Intracellular signaling from the endoplasmic reticulum to the nucleus: The unfolded protein response in yeast and mammals

Current Opinion in Cell Biology

Volumn 13, Issue 3, 2001, Pages 349-355

  Patil, C ^a   Walter, P ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CELL CYCLE; CELL NUCLEUS; CELL SURVIVAL; ENDOPLASMIC RETICULUM; GENETIC TRANSCRIPTION; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; YEAST;

EID: 0035370949     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00219-2     Document Type: Review

References (54)

1. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
2. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
3. The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation
4. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response
5. Translational attenuation mediated by an mRNA intron
6. Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response
7. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
8. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response
9. Unconventional splicing of HAC1/ERN4 mRNA required for the unfolded protein response. Sequence-specific and non-sequential cleavage of the splice sites
10. Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway
11. Signalling from endoplasmic reticulum to nucleus: Transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway
12. Palindrome with spacer of one nucleotide is characteristic of the cis-acting unfolded protein response element in Saccharomyces cerevisiae
13. The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum
14. A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins
15. Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression
16. mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response
17. Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p
18. The transcriptional co-activator ADA5 is required for HAC1 mRNA processing in vivo
19. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response
20. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
21. Cloning of mammalian Ire1 reveals diversity in the ER stress responses
22. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
23. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
24. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
25. Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
26. The unfolded-protein-response pathway in yeast
27. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
28. The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
29. The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex
30. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors
31. Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1
32. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
33. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
34. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
35. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
36. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression
37. Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
38. Perk is essential for translational regulation and cell survival during the unfolded protein response
39. Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis
40. PERK mediates cell-cycle exit during the mammalian unfolded protein response
41. Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression
42. Pausing to decide
43. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
44. The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast
45. Regulation of the dolichol pathway in human fibroblasts by the endoplasmic reticulum unfolded protein response
46. The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein
47. Stress-associated endoplasmic reticulum protein 1 (SERP1)/ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation
48. Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements
49. The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control
50. ER protein quality control and proteasome-mediated protein degradation
51. Retrograde protein translocation: ERADication of secretory proteins in health and disease
52. Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway
53. A regulatory link between ER-associated protein degradation and the unfolded-protein response
54. The engagement of Sec61p in the ER dislocation process