Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 291, Issue 2, 2006, Pages

  Wei, Yuren ^a   Wang, Dong ^a   Topczewski, Farran ^a   Pagliassotti, Michael J ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Lipids; Lipoapoptosis; Unfolded protein response

Indexed keywords

BINDING PROTEIN; CASPASE; CCAAT ENHANCER BINDING PROTEIN; CERAMIDE; CHAPERONE; LINOLEIC ACID; MESSENGER RNA; OLEIC ACID; PALMITIC ACID; PROTEIN IRE1; PROTEIN IRE1ALPHA; PROTEIN X BOX BINDING PROTEIN 1; SATURATED FATTY ACID; STEARIC ACID; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HOMEOSTASIS; HUMAN; HUMAN CELL; LIPOGENESIS; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SEQUENCE HOMOLOGY; STRESS;

ANIMALS; APOPTOSIS; CELL LINE; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; FATTY ACIDS; HEPATOCYTES; OXIDATIVE STRESS; RATS;

EID: 33745828301     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00644.2005     Document Type: Article

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