New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

Cell

Volumn 104, Issue 4, 2001, Pages 517-529

  Saltiel, Alan R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER; GLYCOGEN; INSULIN; INSULIN RECEPTOR; SULFONYLUREA DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

GLUCONEOGENESIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HORMONAL REGULATION; HUMAN; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0035936763     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00239-2     Document Type: Review

References (104)

1. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene
2. A calpain 10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
3. PPARγ is required for placental, cardiac and adipose tissue development
4. CAP defines a second signaling pathway required for insulin-stimulated glucose transport
5. Free fatty acids and the pathogenesis of type 2 diabetes mellitus
6. Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms
7. Mechanism of fatty acid induced inhibition of glucose uptake
8. The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. Evidence for a potential role for DARPP-32 in insulin action
9. The activation of glycogen synthase by insulin switches from kinase inhibition to phosphatase activation during adipogenesis in 3T3-L1 cells
10. Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta and -gamma in the adult rat
11. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
12. Role of brain insulin receptor in control of body weight and reproduction
13. Differential activation of peroxisome proliferator-activated receptor-gamma by Troglitazone and Rosiglitazone
14. Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation
15. Interactions between insulin resistance and insulin secretion in the development of glucose intolerance
16. Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of the small GTP-binding protein TC10
17. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
18. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
19. Signaling mechanisms that regulate glucose transport
20. Insulin receptor-associated protein tyrosine phosphatase(s): Role in insulin action
21. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
22. Glucagon-like peptide 2
23. Insulin degradation: Progress and potential
24. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
25. Add1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
26. Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
27. Obesity in the new millennium
28. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
29. Insulin resistance and cardiovascular disease
30. The coregulator exchange in transcriptional functions of nuclear receptors
31. Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytes
32. Weight-reducing effects of the plasma protein encoded by the obese gene
33. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
34. A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin
35. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in US adults
36. Maturity onset diabetes of the young: Clinical heterogeneity explained by genetic heterogeneity
37. Evidence for 5′ AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
38. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
39. The role of TNFalpha and TNF receptors in obesity and insulin resistance
40. IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
41. Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate
42. Obesity and insulin resistance
43. Dealing with energy demand: The AMP activated protein kinase
44. Gestational diabetes mellitus
45. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
46. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
47. Mechanisms of insulin resistance in fatless mice
48. Regional adiposity and morbidity
49. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
50. Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects
51. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
52. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
53. New insights into the role and mechanism of glycogen synthase activation by insulin
54. An antidiabetic thiazolidinedione is a high affinity ligand for PPARγ
55. NIDDM genes in mice: Deleterious synergism by both parental genomes contributes to diabetogenic thresholds
56. Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells
57. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
58. Improved insulin-sensitivity in mice heterozygous for PPARγ deficiency
59. Synip: A novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes
60. Organizing glucose disposal: Emerging roles of the glycogen targeting subunits of protein phosphatase 1
61. Regulation of gene expression by insulin
62. Effects of an engineered human anti-TNFa antibody (SDP571) on insulin sensitivity and glycemic control in pateints with NIDDM
63. Regulation of insulin gene transcription
64. PPARγ and the treatment of insulin resistance
65. TNF-alpha and insulin resistance: Summary and future prospects
66. Searching for type 2 diabetes genes in the post-genome era
67. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: A 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
68. Signaling pathways in insulin action: Molecular targets of insulin resistance
69. Molecular basis of insulin-stimulated GLUT4 vesicle trafficking. Location! location! location!
70. 13C/31P NMR studies on the mechanism of insulin resistance in obesity
71. Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
72. The glucose fatty-acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
73. Causal linkage between insulin suppression of liver glucose output in dogs
74. Thiazolidinediones and insulin resistance: Peroxisome proliferator activated receptor gamma activation stimulates expression of the CAP gene
75. Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes
76. Mechanism of free fatty acid-induced insulin resistance in humans
77. Thiazolidinediones in the treatment of insulin resistance and type II diabetes
78. Alterations in the expression and cellular localization of protein kinase C isozymes and are associated with insulin resistance in skeletal muscle of the high-fat fed rat
79. Obesity and diabetes in TNF-a receptor-deficient mice
80. Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase-1 in NIDDM
81. From the cover: Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells
82. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
83. Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance
84. Direct antidiabetic effect of leptin through triglyceride depletion of tissues
85. Insulin selectively increases SREBP-1c mRNA in livers of rats with streptozotocin-induced diabetes
86. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
87. Decreased IRS2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
88. Cellular mechanisms of insulin resistance
89. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
90. Obesity and the regulation of energy balance
91. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
92. The hormone resistin links obesity to diabetes
93. Glucocorticoids and insulin: Complex interaction on brown adipose tissue
94. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
95. Syndromes associated with insulin resistance and acanthosis nigricans
96. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
97. Evolution of β-cell dysfunction in the male Zucker diabetic fatty rat
98. Regulation of fatty acid homeostasis in cells: Novel role of leptin
99. Targeted disruption of the tumor necrosis factor alpha gene: Metabolic consequences in obese and nonobese mice
100. Role of the Src homology 2 (SH2) domain and C-terminus tyrosine phosphorylation sites of SH2-containing inositol phosphatase (SHIP) in the regulation of insulin-induced mitogenesis
101. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic patients
102. Disruption of IRS-2 causes type 2 diabetes in mice
103. A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes
104. Discovery of a small molecule insulin mimetic with antidiabetic activity in mice