Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of velcade (PS-341/Bortezomib) cytotoxicity in myeloma cell lines

Cancer Research

Volumn 65, Issue 9, 2005, Pages 3828-3836

  Landowski, Terry H ^a,b   Megli, Christina J ^a,b   Nullmeyer, Kevin D ^a,b   Lynch, Ronald M ^a,b   Dorr, Robert T ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; BORTEZOMIB; CALCIUM ION; CASPASE 12; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; DANTROLENE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID ACETOXYMETHYL ESTER; GENE PRODUCT; OLIGONUCLEOTIDE; PROTEASOME INHIBITOR; RUTHENIUM; RUTHENIUM RED; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CLINICAL PATHWAY; CONTROLLED STUDY; CYTOTOXICITY; DNA MICROARRAY; DRUG MECHANISM; DRUG MEGADOSE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BORONIC ACIDS; CALCIUM; CASPASES; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENE EXPRESSION; HUMANS; ISOENZYMES; MITOCHONDRIA; MULTIPLE MYELOMA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEASE INHIBITORS; PYRAZINES;

EID: 18144431710     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-3684     Document Type: Article

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