Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Wiley, Jesse C ^a   Meabon, James S ^a   Frankowski, Harald ^a   Smith, Elise A ^a   Schecterson, Leslayann C ^a   Bothwell, Mark ^a   Ladiges, Warren C ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID PRECURSOR PROTEIN; ARYLBUTYRIC ACID DERIVATIVE; BREFELDIN A; GAL4VP16 PROTEIN; GAMMA SECRETASE; PROTEIN; THAPSIGARGIN; TRANSCRIPTION FACTOR GAL4; TUNICAMYCIN; UNCLASSIFIED DRUG; 4 PHENYLBUTYRIC ACID; 4-PHENYLBUTYRIC ACID; AMYLOID BETA PROTEIN; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; SECRETASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; ENZYME ASSAY; GENE MUTATION; NERVE CELL; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; RAT; ANIMAL; DOSE RESPONSE; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; TUMOR CELL LINE; WESTERN BLOTTING;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BREFELDIN A; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; NEURONS; PHENYLBUTYRATES; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; THAPSIGARGIN; TRANSFECTION; TUNICAMYCIN;

EID: 77949351808     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009135     Document Type: Article

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