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Volumn 184, Issue 8, 2010, Pages 4538-4546

Evidence for unfolded protein response activation in monocytes from individuals with α-1 antitrypsin deficiency

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ALPHA 1 ANTITRYPSIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; X BOX BINDING PROTEIN 1; CYTOKINE;

EID: 77952770299     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0802864     Document Type: Article
Times cited : (99)

References (63)
  • 1
    • 0033562966 scopus 로고    scopus 로고
    • Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
    • Kaufman, R. J. 1999. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 13: 1211-1233.
    • (1999) Genes Dev. , vol.13 , pp. 1211-1233
    • Kaufman, R.J.1
  • 2
    • 0034716887 scopus 로고    scopus 로고
    • Tripartite management of unfolded proteins in the endoplasmic reticulum
    • Mori, K. 2000. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101: 451-454.
    • (2000) Cell , vol.101 , pp. 451-454
    • Mori, K.1
  • 3
    • 36248949141 scopus 로고    scopus 로고
    • The endoplasmic reticulum and the unfolded protein response
    • Malhotra, J. D., and R. J. Kaufman. 2007. The endoplasmic reticulum and the unfolded protein response. Semin. Cell Dev. Biol. 18: 716-731.
    • (2007) Semin. Cell Dev. Biol. , vol.18 , pp. 716-731
    • Malhotra, J.D.1    Kaufman, R.J.2
  • 4
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic-reticulum- resident kinase
    • Harding, H. P., Y. Zhang, and D. Ron. 1999. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274.
    • (1999) Nature , vol.397 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 6
    • 0032525990 scopus 로고    scopus 로고
    • A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
    • Tirasophon, W., A. A. Welihinda, and R. J. Kaufman. 1998. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12: 1812-1824.
    • (1998) Genes Dev. , vol.12 , pp. 1812-1824
    • Tirasophon, W.1    Welihinda, A.A.2    Kaufman, R.J.3
  • 7
    • 0035966269 scopus 로고    scopus 로고
    • XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
    • Yoshida, H., T. Matsui, A. Yamamoto, T. Okada, and K. Mori. 2001. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107: 881-891.
    • (2001) Cell , vol.107 , pp. 881-891
    • Yoshida, H.1    Matsui, T.2    Yamamoto, A.3    Okada, T.4    Mori, K.5
  • 8
    • 0032509216 scopus 로고    scopus 로고
    • Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors
    • Yoshida, H., K. Haze, H. Yanagi, T. Yura, and K. Mori. 1998. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 273: 33741-33749.
    • (1998) J. Biol. Chem. , vol.273 , pp. 33741-33749
    • Yoshida, H.1    Haze, K.2    Yanagi, H.3    Yura, T.4    Mori, K.5
  • 9
    • 0034724520 scopus 로고    scopus 로고
    • Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
    • Travers, K. J., C. K. Patil, L. Wodicka, D. J. Lockhart, J. S. Weissman, and P. Walter. 2000. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101: 249-258.
    • (2000) Cell , vol.101 , pp. 249-258
    • Travers, K.J.1    Patil, C.K.2    Wodicka, L.3    Lockhart, D.J.4    Weissman, J.S.5    Walter, P.6
  • 10
    • 84907041622 scopus 로고
    • The electrophoretic alpha-globulin pattern of serum in alpha1-antitrypsin deficiency
    • Laurell, C. B., and S. E. Eriksson. 1963. The electrophoretic alpha-globulin pattern of serum in alpha1-antitrypsin deficiency. Scand. J. Clin. Lab. Invest. 15: 132-140.
    • (1963) Scand. J. Clin. Lab. Invest. , vol.15 , pp. 132-140
    • Laurell, C.B.1    Eriksson, S.E.2
  • 11
    • 0032085755 scopus 로고    scopus 로고
    • Genetics and respiratory disease. 2. Alpha 1-antitrypsin deficiency, cirrhosis and emphysema
    • Mahadeva, R., and D. A. Lomas. 1998. Genetics and respiratory disease. 2. Alpha 1-antitrypsin deficiency, cirrhosis and emphysema. Thorax 53: 501-505.
    • (1998) Thorax , vol.53 , pp. 501-505
    • Mahadeva, R.1    Lomas, D.A.2
  • 13
    • 0023795389 scopus 로고
    • Clinical features and history of the destructive lung disease associated with alpha-1-antitrypsin deficiency of adults with pulmonary symptoms
    • Brantly, M. L., L. D. Paul, B. H. Miller, R. T. Falk, M. Wu, and R. G. Crystal. 1988. Clinical features and history of the destructive lung disease associated with alpha-1-antitrypsin deficiency of adults with pulmonary symptoms. Am. Rev. Respir. Dis. 138: 327-336.
    • (1988) Am. Rev. Respir. Dis. , vol.138 , pp. 327-336
    • Brantly, M.L.1    Paul, L.D.2    Miller, B.H.3    Falk, R.T.4    Wu, M.5    Crystal, R.G.6
  • 14
    • 0022852281 scopus 로고
    • Alpha 1-Antitrypsin: Molecular pathology, leukocytes, and tissue damage
    • Carrell, R. W. 1986. alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage. J. Clin. Invest. 78: 1427-1431.
    • (1986) J. Clin. Invest. , vol.78 , pp. 1427-1431
    • Carrell, R.W.1
  • 15
    • 0026755363 scopus 로고
    • The mechanism of Z alpha 1-antitrypsin accumulation in the liver
    • Lomas, D. A., D. L. Evans, J. T. Finch, and R. W. Carrell. 1992. The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature 357: 605-607.
    • (1992) Nature , vol.357 , pp. 605-607
    • Lomas, D.A.1    Evans, D.L.2    Finch, J.T.3    Carrell, R.W.4
  • 16
    • 0037385313 scopus 로고    scopus 로고
    • Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
    • Iwakoshi, N. N., A. H. Lee, P. Vallabhajosyula, K. L. Otipoby, K. Rajewsky, and L. H. Glimcher. 2003. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat. Immunol. 4: 321-329.
    • (2003) Nat. Immunol. , vol.4 , pp. 321-329
    • Iwakoshi, N.N.1    Lee, A.H.2    Vallabhajosyula, P.3    Otipoby, K.L.4    Rajewsky, K.5    Glimcher, L.H.6
  • 17
    • 47049098902 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1
    • Smith, J. A., M. J. Turner, M. L. DeLay, E. I. Klenk, D. P. Sowders, and R. A. Colbert. 2008. Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1. Eur. J. Immunol. 38: 1194-1203.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1194-1203
    • Smith, J.A.1    Turner, M.J.2    DeLay, M.L.3    Klenk, E.I.4    Sowders, D.P.5    Colbert, R.A.6
  • 18
    • 20444461628 scopus 로고    scopus 로고
    • Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: Model of NF-kappaB- And map kinase-dependent inflammation in advanced atherosclerosis
    • Li, Y., R. F. Schwabe, T. DeVries-Seimon, P. M. Yao, M. C. Gerbod-Giannone, A. R. Tall, R. J. Davis, R. Flavell, D. A. Brenner, and I. Tabas. 2005. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J. Biol. Chem. 280: 21763-21772.
    • (2005) J. Biol. Chem. , vol.280 , pp. 21763-21772
    • Li, Y.1    Schwabe, R.F.2    DeVries-Seimon, T.3    Yao, P.M.4    Gerbod-Giannone, M.C.5    Tall, A.R.6    Davis, R.J.7    Flavell, R.8    Brenner, D.A.9    Tabas, I.10
  • 19
    • 0022472015 scopus 로고
    • Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals
    • Mornex, J. F., A. Chytil-Weir, Y. Martinet, M. Courtney, J. P. LeCocq, and R. G. Crystal. 1986. Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals. J. Clin. Invest. 77: 1952-1961.
    • (1986) J. Clin. Invest. , vol.77 , pp. 1952-1961
    • Mornex, J.F.1    Chytil-Weir, A.2    Martinet, Y.3    Courtney, M.4    LeCocq, J.P.5    Crystal, R.G.6
  • 21
    • 0036088988 scopus 로고    scopus 로고
    • Cell-specific involvement of HNF-1beta in alpha(1)-antitrypsin gene expression in human respiratory epithelial cells
    • Hu, C., and D. H. Perlmutter. 2002. Cell-specific involvement of HNF-1beta in alpha(1)-antitrypsin gene expression in human respiratory epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L757-L765.
    • (2002) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.282
    • Hu, C.1    Perlmutter, D.H.2
  • 22
    • 2342614277 scopus 로고
    • The cellular defect in alpha 1-proteinase inhibitor (alpha 1-PI) deficiency is expressed in human monocytes and in Xenopus oocytes injected with human liver mRNA
    • Perlmutter, D. H., R. M. Kay, F. S. Cole, T. H. Rossing, D. Van Thiel, and H. R. Colten. 1985. The cellular defect in alpha 1-proteinase inhibitor (alpha 1-PI) deficiency is expressed in human monocytes and in Xenopus oocytes injected with human liver mRNA. Proc. Natl. Acad. Sci. USA 82: 6918-6921.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 6918-6921
    • Perlmutter, D.H.1    Kay, R.M.2    Cole, F.S.3    Rossing, T.H.4    Van Thiel, D.5    Colten, H.R.6
  • 23
    • 0034721232 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease
    • Barnes, P. J. 2000. Chronic obstructive pulmonary disease. N. Engl. J. Med. 343: 269-280.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 269-280
    • Barnes, P.J.1
  • 24
    • 0023147734 scopus 로고
    • Lung lavage fluid from patients with alpha 1-proteinase inhibitor deficiency or chronic obstructive bronchitis: Anti-elastase function and cell profile
    • Morrison, H. M., J. A. Kramps, D. Burnett, and R. A. Stockley. 1987. Lung lavage fluid from patients with alpha 1-proteinase inhibitor deficiency or chronic obstructive bronchitis: anti-elastase function and cell profile. Clin. Sci. (Lond.) 72: 373-381.
    • (1987) Clin. Sci. (Lond.) , vol.72 , pp. 373-381
    • Morrison, H.M.1    Kramps, J.A.2    Burnett, D.3    Stockley, R.A.4
  • 25
    • 4644313798 scopus 로고    scopus 로고
    • Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered
    • Zaman, M.M.,A.Gelrud, O. Junaidi, M. M. Regan, M.Warny, J. C. Shea, C.Kelly, B. P. O'Sullivan, and S. D. Freedman. 2004. Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered. Clin. Diagn. Lab. Immunol. 11: 819-824.
    • (2004) Clin. Diagn. Lab. Immunol. , vol.11 , pp. 819-824
    • Zaman, M.M.1    Gelrud, A.2    Junaidi, O.3    Regan, M.M.4    Warny, M.5    Shea, J.C.6    Kelly, C.7    O'Sullivan, B.P.8    Freedman, S.D.9
  • 26
    • 33745190973 scopus 로고    scopus 로고
    • Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: Therapeutic implications
    • Vij, N., S. Fang, and P. L. Zeitlin. 2006. Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. J. Biol. Chem. 281: 17369-17378.
    • (2006) J. Biol. Chem. , vol.281 , pp. 17369-17378
    • Vij, N.1    Fang, S.2    Zeitlin, P.L.3
  • 27
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 28
    • 0037011917 scopus 로고    scopus 로고
    • IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    • Calfon,M., H. Zeng, F. Urano, J. H. Till, S. R. Hubbard, H. P. Harding, S. G. Clark, and D. Ron. 2002. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415: 92-96.
    • (2002) Nature , vol.415 , pp. 92-96
    • Calfon, M.1    Zeng, H.2    Urano, F.3    Till, J.H.4    Hubbard, S.R.5    Harding, H.P.6    Clark, S.G.7    Ron, D.8
  • 29
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • Guha, M., and N. Mackman. 2001. LPS induction of gene expression in human monocytes. Cell. Signal. 13: 85-94.
    • (2001) Cell. Signal. , vol.13 , pp. 85-94
    • Guha, M.1    Mackman, N.2
  • 30
    • 0031960313 scopus 로고    scopus 로고
    • A tool coming of age: Thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases
    • Treiman, M., C. Caspersen, and S. B. Christensen. 1998. A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases. Trends Pharmacol. Sci. 19: 131-135.
    • (1998) Trends Pharmacol. Sci. , vol.19 , pp. 131-135
    • Treiman, M.1    Caspersen, C.2    Christensen, S.B.3
  • 31
    • 0018415093 scopus 로고
    • Tunicamycin-mediated depletion of insulin receptors in 3T3-L1 adipocytes
    • Rosen, O. M., G. H. Chia, C. Fung, and C. S. Rubin. 1979. Tunicamycin-mediated depletion of insulin receptors in 3T3-L1 adipocytes. J. Cell. Physiol. 99: 37-42.
    • (1979) J. Cell. Physiol. , vol.99 , pp. 37-42
    • Rosen, O.M.1    Chia, G.H.2    Fung, C.3    Rubin, C.S.4
  • 32
    • 33744962234 scopus 로고    scopus 로고
    • Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78
    • Misra, U. K., R. Deedwania, and S. V. Pizzo. 2006. Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. J. Biol. Chem. 281: 13694-13707.
    • (2006) J. Biol. Chem. , vol.281 , pp. 13694-13707
    • Misra, U.K.1    Deedwania, R.2    Pizzo, S.V.3
  • 33
    • 34250164656 scopus 로고    scopus 로고
    • XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line
    • Hu, M. C., H. Y. Gong, G. H. Lin, S. Y. Hu, M. H. Chen, S. J. Huang, C. F. Liao, and J. L. Wu. 2007. XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line. Biochem. Biophys. Res. Commun. 359: 778-783.
    • (2007) Biochem. Biophys. Res. Commun. , vol.359 , pp. 778-783
    • Hu, M.C.1    Gong, H.Y.2    Lin, G.H.3    Hu, S.Y.4    Chen, M.H.5    Huang, S.J.6    Liao, C.F.7    Wu, J.L.8
  • 34
    • 43349158916 scopus 로고    scopus 로고
    • New concepts in the pathobiology of chronic obstructive pulmonary disease
    • Kim, V., T. J. Rogers, and G. J. Criner. 2008. New concepts in the pathobiology of chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 5: 478-485.
    • (2008) Proc. Am. Thorac. Soc. , vol.5 , pp. 478-485
    • Kim, V.1    Rogers, T.J.2    Criner, G.J.3
  • 36
    • 0019833479 scopus 로고
    • The accumulation of three specific proteins related to glucose-regulated proteins in a temperature-sensitive hamster mutant cell line K12
    • Lee, A. S. 1981. The accumulation of three specific proteins related to glucose-regulated proteins in a temperature-sensitive hamster mutant cell line K12. J. Cell. Physiol. 106: 119-125.
    • (1981) J. Cell. Physiol. , vol.106 , pp. 119-125
    • Lee, A.S.1
  • 37
    • 34447558236 scopus 로고    scopus 로고
    • ER chaperones in mammalian development and human diseases
    • Ni, M., and A. S. Lee. 2007. ER chaperones in mammalian development and human diseases. FEBS Lett. 581: 3641-3651.
    • (2007) FEBS Lett. , vol.581 , pp. 3641-3651
    • Ni, M.1    Lee, A.S.2
  • 39
    • 0033210210 scopus 로고    scopus 로고
    • GRP94, an ER chaperone with protein and peptide binding properties
    • Argon, Y., and B. B. Simen. 1999. GRP94, an ER chaperone with protein and peptide binding properties. Semin. Cell Dev. Biol. 10: 495-505.
    • (1999) Semin. Cell Dev. Biol. , vol.10 , pp. 495-505
    • Argon, Y.1    Simen, B.B.2
  • 40
    • 26244431960 scopus 로고    scopus 로고
    • Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane
    • Lilley, B. N., and H. L. Ploegh. 2005. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proc. Natl. Acad. Sci. USA 102: 14296-14301.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 14296-14301
    • Lilley, B.N.1    Ploegh, H.L.2
  • 41
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • Schröder, M., and R. J. Kaufman. 2005. The mammalian unfolded protein response. Annu. Rev. Biochem. 74: 739-789.
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 739-789
    • Schröder, M.1    Kaufman, R.J.2
  • 42
    • 10344222124 scopus 로고    scopus 로고
    • The role of the unfolded protein response in tumour development: Friend or foe?
    • Ma, Y., and L. M. Hendershot. 2004. The role of the unfolded protein response in tumour development: friend or foe? Nat. Rev. Cancer 4: 966-977.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 966-977
    • Ma, Y.1    Hendershot, L.M.2
  • 43
    • 10344253840 scopus 로고    scopus 로고
    • Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death
    • Hu, P., Z. Han, A. D. Couvillon, and J. H. Exton. 2004. Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J. Biol. Chem. 279: 49420-49429.
    • (2004) J. Biol. Chem. , vol.279 , pp. 49420-49429
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Exton, J.H.4
  • 44
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S. R., A. Brunet, and M. E. Greenberg. 1999. Cellular survival: a play in three Akts. Genes Dev. 13: 2905-2927.
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 45
    • 65949106608 scopus 로고    scopus 로고
    • Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt
    • Jiang, C. C., F. Yang, R. F. Thorne, B. K. Zhu, P. Hersey, and X. D. Zhang. 2009. Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt. Neoplasia 11: 436-447.
    • (2009) Neoplasia , vol.11 , pp. 436-447
    • Jiang, C.C.1    Yang, F.2    Thorne, R.F.3    Zhu, B.K.4    Hersey, P.5    Zhang, X.D.6
  • 46
    • 77953859606 scopus 로고    scopus 로고
    • NF-kappaB as a critical link between inflammation and cancer
    • Karin, M. 2009. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harbor Perspect Biol 1: a000141.
    • (2009) Cold Spring Harbor Perspect Biol , vol.1
    • Karin, M.1
  • 47
    • 1442321303 scopus 로고    scopus 로고
    • Activation signal of nuclear factorkappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2
    • Kaneko,M.,Y. Niinuma, andY. Nomura. 2003. Activation signal of nuclear factorkappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2. Biol. Pharm. Bull. 26: 931-935.
    • (2003) Biol. Pharm. Bull. , vol.26 , pp. 931-935
    • Kaneko, M.1    Niinuma, Y.2    Nomura, Y.3
  • 48
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano, F., X. Wang, A. Bertolotti, Y. Zhang, P. Chung, H. P. Harding, and D. Ron. 2000. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287: 664-666.
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 49
    • 0035033952 scopus 로고    scopus 로고
    • Signalling for survival and death in neurones: The role of stress-activated kinases, JNK and p38
    • Harper, S. J., and P. LoGrasso. 2001. Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38. Cell. Signal. 13: 299-310.
    • (2001) Cell. Signal. , vol.13 , pp. 299-310
    • Harper, S.J.1    LoGrasso, P.2
  • 51
    • 0024423822 scopus 로고
    • Synthesis of stress proteins is increased in individuals with homozygous PiZZ alpha 1-antitrypsin deficiency and liver disease
    • Perlmutter, D. H., M. J. Schlesinger, J. A. Pierce, P. I. Punsal, and A. L. Schwartz. 1989. Synthesis of stress proteins is increased in individuals with homozygous PiZZ alpha 1-antitrypsin deficiency and liver disease. J. Clin. Invest. 84: 1555-1561.
    • (1989) J. Clin. Invest. , vol.84 , pp. 1555-1561
    • Perlmutter, D.H.1    Schlesinger, M.J.2    Pierce, J.A.3    Punsal, P.I.4    Schwartz, A.L.5
  • 52
    • 0025278926 scopus 로고
    • Biosynthesis and secretion of M- and Z-type alpha 1-proteinase inhibitor by human monocytes. Effect of inhibitors of glycosylation and of oligosaccharide processing on secretion and function
    • Gross, V., D. vom Berg, J. Kreuzkamp, U. Ganter, J. Bauer, G. Würtemberger, C. Schulz-Huotari, H. Beeser, and W. Gerok. 1990. Biosynthesis and secretion of M- and Z-type alpha 1-proteinase inhibitor by human monocytes. Effect of inhibitors of glycosylation and of oligosaccharide processing on secretion and function. Biol. Chem. Hoppe Seyler 371: 231-238.
    • (1990) Biol. Chem. Hoppe Seyler , vol.371 , pp. 231-238
    • Gross, V.1    Vom Berg, D.2    Kreuzkamp, J.3    Ganter, U.4    Bauer, J.5    Würtemberger, G.6    Schulz-Huotari, C.7    Beeser, H.8    Gerok, W.9
  • 53
    • 24044535062 scopus 로고    scopus 로고
    • Grp78, Grp94, and Grp170 interact with alpha1-antitrypsin mutants that are retained in the endoplasmic reticulum
    • Schmidt, B. Z., and D. H. Perlmutter. 2005. Grp78, Grp94, and Grp170 interact with alpha1-antitrypsin mutants that are retained in the endoplasmic reticulum. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G444-G455.
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.289
    • Schmidt, B.Z.1    Perlmutter, D.H.2
  • 54
    • 28244499949 scopus 로고    scopus 로고
    • Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response
    • Hidvegi, T., B. Z. Schmidt, P. Hale, and D. H. Perlmutter. 2005. Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response. J. Biol. Chem. 280: 39002-39015.
    • (2005) J. Biol. Chem. , vol.280 , pp. 39002-39015
    • Hidvegi, T.1    Schmidt, B.Z.2    Hale, P.3    Perlmutter, D.H.4
  • 55
    • 2142768895 scopus 로고    scopus 로고
    • Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin de- ficiency
    • Lawless, M. W., C. M. Greene, A. Mulgrew, C. C. Taggart, S. J. O'Neill, and N. G. McElvaney. 2004. Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin de- ficiency. J. Immunol. 172: 5722-5726.
    • (2004) J. Immunol. , vol.172 , pp. 5722-5726
    • Lawless, M.W.1    Greene, C.M.2    Mulgrew, A.3    Taggart, C.C.4    O'Neill, S.J.5    McElvaney, N.G.6
  • 56
    • 0024334846 scopus 로고
    • Interferon beta 2/interleukin 6 modulates synthesis of alpha 1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells
    • Perlmutter, D. H., L. T. May, and P. B. Sehgal. 1989. Interferon beta 2/interleukin 6 modulates synthesis of alpha 1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells. J. Clin. Invest. 84: 138-144.
    • (1989) J. Clin. Invest. , vol.84 , pp. 138-144
    • Perlmutter, D.H.1    May, L.T.2    Sehgal, P.B.3
  • 57
    • 0023911386 scopus 로고
    • Elastase regulates the synthesis of its inhibitor, alpha 1-proteinase inhibitor, and exaggerates the defect in homozygous PiZZ alpha 1 PI deficiency
    • Perlmutter, D. H., J. Travis, and P. I. Punsal. 1988. Elastase regulates the synthesis of its inhibitor, alpha 1-proteinase inhibitor, and exaggerates the defect in homozygous PiZZ alpha 1 PI deficiency. J. Clin. Invest. 81: 1774-1780.
    • (1988) J. Clin. Invest. , vol.81 , pp. 1774-1780
    • Perlmutter, D.H.1    Travis, J.2    Punsal, P.I.3
  • 58
    • 0031893793 scopus 로고    scopus 로고
    • Alpha 1-antitrypsin and protease complexation is induced by lipopolysaccharide, interleukin-1beta, and tumor necrosis factor-alpha in monocytes
    • Knoell, D. L., D. R. Ralston, K. R. Coulter, and M. D. Wewers. 1998. Alpha 1-antitrypsin and protease complexation is induced by lipopolysaccharide, interleukin-1beta, and tumor necrosis factor-alpha in monocytes. Am. J. Respir. Crit. Care Med. 157: 246-255.
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 246-255
    • Knoell, D.L.1    Ralston, D.R.2    Coulter, K.R.3    Wewers, M.D.4
  • 59
    • 0021243692 scopus 로고
    • Secretory products of macrophages and their physiological functions
    • Takemura, R., and Z. Werb. 1984. Secretory products of macrophages and their physiological functions. Am. J. Physiol. 246: C1-C9.
    • (1984) Am. J. Physiol. , vol.246
    • Takemura, R.1    Werb, Z.2
  • 60
    • 0026229834 scopus 로고
    • Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages
    • Hubbard, R. C., G. Fells, J. Gadek, S. Pacholok, J. Humes, and R. G. Crystal. 1991. Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages. J. Clin. Invest. 88: 891-897.
    • (1991) J. Clin. Invest. , vol.88 , pp. 891-897
    • Hubbard, R.C.1    Fells, G.2    Gadek, J.3    Pacholok, S.4    Humes, J.5    Crystal, R.G.6


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