메뉴 건너뛰기




Volumn 81, Issue 2, 2001, Pages 741-766

Alzheimer's disease: Genes, proteins, and therapy

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2;

EID: 0035066332     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2001.81.2.741     Document Type: Review
Times cited : (5427)

References (216)
  • 45
    • 0032525964 scopus 로고    scopus 로고
    • LIN-12/Notch signaling: Lessons from worms and flies
    • (1998) Genes Dev , vol.12 , pp. 1751-1762
    • Greenwald, I.1
  • 49
    • 0026325645 scopus 로고
    • Processing of β-amyloid precursor protein in microglia and astrocytes favors a localization in internal vesicles over constitutive secretion
    • (1991) J Neurosci , vol.11 , pp. 3783-3793
    • Haass, C.1    Hung, A.Y.2    Selkoe, D.J.3
  • 66
    • 0028057224 scopus 로고
    • Selective ectodomain phosphorylation and regulated cleavage of β-amyloid precursor protein
    • (1994) EMBO J , vol.13 , pp. 534-542
    • Hung, A.Y.1    Selkoe, D.J.2
  • 81
    • 0028276801 scopus 로고
    • Evidence that production and release of amyloid β-protein involves the endocytic pathway
    • (1994) J Biol Chem , vol.269 , pp. 17386-17389
    • Koo, E.H.1    Squazzo, S.2
  • 93
    • 0029116848 scopus 로고
    • Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
    • (1995) Nature , vol.377 , pp. 351-354
    • Levitan, D.1    Greenwald, I.2
  • 97
    • 0034621824 scopus 로고    scopus 로고
    • Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
    • (2000) Nature , vol.405 , pp. 689-694
    • Li, Y.-M.1    Xu, M.2    Lai, M.-T.3
  • 106
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • (1995) Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 113
    • 0022723508 scopus 로고
    • One of the antigenic determinants of paired helical filaments is related to tau protein
    • (1986) J Biochem , vol.99 , pp. 1541-1544
    • Nukina, N.1    Ihara, Y.2
  • 149
    • 0031038918 scopus 로고    scopus 로고
    • Alzheimer's disease: Genotypes, phenotype, and treatments
    • (1997) Science , vol.275 , pp. 630-631
    • Selkoe, D.J.1
  • 150
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • (1999) Nature , vol.399
    • Selkoe, D.J.1
  • 171
    • 0033639117 scopus 로고    scopus 로고
    • Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
    • (2000) Mol Cell , vol.6 , pp. 625-636
    • Struhl, G.1    Adachi, A.2
  • 172
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • (1999) Nature , vol.398 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 184
    • 0029569152 scopus 로고
    • Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: Focusing on phosphatases
    • (1995) FASEB J , vol.9 , pp. 1570-1576
    • Trojanowski, J.Q.1    Lee, V.M.2
  • 210
    • 0032440973 scopus 로고    scopus 로고
    • Characterization of Drosophila Presenilin and its colocalization with Notch during development
    • (1998) Mech Dev , vol.79 , pp. 199-211
    • Ye, Y.1    Fortini, M.E.2
  • 216
    • 0030604067 scopus 로고    scopus 로고
    • Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier
    • (1996) Life Sci , vol.59 , pp. 1483-1497
    • Zlokovic, B.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.