Potential for therapeutic manipulation of the UPR in disease

Seminars in Immunopathology

Volumn 35, Issue 3, 2013, Pages 351-373

  Park, Sang Won ^a   Ozcan, Umut ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Chemical chaperone; Endoplasmic reticulum (ER) stress; Insulin resistance; Type 2 diabetes; XBP1

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 6; ACTIVATING TRANSCRIPTION FACTOR 6ALPHA; BORTEZOMIB; CALCIUM; CHAPERONE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN IRE1; PROTEIN KINASE; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ALZHEIMER DISEASE; APOPTOSIS; AUTOSOMAL RECESSIVE DISORDER; CALCIUM HOMEOSTASIS; CELL DESTRUCTION; CYSTIC FIBROSIS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GLIOBLASTOMA; GLIOMA; GLUCOSE INTOLERANCE; HEMATOLOGIC MALIGNANCY; HUMAN; HUNTINGTON CHOREA; HYPERGLYCEMIA; HYPOINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; MULTIPLE MYELOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MISFOLDING; REVIEW; TUBEROUS SCLEROSIS; TUMOR GROWTH; UNFOLDED PROTEIN RESPONSE; WOLCOTT RALLISON SYNDROME;

ANIMALS; DRUG THERAPY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMANS; MOLECULAR CHAPERONES; UNFOLDED PROTEIN RESPONSE;

EID: 84881478531     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-013-0370-z     Document Type: Review

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