Activating transcription factor 6 limits intracellular accumulation of mutant α 1-antitrypsin Z and mitochondrial damage in hepatoma cells

Journal of Biological Chemistry

Volumn 286, Issue 48, 2011, Pages 41563-41577

  Smith, Steven E ^a   Granell, Susana ^a   Salcedo Sicilia, Laia ^b   Baldini, Giovanna ^c   Egea, Gustavo ^b   Teckman, Jeff H ^d   Baldini, Giulia ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF TRIESTE   (Italy)

^d SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; ANTITRYPSIN; APOPTOTIC; AUTOPHAGY; CCAAT/ENHANCER-BINDING PROTEINS; CELL TOXICITY; DNA FRAGMENTATION; E3 LIGASE; ENDOPLASMIC RETICULUM; HEPATOCYTES; HEPATOMA CELLS; HOMOLOGOUS PROTEINS; INTRACELLULAR ACCUMULATION; MITOCHONDRIAL DAMAGE; PRO-APOPTOTIC FACTORS; PROTEASOMES; PROTEIN SYNTHESIS; SERINE PROTEASE INHIBITOR; TRANSGENIC MICE; UNFOLDED PROTEIN RESPONSE;

AMINO ACIDS; BIOSYNTHESIS; CELL MEMBRANES; CHEMICAL ACTIVATION; DEGRADATION; ENZYME INHIBITION; MITOCHONDRIA; TRANSCRIPTION; TRANSCRIPTION FACTORS; TUMORS;

ENZYME ACTIVITY;

ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA 1 ANTITRYPSIN; ALPHA 1 ANTITRYPSIN Z; CELL DNA; GLUTAMIC ACID; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LYSINE; MUTANT PROTEIN; PROTEASOME; PROTEIN HRD1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOACCUMULATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM; HEPATOMA CELL; HOMEOSTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; PROTEIN UNFOLDING; PROTEIN VARIANT; TRANSCRIPTION INITIATION;

ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA 1-ANTITRYPSIN; AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM; MICE; MITOCHONDRIA, LIVER; MUTATION, MISSENSE; NEOPLASM PROTEINS; PROTEOLYSIS; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE;

EID: 82355184462     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.280073     Document Type: Article

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