메뉴 건너뛰기




Volumn 72, Issue , 2009, Pages 219-246

Macrophages, inflammation, and insulin resistance

Author keywords

Adipose tissue; Kupffer cell; Obesity; Skeletal muscle

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADVANCED GLYCATION END PRODUCT; CHEMOKINE; DOCOSAHEXAENOIC ACID; ETANERCEPT; FATTY ACID; GLUCOSE; ICOSAPENTAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SALICYLIC ACID; SALSALATE; STAT6 PROTEIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; ANTIINFLAMMATORY AGENT;

EID: 77951918926     PISSN: 00664278     EISSN: 15451585     Source Type: Book Series    
DOI: 10.1146/annurev-physiol-021909-135846     Document Type: Review
Times cited : (2209)

References (155)
  • 1
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: Modulation by nutrients and inflammation
    • Schenk S, Saberi M, Olefsky JM. 2008. Insulin sensitivity: modulation by nutrients and inflammation. J. Clin. Investig. 118:2992-3002
    • (2008) J. Clin. Investig. , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 3
    • 47149096915 scopus 로고    scopus 로고
    • Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity
    • Heilbronn LK, Campbell LV. 2008. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr. Pharm. Des. 14:1225-1230
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 1225-1230
    • Heilbronn, L.K.1    Campbell, L.V.2
  • 5
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. 2003. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Investig. 112:1821-1830
    • (2003) J. Clin. Investig. , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5
  • 6
    • 18744402065 scopus 로고    scopus 로고
    • Epidemiology of type 2 diabetes mellitus
    • ed.DLeRoith, SITaylor, JMOlefsky Philadelphia: Lippincott Williams &Wilkins
    • Dabelea D, Hamman RF. 2004. Epidemiology of type 2 diabetes mellitus. In Type 2 Diabetes Mellitus: A Fundamental and Clinical Text, ed.DLeRoith, SITaylor, JMOlefsky, pp. 785-796 Philadelphia: Lippincott Williams &Wilkins
    • (2004) Type 2 Diabetes Mellitus: A Fundamental and Clinical Text , pp. 785-796
    • Dabelea, D.1    Hamman, R.F.2
  • 7
    • 22844449583 scopus 로고    scopus 로고
    • The insulin resistance syndrome: Definition and dietary approaches to treatment
    • Reaven GM. 2005. The insulin resistance syndrome: definition and dietary approaches to treatment. Annu. Rev. Nutr. 25:391-406
    • (2005) Annu. Rev. Nutr. , vol.25 , pp. 391-406
    • Reaven, G.M.1
  • 8
    • 69449107263 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus: Etiology, pathogenesis, and natural history
    • 5th ed, ed. LJ DeGroot, JL Jameson, D deKrestser, AB Grossman, JC Marshall, et al., ch. Philadelphia: WB Saunders and Co.
    • Olefsky JM, Courtney CH. 2005. Type 2 diabetes mellitus: etiology, pathogenesis, and natural history. In DeGroot Textbook of Endocrinology, 5th ed, ed. LJ DeGroot, JL Jameson, D deKrestser, AB Grossman, JC Marshall, et al., ch. 56, pp. 1093-1117 Philadelphia: WB Saunders and Co.
    • (2005) DeGroot Textbook of Endocrinology , vol.56 , pp. 1093-1117
    • Olefsky, J.M.1    Courtney, C.H.2
  • 9
    • 0002678511 scopus 로고
    • Pathogenesis of noninsulin dependent (type II) diabetes mellitus
    • ed. GR Kahn, GC Weir Philadelphia: Lea & Febiger/Waverly
    • Weir GC, Leahy JL. 1 994. Pathogenesis of noninsulin dependent (type II) diabetes mellitus. In Joslin's Diabetes Mellitus, ed. GR Kahn, GCWeir, pp. 240-264 Philadelphia: Lea & Febiger/Waverly
    • (1994) Joslin's Diabetes Mellitus , pp. 240-264
    • Weir, G.C.1    Leahy, J.L.2
  • 10
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • Stumvoll M, Goldstein BJ, van Haeften TW. 2005. Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365:1333-1346
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    Van Haeften, T.W.3
  • 12
    • 33745899755 scopus 로고    scopus 로고
    • Insulin resistance
    • ed. D Porte Jr, RS Sherwin, A Baron New York: McGraw-Hill
    • Olefsky JM, Kruszynska YT. 2002. Insulin resistance. In Ellenberg & Rifkin's Diabetes Mellitus, ed. D Porte Jr, RS Sherwin, A Baron, pp. 367-400. New York: McGraw-Hill
    • (2002) Ellenberg & Rifkin's Diabetes Mellitus , pp. 367-400
    • Olefsky, J.M.1    Kruszynska, Y.T.2
  • 13
    • 0026641354 scopus 로고
    • Concordance for type 1 (insulin-dependent) and type 2 (noninsulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland
    • Kaprio J, Tuomilehto J, Koskenvuo M, Romanov K, Reunanen A, et al. 1992. Concordance for type 1 (insulin-dependent) and type 2 (noninsulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 35:1060-1067
    • (1992) Diabetologia , vol.35 , pp. 1060-1067
    • Kaprio, J.1    Tuomilehto, J.2    Koskenvuo, M.3    Romanov, K.4    Reunanen, A.5
  • 15
    • 0003014882 scopus 로고    scopus 로고
    • Metabolic consequences of a family history of NIDDM (the Botnia study): Evidence for sex-specific parental effects
    • Groop L, Forsblom C, Lehtovirta M, Tuomi T, Karanko S, et al. 1996. Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes 45:1585-1593
    • (1996) Diabetes , vol.45 , pp. 1585-1593
    • Groop, L.1    Forsblom, C.2    Lehtovirta, M.3    Tuomi, T.4    Karanko, S.5
  • 16
    • 43049146524 scopus 로고    scopus 로고
    • A HapMap harvest of insights into the genetics of common disease
    • Manolio TA, Brooks LD, Collins FS. 2008. A HapMap harvest of insights into the genetics of common disease. J. Clin. Investig. 118:1590-1605
    • (2008) J. Clin. Investig. , vol.118 , pp. 1590-1605
    • Manolio, T.A.1    Brooks, L.D.2    Collins, F.S.3
  • 17
    • 64549105734 scopus 로고    scopus 로고
    • Genome-wide association study for type 2 diabetes: Clinical applications
    • Lyssenko V, Groop L. 2009. Genome-wide association study for type 2 diabetes: clinical applications. Curr. Opin. Lipidol. 20:87-91
    • (2009) Curr. Opin. Lipidol. , vol.20 , pp. 87-91
    • Lyssenko, V.1    Groop, L.2
  • 18
    • 65949107547 scopus 로고    scopus 로고
    • Common genetic variation and human traits
    • Goldstein DB. 2009. Common genetic variation and human traits. N. Engl. J. Med. 360:1696-1698
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1696-1698
    • Goldstein, D.B.1
  • 19
    • 65949124249 scopus 로고    scopus 로고
    • Genomewide association studies-illuminating biologic pathways
    • Hirschhorn JN. 2009. Genomewide association studies-illuminating biologic pathways. N. Engl. J. Med. 360:1699-1701
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1699-1701
    • Hirschhorn, J.N.1
  • 20
    • 65949099120 scopus 로고    scopus 로고
    • Genetic risk prediction-Are we there yet?
    • Kraft P, Hunter DJ. 2009. Genetic risk prediction-Are we there yet? N. Engl. J. Med. 360:1701-1703
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1701-1703
    • Kraft, P.1    Hunter, D.J.2
  • 21
    • 40749105508 scopus 로고    scopus 로고
    • Variations in DNA elucidate molecular networks that cause disease
    • Chen Y, Zhu J, Lum PY, Yang X, Pinto S, et al. 2008. Variations in DNA elucidate molecular networks that cause disease. Nature 452:429-435
    • (2008) Nature , vol.452 , pp. 429-435
    • Chen, Y.1    Zhu, J.2    Lum, P.Y.3    Yang, X.4    Pinto, S.5
  • 23
    • 63449132586 scopus 로고    scopus 로고
    • Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
    • Yang X, Deignan JL, Qi H, Zhu J, Qian S, et al. 2009. Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat. Genet. 41:415-423
    • (2009) Nat. Genet. , vol.41 , pp. 415-423
    • Yang, X.1    Deignan, J.L.2    Qi, H.3    Zhu, J.4    Qian, S.5
  • 24
    • 44449124672 scopus 로고    scopus 로고
    • The secretory function of adipocytes in the physiology of white adipose tissue
    • Wang P, Mariman E, Renes J, Keijer J. 2008. The secretory function of adipocytes in the physiology of white adipose tissue. J. Cell Physiol. 216:3-13
    • (2008) J. Cell Physiol. , vol.216 , pp. 3-13
    • Wang, P.1    Mariman, E.2    Renes, J.3    Keijer, J.4
  • 25
    • 33747356154 scopus 로고    scopus 로고
    • Adipose tissue: From lipid storage compartment to endocrine organ
    • Scherer PE. 2006. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55:1537-1545
    • (2006) Diabetes , vol.55 , pp. 1537-1545
    • Scherer, P.E.1
  • 27
    • 33644815769 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein in Japanese patients with type 2 diabetes
    • Tajiri Y, Mimura K, Umeda F. 2005. High-sensitivity C-reactive protein in Japanese patients with type 2 diabetes. Obes. Res. 13:1810-1816
    • (2005) Obes. Res. , vol.13 , pp. 1810-1816
    • Tajiri, Y.1    Mimura, K.2    Umeda, F.3
  • 28
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. 1995. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J. Clin. Investig. 95:2409-2415
    • (1995) J. Clin. Investig. , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 30
    • 22944434929 scopus 로고    scopus 로고
    • Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    • Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, et al. 2005. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436:356-362
    • (2005) Nature , vol.436 , pp. 356-362
    • Yang, Q.1    Graham, T.E.2    Mody, N.3    Preitner, F.4    Peroni, O.D.5
  • 31
    • 31044456061 scopus 로고    scopus 로고
    • Diet induction of monocyte chemoattractant protein-1 and its impact on obesity
    • Chen A, Mumick S, Zhang C, Lamb J, Dai H, et al. 2005. Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. Obes. Res. 13:1311-1320
    • (2005) Obes. Res. , vol.13 , pp. 1311-1320
    • Chen, A.1    Mumick, S.2    Zhang, C.3    Lamb, J.4    Dai, H.5
  • 33
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, et al. 2002. A central role for JNK in obesity and insulin resistance. Nature 420:333-336
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3    Gorgun, C.Z.4    Uysal, K.T.5
  • 34
    • 23644448924 scopus 로고    scopus 로고
    • Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle
    • Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM. 2005. Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle. Diabetes 54:2351-2359
    • (2005) Diabetes , vol.54 , pp. 2351-2359
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 35
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and I-α
    • Itani SI, Ruderman NB, Schmieder F, Boden G. 2002. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and I -α. Diabetes 51:2005-2011
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 36
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, et al. 2007. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J. Biol. Chem. 282:35279-35292
    • (2007) J. Biol. Chem. , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3    Reichart, D.4    Scott, P.A.5
  • 37
    • 35548943962 scopus 로고    scopus 로고
    • JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
    • Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, et al. 2007. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 6:386-397
    • (2007) Cell Metab. , vol.6 , pp. 386-397
    • Solinas, G.1    Vilcu, C.2    Neels, J.G.3    Bandyopadhyay, G.K.4    Luo, J.L.5
  • 38
    • 20044387026 scopus 로고    scopus 로고
    • IKK-β links inflammation to obesityinduced insulin resistance
    • Arkan MC,Hevener AL, Greten FR, Maeda S, Li ZW, et al. 2005. IKK-β links inflammation to obesityinduced insulin resistance. Nat. Med. 11:191-198
    • (2005) Nat. Med. , vol.11 , pp. 191-198
    • Arkan McHevener, A.L.1    Greten, F.R.2    Maeda, S.3    Li, Z.W.4
  • 41
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. 1993. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259:87-91
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 42
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, et al. 2005. Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat. Med. 11:183-190
    • (2005) Nat. Med. , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5
  • 43
    • 0346880505 scopus 로고    scopus 로고
    • Inflammation and the IKKβ/I-β/NF-κB axis in obesity-and dietinduced insulin resistance
    • Shoelson SE, Lee J, Yuan M. 2003. Inflammation and the IKKβ/I-β/NF-κB axis in obesity-and dietinduced insulin resistance. Int. J. Obes. Relat. Metab. Disord. 27(Suppl. 3):S49-52
    • (2003) Int. J. Obes. Relat. Metab. Disord. , vol.27 , Issue.SUPPL. 3
    • Shoelson, S.E.1    Lee, J.2    Yuan, M.3
  • 44
    • 33845522287 scopus 로고    scopus 로고
    • Loss of resistin improves glucose homeostasis in leptin deficiency
    • Qi Y, Nie Z, Lee YS, Singhal NS, Scherer PE, et al. 2006. Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes 55:3083-3090
    • (2006) Diabetes , vol.55 , pp. 3083-3090
    • Qi, Y.1    Nie, Z.2    Lee, Y.S.3    Singhal, N.S.4    Scherer, P.E.5
  • 46
    • 0035487109 scopus 로고    scopus 로고
    • Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-γ action in humans
    • Savage DB, Sewter CP, Klenk ES, Segal DG, Vidal-Puig A, et al. 2001. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-γ action in humans. Diabetes 50:2199-2202
    • (2001) Diabetes , vol.50 , pp. 2199-2202
    • Savage, D.B.1    Sewter, C.P.2    Klenk, E.S.3    Segal, D.G.4    Vidal-Puig, A.5
  • 49
    • 67649869416 scopus 로고    scopus 로고
    • Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice
    • Qatanani M, Szwergold NR, Greaves DR, Ahima RS, Lazar MA. 2009. Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J. Clin. Investig. 119:531-539
    • (2009) J. Clin. Investig. , vol.119 , pp. 531-539
    • Qatanani, M.1    Szwergold, N.R.2    Greaves, D.R.3    Ahima, R.S.4    Lazar, M.A.5
  • 50
    • 46249117032 scopus 로고    scopus 로고
    • T-lymphocyte infiltration in visceral adipose tissue: A primary event in adipose tissue inflammation and the development of obesitymediated insulin resistance
    • Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, et al. 2008. T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesitymediated insulin resistance. Arterioscler. Thromb. Vasc. Biol. 28:1304-1310
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 1304-1310
    • Kintscher, U.1    Hartge, M.2    Hess, K.3    Foryst-Ludwig, A.4    Clemenz, M.5
  • 51
    • 65449140511 scopus 로고    scopus 로고
    • T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice
    • Sultan A, Strodthoff D, Robertson AK, Paulsson-Berne G, Fauconnier J, et al. 2009. T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice. Circ. Res. 104:961-968
    • (2009) Circ. Res. , vol.104 , pp. 961-968
    • Sultan, A.1    Strodthoff, D.2    Robertson, A.K.3    Paulsson-Berne, G.4    Fauconnier, J.5
  • 52
    • 54049086276 scopus 로고    scopus 로고
    • Interferon-γ, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity
    • Rocha VZ, Folco EJ, Sukhova G, Shimizu K, Gotsman I, et al. 2008. Interferon-γ, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ. Res. 103:467-476
    • (2008) Circ. Res. , vol.103 , pp. 467-476
    • Rocha, V.Z.1    Folco, E.J.2    Sukhova, G.3    Shimizu, K.4    Gotsman, I.5
  • 53
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer S, Chan Y, Paltser G, Truong D, Tsui H, et al. 2009. Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 15:921-929
    • (2009) Nat. Med. , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3    Truong, D.4    Tsui, H.5
  • 54
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, et al. 2009. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15:914-920
    • (2009) Nat. Med. , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5
  • 55
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, et al. 2009. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15:930-939
    • (2009) Nat. Med. , vol.15 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3    Naaz, A.4    Wong, J.5
  • 56
    • 53149119231 scopus 로고    scopus 로고
    • Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
    • Elgazar-Carmon V, Rudich A, Hadad N, Levy R. 2008. Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J. Lipid Res. 49:1894-1903
    • (2008) J. Lipid Res. , vol.49 , pp. 1894-1903
    • Elgazar-Carmon, V.1    Rudich, A.2    Hadad, N.3    Levy, R.4
  • 57
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG. 2008. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell. Metab. 8:301-309
    • (2008) Cell. Metab. , vol.8 , pp. 301-309
    • Patsouris, D.1    Li, P.P.2    Thapar, D.3    Chapman, J.4    Olefsky, J.M.5    Neels, J.G.6
  • 58
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-κB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. 2009. Regulation and function of NF-κB transcription factors in the immune system. Annu. Rev. Immunol. 27:693-733
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 60
    • 5144232850 scopus 로고    scopus 로고
    • A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation
    • Ogawa S, Lozach J, Jepsen K, Sawka-Verhelle D, Perissi V, et al. 2004. A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc. Natl. Acad. Sci. USA 101:14461-14466
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 14461-14466
    • Ogawa, S.1    Lozach, J.2    Jepsen, K.3    Sawka-Verhelle, D.4    Perissi, V.5
  • 61
    • 67649668789 scopus 로고    scopus 로고
    • Transcriptional integration of TLR2 and TLR4 signaling at the NCoR depression checkpoint
    • Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK. 2009. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR depression checkpoint. Mol. Cell 35:48-57
    • (2009) Mol. Cell , vol.35 , pp. 48-57
    • Huang, W.1    Ghisletti, S.2    Perissi, V.3    Rosenfeld, M.G.4    Glass, C.K.5
  • 62
    • 29244462334 scopus 로고    scopus 로고
    • Insulin signaling and the regulation of glucose transport
    • Chang L, Chiang SH, Saltiel AR. 2004. Insulin signaling and the regulation of glucose transport. Mol. Med. 10:65-71
    • (2004) Mol. Med. , vol.10 , pp. 65-71
    • Chang, L.1    Chiang, S.H.2    Saltiel, A.R.3
  • 63
    • 34147122535 scopus 로고    scopus 로고
    • Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance
    • Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, et al. 2007. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat. Med. 13:455-462
    • (2007) Nat. Med. , vol.13 , pp. 455-462
    • Lesniewski, L.A.1    Hosch, S.E.2    Neels, J.G.3    De Luca, C.4    Pashmforoush, M.5
  • 64
    • 48249117202 scopus 로고    scopus 로고
    • Blockade of α4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity
    • Feral CC, Neels JG, Kummer C, Slepak M, Olefsky JM, Ginsberg MH. 2008. Blockade of α4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity. Diabetes 57:1842-1851
    • (2008) Diabetes , vol.57 , pp. 1842-1851
    • Feral, C.C.1    Neels, J.G.2    Kummer, C.3    Slepak, M.4    Olefsky, J.M.5    Ginsberg, M.H.6
  • 65
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H,Tateya S,Tamori Y, Kotani K, Hiasa K, et al. 2006. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Investig. 116:1494-1505
    • (2006) J. Clin. Investig. , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3    Kotani, K.4    Hiasa, K.5
  • 66
    • 34548434020 scopus 로고    scopus 로고
    • Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue
    • Inouye KE, Shi H, Howard JK, Daly CH, Lord GM, et al. 2007. Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes 56:2242-2250
    • (2007) Diabetes , vol.56 , pp. 2242-2250
    • Inouye, K.E.1    Shi, H.2    Howard, J.K.3    Daly, C.H.4    Lord, G.M.5
  • 67
    • 34548419344 scopus 로고    scopus 로고
    • Adipocyte stress: The endoplasmic reticulum and metabolic disease
    • Gregor MG,Hotamisligil GS. 2007. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J. Lipid Res. 48:1905-1914
    • (2007) J. Lipid Res. , vol.48 , pp. 1905-1914
    • Gregor, M.G.1    Hotamisligil, G.S.2
  • 68
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D, Walter P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8:519-529
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 69
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK, Cnop M. 2008. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr. Rev. 29:42-61
    • (2008) Endocr. Rev. , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 70
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, et al. 2004. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-461
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3    Lee, A.H.4    Iwakoshi, N.N.5
  • 71
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, et al. 2006. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313:1137-1140
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vaillancourt, E.5
  • 72
    • 37449014525 scopus 로고    scopus 로고
    • Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice
    • Yoshiuchi K, Kaneto H, MatsuokaTA, Kohno K, Iwawaki T, et al. 2008. Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice. Biochem. Biophys. Res. Commun. 366:545-550
    • (2008) Biochem. Biophys. Res. Commun. , vol.366 , pp. 545-550
    • Yoshiuchi, K.1    Kaneto, H.2    Matsuokata Kohno, K.3    Iwawaki, T.4
  • 73
    • 46749084688 scopus 로고    scopus 로고
    • Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice
    • Furuhashi M, Fucho R, Gorgun CZ,Tuncman G, Cao H, Hotamisligil GS. 2008. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J. Clin. Investig. 118:2640-2650
    • (2008) J. Clin. Investig. , vol.118 , pp. 2640-2650
    • Furuhashi, M.1    Fucho, R.2    Gorgun Cztuncman, G.3    Cao, H.4    Hotamisligil, G.S.5
  • 74
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. 2007. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56:16-23
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 75
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR. 2007. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Investig. 117:175-184
    • (2007) J. Clin. Investig. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 76
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. 2003. Alternative activation of macrophages. Nat. Rev. Immunol. 3:23-35
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 77
    • 33745187112 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
    • Song MJ, Kim KH, Yoon JM, Kim JB. 2006. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem. Biophys. Res. Commun. 346:739-745
    • (2006) Biochem. Biophys. Res. Commun. , vol.346 , pp. 739-745
    • Song, M.J.1    Kim, K.H.2    Yoon, J.M.3    Kim, J.B.4
  • 78
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee JY, Sohn KH, Rhee SH,Hwang D. 2001. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 276:16683-16689
    • (2001) J. Biol. Chem. , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee Shhwang, D.3
  • 80
    • 34547602916 scopus 로고    scopus 로고
    • Loss-offunction mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, et al. 2007. Loss-offunction mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56:1986-1998
    • (2007) Diabetes , vol.56 , pp. 1986-1998
    • Tsukumo, D.M.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.3    Prada, P.O.4    Hirabara, S.M.5
  • 81
    • 70350389389 scopus 로고    scopus 로고
    • Hematopoeitic cell specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high fat-fed mice
    • Saberi M, Woods N-B, Luca C, Schnek S, Chin J, et al. 2009. Hematopoeitic cell specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high fat-fed mice. Cell Metab. In press
    • (2009) Cell Metab. in Press
    • Saberi, M.1    Woods, N.-B.2    Luca, C.3    Schnek, S.4    Chin, J.5
  • 82
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: Opening the x-files
    • DOI 10.1126/science.294.5548.1866
    • Chawla A, Repa J, Evans R, Mangelsdorf D. 2001. Nuclear receptors and lipid physiology: opening the X-files. Science 294:1866-1870 (Pubitemid 33101573)
    • (2001) Science , vol.294 , Issue.5548 , pp. 1866-1870
    • Chawta, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4
  • 83
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. 1998. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391:79-82
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 84
    • 0032560545 scopus 로고    scopus 로고
    • Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
    • Ricote M, Huang J, Fajas L, Li A,Welch J, et al. 1998. Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc. Natl. Acad. Sci. USA 95:7614-7619
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7614-7619
    • Ricote, M.1    Huang, J.2    Fajas, L.3    Li Awelch, J.4
  • 85
    • 0031888958 scopus 로고    scopus 로고
    • PPARγ agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C,TingAT, Seed B. 1998. PPARγ agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82-86
    • (1998) Nature , vol.391 , pp. 82-86
    • Ctingat, J.1    Seed, B.2
  • 86
    • 0031870652 scopus 로고    scopus 로고
    • Macrophages in human atheroma contain PPARγ: Differentiation- dependent peroxisomal proliferator-activated receptor γ expression and reduction of MMP-9 activity through PPARγ activation in mononuclear phagocytes in vitro
    • Marx N, Sukhova G, Murphy C, Libby P, Plutzky J. 1998. Macrophages in human atheroma contain PPARγ: differentiation-dependent peroxisomal proliferator-activated receptor γ expression and reduction of MMP-9 activity through PPARγ activation in mononuclear phagocytes in vitro. Am. J. Pathol. 153:17-23
    • (1998) Am. J. Pathol. , vol.153 , pp. 17-23
    • Marx, N.1    Sukhova, G.2    Murphy, C.3    Libby, P.4    Plutzky, J.5
  • 87
    • 34249907880 scopus 로고    scopus 로고
    • Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
    • Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, et al. 2007. Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J. Clin. Investig. 117:1658-1669
    • (2007) J. Clin. Investig. , vol.117 , pp. 1658-1669
    • Hevener, A.L.1    Olefsky, J.M.2    Reichart, D.3    Nguyen, M.T.4    Bandyopadyhay, G.5
  • 88
    • 34347354309 scopus 로고    scopus 로고
    • Macrophagespecific PPARγ controls alternative activation and improves insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Goforth MH,Morel CR, Subramanian V, et al. 2007. Macrophagespecific PPARγ controls alternative activation and improves insulin resistance. Nature 447:1116-1120
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth Mhmorel, C.R.3    Subramanian, V.4
  • 89
    • 64749086158 scopus 로고    scopus 로고
    • Preserved glucose tolerance in highfat-fed C57BL/6 mice transplanted with PPARγ -/-, PPARδ -/-, PPARγδ -/-, or LXRαβ -/-bone marrow
    • Marathe C, Bradley MN, Hong C, Chao L,Wilpitz D, et al. 2009. Preserved glucose tolerance in highfat-fed C57BL/6 mice transplanted with PPARγ -/-, PPARδ -/-, PPARγδ -/-, or LXRαβ -/-bone marrow. J. Lipid Res. 50:214-224
    • (2009) J. Lipid Res. , vol.50 , pp. 214-224
    • Marathe, C.1    Bradley, M.N.2    Hong, C.3    Chao Lwilpitz, D.4
  • 90
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARδ regulate macrophage polarization and insulin sensitivity
    • Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, et al. 2008. Adipocyte-derived Th2 cytokines and myeloid PPARδ regulate macrophage polarization and insulin sensitivity. Cell Metab. 7:485-495
    • (2008) Cell Metab. , vol.7 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3    Gangl, M.R.4    Fitzgerald, K.5
  • 91
    • 33746920337 scopus 로고    scopus 로고
    • Advanced glycation end products: Sparking the development of diabetic vascular injury
    • Goldin A, Beckman JA, Schmidt AM, Creager MA. 2006. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 114:597-605
    • (2006) Circulation , vol.114 , pp. 597-605
    • Goldin, A.1    Beckman, J.A.2    Schmidt, A.M.3    Creager, M.A.4
  • 92
    • 0344286498 scopus 로고    scopus 로고
    • Activation of receptor for advanced glycation end products: A mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis
    • Schmidt AM, Yan SD, Wautier JL, Stern D. 1999. Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ. Res. 84:489-497
    • (1999) Circ. Res. , vol.84 , pp. 489-497
    • Schmidt, A.M.1    Yan, S.D.2    Wautier, J.L.3    Stern, D.4
  • 93
    • 18544375186 scopus 로고    scopus 로고
    • RAGE is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease
    • Bucciarelli LG,Wendt T, Rong L, Lalla E, Hofmann MA, et al. 2002. RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease. Cell Mol. Life Sci. 59:1117-1128
    • (2002) Cell Mol. Life Sci. , vol.59 , pp. 1117-1128
    • Bucciarelli, L.G.1    Wendt, T.2    Rong, L.3    Lalla, E.4    Hofmann, M.A.5
  • 94
    • 0033538569 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways
    • Huttunen HJ, Fages C, Rauvala H. 1999. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J. Biol. Chem. 274:19919-19924
    • (1999) J. Biol. Chem. , vol.274 , pp. 19919-19924
    • Huttunen, H.J.1    Fages, C.2    Rauvala, H.3
  • 95
    • 0030994347 scopus 로고    scopus 로고
    • Induction ofTNFα and IL-1βmRNAin monocytes by methylglyoxal-and advanced glycated endproduct-modified human serum albumin
    • Webster L, Abordo EA, Thornalley PJ, Limb GA. 1997. Induction ofTNFα and IL-1βmRNAin monocytes by methylglyoxal-and advanced glycated endproduct-modified human serum albumin. Biochem. Soc. Trans. 25:S250
    • (1997) Biochem. Soc. Trans. , vol.25
    • Webster, L.1    Abordo, E.A.2    Thornalley, P.J.3    Limb, G.A.4
  • 98
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R. 2001. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:135-145
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 135-145
    • Medzhitov, R.1
  • 99
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO. 2009. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458:1191-1195
    • (2009) Nature , vol.458 , pp. 1191-1195
    • Park, B.S.1    Song, D.H.2    Kim, H.M.3    Choi, B.S.4    Lee, H.5    Lee, J.O.6
  • 100
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3    Liu, M.Y.4    Van Huffel, C.5
  • 101
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S. 2005. Toll-like receptors in innate immunity. Int. Immunol. 17:1-14
    • (2005) Int. Immunol. , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 102
    • 27744456905 scopus 로고    scopus 로고
    • Domain exchange between human tolllike receptors 1 and 6 reveals a region required for lipopeptide discrimination
    • Omueti KO, Beyer JM, Johnson CM,Lyle EA,Tapping RI. 2005. Domain exchange between human tolllike receptors 1 and 6 reveals a region required for lipopeptide discrimination. J. Biol. Chem. 280:36616-36625
    • (2005) J. Biol. Chem. , vol.280 , pp. 36616-36625
    • Omueti, K.O.1    Beyer, J.M.2    Johnson, C.M.3    Lyle, E.A.4    Tapping, R.I.5
  • 103
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, et al. 2005. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46:2347-2355
    • (2005) J. Lipid Res. , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3    Murano, I.4    Ceresi, E.5
  • 107
  • 109
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • Backhed F, Ding H,Wang T, Hooper LV, Koh GY, et al. 2004. The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. USA 101:15718-15723
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15718-15723
    • Backhed, F.1    Ding Hwang, T.2    Hooper, L.V.3    Koh, G.Y.4
  • 112
    • 24944489952 scopus 로고    scopus 로고
    • Stimulus specificity of gene expression programs determined by temporal control of IKK activity
    • Werner SL, Barken D, Hoffmann A. 2005. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science 309:1857-1861
    • (2005) Science , vol.309 , pp. 1857-1861
    • Werner, S.L.1    Barken, D.2    Hoffmann, A.3
  • 113
    • 0035444539 scopus 로고    scopus 로고
    • Signal transduction by tumor necrosis factor and its relatives
    • Baud V, Karin M. 2001. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 11:372-377
    • (2001) Trends Cell Biol. , vol.11 , pp. 372-377
    • Baud, V.1    Karin, M.2
  • 115
    • 33845970925 scopus 로고    scopus 로고
    • Parallel SUMOylation-dependent pathways mediate gene-and signal-specific transrepression by LXRs and PPARγ
    • Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, et al. 2007. Parallel SUMOylation-dependent pathways mediate gene-and signal-specific transrepression by LXRs and PPARγ. Mol. Cell 25:57-70
    • (2007) Mol. Cell , vol.25 , pp. 57-70
    • Ghisletti, S.1    Huang, W.2    Ogawa, S.3    Pascual, G.4    Lin, M.E.5
  • 116
    • 24144465889 scopus 로고    scopus 로고
    • Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
    • Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, et al. 2005. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 122:707-721
    • (2005) Cell , vol.122 , pp. 707-721
    • Ogawa, S.1    Lozach, J.2    Benner, C.3    Pascual, G.4    Tangirala, R.K.5
  • 117
    • 63049122784 scopus 로고    scopus 로고
    • Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
    • Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, et al. 2009. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 23:681-693
    • (2009) Genes Dev. , vol.23 , pp. 681-693
    • Ghisletti, S.1    Huang, W.2    Jepsen, K.3    Benner, C.4    Hardiman, G.5
  • 118
    • 1342264315 scopus 로고    scopus 로고
    • A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
    • Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. 2004. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 116:511-526
    • (2004) Cell , vol.116 , pp. 511-526
    • Perissi, V.1    Aggarwal, A.2    Glass, C.K.3    Rose, D.W.4    Rosenfeld, M.G.5
  • 119
    • 0034192756 scopus 로고    scopus 로고
    • A Core SMRT corepressor complex containing HDAC3 and TBL1, aWD40-repeat protein linked to deafness
    • Guenther M, Lane W, Fischle W, Verdin E, Lazar M. 2000. A Core SMRT corepressor complex containing HDAC3 and TBL1, aWD40-repeat protein linked to deafness. Genes Dev. 14:1048-1057
    • (2000) Genes Dev. , vol.14 , pp. 1048-1057
    • Guenther, M.1    Lane, W.2    Fischle, W.3    Verdin, E.4    Lazar, M.5
  • 120
    • 26444471700 scopus 로고    scopus 로고
    • A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
    • Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, et al. 2005. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ. Nature 437:759-763
    • (2005) Nature , vol.437 , pp. 759-763
    • Pascual, G.1    Fong, A.L.2    Ogawa, S.3    Gamliel, A.4    Li, A.C.5
  • 121
    • 33745833066 scopus 로고    scopus 로고
    • Activation of Ca2+-dependent signaling by TLR2
    • Chun J, Prince A. 2006. Activation of Ca2+-dependent signaling by TLR2. J. Immunol. 177:1330-1337
    • (2006) J. Immunol. , vol.177 , pp. 1330-1337
    • Chun, J.1    Prince, A.2
  • 122
    • 36749087548 scopus 로고    scopus 로고
    • Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    • Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, et al. 2007. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450:712-716
    • (2007) Nature , vol.450 , pp. 712-716
    • Milne, J.C.1    Lambert, P.D.2    Schenk, S.3    Carney, D.P.4    Smith, J.J.5
  • 123
    • 0037044575 scopus 로고    scopus 로고
    • The I-β-NF-κB signaling module: Temporal control and selective gene activation
    • Hoffmann A, Levchenko A, Scott ML, Baltimore D. 2002. The I-β-NF-κB signaling module: temporal control and selective gene activation. Science 298:1241-1245
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 124
    • 33646547951 scopus 로고    scopus 로고
    • Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
    • Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, et al. 2006. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 441:173-178
    • (2006) Nature , vol.441 , pp. 173-178
    • Gilchrist, M.1    Thorsson, V.2    Li, B.3    Rust, A.G.4    Korb, M.5
  • 125
    • 63049083734 scopus 로고    scopus 로고
    • ANurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    • Saijo K,Winner B, Carson CT, Collier JG, Boyer L, et al. 2009. ANurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137:47-59
    • (2009) Cell , vol.137 , pp. 47-59
    • Saijo Kwinner, B.1    Carson, C.T.2    Collier, J.G.3    Boyer, L.4
  • 126
    • 12144290761 scopus 로고    scopus 로고
    • Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo
    • Kim HJ, Higashimori T, Park SY, Choi H, Dong J, et al. 2004. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 53:1060-1067
    • (2004) Diabetes , vol.53 , pp. 1060-1067
    • Kim, H.J.1    Higashimori, T.2    Park, S.Y.3    Choi, H.4    Dong, J.5
  • 127
    • 42649140235 scopus 로고    scopus 로고
    • Immunobiology of the TAM receptors
    • Lemke G, Rothlin CV. 2008. Immunobiology of the TAM receptors. Nat. Rev. Immunol. 8:327-336
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 327-336
    • Lemke, G.1    Rothlin, C.V.2
  • 128
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. 2007. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131:1124-1136
    • (2007) Cell , vol.131 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.4    Lemke, G.5
  • 129
    • 0033559140 scopus 로고    scopus 로고
    • A novel receptor tyrosine kinase, Mer, inhibits TNF-α production and lipopolysaccharide-induced endotoxic shock
    • Camenisch TD, Koller BH, Earp HS, Matsushima GK. 1999. A novel receptor tyrosine kinase, Mer, inhibits TNF-α production and lipopolysaccharide- induced endotoxic shock. J. Immunol. 162:3498-3503
    • (1999) J. Immunol. , vol.162 , pp. 3498-3503
    • Camenisch, T.D.1    Koller, B.H.2    Earp, H.S.3    Matsushima, G.K.4
  • 130
    • 33746894720 scopus 로고    scopus 로고
    • Twist mediates suppression of inflammation by type i IFNs and Axl
    • Sharif MN, Sosic D, Rothlin CV, Kelly E, Lemke G, et al. 2006. Twist mediates suppression of inflammation by type I IFNs and Axl. J. Exp. Med. 203:1891-1901
    • (2006) J. Exp. Med. , vol.203 , pp. 1891-1901
    • Sharif, M.N.1    Sosic, D.2    Rothlin, C.V.3    Kelly, E.4    Lemke, G.5
  • 131
    • 0034284038 scopus 로고    scopus 로고
    • Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    • Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, et al. 2000. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96:1723-1732
    • (2000) Blood , vol.96 , pp. 1723-1732
    • Yokota, T.1    Oritani, K.2    Takahashi, I.3    Ishikawa, J.4    Matsuyama, A.5
  • 132
    • 4544334655 scopus 로고    scopus 로고
    • Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes
    • Wolf AM, Wolf D, Rumpold H, Enrich B, Tilg H. 2004. Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem. Biophys. Res. Commun. 323:630-635
    • (2004) Biochem. Biophys. Res. Commun. , vol.323 , pp. 630-635
    • Wolf, A.M.1    Wolf, D.2    Rumpold, H.3    Enrich, B.4    Tilg, H.5
  • 135
    • 40749111945 scopus 로고    scopus 로고
    • Mechanisms for the anti-inflammatory effects of adiponectin in macrophages
    • Huang H, Park PH, McMullen MR, Nagy LE. 2008. Mechanisms for the anti-inflammatory effects of adiponectin in macrophages. J. Gastroenterol. Hepatol. 23(Suppl. 1):S50-53
    • (2008) J. Gastroenterol. Hepatol. , vol.23 , Issue.SUPPL. 1
    • Huang, H.1    Park, P.H.2    McMullen, M.R.3    Nagy, L.E.4
  • 136
    • 0028972025 scopus 로고
    • 15-Deoxy-D12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
    • Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 1995. 15-Deoxy-D12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803-812
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.M.1    Tontonoz, P.2    Chen, J.3    Brun, R.P.4    Spiegelman, B.M.5    Evans, R.M.6
  • 137
    • 0034712933 scopus 로고    scopus 로고
    • 15-deoxy-δ 12,14-prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway
    • Straus DS, Pascual G, Li M,Welch JS, Ricote M, et al. 2000. 15-deoxy-δ 12,14-prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway. Proc. Natl. Acad. Sci. USA 97:4844-4849
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 4844-4849
    • Straus, D.S.1    Pascual, G.2    Li Mwelch, J.S.3    Ricote, M.4
  • 139
    • 33947500462 scopus 로고    scopus 로고
    • Resolvins and protectins in the termination program of acute inflammation
    • Ariel A, Serhan CN. 2007. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol. 28:176-183
    • (2007) Trends Immunol. , vol.28 , pp. 176-183
    • Ariel, A.1    Serhan, C.N.2
  • 140
    • 0038143617 scopus 로고    scopus 로고
    • Differential modulation of Toll-like receptors by fatty acids: Preferential inhibition by n-3 polyunsaturated fatty acids
    • Lee JY, Plakidas A, Lee WH, Heikkinen A, Chanmugam P, et al. 2003. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J. Lipid Res. 44:479-486
    • (2003) J. Lipid Res. , vol.44 , pp. 479-486
    • Lee, J.Y.1    Plakidas, A.2    Lee, W.H.3    Heikkinen, A.4    Chanmugam, P.5
  • 141
    • 34047166373 scopus 로고    scopus 로고
    • N-3 fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-α-dependent manner
    • Neschen S, Morino K, Dong J, Wang-Fischer Y, Cline GW, et al. 2007. n-3 fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-α-dependent manner. Diabetes 56:1034-1041
    • (2007) Diabetes , vol.56 , pp. 1034-1041
    • Neschen, S.1    Morino, K.2    Dong, J.3    Wang-Fischer, Y.4    Cline, G.W.5
  • 142
    • 0033595261 scopus 로고    scopus 로고
    • Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
    • Huang JT,Welch JS, Ricote M, Binder CJ,WillsonTM,et al. 1999. Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase. Nature 400:378-382
    • (1999) Nature , vol.400 , pp. 378-382
    • Huang Jtwelch, J.S.1    Ricote, M.2    Binder, C.J.3    Willson, T.M.4
  • 143
    • 33745428666 scopus 로고    scopus 로고
    • Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
    • Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, et al. 2006. Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation. Cell Metab. 4:13-24
    • (2006) Cell Metab. , vol.4 , pp. 13-24
    • Vats, D.1    Mukundan, L.2    Odegaard, J.I.3    Zhang, L.4    Smith, K.L.5
  • 144
    • 34347354309 scopus 로고    scopus 로고
    • Macrophagespecific PPARγ controls alternative activation and improves insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Goforth MH,Morel CR, Subramanian V, et al. 2007. Macrophagespecific PPARγ controls alternative activation and improves insulin resistance. Nature 447:1116-1120
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth Mhmorel, C.R.3    Subramanian, V.4
  • 145
    • 44349161098 scopus 로고    scopus 로고
    • Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, et al. 2008. Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance. Cell Metab. 7:496-507
    • (2008) Cell Metab. , vol.7 , pp. 496-507
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Red Eagle, A.3    Vats, D.4    Morel, C.R.5
  • 149
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, et al. 2001. Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ. Science 293:1673-1677
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5
  • 150
    • 64149121817 scopus 로고    scopus 로고
    • Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes
    • Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, et al. 2008. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin. Transl. Sci. 1:36-43
    • (2008) Clin. Transl. Sci. , vol.1 , pp. 36-43
    • Goldfine, A.B.1    Silver, R.2    Aldhahi, W.3    Cai, D.4    Tatro, E.5
  • 151
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
    • Lehmann JM,Moore LB, Smith-Oliver TA,Wilkison WO,Willson TM, Kliewer SA. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270:12953-12956
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann Jmmoore, L.B.1    Smith-Oliver, T.A.2    Wilkison, W.O.3    Willson, T.M.4    Kliewer, S.A.5
  • 152
    • 0031898610 scopus 로고    scopus 로고
    • PPARγ: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman BM. 1998. PPARγ: adipogenic regulator and thiazolidinedione receptor. Diabetes 47:507-514
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 153
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferatoractivated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
    • He W, Barak Y, Hevener A, Olson P, Liao D, et al. 2003. Adipose-specific peroxisome proliferatoractivated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proc. Natl. Acad. Sci. USA 100:15712-15717
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3    Olson, P.4    Liao, D.5
  • 154
    • 0346027235 scopus 로고    scopus 로고
    • Muscle-specific PPARγ deletion causes insulin resistance
    • Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, et al. 2003. Muscle-specific PPARγ deletion causes insulin resistance. Nat. Med. 9:1491-1497
    • (2003) Nat. Med. , vol.9 , pp. 1491-1497
    • Hevener, A.L.1    He, W.2    Barak, Y.3    Le, J.4    Bandyopadhyay, G.5
  • 155
    • 85047693638 scopus 로고    scopus 로고
    • Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    • Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, et al. 2003. Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J. Clin. Investig. 112:608-618
    • (2003) J. Clin. Investig. , vol.112 , pp. 608-618
    • Norris, A.W.1    Chen, L.2    Fisher, S.J.3    Szanto, I.4    Ristow, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.