; DISULFIDES; ENDOPEPTIDASES; ENZYME INHIBITORS; FEMALE; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICROSOMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; OXIDATION-REDUCTION; PREGNANCY; PRESENILIN-1; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STEM CELLS;

EID: 33745152311     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060107k     Document Type: Article

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