Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

Biochemical Journal

Volumn 355, Issue 1, 2001, Pages 19-28

  Haze, K ^a   Okada, T ^a   Yoshida, H ^a   Yanagi, H ^a   Yura, T ^a   Negishi, M ^a   Mori, K ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Chaperone; Endoplasmic reticulum; Nucleus; Proteolysis; Signalling

Indexed keywords

CELLS; GENES; MUTAGENS; PROTEINS;

UNFOLDED PROTEIN RESPONSE (UPR);

BIOCHEMISTRY;

ACTIVATING TRANSCRIPTION FACTOR 6; CHAPERONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GENE PRODUCT; LEUCINE ZIPPER PROTEIN; MEMBRANE PROTEIN; PROTEIN G13; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; ENDOPLASMIC RETICULUM; EUKARYOTIC CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MAMMAL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN INDUCTION; PROTEIN LOCALIZATION; TRANSCRIPTION REGULATION;

ACTIVATING TRANSCRIPTION FACTOR 6; CELL LINE; CELL NUCLEUS; CREB-BINDING PROTEIN; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; HUMANS; HYDROLYSIS; NUCLEAR PROTEINS; POINT MUTATION; PROTEIN FOLDING; PROTEIN TRANSPORT; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EUKARYOTA; MAMMALIA;

EID: 0035310752     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3550019     Document Type: Article

References (29)

1. Protein folding in the cell
2. The endoplasmic retJculum as a protein folding compartment
3. Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells
4. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins
5. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
6. A transmembrane protein with a cdc2 +/CDC28-refated kinase activity is required for signaling from the ER to the nucleus
7. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
8. Tripartite management of unfolded proteins in the endoplasmic reticulum
9. Identification of the cis-acting endoplasmic reticulum stress response erement responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic-leucine zipper transcription factors
10. The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex
11. Calcium-sensitive transcriptional activation of the proximal CCAAT regulatory element of the grp78/BiP promoter by the human nuclear factor CBF/NF-Y
12. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
13. Stress induction of the mammalian GRP78/BiP protein gene: In vivo genomic footprinting and identification of p7OCORE from human nuclear extract as a DNA-binding component specific to the stress regulatory element
14. ATF6 activated by proteolysis directly binds in the presence of NF-Y (CBF) to the cis-acting element responsible for the mammalian unfolded protein response
15. Interaction of ATF6 and serum response factor
16. The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein
17. A novel Creb family gene telomeric of HLA-DRA in the HLA complex
18. Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce 0ct-2 phospherylation
19. 2+ -ATPase inhibitor thapsigargin
20. Nuclear targeting sequences-a consensus?
21. A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins
22. ATF6 as a transcription activator of the endoplasmic reticulum stress element: Thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1
23. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
24. Cloning of mammalian Ire1 reveals diversity in the ER stress responses
25. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response
26. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
27. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
28. A simple method for displaying the hydropathic character of a protein