When loss is gain: Reduced presenilin proteolytic function leads to increased Aβ42/Aβ40. Talking Point on the role of presenilin mutations in Alzheimer disease

EMBO Reports

Volumn 8, Issue 2, 2007, Pages 136-140

  Wolfe, Michael S ^a  

^a Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; ASPARTIC ACID; BETA SECRETASE; EPIDERMAL GROWTH FACTOR RECEPTOR 4; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GROWTH HORMONE RECEPTOR; HERMES ANTIGEN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; NECTIN 1; NERVE CELL ADHESION MOLECULE; NEU DIFFERENTIATION FACTOR; NICASTRIN; NONSTEROID ANTIINFLAMMATORY AGENT; PRESENILIN 1; PRESENILIN 2; PROTEIN PS2; PROTEINASE; TAU PROTEIN; UVOMORULIN;

ALLELE; ALZHEIMER DISEASE; BINDING SITE; BIOCHEMISTRY; CELL SURVIVAL; CHROMOSOME 21; DEATH; DISEASE SEVERITY; DOWN SYNDROME; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; MEMORY DISORDER; MISSENSE MUTATION; NEUROFIBRILLARY TANGLE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; HUMANS; MODELS, BIOLOGICAL; MUTATION; PEPTIDE FRAGMENTS; PRESENILINS;

EID: 33947242870     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400896     Document Type: Review

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