Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

Human Molecular Genetics

Volumn 10, Issue 10, 2001, Pages 1049-1059

  Jana, Nihar Ranjan ^a   Zemskov, Evgueni A ^a   Wang, Guang Hui ^a   Nukina, Nobuyuki ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CASPASE 3; CASPASE 9; CYTOCHROME C; CYTOSINE; ECDYSONE; GUANINE; HUNTINGTIN; POLYGLUTAMINE; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN P53; PROTEINASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CATALYSIS; CELL DEATH; CELL LINE; CELL MEMBRANE POTENTIAL; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; DEGENERATIVE DISEASE; ENZYME ACTIVATION; EXON; FEMALE; GENE TARGETING; GENETIC CODE; HUNTINGTON CHOREA; MALE; MITOCHONDRIAL MEMBRANE; MOUSE; NERVE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT;

ANIMALS; APOPTOSIS; CASPASES; CELL LINE; CYSTEINE ENDOPEPTIDASES; CYTOCHROME C GROUP; ENDOPEPTIDASES; ENZYME ACTIVATION; HUMANS; HUNTINGTON DISEASE; IMMUNOBLOTTING; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MULTIENZYME COMPLEXES; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; REPETITIVE SEQUENCES, NUCLEIC ACID; UBIQUITINS;

ANIMALIA; MUS MUSCULUS;

EID: 0035336658     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.10.1049     Document Type: Article

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