Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

Journal of Biological Chemistry

Volumn 279, Issue 49, 2004, Pages 50790-50798

  Friedmann, Elena ^a   Lemberg, Marius K ^a,c   Weihofen, Andreas ^a,d   Dev, Kumlesh K ^b   Dengler, Uwe ^b   Rovelli, Giorgio ^b   Martoglio, Bruno ^a  

^a ETH ZURICH   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CATALYSIS; GENES; HYDROPHILICITY; SUBSTRATES;

GENOME ENCODES; IMMUNE SURVEILLANCE; MEMBRANE INSERTION; PROTEASES;

ENZYMES;

ASPARTIC PROTEINASE; GLYCAN DERIVATIVE; PEPTIDASE; PRESENILIN 1; PRESENILIN 2; PROTEIN SPPL; PROTEIN SPPL2A; PROTEIN SPPL2B; PROTEIN SPPL2C; PROTEIN SPPL3; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPARATIVE STUDY; CONSENSUS SEQUENCE; CONTROLLED STUDY; CYTOSOL; EXTRACELLULAR SPACE; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ASPARTIC ENDOPEPTIDASES; BINDING SITES; BLOTTING, WESTERN; CATALYSIS; CATALYTIC DOMAIN; CELL LINE; CELL-FREE SYSTEM; CLONING, MOLECULAR; CYTOSOL; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE LIBRARY; GLYCOSYLATION; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHYLOGENY; PLASMIDS; POLYSACCHARIDES; PRESENILIN-1; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RNA, MESSENGER; TISSUE DISTRIBUTION; TRANSCRIPTION, GENETIC;

EID: 10944270703     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407898200     Document Type: Article

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