Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

Current Biology

Volumn 14, Issue 18, 2004, Pages 1650-1656

  Shah, O Jameel ^a   Wang, Zhiyong ^a   Hunter, Tony ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROPEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PROTEIN; PROTEIN KINASE; REPRESSOR PROTEIN; RHEB PROTEIN, HUMAN; S6 KINASE; SOMATOMEDIN C; TUBERIN; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CELL CULTURE; CELL SURVIVAL; COMPARATIVE STUDY; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN RESISTANCE; METABOLISM; NORTHERN BLOTTING; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUBEROUS SCLEROSIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BLOTTING, NORTHERN; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; PHOSPHOPROTEINS; PROTEIN KINASES; PROTEINS; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 4544343980     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2004.08.026     Document Type: Article

References (12)

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