Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets

EMBO Journal

Volumn 21, Issue 15, 2002, Pages 3980-3988

  McLauchlan, John ^a   Lemberg, Marius K ^a   Hope, Graham ^a   Martoglio, Bruno ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Aspartic protease; HCV; Lipid metabolism; SPP; Viral polyprotein processing

Indexed keywords

CORE PROTEIN; ENVELOPE PROTEIN; GLYCOPROTEIN E1; LIPID; POLYPROTEIN; RNA; SIGNAL PEPTIDASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; ENDOPLASMIC RETICULUM; HEPATITIS C VIRUS; LIPID TRANSPORT; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RNA ANALYSIS; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CRICETINAE; ENDOPLASMIC RETICULUM; HEPACIVIRUS; INCLUSION BODIES; KIDNEY; LIPID METABOLISM; MEMBRANE PROTEINS; MESOCRICETUS; MOLECULAR SEQUENCE DATA; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; SERINE ENDOPEPTIDASES; VIRAL CORE PROTEINS; VIRAL ENVELOPE PROTEINS;

HEPATITIS C VIRUS; INSERTION SEQUENCES; RNA VIRUSES;

EID: 0036683052     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf414     Document Type: Article

References (45)

1. Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing
2. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
3. An infectious molecular clone of a Japanese genotype 1b hepatitis C virus
4. Lipid droplets: Proteins floating on a pool of fat
5. Sequence analysis of the core gene of 14 hepatitis C virus genotypes
6. Molecular virology of hepatitis C virus
7. A retention signal necessary and sufficient for endoplasmic reticulum localization maps to the transmembrane domain of hepatitis C virus glycoprotein E2
8. The transmembrane domain of hepatitis C virus glycoprotein E1 is a signal for static retention in the endoplasmic reticulum
9. Pathology of hepatitis C virus infection
10. Cytosolic deglycosylation process of newly synthesized glycoproteins generates oligomannosides possessing one GIcNAc residue at the reducing end
11. Purification of microsomal signal peptidase as a complex
12. The C-terminal region of the hepatitis C virus E1 glycoprotein confers localization within the endoplasmic reticulum
13. Isolation of intracellular membranes by means of sodium carbonate treatment: Application to endoplasmic reticulum
14. Expression and identification of hepatitis C virus polyprotein cleavage products
15. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis
16. Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein
17. Hepatitis C virus core protein: Carboxy-terminal boundaries of two processed species suggest cleavage by a signal peptide peptidase
18. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA
19. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
20. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
21. Rubella virus E2 signal peptide is required for perinuclear localization of capsid protein and virus assembly
22. Intramembrane proteolysis of signal peptides: An essential step in the generation of HLA-E epitopes
23. Flaviviridae: The viruses and their replication
24. Regulated processing of hepatitis C virus core protein is linked to subcellular localization
25. Signal sequences: More than just greasy peptides
26. Cotranslational translocation of proteins into microsomes derived from the rough endoplasmic reticulum of mammalian cells
27. Processing of the Semliki Forest virus structural polyprotein: Role of the capsid protease
28. Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core protein
29. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
30. Mechanisms of lipid-body formation
31. Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets
32. Covalent interactions are not required to permit or stabilize the non-covalent association of hepatitis C virus glycoproteins E1 and E2
33. The transmembrane domain of the hepatitis C virus E2 glycoprotein is required for correct folding of the E1 glycoprotein and native complex formation
34. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: A model of viral-related steatosis
35. Persistent and transient replication of full-length hepatitis C virus genomes in cell culture
36. Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses
37. Biosynthesis and biochemical properties of the hepatitis C virus core protein
38. Togaviridae: The viruses and their replication
39. Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane
40. Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor
41. Identification of signal peptide peptidase, a presenilin-type aspartic protease
42. Improved electrophoretic separation and immunoblotting of β-amyloid (Aβ) peptides 1-40, 1-42 and 1-43
43. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee
44. Hepatitis C virus: An infectious molecular clone of a second major genotype (2a) and lack of viability of intertypic la and 2a chimeras
45. The native form and maturation process of hepatitis C virus core protein