The levels of mature glycosylated nicastrin are regulated and correlate with γ-secretase processing of amyloid β-precursor protein

Journal of Neurochemistry

Volumn 83, Issue 5, 2002, Pages 1065-1071

  Arawaka, Shigeki ^a,b   Hasegawa, Hiroshi ^a   Tandon, Anurag ^a   Janus, Christopher ^a   Chen, Fusheng ^a   Yu, Gang ^a   Kikuchi, Kenji ^b   Koyama, Shingo ^b   Kato, Takeo ^b   Fraser, Paul E ^a,c   St George Hyslop, Peter ^a,c,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b YAMAGATA UNIVERSITY   (Japan)

^c UNIVERSITY OF TORONTO   (Canada)

^d TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

amyloid precursor protein; Nicastrin; Notch; Presenilin; Secretase

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; MUTANT PROTEIN; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1;

ALZHEIMER DISEASE; ARTICLE; CELL MUTANT; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING;

AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL LINE; ENDOPEPTIDASES; GLYCOSIDE HYDROLASES; GLYCOSYLATION; HUMANS; KIDNEY; MEMBRANE GLYCOPROTEINS; MUTATION; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 18744371544     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01207.x     Document Type: Article

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